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Trial - Brain Tumor (100 unread)

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Cognitive Support Program for Patients With Brain Metastases

Posted: May 25th, 2018, 2:00pm GMT

Condition: Metastases, CNS
Intervention: Behavioral: Cognitive Support Program
Sponsor: University Health Network, Toronto
Recruiting
Ibrutinib With Radiation and Temozolomide in Patients With Newly Diagnosed Glioblastoma

Posted: May 24th, 2018, 2:00pm GMT

Condition: Glioblastoma
Interventions: Drug: Ibrutinib; Radiation: Radiation; Drug: Temozolomide (TMZ)
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Osimertinib With Stereotactic Radiosurgery (SRS) in Brain Metastases From EGFR Positive NSCLC

Posted: May 24th, 2018, 2:00pm GMT

Conditions: NSCLC; Non-small Cell Lung Cancer
Intervention: Drug: Osimertinib
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Lactate Levels Correlates With Ki-67 in Brain Tumor Surgery

Posted: May 21st, 2018, 2:00pm GMT

Conditions: Brain Tumor; Anesthesia
Intervention: Other: Data correlation
Sponsor: Ricard Valero
Not yet recruiting
Intraoperative Ultrasound Guided Glioma Surgery; a Randomised, Controlled Trial.

Posted: May 21st, 2018, 2:00pm GMT

Condition: Glioma
Intervention: Procedure: ultrasound guided surgery.
Sponsors: Erasmus Medical Center; Stichting Coolsingel
Recruiting
TN-TC11G (THC+CBD) Combination With Temozolomide and Radiotherapy in Patients With Newly-diagnosed Glioblastoma

Posted: May 18th, 2018, 2:00pm GMT

Condition: Glioblastoma
Interventions: Drug: TN-TC11G; Drug: Temozolomide Oral Product; Radiation: Radiotherapy
Sponsors: Grupo Español de Investigación en Neurooncología; Medical Cannabis Bike Tour; Voices Against Brain Cancer; Tilray
Not yet recruiting
CB-839 With Radiation Therapy and Temozolomide in Treating Participants With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma

Posted: May 18th, 2018, 2:00pm GMT

Conditions: Anaplastic Astrocytoma, IDH-Mutant; Diffuse Astrocytoma, IDH-Mutant; IDH1 Gene Mutation; IDH2 Gene Mutation
Interventions: Drug: Glutaminase Inhibitor CB-839 Hydrochloride; Other: Questionnaire Administration; Radiation: Radiation Therapy; Drug: Temozolomide
Sponsor: National Cancer Institute (NCI)
Not yet recruiting
Prospective Cohort of Patients With Newly Diagnosed Glioblastoma: Analysis of MMP2 and MMP9 Expression and Correlation to Neuro-imaging Features.

Posted: May 16th, 2018, 2:00pm GMT

Condition: Brain Tumor
Interventions: Biological: Blood sample; Biological: Tumor sample
Sponsor: Assistance Publique Hopitaux De Marseille
Recruiting
Molecular Imaging and Spectroscopy With Stable Isotopes in Oncology and Neurology

Posted: May 16th, 2018, 2:00pm GMT

Condition: Ovarian Cancer
Intervention: Diagnostic Test: MRI scan and FDG-PET scan
Sponsor: Cambridge University Hospitals NHS Foundation Trust
Recruiting
Atezolizumab in Combination With Carboplatin Plus Pemetrexed in Chemotherapy-naïve Patients With Asymptomatic Brain Metastasis

Posted: May 16th, 2018, 2:00pm GMT

Condition: Non-small Cell Lung Cancer Stage IV
Intervention: Drug: Atezolizumab
Sponsor: Spanish Lung Cancer Group
Not yet recruiting
Comparison of 6-fluoro-[18F]-L-dihydroxyphenylalanine (18F-DOPA) Positron Emission Tomography (PET) and Multiparametric Resonance Magnetic Imagery (RMI) in Initial Exploration of Glial Tumors

Posted: May 15th, 2018, 2:00pm GMT

Conditions: Brain Neoplasms; Adult Brain Tumor
Intervention: Diagnostic Test: PET imagery
Sponsor: Center Eugene Marquis
Not yet recruiting
Short Course Radiation Therapy in Palliative Treatment of Brain Metastases

Posted: May 15th, 2018, 2:00pm GMT

Conditions: Brain Metastases; Radiotherapy; Palliative Care
Interventions: Radiation: standard treatment; Radiation: short course treatment
Sponsor: Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi
Recruiting
Regorafenib and Methotrexate in Treating Participants With Recurrent or Metastatic KRAS Mutated Non-Small Cell Lung Cancer

Posted: May 10th, 2018, 2:00pm GMT

Conditions: KRAS Gene Mutation; Metastatic Malignant Neoplasm in the Brain; Recurrent Non-Small Cell Lung Carcinoma; Stage IV Non-Small Cell Lung Cancer AJCC v7
Interventions: Drug: Methotrexate; Other: Pharmacokinetic Study; Drug: Regorafenib
Sponsor: Stanford University
Not yet recruiting
PD-L1 PET Imaging in Melanoma Patients

Posted: May 10th, 2018, 2:00pm GMT

Condition: Melanoma
Intervention: Other: PD-L1 PET imaging
Sponsor: University Medical Center Groningen
Recruiting
Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases

Posted: May 9th, 2018, 2:00pm GMT

Condition: Leptomeningeal Metastases
Intervention: Radiation: Proton craniospinal irradiation (CSI)
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
Linking Digital Smartphone Behaviour With Brain Function

Posted: May 4th, 2018, 2:00pm GMT

Conditions: Brain Tumor; Hydrocephalus
Intervention: Other: There is no study-specific intervention
Sponsor: University of Zurich
Recruiting
Endocrine Outcome of Surgery for Pituitary Adenoma

Posted: May 3rd, 2018, 2:00pm GMT

Condition: Pituitary Adenoma
Interventions: Procedure: Endoscopic resection; Procedure: Microsurgical resection
Sponsor: University of Ulm
Recruiting
Ruxolitinib With Radiation and Temozolomide for Grade III Gliomas and Glioblastoma

Posted: May 2nd, 2018, 2:00pm GMT

Conditions: Glioma; Glioblastoma
Interventions: Drug: ruxolitinib; Radiation: radiation; Drug: temozolomide
Sponsor: Case Comprehensive Cancer Center
Not yet recruiting
Panitumumab-IRDye800 in Diagnosing Participants With Malignant Glioma Undergoing Surgery

Posted: April 27th, 2018, 2:00pm GMT

Conditions: Malignant Brain Neoplasm; Malignant Glioma
Interventions: Procedure: Near-Infrared Fluorescence Imaging; Biological: Panitumumab; Drug: Panitumumab-IRDye800; Other: Pharmacokinetic Study; Procedure: Surgical Procedure
Sponsor: Eben Rosenthal
Recruiting
Neurocognitive Decline in Patients With Brain Metastases

Posted: April 26th, 2018, 2:00pm GMT

Condition: Brain Metastases
Intervention: Radiation: Stereotactic Radiosurgery
Sponsor: University of Texas Southwestern Medical Center
Recruiting
Neurocognitive and Neuroimaging Outcomes in Older Patients With Multiple Myeloma Treated With Autologous Stem Cell Transplantation

Posted: April 26th, 2018, 2:00pm GMT

Condition: Multiple Myeloma
Interventions: Diagnostic Test: Structural Image; Diagnostic Test: Functional Image; Behavioral: Digit Span subtest; Behavioral: Brief Test of Attention; Behavioral: Trail Making Test (Parts A & B); Behavioral: Auditory Consonant Trigrams Test; Behavioral: Controlled Oral Word Association Test; Behavioral: Hopkins Verbal Learning Test-Revised; Behavioral: The Center for Epidemiological Study-Depression; Radiation: The Functional Assessment of Chronic Illness Therapy-Fatigue Subscale, Version 4
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors

Posted: April 25th, 2018, 2:00pm GMT

Condition: Leptomeningeal Metastasis
Interventions: Drug: Pemetrexed; Drug: Dexamethasone; Radiation: Radiotherapy
Sponsor: First Hospital of Jilin University
Recruiting
Bridging Brain Structure and Function by Correlating Structural Connectivity, Cortico-Cortical Transmission and Direct Electro-Stimulation

Posted: April 19th, 2018, 2:00pm GMT

Condition: Tumor, Brain
Interventions: Other: electrocorticography with electrostimulation; Other: dRMI
Sponsors: Centre Hospitalier Universitaire de Nice; INRIA sophia antipolis
Not yet recruiting
Tucatinib, Trastuzumab, and Capecitabine for the Treatment of HER2+ LMD

Posted: April 18th, 2018, 2:00pm GMT

Conditions: Metastatic Breast Cancer; Leptomeningeal Disease
Interventions: Drug: Tucatinib; Drug: Trastuzumab; Drug: Capecitabine
Sponsors: University of Alabama at Birmingham; Cascadian Therapeutics Inc.; Translational Breast Cancer Research Consortium
Not yet recruiting
Quality of Life of Patients With Glioblatoma (GBM) Treated With Tumor-Treating Fields

Posted: April 17th, 2018, 2:00pm GMT

Condition: Malignant Glioma
Intervention: Device: NovoTTF
Sponsors: Duke University; NovoCure Ltd.
Recruiting
$Permalink for 'HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors'$
HER2-specific CAR T Cell Locoregional Immunotherapy for HER2-positive Recurrent/Refractory Pediatric CNS Tumors

Posted: April 17th, 2018, 2:00pm GMT

Condition: Central Nervous System Tumor, Pediatric
Intervention: Biological: HER2-specific chimeric antigen receptor (CAR) T cell
Sponsor: Seattle Children's Hospital
Not yet recruiting
A Randomised Phase II Trial of Osimertinib With or Without SRS for EGFR Mutated NSCLC With Brain Metastases

Posted: April 13th, 2018, 2:00pm GMT

Condition: Metastatic Non Small Cell Lung Cancer
Interventions: Drug: Osimertinib; Radiation: Stereotactic Radiosurgery (SRS)
Sponsor: Trans-Tasman Radiation Oncology Group (TROG)
Not yet recruiting
Evaluation of Functional Magnetic Resonance Imaging (fMRI) in Patients Who Speak Two Languages Fluently

Posted: April 12th, 2018, 2:00pm GMT

Conditions: Glioma; Glioma of Brain; Glioma of Spinal Cord
Interventions: Behavioral: Multilingual Aphasia Examination; Diagnostic Test: Language paradigms + RS fMRI; Diagnostic Test: Language paradigms + RS fMRI + one anatomical sequence
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
Cytokine Microdialysis for Real-Time Immune Monitoring in Glioblastoma Patients Undergoing Checkpoint Blockade

Posted: April 11th, 2018, 2:00pm GMT

Condition: Glioblastoma
Interventions: Drug: Nivolumab; Drug: BMS-986016
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting
Radiosurgery Plus NovoTTF-200A for Metastatic Small Cell Lung Cancer to the Brain

Posted: April 5th, 2018, 2:00pm GMT

Conditions: Brain Metastases; Small Cell Lung Cancer
Interventions: Device: NovoTTF-200A; Radiation: Stereotactic Radiosurgery (SRS)
Sponsors: Drexell Hunter Boggs; NovoCure Ltd.
Not yet recruiting
In Situ Immune Parameters and Their Prognostic Role on the Survival of Patients With Glioblastoma

Posted: March 29th, 2018, 2:00pm GMT

Condition: Glioblastoma
Intervention:
Sponsor: Centre Georges Francois Leclerc
Not yet recruiting
Pre-operative RT and TMZ in Patients With Newly Diagnosed GBM Diagnosed Glioblastoma. A Phase I Study. (PARADIGMA)

Posted: March 29th, 2018, 2:00pm GMT

Condition: Glioblastoma Multiforme, Adult
Interventions: Drug: Temozolomide; Radiation: Pre-Operative Radiation
Sponsor: McGill University Health Center
Recruiting
Atezolizumab + Stereotactic Radiosurgery in Triple-negative Breast Cancer and Brain Metastasis

Posted: March 29th, 2018, 2:00pm GMT

Condition: Breast Cancer
Interventions: Drug: Atezolizumab; Procedure: Stereotactic radiosurgery (SRS)
Sponsors: Dana-Farber Cancer Institute; Genentech, Inc.
Recruiting
$Permalink for 'Dose Escalation Study of CLR 131 in Children and Adolescents With Relapsed or Refractory Malignant Brain Cancer, Neuroblastoma, Rhabdomyosarcoma, Ewings Sarcoma, and Osteosarcoma'$
Dose Escalation Study of CLR 131 in Children and Adolescents With Relapsed or Refractory Malignant Brain Cancer, Neuroblastoma, Rhabdomyosarcoma, Ewings Sarcoma, and Osteosarcoma

Posted: March 27th, 2018, 2:00pm GMT

Conditions: Pediatric Solid Tumor; Pediatric Lymphoma; Pediatric Brain Tumor
Intervention: Drug: CLR 131
Sponsor: Cellectar Biosciences, Inc.
Not yet recruiting
Testing Ramipril to Prevent Memory Loss in People With Glioblastoma

Posted: March 23rd, 2018, 2:00pm GMT

Conditions: Glioblastoma; Radiotherapy; Complications; Cognitive Decline; Chemoradiation
Intervention: Drug: Ramipril
Sponsors: Wake Forest University Health Sciences; National Cancer Institute (NCI)
Not yet recruiting
Adolescent and Young Adult Cancer Patients: Cognitive Toxicity on Survivorship (ACTS)

Posted: March 23rd, 2018, 2:00pm GMT

Conditions: Breast Cancer; Lymphoma; Germ Cell Tumor; Cognitive Impairment
Intervention:
Sponsor: National University, Singapore
Not yet recruiting
Seoul National University Pituitary Disease Cohort Study

Posted: March 22nd, 2018, 2:00pm GMT

Conditions: Pituitary Disease; Pituitary Incidentaloma; Acromegaly; Central Diabetes Insipidus; Pituitary Stalk Compression Hyperprolactinaemia; Cushing's Disease; Pituitary Tumor; Prolactinoma
Intervention: Other: Dynamic hormone study and Magnetic resonance imaging
Sponsor: Seoul National University Hospital
Recruiting
A Secondary Study Evaluating Aqueduct's Smart External Drain (SED)

Posted: March 21st, 2018, 2:00pm GMT

Conditions: Hydrocephalus; Hydrocephalus in Children; Tumor, Brain; Subarachnoid Hemorrhage
Intervention: Device: Smart External Drain - SED
Sponsor: Aqueduct Critical Care
Recruiting
Early Palliative Care Intervention in Malignant Glioma

Posted: March 20th, 2018, 2:00pm GMT

Condition: Malignant Glioma
Intervention: Behavioral: Palliative Care
Sponsors: Duke University; Duke Cancer Institute
Not yet recruiting
Advanced MRI for Posterior Fossa Tumours

Posted: March 20th, 2018, 2:00pm GMT

Conditions: Cerebellar Mutism; Posterior Fossa Syndrome
Intervention: Diagnostic Test: Advanced MRI sequences
Sponsor: Great Ormond Street Hospital for Children NHS Foundation Trust
Not yet recruiting
Resilience and Quality of Life Among Cancer Survivors

Posted: March 15th, 2018, 2:00pm GMT

Condition: Mental Health Wellness 1
Intervention: Other: Non applicable
Sponsor: Aga Khan University
Not yet recruiting
Glasdegib (PF-04449913) With Temozolomide Newly Diagnosed Glioblastoma

Posted: March 15th, 2018, 2:00pm GMT

Condition: Glioblastoma
Interventions: Drug: PF-04449913; Drug: Temozolomide Oral Capsule
Sponsor: Grupo Español de Investigación en Neurooncología
Recruiting
A First in Human Study Using 89Zr-cRGDY Ultrasmall Silica Particle Tracers for Malignant Brain Tumors

Posted: March 14th, 2018, 2:00pm GMT

Condition: Brain Cancer
Interventions: Drug: 89Zr-DFO-cRGDY-PEG-Cy5-C' dots PET Imaging; Other: Blood and Urine samples
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting
Comparison of Propofol Requirement Between Patients With Pituitary Somatotroph Tumor and With Nonfunctioning Pituitary Tumor in Transsphenoidal Pituitary Surgery Under Total Intravenous Anesthesia

Posted: March 14th, 2018, 2:00pm GMT

Condition: Pituitary Tumor
Intervention: Procedure: Not applicable (measuring subject's effect site concentration of propofol during the induction of general anesthesia)
Sponsor: Yonsei University
Recruiting
Hydroxy-urea and Temozolomide in Patients With a Recurrent Malignant Brain Tumor (Glioblastoma)

Posted: March 13th, 2018, 2:00pm GMT

Conditions: Glioma; Glioblastoma
Interventions: Drug: Hydroxyurea; Drug: Temozolomide
Sponsors: M.E. van Linde; Massachusetts General Hospital
Recruiting
Comparative Study Between Different Approaches to CPA-petroclival Meningiomas

Posted: March 13th, 2018, 2:00pm GMT

Condition: Brain Neoplasms
Intervention:
Sponsor: Assiut University
Not yet recruiting
Open-label PET Study to Determine Brain Exposure With [11C]Osimertinib in Patients With EGFRm NSCLC and Brain Metastases

Posted: March 13th, 2018, 2:00pm GMT

Condition: Non-small Cell Lung Cancer
Interventions: Drug: Osimertinib; Drug: [11C]osimertinib
Sponsor: AstraZeneca
Not yet recruiting
Improved Therapy Response Assessment in Metastatic Brain Tumors

Posted: March 8th, 2018, 3:00pm GMT

Condition: Brain Metastases
Interventions: Diagnostic Test: Magnetic Resonance Imaging; Radiation: Stereotactic Radiosurgery; Drug: Ipilimumab, nivolumab or pembrolizumab
Sponsors: Oslo University Hospital; Hospital of Southern Norway Trust; Ostfold Hospital Trust; St. Olavs Hospital; Massachusetts General Hospital; Dana-Farber Cancer Institute; University Medical Center Groningen; University of Texas Southwestern Medical Center; South-Eastern Norway Regional Health Authority; Norwegian Cancer Society
Recruiting
Radiologic Pathologic Correlation of Advanced MR Imaging to Guide the Biopsy of Cerebral Malignancies

Posted: March 8th, 2018, 3:00pm GMT

Condition: Brain Lesion
Interventions: Procedure: Advanced Magnetic Resonance Imaging Scan; Procedure: Standard of Care Brain Biopsy and Tumor Removal
Sponsor: M.D. Anderson Cancer Center
Recruiting
Nurse-led Family and Network Consultations

Posted: March 8th, 2018, 3:00pm GMT

Condition: High-grade Glioma
Intervention: Behavioral: Family and Network Consultations
Sponsors: Rigshospitalet, Denmark; The Novo Nordic Foundation
Recruiting
Comparison of Treatment Outcome of Cabergoline According to Target Prolactin Levels in Patients With Prolactinoma

Posted: March 7th, 2018, 3:00pm GMT

Conditions: Pituitary Adenoma; Prolactinoma; Pituitary Tumor; Recurrence Tumor
Intervention: Drug: Cabergoline
Sponsor: Seoul National University Hospital
Not yet recruiting
Comparison of the Effect of Low and High Fraction of Inspired Oxygen on Postoperative Surgical Field Infection

Posted: March 6th, 2018, 3:00pm GMT

Condition: Supratentorial Brain Tumor
Intervention: Procedure: Craniotomy
Sponsor: Istanbul University
Not yet recruiting
A Study Evaluating the Safety and Activity of Pegylated Recombinant Human Arginase (BCT-100)

Posted: March 6th, 2018, 3:00pm GMT

Conditions: Cancer; Pediatric Solid Tumor; Pediatric AML; Pediatric ALL
Intervention: Drug: PEG- BCT-100
Sponsor: University of Birmingham
Not yet recruiting
EDO-S101 for MGMT Unmethylated Glioblastoma (nGBM)

Posted: March 2nd, 2018, 3:00pm GMT

Conditions: Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System; Unmethylated Glioblastoma
Interventions: Drug: EDO-S101; Radiation: Radiation Therapy
Sponsors: M.D. Anderson Cancer Center; Mundipharma-EDO GmbH
Not yet recruiting
FET-PET/MRI for Surgical Assessment of Pediatric Brain Tumors

Posted: March 1st, 2018, 3:00pm GMT

Condition: Pediatric Brain Tumors
Intervention: Drug: FET PET/MRI
Sponsor: University of Alabama at Birmingham
Recruiting
Pembrolizumab And Stereotactic Radiosurgery (Srs) Of Selected Brain Metastases In Breast Cancer Patients

Posted: February 28th, 2018, 3:00pm GMT

Conditions: Metastatic Breast Cancer; Brain Metastases
Intervention: Drug: Pembrolizumab
Sponsor: Weill Medical College of Cornell University
Not yet recruiting
Feasibility of Home-Based Neurofeedback to Treat Chemotherapy-Induced Peripheral Neuropathy

Posted: February 16th, 2018, 3:00pm GMT

Condition: Malignant Neoplasms of Independent (Primary) Multiple Sites
Interventions: Behavioral: Neurofeedback Training; Behavioral: Questionnaires; Procedure: Electroencephalogram
Sponsor: M.D. Anderson Cancer Center
Not yet recruiting
A Longitudinal Assessment of Tumor Evolution in Patients With Brain Cancer

Posted: February 7th, 2018, 3:00pm GMT

Condition: Newly Diagnosed Glioblastoma
Interventions: Drug: Temozolomide; Radiation: conformal brain radiation therapy; Drug: Nivolumab; Drug: Ipilimumab
Sponsor: John Wayne Cancer Institute
Recruiting
A Dose Escalation Trial of Five Fraction Stereotactic Radiation Therapy for Brain Metastases

Posted: January 26th, 2018, 3:00pm GMT

Condition: Brain Metastases
Intervention: Radiation: Dose Escalated Five Fraction Stereotactic Radiosurgery
Sponsor: University of Alabama at Birmingham
Not yet recruiting
Standardized Protocol of Surgery and Radiation for Patients With Brain Metastases in Relapsed Neuroblastoma

Posted: January 23rd, 2018, 3:00pm GMT

Condition: Relapsed Neuroblastoma
Interventions: Radiation: Cerebral Spinal (CS) radiation; Radiation: Focal radiotherapy (SRS)
Sponsor: Giselle Sholler
Recruiting
Brain Stem Gliomas Treated With Adoptive Cellular Therapy During Focal Radiotherapy Recovery Alone or With Dose-intensified Temozolomide (Phase I)

Posted: January 11th, 2018, 3:00pm GMT

Condition: Diffuse Intrinsic Pontine Glioma (DIPG)
Interventions: Biological: TTRNA-DC vaccines with GM-CSF; Biological: TTRNA-xALT; Drug: Cyclophosphamide + Fludarabine Lymphodepletive Conditioning; Drug: Dose-Intensified TMZ; Drug: Td vaccine; Biological: Autologous Hematopoietic Stem Cells (HSC)
Sponsor: University of Florida
Recruiting
Efficiency of Vaccination With Lysate-loaded Dendritic Cells in Patients With Newly Diagnosed Glioblastoma

Posted: January 10th, 2018, 3:00pm GMT

Condition: Glioblastoma
Interventions: Biological: Autologous, tumor lysate-loaded, mature dendritic cells (DC); Drug: standard therapy
Sponsors: Heinrich-Heine University, Duesseldorf; German Federal Ministry of Education and Research
Recruiting
A Study of Neoadjuvant Stereotactic Radiosurgery for Large Brain Metastases

Posted: December 11th, 2017, 3:00pm GMT

Condition: Brain Metastases
Intervention: Radiation: Stereotactic Radiosurgery
Sponsor: University Health Network, Toronto
Recruiting
$Permalink for 'Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway.'$
Trametinib for Pediatric Neuro-oncology Patients With Refractory Tumor and Activation of the MAPK/ERK Pathway.

Posted: December 6th, 2017, 3:00pm GMT

Conditions: Low-grade Glioma; Plexiform Neurofibroma; Central Nervous System Glioma
Intervention: Drug: Trametinib
Sponsors: St. Justine's Hospital; Montreal Children's Hospital of the MUHC; CHU de Québec
Not yet recruiting
A Study of Ribociclib and Everolimus Following Radiation Therapy in Children With Newly Diagnosed Non-biopsied Diffuse Pontine Gliomas (DIPG) and RB+ Biopsied DIPG and High Grade Gliomas (HGG)

Posted: November 28th, 2017, 3:00pm GMT

Conditions: Diffuse Intrinsic Pontine Glioma; Malignant Glioma of Brain; High Grade Glioma; Bithalamic High Grade Glioma; Brainstem Glioma; Glioblastoma; Anaplastic Astrocytoma
Interventions: Drug: ribociclib; Drug: Everolimus
Sponsors: Children's Hospital Medical Center, Cincinnati; Novartis
Recruiting
Intracerebral EGFR-vIII CAR-T Cells for Recurrent GBM

Posted: September 14th, 2017, 2:00pm GMT

Conditions: Recurrent Glioblastoma Multiforme; Recurrent Brain Tumor, Adult
Intervention: Biological: EGFRvIII-CARs
Sponsors: Gary Archer Ph.D.; National Cancer Institute (NCI); Duke Cancer Institute
Not yet recruiting
Therapeutic Benefit of Preoperative Supplemental Vitamin D in Patients Undergoing Brain Tumor Surgery

Posted: August 14th, 2017, 2:00pm GMT

Condition: Brain Neoplasms
Interventions: Drug: vitamin D; Other: control
Sponsor: Shahid Beheshti University
Recruiting
An Online Dyadic Mind-Body Intervention for Glioma Patients and Their Partners

Posted: August 10th, 2017, 2:00pm GMT

Conditions: Malignant Neoplasms of Eye; High Grade Glioma; Malignant Neoplasms of Brain; Malignant Neoplasms of Central Nervous System
Interventions: Behavioral: Questionnaires; Behavioral: Mind-Body Intervention; Other: Compact Discs (CD's) + Printed Materials; Behavioral: Phone Calls
Sponsors: M.D. Anderson Cancer Center; Hackett Family Foundation Award
Recruiting
Pilot Study of Acute Stroke Using the Brainpulse™

Posted: August 1st, 2017, 2:00pm GMT

Condition: Stroke, Acute
Intervention: Device: BrainPulse Device
Sponsor: Jan Medical, Inc.
Recruiting
Memantine for Prevention of Cognitive Late Effects in Pediatric Patients Receiving Cranial Radiation Therapy for Localized Brain Tumors

Posted: June 21st, 2017, 2:00pm GMT

Conditions: Glioma of Brain; Craniopharyngioma; Ependymoma; Germ Cell Tumor
Interventions: Drug: Memantine; Other: Placebo; Other: Cognitive Assessment
Sponsors: St. Jude Children's Research Hospital; National Cancer Institute (NCI)
Recruiting
NovoTTF Treatment Signatures in Glioblastoma Patients at Autopsy

Posted: June 21st, 2017, 2:00pm GMT

Condition: Glioblastoma
Interventions: Other: Tumor samples from patients treated with TTFields at initial diagnosis.; Other: Tumor samples from patients treated with TTFields at tumor recurrence.
Sponsor: Medical College of Wisconsin
Recruiting
Proton Beam or Intensity-Modulated Radiation Therapy in Preserving Brain Function in Patients With IDH Mutant Grade II or III Glioma

Posted: June 8th, 2017, 2:00pm GMT

Conditions: 1p/19q Co-deletion; Anaplastic Astrocytoma; Diffuse Astrocytoma; Glioma; IDH1 Gene Mutation; IDH2 Gene Mutation; Oligoastrocytoma; Oligodendroglioma; WHO Grade III Glioma
Interventions: Radiation: IMRT (Intensity-Modulated Radiation Therapy); Radiation: Proton Beam Radiation Therapy; Drug: Temozolomide
Sponsors: NRG Oncology; National Cancer Institute (NCI)
Recruiting
Scalp Block: Hemodynamic Stability and Patient Comfort In Craniotomy Patients

Posted: June 6th, 2017, 2:00pm GMT

Conditions: Tumor, Brain; Anesthesia, Local
Interventions: Drug: Lidocaine; Drug: Sodium chloride; Drug: Bupivacaine
Sponsor: Washington University School of Medicine
Not yet recruiting
LITT Palliative Treatment for Patients With Malignant Gliomas

Posted: June 5th, 2017, 2:00pm GMT

Conditions: Malignant Glioma of Brain; Glioblastoma
Intervention: Other: Palliative regimen consisting of LITT
Sponsors: Duke University; Monteris Medical
Recruiting
Study of BEvacizumab in Combination With ATezolizumab in Patients With Untreated Melanoma Brain Metastases

Posted: June 5th, 2017, 2:00pm GMT

Condition: Melanoma and Other Malignant Neoplasms of Skin
Interventions: Behavioral: Neurocognitive Exam; Behavioral: Questionnaires; Drug: Bevacizumab; Drug: Atezolizumab
Sponsors: M.D. Anderson Cancer Center; Genentech, Inc.
Recruiting
Immune Checkpoint Inhibitor Nivolumab in People With Select Rare CNS Cancers

Posted: June 2nd, 2017, 2:00pm GMT

Conditions: Ependymoma; Meningioma; Chordoma
Intervention: Drug: Nivolumab
Sponsor: National Cancer Institute (NCI)
Recruiting
Dose Escalation Trial of Neoadjuvant Radiosurgery for the Treatment of Metastatic Brain Tumors

Posted: May 23rd, 2017, 2:00pm GMT

Condition: Brain Metastases
Interventions: Radiation: Neoadjuvant stereotactic radiosurgery; Procedure: Neurosurgical resection
Sponsor: Cedars-Sinai Medical Center
Recruiting
Early Detection and Paramedical Care of Sexual Difficulties in Nervous System Diseases: Example of Multiple Sclerosis and Brain Tumors (NEUROSEX)

Posted: May 16th, 2017, 2:00pm GMT

Conditions: Low Grade Glioma of Brain; Multiple Sclerosis; Sexual Dysfunctions
Intervention: Other: Paramedical care
Sponsor: Assistance Publique - Hôpitaux de Paris
Recruiting
A Study Assessing BGB-290 With Radiation and/or Temozolomide (TMZ) in Subjects With Newly Diagnosed or Recurrent Glioblastoma

Posted: May 12th, 2017, 2:00pm GMT

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: BGB-290; Drug: TMZ; Radiation: Radiation
Sponsor: BeiGene USA, Inc.
Recruiting
A Study of DSP-7888 Dosing Emulsion in Combination With Bevacizumab in Patients With Recurrent or Progressive Glioblastoma Following Initial Therapy

Posted: May 11th, 2017, 2:00pm GMT

Condition: Glioblastoma
Interventions: Drug: DSP-7888 Dosing Emulsion; Drug: Bevacizumab
Sponsor: Boston Biomedical, Inc
Recruiting
A Study to Investigate the Regional Brain Kinetics of Brain Drug Transporters Using P-glycoprotein and Breast Cancer Resistance Protein Substrates and by Using the Positron Emission Tomography Ligand 11C-JNJ-63779586 in the Human Brain

Posted: March 24th, 2017, 2:00pm GMT

Condition: Alzheimer Disease
Intervention: Drug: 11C-JNJ-63779586
Sponsor: Janssen Research & Development, LLC
Recruiting
Head and Neck Maskless Immobilization Device in Immobilizing Patients With Intracranial Tumors Undergoing Radiation Therapy

Posted: March 10th, 2017, 3:00pm GMT

Conditions: Brain and Nervous System; Intracranial Neoplasm
Interventions: Procedure: Computed Tomography; Device: Medical Device; Procedure: Cone-Beam Computed Tomography
Sponsor: Sidney Kimmel Cancer Center at Thomas Jefferson University
Recruiting
Metabolic Characteristics of Brain Tumors Using Hyperpolarized Carbon-13 Magnetic Resonance Spectroscopic Imaging (MRSI)

Posted: March 1st, 2017, 3:00pm GMT

Condition: Brain Tumor Adult
Interventions: Drug: Hyperpolarized 13C-Pyruvate; Drug: Gadolinium
Sponsor: University of Texas Southwestern Medical Center
Not yet recruiting
INtraoperative photoDYnamic Therapy of GliOblastoma

Posted: February 9th, 2017, 3:00pm GMT

Condition: Glioblastoma
Interventions: Device: "perPDT"; Drug: GLIOLAN
Sponsors: University Hospital, Lille; Institut National de la Santé Et de la Recherche Médicale, France
Recruiting
18F-DOPA PET Imaging: an Evaluation of Biodistribution and Safety

Posted: February 3rd, 2017, 3:00pm GMT

Conditions: Congenital Hyperinsulinism; Neuroblastoma; Neuroendocrine Tumors; Parkinson Disease; Brain Glioma
Intervention: Drug: 18F-DOPA
Sponsors: University of Alberta; Alberta Health Services
Recruiting
A Feasibility Safety Study of Benign Centrally-Located Intracranial Tumors in Pediatric and Young Adult Subjects

Posted: January 23rd, 2017, 3:00pm GMT

Condition: Benign Centrally-Located Intracranial Tumors
Intervention: Device: ExAblate 4000 System
Sponsor: InSightec
Recruiting
Radiation Therapy Plus Temozolomide and Pembrolizumab With and Without HSPPC-96 in Newly Diagnosed Glioblastoma (GBM)

Posted: January 12th, 2017, 3:00pm GMT

Condition: Glioblastoma
Interventions: Drug: Pembrolizumab; Biological: HSPPC-96; Drug: Temozolomide; Other: Placebo; Radiation: radiation treatment
Sponsor: National Cancer Institute (NCI)
Recruiting
Cranial Nerves Tractography

Posted: December 1st, 2016, 3:00pm GMT

Condition: Cranial Nerve Palsy
Intervention: Procedure: preoperative cerebral MRI and operative findings
Sponsor: Hospices Civils de Lyon
Recruiting
Osimertinib With or Without Bevacizumab in Treating Patients With EGFR Positive Non-small Cell Lung Cancer and Brain Metastases

Posted: November 23rd, 2016, 3:00pm GMT

Conditions: EGFR Activating Mutation; EGFR NP_005219.2:p.T790M; Lung Carcinoma Metastatic in the Brain; Non-Small Cell Lung Carcinoma
Interventions: Biological: Bevacizumab; Other: Laboratory Biomarker Analysis; Drug: Osimertinib
Sponsor: National Cancer Institute (NCI)
Recruiting
The NEUROlogically-impaired Extubation Timing Trial

Posted: September 30th, 2016, 2:00pm GMT

Condition: Acute Brain Injury
Interventions: Procedure: Extubation; Procedure: Usual Care
Sponsors: Sunnybrook Health Sciences Centre; Canadian Institutes of Health Research (CIHR)
Recruiting
Cancer and Other Disease Risks in U.S. Nuclear Medicine Technologists

Posted: September 22nd, 2016, 2:00pm GMT

Conditions: Brain Cancer; Thyroid Cancer; Circulatory Disease; Breast Cancer
Intervention:
Sponsor: National Cancer Institute (NCI)
Recruiting
Study of Marizomib With Temozolomide and Radiotherapy in Patients With Newly Diagnosed Brain Cancer

Posted: September 16th, 2016, 2:00pm GMT

Conditions: Glioblastoma; Malignant Glioma
Interventions: Drug: MRZ; Drug: TMZ; Radiation: RT; Device: Optune
Sponsors: Celgene; Triphase
Recruiting
Efficacy and Safety of FS VH S/D 500 S-apr as an Adjunct to Sutured Dural Repair in Cranial Surgery

Posted: September 7th, 2016, 2:00pm GMT

Condition: Cerebrospinal Fluid Leak
Interventions: Drug: FS VH S/D 500 s-apr; Device: DuraSeal Dural Sealant
Sponsor: Baxter Healthcare Corporation
Recruiting
$Permalink for 'A Study Evaluating the Association of Hypofractionated Stereotactic Radiation Therapy and Durvalumab for Patients With Recurrent Glioblastoma'$
A Study Evaluating the Association of Hypofractionated Stereotactic Radiation Therapy and Durvalumab for Patients With Recurrent Glioblastoma

Posted: August 15th, 2016, 2:00pm GMT

Condition: Glioblastoma
Interventions: Radiation: Hypofractionated stereotactic radiation therapy; Drug: Durvalumab
Sponsors: Institut Claudius Regaud; AstraZeneca
Recruiting
Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma

Posted: August 8th, 2016, 2:00pm GMT

Conditions: Glioblastoma; Grade IV Astrocytoma; Glioblastoma Multiforme; Grade IV Glioma
Intervention: Drug: MDNA55
Sponsor: Medicenna Therapeutics, Inc.
Recruiting
Intranasal Oxytocin in Hypothalamic Obesity

Posted: July 29th, 2016, 2:00pm GMT

Conditions: Craniopharyngioma; Hypothalamic Obesity
Interventions: Drug: Syntocinon; Drug: Placebo (for Syntocinon)
Sponsor: Shana McCormack, MD
Recruiting
Understanding Communication in Healthcare to Achieve Trust (U-CHAT)

Posted: July 27th, 2016, 2:00pm GMT

Conditions: Brain Tumors; Solid Tumor
Intervention:
Sponsor: St. Jude Children's Research Hospital
Recruiting
Study to Evaluate Eflornithine + Lomustine vs Lomustine in Recurrent Anaplastic Astrocytoma (AA) Patients

Posted: June 10th, 2016, 2:00pm GMT

Conditions: Anaplastic Astrocytoma; Recurrent Anaplastic Astrocytoma
Interventions: Drug: Eflornithine; Drug: Lomustine
Sponsor: Orbus Therapeutics, Inc.
Recruiting
Feasibility Trial of the Modified Atkins Diet and Bevacizumab for Recurrent Glioblastoma

Posted: May 11th, 2016, 2:00pm GMT

Conditions: Glioblastoma; Brain Tumor
Interventions: Drug: Bevacizumab; Behavioral: Modified Atkins Diet
Sponsors: Case Comprehensive Cancer Center; University of Cincinnati; OhioHealth Research Institute
Recruiting
Pasireotide LAR Therapy of Silent Corticotroph Pituitary Tumors

Posted: April 22nd, 2016, 2:00pm GMT

Conditions: Pituitary Tumor; ACTH-producing Pituitary Tumour
Intervention: Drug: Pasireotide LAR
Sponsor: Columbia University
Recruiting

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