Condition: Recurrent Glioblastoma
Interventions: Diagnostic Test: ChemoID assay; Drug: Chemotherapy
Sponsor: Cordgenics, LLC
Recruiting
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Standard Chemotherapy vs. Chemotherapy Guided by Cancer Stem Cell Test in Recurrent Glioblastoma
Posted: August 15th, 2018, 2:00pm GMT
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Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM
Posted: August 14th, 2018, 2:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme; GBM; Brain Cancer
Intervention: Procedure: Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB)
Sponsor: Northwell Health
Recruiting -
Study to Develop Head Stabilizer for Use During Brain Radiation Therapy
Posted: August 14th, 2018, 2:00pm GMT
Conditions: Brain Diseases; Brain Cancer
Interventions: Device: Wiersma Head Stabilizer; Device: AlignRT system
Sponsor: University of Chicago
Recruiting -
Combination Chemotherapy With Pazopanib in Children and Adolescents With Relapsed/Refractory Solid Tumors
Posted: August 14th, 2018, 2:00pm GMT
Conditions: Relapsed Pediatric Solid Tumor; Refractory Pediatric Solid Tumor
Intervention: Drug: Pazopanib+conventional chemotherapy
Sponsors: Samsung Medical Center; Ministry of health & welfare, Republic of Korea
Recruiting -
The Impact of Neurocognitive Function in Patients With Multiple Brain Metastases Receiving Whole Brain Radiation Therapy
Posted: August 13th, 2018, 2:00pm GMT
Condition: Brain Metastases
Intervention:
Sponsor: Guangdong Association of Clinical Trials
Not yet recruiting -
Safety of BBB Disruption Using NaviFUS System in Recurrent Glioblastoma Multiforme (GBM) Patients
Posted: August 13th, 2018, 2:00pm GMT
Conditions: Glioblastoma Multiforme; Brain Tumor; Neoplasms; Neoplasms, Nerve Tissue; Neoplasms, Glandular and Epithelial; Neoplasms, Germ Cell and Embryonal; Neoplasms, Neuroepithelial; Neuroectodermal Tumors; Neoplasms by Histologic Type
Intervention: Device: NaviFUS System
Sponsors: NaviFUS Corporation; Chang Gung Memorial Hospital
Not yet recruiting -
Prediction of Sphenoid Septation in MRI Compared With CT and Intraoperative Findings During Endoscopic Pituitary Adenoma Surgery
Posted: August 9th, 2018, 2:00pm GMT
Condition: Pituitary Adenoma
Intervention: Procedure: comparison of data from MRI with data from CT compared with intraoperative data from endoscopic pituitary adenoma surgery
Sponsor: University Hospital, Basel, Switzerland
Recruiting -
Role of MR Spectroscopy in Brain Tumors
Posted: August 8th, 2018, 2:00pm GMT
Condition: Brain Neoplasms
Intervention: Device: MRI Spectroscopy
Sponsor: Assiut University
Recruiting -
Randomized Control Trial for Awake vs. Asleep Craniotomy for Non-eloquent Gliomas
Posted: August 8th, 2018, 2:00pm GMT
Condition: Intracranial Glioma
Interventions: Procedure: Awake Anesthesia Protocol; Procedure: Non-awake Anesthesia Protocol
Sponsor: Mayo Clinic
Not yet recruiting -
Assessment of Sensory Gating, Attention, and Executive Control in Breast Cancer
Posted: August 7th, 2018, 2:00pm GMT
Condition: Breast Cancer
Interventions: Other: SAE battery; Behavioral: Assessments
Sponsors: Memorial Sloan Kettering Cancer Center; The City College of New York
Recruiting -
Brain Monitoring for High Risk of Brain Metastases in Metastatic Breast Cancer
Posted: August 6th, 2018, 2:00pm GMT
Conditions: Metastatic Breast Cancer With HER2 Positive; Triple Negative Breast Cancer
Intervention: Procedure: Brain MRI
Sponsor: Yonsei University
Not yet recruiting -
Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption for Treatment of Glioma
Posted: August 6th, 2018, 2:00pm GMT
Condition: Glioblastoma
Intervention: Device: Focused Ultrasound (FUS) BBB Disruption
Sponsor: InSightec
Not yet recruiting -
Predictive Role and HuR Mechanisms of Regulation in the Brain Tumours
Posted: August 3rd, 2018, 2:00pm GMT
Condition: Brain Tumours
Intervention:
Sponsor: Central Hospital, Nancy, France
Recruiting -
The Effect of Vitamin D3 on Postoperative Pain in Patients Undergoing Craniotomy
Posted: August 3rd, 2018, 2:00pm GMT
Condition: Brain Neoplasms
Intervention: Drug: vitamin D
Sponsor: Shahid Beheshti University
Recruiting -
Cytomegalovirus (CMV) RNA-Pulsed Dendritic Cells for Pediatric Patients With Newly Diagnosed Glioblastoma, Recurrent Malignant Glioma or Recurrent Medulloblastoma
Posted: August 3rd, 2018, 2:00pm GMT
Conditions: Glioblastoma; Malignant Glioma; Medulloblastoma Recurrent; Pediatric Glioblastoma Multiforme; Pediatric Brain Tumor, Recurrent; Pediatric Brain Tumor
Interventions: Biological: CMV-DCs with GM-CSF; Biological: Td (tetanus toxoid)
Sponsors: Gary Archer Ph.D.; National Institutes of Health (NIH)
Not yet recruiting -
ANG1005 in Leptomeningeal Disease From Breast Cancer
Posted: August 3rd, 2018, 2:00pm GMT
Conditions: Leptomeningeal Carcinomatosis; Leptomeningeal Metastases; Brain Metastases; HER2-negative Breast Cancer
Interventions: Drug: ANG1005; Drug: Physician's Best Choice
Sponsor: Angiochem Inc
Not yet recruiting -
Neurocognitive Risks in Children With Solid Tumors
Posted: August 1st, 2018, 2:00pm GMT
Condition: Solid Tumor in Children
Interventions: Other: The WISC-IV; Other: The CMS (CHILD MEMORY SCALE); Other: CONNERS; Other: BRIEF; Other: PEDS-QL; Other: State Trait Anxiety Inventory; Other: Child Depression Inventory
Sponsor: Gustave Roussy, Cancer Campus, Grand Paris
Recruiting -
A Trial for Treatment of Cancer Patients With Multiple Brain Metastases Undergoing Whole-Brain Radiotherapy
Posted: July 31st, 2018, 2:00pm GMT
Condition: Multiple Brain Metastases
Interventions: Drug: BMX-001; Radiation: Whole Brain Radiation Therapy
Sponsors: BioMimetix JV, LLC; Duke Cancer Institute; National Cancer Institute (NCI)
Not yet recruiting -
Navigated Repetitive Transcranial Magnetic Stimulation in Improving Motor Rehabilitation in Participants With Grade II-IV Brain Tumors
Posted: July 30th, 2018, 2:00pm GMT
Condition: Brain Neoplasm
Interventions: Other: Questionnaire Administration; Procedure: Transcranial Magnetic Stimulation
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Not yet recruiting -
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Posted: July 30th, 2018, 2:00pm GMT
Conditions: High Grade Glioma; Diffuse Intrinsic Pontine Glioma
Intervention: Drug: PTC596
Sponsors: Children's Hospital Medical Center, Cincinnati; PTC Therapeutics
Not yet recruiting -
CBF and NCF Changes With Brain Radiation
Posted: July 30th, 2018, 2:00pm GMT
Conditions: Neurocognitive Dysfunction; Brain Metastases
Interventions: Radiation: SRS and neurocognitive assessments; Radiation: WBRT and neurocognitive assessments
Sponsor: University Health Network, Toronto
Not yet recruiting -
Evaluation of Preoperative Functional Magnetic Resonance Imaging (fMRI) in Patients With Brain Tumors
Posted: July 27th, 2018, 2:00pm GMT
Condition: Brain Tumor
Intervention: Device: fMRI Paradigms
Sponsors: Memorial Sloan Kettering Cancer Center; Weill Medical College of Cornell University
Recruiting -
A Study of the Effect of Blood Stem Cell Transplant After Chemotherapy Alone in Patients With Fanconi Anemia
Posted: July 26th, 2018, 2:00pm GMT
Conditions: Fanconi Anemia; Myelodysplastic Syndrome (MDS); Acute Myelogenous Leukemia (AML)
Interventions: Drug: Busulfan; Drug: Fludarabine; Drug: Cyclophosphamide; Drug: Anti-Thymocyte Globulin (Rabbit); Device: The CliniMACS device; Drug: G-CSF
Sponsors: Memorial Sloan Kettering Cancer Center; Pediatric Brain Tumor Consortium
Recruiting -
Volitinib in Treating Participants With Recurrent or Refractory Primary CNS Tumors
Posted: July 25th, 2018, 2:00pm GMT
Conditions: MET Fusion Gene Positive; MET Gene Mutation; Primary Central Nervous System Neoplasm; Progressive Medulloblastoma; Recurrent Diffuse Intrinsic Pontine Glioma; Recurrent Malignant Glioma; Recurrent Medulloblastoma; Refractory Diffuse Intrinsic Pontine Glioma; Refractory Malignant Glioma; Refractory Medulloblastoma
Intervention: Drug: Volitinib
Sponsor: National Cancer Institute (NCI)
Not yet recruiting -
Trial of Parotid Sparing Whole Brain Radiation
Posted: July 23rd, 2018, 2:00pm GMT
Condition: Xerostomia
Interventions: Radiation: Parotid sparing WBRT; Radiation: Standard WBRT
Sponsors: UNC Lineberger Comprehensive Cancer Center; UNC Department of Radiation Oncology
Recruiting -
A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas
Posted: July 20th, 2018, 2:00pm GMT
Conditions: Glioma; BRAF V600E; Pleomorphic Xantho-Astrocytoma; Glioblastoma
Intervention: Procedure: Surgical Cohort
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Musella Foundation
Recruiting -
Neurosurgical Transitional Care Programme
Posted: July 20th, 2018, 2:00pm GMT
Conditions: Surgery; Brain Tumor; Brain Tumor, Recurrent; Brain Pathology; Spinal Diseases; Spinal Stenosis; Spinal Fusion; Trigeminal Neuralgia; Hydrocephalus; Fusion of Spine; Aneurysm; SPINAL Fracture; Chiari; Net; Skull Injuries; Brain Cancer; Brain Metastases; Brain Diseases; Brain Lesion; Brain Cyst; Spinal Curvature; Spinal Instability; Spinal Cord Neoplasms
Intervention: Other: Transitional Care Programme
Sponsors: Barts & The London NHS Trust; Brigham and Women's Hospital; Harvard Medical School
Recruiting -
Therapeutic Targeting of Sex Differences in Pediatric Brain Tumor Glycolysis
Posted: July 19th, 2018, 2:00pm GMT
Condition: Pediatric Brain Tumor
Interventions: Procedure: Ketogenic diet; Drug: BCNU
Sponsor: Washington University School of Medicine
Not yet recruiting -
Clinical Study of Structural and Functional Evaluation of the Visual Pathway
Posted: July 19th, 2018, 2:00pm GMT
Conditions: Pituitary Adenoma; Visual Impairment; Sellar Tumor; Neuroimaging
Interventions: Diagnostic Test: resting state fMRI; Diagnostic Test: visual tasking state fMRI; Diagnostic Test: diffusion tensor imaging; Diagnostic Test: automated visual field; Diagnostic Test: visual acuity
Sponsor: Xiangya Hospital of Central South University
Not yet recruiting -
Creating a Decision Support System for the Corporate Management of Physical Therapy
Posted: July 13th, 2018, 2:00pm GMT
Conditions: Childhood Acute Lymphoblastic Leukemia in Remission; Childhood Brain Tumor; Physical Activity; Physical Disability
Intervention:
Sponsor: Federal Research Institute of Pediatric Hematology, Oncology and Immunology
Recruiting -
Neuropsychological and Brain Medical Imaging Study in Patients With Brain Damage 2
Posted: July 13th, 2018, 2:00pm GMT
Conditions: Cerebrovascular Disorders; Brain Lesion; Degenerative Disease; Developmental Disability
Interventions: Behavioral: Neuropsychological testing; Other: Brain Imaging; Other: Galvanic Vestibular Stimulation (GVS)
Sponsor: University Hospital, Caen
Recruiting -
Dose and Volume Escalation of Preoperative Brain Irradiation in GBM Patients -the POBIG Trial -
Posted: July 11th, 2018, 2:00pm GMT
Condition: Glioblastoma Multiforme
Intervention: Radiation: Preoperative brain irradiation (single fraction)
Sponsor: The Netherlands Cancer Institute
Not yet recruiting -
DOTATOC PET/CT for Imaging NET Patients
Posted: July 11th, 2018, 2:00pm GMT
Conditions: Neuroendocrine Tumors; Insulinoma; Gastrinoma; Glucagonoma; Vipoma; Pheochromocytoma; Paraganglioma; Neuroblastoma; Ganglioneuroma; Medullary Carcinoma; Pituitary Adenoma; Medulloblastoma; Merkel Cell Carcinoma; Small-cell Lung Cancer; Meningioma; Carcinoid
Interventions: Diagnostic Test: 68Ga-DOTATOC PET/CT; Diagnostic Test: 18F-FDG PET/CT
Sponsor: British Columbia Cancer Agency
Recruiting -
Study of Tozuleristide and the Canvas Imaging System in Pediatric Subjects With CNS Tumors Undergoing Surgery
Posted: July 6th, 2018, 2:00pm GMT
Condition: Pediatric Central Nervous System Tumor
Interventions: Drug: tozuleristide; Device: Canvas System
Sponsors: Blaze Bioscience Inc.; Pacific Pediatric Neuro-Oncology Consortium
Not yet recruiting -
Effect of Exercise on Cancer-Related Fatigue
Posted: July 3rd, 2018, 2:00pm GMT
Conditions: Cancer-related Problem/Condition; Exercise
Interventions: Behavioral: TEHE only; Behavioral: Auricular Point Acupressure; Behavioral: Mindfulness body scan
Sponsor: Johns Hopkins University
Not yet recruiting -
Magnesium Sulphate Versus Lidocaine for Control of Emergence Hypertension
Posted: June 25th, 2018, 2:00pm GMT
Conditions: Craniotomy; Hypertension
Interventions: Drug: Magnesium sulphate; Drug: Lidocaine Hydrochloride; Drug: Normal saline
Sponsor: Ahmed Mohamed ELbadawy
Recruiting -
Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Detecting Lactate and Bicarbonate in Participants With Central Nervous System Tumors
Posted: June 21st, 2018, 2:00pm GMT
Conditions: Malignant Central Nervous System Neoplasm; Metastatic Malignant Neoplasm in the Central Nervous System
Interventions: Other: Gadolinium; Drug: Hyperpolarized Carbon C 13 Pyruvate; Procedure: Magnetic Resonance Imaging; Procedure: Magnetic Resonance Spectroscopic Imaging
Sponsor: Daniel M. Spielman
Not yet recruiting -
Hypofractionated Brain Radiationcavity
Posted: June 19th, 2018, 2:00pm GMT
Conditions: Brain Metastases, Adult; Cancer Brain
Interventions: Radiation: IGRT; Radiation: SRS
Sponsor: Oncology Institute of Southern Switzerland
Recruiting -
3D-Prediction of Patient-Specific Response
Posted: June 19th, 2018, 2:00pm GMT
Condition: Cancer, Advanced
Intervention: Diagnostic Test: EV3D Assay
Sponsor: Kiyatec
Recruiting -
Stereotactic Radiosurgery Compared With Whole Brain Radiotherapy (WBRT) for 5-15 Brain Metastases
Posted: June 8th, 2018, 2:00pm GMT
Condition: Brain Metastases
Interventions: Drug: Memantine; Radiation: Whole Brain Radiotherapy (WBRT); Procedure: Stereotactic Radiosurgery (SRS)
Sponsors: Canadian Cancer Trials Group; Alliance for Clinical Trials in Oncology
Not yet recruiting -
Dendritic Cell Immunotherapy Against Cancer Stem Cells in Glioblastoma Patients Receiving Standard Therapy
Posted: June 7th, 2018, 2:00pm GMT
Condition: Glioblastoma
Interventions: Biological: Dendritic cell immunization; Drug: Adjuvant temozolomide
Sponsor: Oslo University Hospital
Recruiting -
Radiation- Induced Alopecia in Patients Undergoing Radiation Therapy to the Brain
Posted: June 1st, 2018, 2:00pm GMT
Condition: Alopecia; X-Rays
Intervention: Radiation: radiation therapy to brain
Sponsor: Fortis Memorial Research Institute
Recruiting -
Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas
Posted: May 31st, 2018, 2:00pm GMT
Condition: Brain Tumor Adult
Interventions: Other: MR Perfusion Scan; Other: 2HG Spectroscopy Scan
Sponsor: University of Utah
Recruiting -
Feasibility and Preliminary Efficacy of a Mindfulness-based Intervention for Children With High Grade Brain Tumors and Their Caregivers
Posted: May 28th, 2018, 2:00pm GMT
Conditions: Gliomas; Glioblastomas; Astrocytoma; Brain Neoplasm; Brain Cancer
Interventions: Behavioral: Enhanced Mindfulness Intervention; Behavioral: Psychoeducation
Sponsor: National Cancer Institute (NCI)
Recruiting -
[18F]DASA-23 and PET Scan in Evaluating Pyruvate Kinase M2 Expression in Patients With Intracranial Tumors or Recurrent Glioblastoma and Healthy Volunteers
Posted: May 28th, 2018, 2:00pm GMT
Conditions: Healthy Subject; Intracranial Neoplasm; Recurrent Glioblastoma
Interventions: Drug: Fluorine F 18 DASA-23; Procedure: Positron Emission Tomography
Sponsor: Sanjiv Sam Gambhir
Recruiting -
Cognitive Support Program for Patients With Brain Metastases
Posted: May 25th, 2018, 2:00pm GMT
Condition: Metastases, CNS
Intervention: Behavioral: Cognitive Support Program
Sponsor: University Health Network, Toronto
Recruiting -
Ibrutinib With Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma
Posted: May 24th, 2018, 2:00pm GMT
Condition: Glioblastoma
Interventions: Drug: Ibrutinib; Radiation: Radiation; Drug: Temozolomide (TMZ)
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting -
Osimertinib With Stereotactic Radiosurgery (SRS) in Brain Metastases From EGFR Positive NSCLC
Posted: May 24th, 2018, 2:00pm GMT
Conditions: NSCLC; Non-small Cell Lung Cancer
Intervention: Drug: Osimertinib
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting -
Lactate Levels Correlates With Ki-67 in Brain Tumor Surgery
Posted: May 21st, 2018, 2:00pm GMT
Conditions: Brain Tumor; Anesthesia
Intervention: Other: Data correlation
Sponsor: Ricard Valero
Recruiting -
Intraoperative Ultrasound Guided Glioma Surgery; a Randomised, Controlled Trial.
Posted: May 21st, 2018, 2:00pm GMT
Condition: Glioma
Intervention: Procedure: ultrasound guided surgery.
Sponsors: Erasmus Medical Center; Stichting Coolsingel
Recruiting -
TN-TC11G (THC+CBD) Combination With Temozolomide and Radiotherapy in Patients With Newly-diagnosed Glioblastoma
Posted: May 18th, 2018, 2:00pm GMT
Condition: Glioblastoma
Interventions: Drug: TN-TC11G; Drug: Temozolomide Oral Product; Radiation: Radiotherapy
Sponsors: Grupo Español de Investigación en Neurooncología; Medical Cannabis Bike Tour; Voices Against Brain Cancer; Tilray
Not yet recruiting -
CB-839 With Radiation Therapy and Temozolomide in Treating Participants With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma
Posted: May 18th, 2018, 2:00pm GMT
Conditions: Anaplastic Astrocytoma, IDH-Mutant; Diffuse Astrocytoma, IDH-Mutant; IDH1 Gene Mutation; IDH2 Gene Mutation
Interventions: Drug: Glutaminase Inhibitor CB-839 Hydrochloride; Other: Questionnaire Administration; Radiation: Radiation Therapy; Drug: Temozolomide
Sponsor: National Cancer Institute (NCI)
Not yet recruiting -
Prospective Cohort of Patients With Newly Diagnosed Glioblastoma: Analysis of MMP2 and MMP9 Expression and Correlation to Neuro-imaging Features.
Posted: May 16th, 2018, 2:00pm GMT
Condition: Brain Tumor
Interventions: Biological: Blood sample; Biological: Tumor sample
Sponsor: Assistance Publique Hopitaux De Marseille
Recruiting -
Molecular Imaging and Spectroscopy With Stable Isotopes in Oncology and Neurology
Posted: May 16th, 2018, 2:00pm GMT
Condition: Ovarian Cancer
Intervention: Diagnostic Test: MRI scan and FDG-PET scan
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Recruiting -
Atezolizumab in Combination With Carboplatin Plus Pemetrexed in Chemotherapy-naïve Patients With Asymptomatic Brain Metastasis
Posted: May 16th, 2018, 2:00pm GMT
Condition: Non-small Cell Lung Cancer Stage IV
Intervention: Drug: Atezolizumab
Sponsor: Spanish Lung Cancer Group
Recruiting -
Comparison of 6-fluoro-[18F]-L-dihydroxyphenylalanine (18F-DOPA) Positron Emission Tomography (PET) and Multiparametric Resonance Magnetic Imagery (RMI) in Initial Exploration of Glial Tumors
Posted: May 15th, 2018, 2:00pm GMT
Conditions: Brain Neoplasms; Adult Brain Tumor
Intervention: Diagnostic Test: PET imagery
Sponsor: Center Eugene Marquis
Not yet recruiting -
Short Course Radiation Therapy in Palliative Treatment of Brain Metastases
Posted: May 15th, 2018, 2:00pm GMT
Conditions: Brain Metastases; Radiotherapy; Palliative Care
Interventions: Radiation: standard treatment; Radiation: short course treatment
Sponsor: Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi
Recruiting -
Regorafenib and Methotrexate in Treating Participants With Recurrent or Metastatic KRAS Mutated Non-Small Cell Lung Cancer
Posted: May 10th, 2018, 2:00pm GMT
Conditions: KRAS Gene Mutation; Metastatic Malignant Neoplasm in the Brain; Recurrent Non-Small Cell Lung Carcinoma; Stage IV Non-Small Cell Lung Cancer AJCC v7
Interventions: Drug: Methotrexate; Other: Pharmacokinetic Study; Drug: Regorafenib
Sponsor: Stanford University
Not yet recruiting -
PD-L1 PET Imaging in Melanoma Patients
Posted: May 10th, 2018, 2:00pm GMT
Condition: Melanoma
Intervention: Other: PD-L1 PET imaging
Sponsor: University Medical Center Groningen
Recruiting -
Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases
Posted: May 9th, 2018, 2:00pm GMT
Condition: Leptomeningeal Metastases
Intervention: Radiation: Proton craniospinal irradiation (CSI)
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting -
Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery
Posted: April 27th, 2018, 2:00pm GMT
Conditions: Malignant Brain Neoplasm; Malignant Glioma
Interventions: Procedure: Near-Infrared Fluorescence Imaging; Biological: Panitumumab; Drug: Panitumumab-IRDye800; Other: Pharmacokinetic Study; Procedure: Surgical Procedure
Sponsor: Eben Rosenthal
Recruiting -
Neurocognitive Decline in Patients With Brain Metastases
Posted: April 26th, 2018, 2:00pm GMT
Condition: Brain Metastases
Intervention: Radiation: Stereotactic Radiosurgery
Sponsor: University of Texas Southwestern Medical Center
Recruiting -
Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD
Posted: April 18th, 2018, 2:00pm GMT
Conditions: Metastatic Breast Cancer; Leptomeningeal Disease
Interventions: Drug: Tucatinib; Drug: Trastuzumab; Drug: Capecitabine
Sponsors: University of Alabama at Birmingham; Cascadian Therapeutics Inc.; Translational Breast Cancer Research Consortium
Not yet recruiting -
INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)
Posted: April 9th, 2018, 2:00pm GMT
Condition: Glioblastoma
Interventions: Biological: INO-5401; Biological: INO-9012; Biological: Cemiplimab; Radiation: Radiation Therapy; Drug: Temozolomide
Sponsor: Inovio Pharmaceuticals
Recruiting -
Radiosurgery Plus NovoTTF-200A for Metastatic Small Cell Lung Cancer to the Brain
Posted: April 5th, 2018, 2:00pm GMT
Conditions: Brain Metastases; Small Cell Lung Cancer
Interventions: Device: NovoTTF-200A; Radiation: Stereotactic Radiosurgery (SRS)
Sponsors: Drexell Hunter Boggs; NovoCure Ltd.
Not yet recruiting -
In Situ Immune Parameters and Their Prognostic Role on the Survival of Patients With Glioblastoma
Posted: March 29th, 2018, 2:00pm GMT
Condition: Glioblastoma
Intervention:
Sponsor: Centre Georges Francois Leclerc
Not yet recruiting -
Pre-operative RT and TMZ in Patients With Newly Diagnosed GBM Diagnosed Glioblastoma. A Phase I Study. (PARADIGMA)
Posted: March 29th, 2018, 2:00pm GMT
Condition: Glioblastoma Multiforme, Adult
Interventions: Drug: Temozolomide; Radiation: Pre-Operative Radiation
Sponsor: McGill University Health Center
Recruiting -
Advanced MRI for Posterior Fossa Tumours
Posted: March 20th, 2018, 2:00pm GMT
Conditions: Cerebellar Mutism; Posterior Fossa Syndrome
Intervention: Diagnostic Test: Advanced MRI sequences
Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust
Recruiting -
Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients
Posted: February 28th, 2018, 3:00pm GMT
Conditions: Metastatic Breast Cancer; Brain Metastases
Intervention: Drug: Pembrolizumab
Sponsor: Weill Medical College of Cornell University
Not yet recruiting -
The Therapeutic Time Window of Mannitol During Craniotomy for Optimal Brain Relaxation in Patients With Supratentorial Tumours
Posted: February 23rd, 2018, 3:00pm GMT
Condition: Supratentorial Tumors
Intervention: Drug: Mannitol
Sponsor: Huashan Hospital
Recruiting -
Phase II Trial of Seizure Prophylaxis in Suspected Primary Glioma Patients Undergoing Craniotomy
Posted: February 16th, 2018, 3:00pm GMT
Conditions: Glioma; Glioma of Brain; Brain Tumor
Interventions: Drug: Lacosamide; Drug: Levetiracetam
Sponsor: Duke University
Not yet recruiting -
A Study to Assess the Safety and Tolerability of AZD1390 Given With Radiation Therapy in Patients With Brain Cancer
Posted: February 6th, 2018, 3:00pm GMT
Conditions: Recurrent Glioblastoma Multiforme; Primary Glioblastoma Multiforme; Brain Neoplasms, Malignant; Leptomeningeal Disease (LMD)
Interventions: Radiation: Radiation Therapy; Drug: AZD1390
Sponsor: AstraZeneca
Recruiting -
Standardized Protocol of Surgery and Radiation for Patients With Brain Metastases in Relapsed Neuroblastoma
Posted: January 23rd, 2018, 3:00pm GMT
Condition: Relapsed Neuroblastoma
Interventions: Radiation: Cerebral Spinal (CS) radiation; Radiation: Focal radiotherapy (SRS)
Sponsor: Giselle Sholler
Recruiting -
Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)
Posted: January 11th, 2018, 3:00pm GMT
Condition: Diffuse Intrinsic Pontine Glioma (DIPG)
Interventions: Biological: TTRNA-DC vaccines with GM-CSF; Biological: TTRNA-xALT; Drug: Cyclophosphamide + Fludarabine Lymphodepletive Conditioning; Drug: Dose-Intensified TMZ; Drug: Td vaccine; Biological: Autologous Hematopoietic Stem Cells (HSC)
Sponsor: University of Florida
Recruiting -
Stereotactic Radiation in Patients With Small Cell Lung Cancer and 1-6 Brain Metastases
Posted: January 5th, 2018, 3:00pm GMT
Conditions: Brain Metastases; Small Cell Lung Cancer
Intervention: Radiation: Stereotactic Radiation
Sponsor: Dana-Farber Cancer Institute
Recruiting -
Assessment of Positron Emission Tomography to Early Detect Frailty in Onco-geriatry
Posted: December 12th, 2017, 3:00pm GMT
Condition: Patients Over 75 Years Old With a Cancer Discovery
Intervention: Radiation: Brain PET/CT step
Sponsor: Central Hospital, Nancy, France
Not yet recruiting -
Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway.
Posted: December 6th, 2017, 3:00pm GMT
Conditions: Low-grade Glioma; Plexiform Neurofibroma; Central Nervous System Glioma
Intervention: Drug: Trametinib
Sponsors: St. Justine's Hospital; Montreal Children's Hospital of the MUHC; CHU de Quebec-Universite Laval
Recruiting -
A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)
Posted: November 28th, 2017, 3:00pm GMT
Conditions: Diffuse Intrinsic Pontine Glioma; Malignant Glioma of Brain; High Grade Glioma; Bithalamic High Grade Glioma; Brainstem Glioma; Glioblastoma; Anaplastic Astrocytoma
Interventions: Drug: ribociclib; Drug: Everolimus
Sponsors: Children's Hospital Medical Center, Cincinnati; Novartis
Recruiting -
Feasibility of Aromatherapy in an Awake Craniotomy Environment
Posted: November 1st, 2017, 2:00pm GMT
Condition: Intracranial Pathology
Intervention: Drug: Lavender (Lavandula angustifolia)
Sponsor: Aurora Health Care
Not yet recruiting -
Chemotherapy-Induced Cognitive Impairment in Ovarian Cancer Patients
Posted: October 30th, 2017, 2:00pm GMT
Condition: Chemotherapy-induced Cognitive Impairment
Intervention: Behavioral: Neurocognitive assessments
Sponsors: University of Kentucky; Office of US Army Medical Research and Material Command
Recruiting -
Cerebral Neuroinflammation During Major Depressive Episode
Posted: October 19th, 2017, 2:00pm GMT
Condition: Depressive Disorder
Intervention: Diagnostic Test: Cerebral neuroinflammation evaluation
Sponsors: University Hospital, Toulouse; Institut National de la Santé Et de la Recherche Médicale, France
Not yet recruiting -
International Cooperative Phase III Trial of the HIT-HGG Study Group (HIT-HGG-2013)
Posted: August 9th, 2017, 2:00pm GMT
Conditions: Glioblastoma WHO Grade IV; Diffuse Midline Glioma Histone 3 K27M WHO Grade IV; Anaplastic Astrocytoma WHO Grade III; Diffuse Intrinsic Pontine Glioma; Gliomatosis Cerebri
Interventions: Drug: Temozolomide + Valproic Acid; Drug: Temozolomide + Chloroquine
Sponsors: University of Göttingen; Deutsche Kinderkrebsstiftung; Hannover Clinical Trial Center GmbH
Recruiting -
Phase 1/2 Study of LOXO-195 in Patients With Previously Treated NTRK Fusion Cancers
Posted: July 12th, 2017, 2:00pm GMT
Conditions: Carcinoma, Non-Small-Cell Lung; Thyroid Neoplasms; Sarcoma; Colorectal Neoplasms; Salivary Gland Neoplasms; Biliary Tract Neoplasms; Brain Neoplasm, Primary; Melanoma; Glioblastoma; Bile Duct Neoplasms; Astrocytoma; Head and Neck Squamous Cell Carcinoma; Pontine Glioma; Pancreatic Neoplasms; Ovarian Neoplasms; Carcinoma, Renal Cell; Cholangiocarcinoma; Skin Carcinoma; Carcinoma, Bronchogenic; Bronchial Neoplasms; Lung Neoplasms; Respiratory Tract Neoplasms; Thoracic Neoplasms; Neoplasms, Nerve Tissue; Nevi and Melanomas; Intestinal Neoplasms; Thyroid Cancer; GIST; Malignant Peripheral Nerve Sheath Tumors; Breast Secretory Carcinoma; Uterine Neoplasms; Fibrosarcoma; Infantile Fibrosarcoma; Congenital Mesoblastic Nephroma; Central Nervous System Neoplasms
Intervention: Drug: LOXO-195
Sponsors: Loxo Oncology, Inc.; Bayer
Recruiting -
Oral Capecitabine and Temozolomide (CAPTEM) for Newly Diagnosed GBM
Posted: July 11th, 2017, 2:00pm GMT
Conditions: Glioblastoma Multiforme (GBM); Glioblastoma; Glioma of Brain; Glioblastoma, Adult; Brain Tumor; Brain Tumor, Primary; Brain Tumor Adult; Cancer; Brain Cancer
Interventions: Drug: Capecitabine; Drug: Temozolomide
Sponsor: Northwell Health
Recruiting -
Treatment of Children With Recurrent Refractory Brain/Solid Tumors and Recurrent Ependymoma
Posted: July 2nd, 2017, 2:00pm GMT
Conditions: Recurrent Childhood CNS Tumor; Ependymoma, Recurrent Childhood; Childhood Solid Tumor
Intervention: Drug: 5 Azacytidine
Sponsor: The Hospital for Sick Children
Recruiting -
T-DM1 Alone Versus T-DM1 and Metronomic Temozolomide in Secondary Prevention of HER2-Positive Breast Cancer Brain Metastases Following Stereotactic Radiosurgery
Posted: June 19th, 2017, 2:00pm GMT
Conditions: Breast Cancer; Brain Metastasis; Brain Cancer
Interventions: Drug: T-DM1; Drug: TMZ
Sponsor: National Cancer Institute (NCI)
Recruiting -
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma
Posted: June 8th, 2017, 2:00pm GMT
Conditions: 1p/19q Co-deletion; Anaplastic Astrocytoma; Diffuse Astrocytoma; Glioma; IDH1 Gene Mutation; IDH2 Gene Mutation; Oligoastrocytoma; Oligodendroglioma; WHO Grade III Glioma
Interventions: Radiation: IMRT (Intensity-Modulated Radiation Therapy); Radiation: Proton Beam Radiation Therapy; Drug: Temozolomide
Sponsors: NRG Oncology; National Cancer Institute (NCI)
Recruiting -
Study Evaluating the Efficacy of Radiotherapy With SIB-IMRT, Associated With Temozolomide in Glioblastomas
Posted: June 8th, 2017, 2:00pm GMT
Condition: Glioblastoma, Adult
Intervention: Device: Radiotherapy
Sponsor: Centre Georges Francois Leclerc
Recruiting -
Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients
Posted: June 6th, 2017, 2:00pm GMT
Conditions: Tumor, Brain; Anesthesia, Local
Interventions: Drug: Lidocaine; Drug: Sodium chloride; Drug: Bupivacaine
Sponsor: Washington University School of Medicine
Not yet recruiting -
Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers
Posted: June 2nd, 2017, 2:00pm GMT
Conditions: Ependymoma; Meningioma; Chordoma
Intervention: Drug: Nivolumab
Sponsor: National Cancer Institute (NCI)
Recruiting -
A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2
Posted: May 15th, 2017, 2:00pm GMT
Conditions: Malignant Glioma of Brain; Astrocytoma; Malignant Astrocytoma; Oligodendroglioma; Anaplastic Oligodendroglioma of Brain (Diagnosis); Mixed Oligo-Astrocytoma; Ependymoma; Ganglioglioma; Pylocytic/Pylomyxoid Astrocytoma; Brain Tumor; Glioma; Brain Cancer; Glioblastoma; Glioblastoma Multiforme
Interventions: Drug: rQNestin; Drug: Cyclophosphamide; Procedure: Stereotactic biopsy
Sponsors: Dana-Farber Cancer Institute; National Institutes of Health (NIH); Advantagene, Inc.
Recruiting -
Reducing Breast Cancer-related Fatigue and Improving Cognition With Non-Invasive Brain Stimulation
Posted: May 8th, 2017, 2:00pm GMT
Conditions: Breast Cancer; Cognitive Dysfunction; Fatigue
Intervention: Device: TDCS
Sponsors: Johns Hopkins University; Under Armour, Inc.
Recruiting -
Familial Investigations of Childhood Cancer Predisposition
Posted: February 10th, 2017, 3:00pm GMT
Conditions: Acute Leukemia; Adenomatous Polyposis; Adrenocortical Carcinoma; AML; BAP1 Tumor Predisposition Syndrome; Carney Complex; Choroid Plexus Carcinoma; Constitutional Mismatch Repair Deficiency Syndrome; Diamond-Blackfan Anemia; DICER1 Syndrome; Dyskeratosis Congenita; Emberger Syndrome; Familial Acute Myeloid Leukemia; Familial Adenomatous Polyposis; Fanconi Anemia; Familial Cancer; Familial Wilms Tumor; Familial Neuroblastoma; GIST; Hereditary Breast and Ovarian Cancer; Hereditary Paraganglioma-Pheochromocytoma Syndrome; Hodgkin Lymphoma; Juvenile Polyposis; Li-Fraumeni Syndrome; Lynch Syndrome; MDS; Melanoma Syndrome; Multiple Endocrine Neoplasia Type 1; Multiple Endocrine Neoplasia Type 2; Neuroblastoma; Neurofibromatosis Type 1; Neurofibromatosis Type II; Nevoid Basal Cell Carcinoma Syndrome; Non Hodgkin Lymphoma; Noonan Syndrome and Other Rasopathy; Overgrowth Syndromes; Pancreatic Cancer; Peutz-Jeghers Syndrome; Pheochromocytoma/Paraganglioma; PTEN Hamartoma Tumor Syndrome; Retinoblastoma; Rhabdoid Tumor Predisposition Syndrome; Rhabdomyosarcoma; Rothmund-Thomson Syndrome; Tuberous Sclerosis; Von Hippel-Lindau Disease
Intervention:
Sponsor: St. Jude Children's Research Hospital
Recruiting -
Study of the Depth of Anesthesia on Postoperative Clinical Outcome in Patients With Supratentorial Tumor
Posted: January 27th, 2017, 3:00pm GMT
Condition: Anesthesia, Brain Tumor, Supratentorial,Outcome
Interventions: Other: Bispectral index will be targeted at 50; Other: Bispectral index will be targeted at 35
Sponsors: Beijing Tiantan Hospital; Shaanxi Provincial People's Hospital; The second People's Hospital of Guiyang, China; Beijing Sanbo Brain Hospital; The Second Hospital of Hebei Medical University; The Affiliated Hospital of Inner Mongolia Medical University; Chinese PLA General Hospital; Anhui Provincial Hospital; Guangdong 999 Brain Hospital; Zhejiang University
Recruiting -
Protein Phosphatase 2A Inhibitor, in Recurrent Glioblastoma
Posted: January 23rd, 2017, 3:00pm GMT
Conditions: Astrocytoma, Grade IV; Glioblastoma Multiforme; Giant Cell Glioblastoma
Intervention: Drug: LB-100
Sponsor: National Cancer Institute (NCI)
Not yet recruiting -
Study of Laser Interstitial Thermal Therapy (LITT) in Recurrent Glioblastoma
Posted: January 16th, 2017, 3:00pm GMT
Conditions: Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System; Glioblastoma; Anaplastic Astrocytoma
Interventions: Procedure: Laser Interstitial Thermal Therapy; Drug: Lomustine; Behavioral: Quality of Life Questionnaires; Device: The NeuroBlate System
Sponsors: M.D. Anderson Cancer Center; Monteris Medical
Recruiting -
Radiation Therapy Plus Temozolomide and Pembrolizumab With and Without HSPPC-96 in Newly Diagnosed Glioblastoma (GBM)
Posted: January 12th, 2017, 3:00pm GMT
Condition: Glioblastoma
Interventions: Drug: Pembrolizumab; Biological: HSPPC-96; Drug: Temozolomide; Other: Placebo; Radiation: radiation treatment
Sponsor: National Cancer Institute (NCI)
Recruiting -
Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions
Posted: January 9th, 2017, 3:00pm GMT
Conditions: Antibiotics; Pituitary Adenoma
Interventions: Drug: Placebo; Drug: Oral Antibiotics cefdinir or trimethoprim/sulfamethoxazole
Sponsors: St. Joseph's Hospital and Medical Center, Phoenix; Thomas Jefferson University; The Cleveland Clinic
Recruiting -
Brain Awake Surgery Using Virtual Reality Headset
Posted: January 5th, 2017, 3:00pm GMT
Conditions: Brain Tumor; Virtual Reality
Intervention: Device: Virtual reality headset
Sponsor: University Hospital, Angers
Recruiting -
Pilot Study of Nivolumab in Pediatric Patients With Hypermutant Cancers
Posted: December 14th, 2016, 3:00pm GMT
Conditions: Refractory or Recurrent Hypermutated Malignancies; Biallelic Mismatch Repair Deficiency (bMMRD) Positive Patients
Intervention: Drug: Nivolumab
Sponsor: The Hospital for Sick Children
Recruiting
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