Condition: Pediatric Recurrent Brain Tumor
Interventions: Biological: Personalized neoantigen DNA vaccine; Device: TDS-IM System; Procedure: Peripheral blood draw
Sponsors: Washington University School of Medicine; Children's Discovery Institute
Not yet recruiting
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Acinar Cell Carcinoma
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Acinic Cell Carcinoma
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Adenoid Cystic Carcinoma
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Adrenal Gland Cancer
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Ampulla Of Vater
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Brain and CNS
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Carcinoid
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Endocrine/Neuroendocrine
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Gall Bladder Cancer
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Hemangioendothelioma
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Hepatoblastoma
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Pancreas
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PMP and Mucinous Tumors
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Rhabdomyosarcoma
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Sarcoma
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Trial - Brain Tumor (100 unread)
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Neoepitope-based Personalized DNA Vaccine Approach in Pediatric Patients With Recurrent Brain Tumors
Posted: June 17th, 2019, 2:00pm GMT
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Impact of nrTMS Therapy on the Progress of Neurorehabilitation
Posted: June 11th, 2019, 2:00pm GMT
Condition: Transcranial Magnetic Stimulation, Repetitive
Interventions: Device: navigated repetitive transcranial magnetic stimulation; Procedure: physical therapy
Sponsor: Technische Universität München
Recruiting -
FBY PET/CT in Patients With Brain Tumors
Posted: June 10th, 2019, 2:00pm GMT
Condition: Brain Tumor
Intervention: Diagnostic Test: FBY-PET Examination Group: Patients receive FBY-PET examination after entrance
Sponsors: Peking Union Medical College Hospital; Peking University; Beijing Cancer Hospital
Recruiting -
Study on Physical Activity's Relationship With Cancer and Cognition
Posted: June 10th, 2019, 2:00pm GMT
Conditions: Breast Cancer; Breast Neoplasm Female
Intervention: Behavioral: Walking
Sponsor: University of Nebraska
Not yet recruiting -
MEK and Autophagy Inhibition in Metastatic/Locally Advanced, Unresectable Neuroblastoma RAS (NRAS) Melanoma
Posted: June 7th, 2019, 2:00pm GMT
Condition: Metastatic NRAS Melanoma
Interventions: Drug: Trametinib plus hydroxychloroquine in patients with NRAS Melanoma (Dose 1); Drug: Trametinib plus hydroxychloroquine in patients with NRAS Melanoma (Dose 2); Drug: Trametinib plus hydroxychloroquine in patients with NRAS Melanoma (Dose 3)
Sponsor: Hospices Civils de Lyon
Not yet recruiting -
Feasibility of 11C-MET PET/MRI Imaging in Pediatric Brain Fossa Tumors
Posted: June 6th, 2019, 2:00pm GMT
Condition: Posterior Brain Fossa Tumors in Children
Intervention: Procedure: 11C-MET PET/MRI
Sponsor: Hospices Civils de Lyon
Not yet recruiting -
Enhanced Recovery After Surgery Using TMS on Cerebellar Language Area for Brain Tumor Patients
Posted: June 5th, 2019, 2:00pm GMT
Conditions: Cerebellar Function; Transcranial Magnetic Stimulation; Language Disorders
Intervention: Combination Product: Transcranial magnetic stimulation
Sponsors: Huashan Hospital; Shanghai Jing'an Central Hospital; Huashan Hospital North Hospital
Recruiting -
Pediatric Long-Term Follow-up and Rollover Study
Posted: June 5th, 2019, 2:00pm GMT
Conditions: Diffuse Astrocytoma; Anaplastic Astrocytoma; Astrocytoma; Oligodendroglioma, Childhood; Anaplastic Oligodendroglioma; Glioblastoma; Pilocytic Astrocytoma; Giant Cell Astrocytoma; Pleomorphic Xanthoastrocytoma; Anaplastic Pleomorphic Xanthoastrocytoma; Angiocentric Glioma; Chordoid Glioma of Third Ventricle; Gangliocytoma; Ganglioglioma; Anaplastic Ganglioglioma; Dysplastic Gangliocytoma of Cerebrellum; Desmoplastic Infantile Astrocytoma and Ganglioglioma; Papillary Glioneuronal Tumor; Rosette-forming Glioneurona Tumor; Central Neurocytoma; Extraventricular Neurocytoma; Cerebellar Liponeurocytoma; Neurofibromatosis Type 1
Interventions: Drug: dabrafenib; Drug: trametinib
Sponsor: Novartis Pharmaceuticals
Not yet recruiting -
Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG
Posted: June 4th, 2019, 2:00pm GMT
Conditions: High Grade Glioma; BRAF V600E; BRAF V600K; Anaplastic Astrocytoma; Anaplastic Pleomorphic Xanthoastrocytoma; Gliosarcoma; Glioblastoma
Interventions: Drug: Encorafenib; Drug: Binimetinib; Biological: Research Bloods; Biological: Tumor Tissue
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; National Cancer Institute (NCI); Array BioPharma
Not yet recruiting -
Combination of PVSRIPO and Atezolizumab for Adults With Recurrent Malignant Glioma
Posted: June 4th, 2019, 2:00pm GMT
Condition: Malignant Glioma
Interventions: Biological: PVSRIPO; Drug: Atezolizumab
Sponsors: Darell D. Bigner, MD, PhD; Istari Oncology, Inc.; Genentech, Inc.
Not yet recruiting -
Epidemiology of Pituitary Tumours: Prevalence of Associated Neoplasia
Posted: June 4th, 2019, 2:00pm GMT
Conditions: Pituitary Tumor; Endocrine Neoplasia; Hyperparathyroidism; Solid Tumor; Familial Tumor Syndrome
Intervention: Other: Registration of familial forms and associated neoplasia
Sponsor: Neuromed IRCCS
Not yet recruiting -
Observational Trial of the Impact of Radiation Dose in Children With Brain and Skull Base Tumors.
Posted: June 3rd, 2019, 2:00pm GMT
Conditions: Brain Tumor; Brain Cancer; Skull Base Tumor
Intervention:
Sponsor: Baptist Health South Florida
Recruiting -
Organoids Derived From Induced-Pluripotent Stem Cells (iPS) From Patients With High Grade Astrocytoma
Posted: June 3rd, 2019, 2:00pm GMT
Condition: Glioma
Intervention: Biological: Blood sample
Sponsor: Assistance Publique Hopitaux De Marseille
Recruiting -
Determining Dose of Regadenoson Most Likely to Transiently Alter the Integrity of the Blood-Brain Barrier in Patients With High Grade Gliomas
Posted: June 3rd, 2019, 2:00pm GMT
Conditions: High Grade Glioma; Anaplastic Astrocytoma; Anaplastic Oligodendroglioma; Glioblastoma
Interventions: Drug: Regadenoson 0.05mg; Drug: Regadensoson 0.1mg; Drug: Regadensoson 0.2mg; Drug: Regadensoson 0.4mg; Drug: Regadensoson 0.7mg; Drug: Regadensoson 1.0mg; Drug: Regadensoson 1.4mg
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; National Cancer Institute (NCI)
Not yet recruiting -
Ultrasound Elastography and Ultrasentive Doppler for Surgery of Brain Tumors
Posted: May 31st, 2019, 2:00pm GMT
Condition: Brain Tumor, Primary
Intervention: Procedure: brain tumor resection
Sponsors: University Hospital, Tours; Institut National de la Santé Et de la Recherche Médicale, France
Recruiting -
A Study of BXQ-350 in Children and Young Adults With Relapsed Solid Tumors
Posted: May 30th, 2019, 2:00pm GMT
Condition: Neoplasms
Intervention: Drug: BXQ-350
Sponsors: Bexion Pharmaceuticals, Inc.; CTI Clinical Trial and Consulting Services
Recruiting -
A Phase 2 Study of Cabozantinib in Metastatic Renal Cell Carcinoma (mRCC) With Brain Metastases
Posted: May 30th, 2019, 2:00pm GMT
Condition: Metastatic Renal Cell Carcinoma
Intervention: Drug: Cabozantinib
Sponsor: Centre Leon Berard
Not yet recruiting -
AXL Inhibitor BGB324 in Treating Participants With Recurrent Glioblastoma Undergoing Surgery
Posted: May 29th, 2019, 2:00pm GMT
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: BGB 324 (before surgery); Drug: BGB 324 (after surgery)
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; National Cancer Institute (NCI)
Not yet recruiting -
Resting-State Functional MRI in Glioma Patients Before and After Surgery
Posted: May 27th, 2019, 2:00pm GMT
Conditions: Brain Mass; Glioma
Interventions: Procedure: Functional Magnetic Resonance Imaging; Procedure: Magnetic Resonance Imaging; Procedure: Resting State Functional Connectivity Magnetic Resonance Imaging
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting -
Study of Stereotactic Radiosurgery to the Subventricular Zone in Malignant Gliomas
Posted: May 21st, 2019, 2:00pm GMT
Conditions: Glioblastoma; Astrocytoma, Grade III; Astrocytoma, Grade IV; Malignant Glioma
Intervention: Radiation: Stereotactic Radiosurgery
Sponsor: Northwell Health
Recruiting -
A Multicentric Phase II, Open-label Study Evaluating the Efficacy of the Combination of Hypofractionated Stereotactic Radiation Therapy With the Anti-PDL1 Immune Checkpoint Inhibitor Durvalumab in NSCLC Patients With 1 to 4 Brain Metastases
Posted: May 20th, 2019, 2:00pm GMT
Conditions: Brain Metastases; NSCLC
Interventions: Radiation: Radiotherapy; Combination Product: Radiotherapy + durvalumab
Sponsor: Institut Claudius Regaud
Not yet recruiting -
Strict Classic Ketogenic Diet as a Therapy for Recurrent or Progressive and Refractory Brain Tumors in Children
Posted: May 17th, 2019, 2:00pm GMT
Conditions: Brain Tumor; Ketogenic Dieting
Intervention: Other: Strict Classic Ketogenic Diet
Sponsor: Daniel Bowers
Not yet recruiting -
Targeting Potassium Channels to Reprogram Glioblastoma Microenvironment: in Vitro and in Vivo Studies
Posted: May 17th, 2019, 2:00pm GMT
Condition: Cancer of Head and Neck
Intervention: Other: brain tumor-immune cells communication
Sponsor: Neuromed IRCCS
Not yet recruiting -
Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy
Posted: May 16th, 2019, 2:00pm GMT
Conditions: Glioma; Gliomas; High Grade Glioma; Malignant Glioma; Low Grade Glioma
Intervention: Device: 3T MRI scanner
Sponsor: National Cancer Institute (NCI)
Not yet recruiting -
Imaging Perfusion Restrictions From Extracellular Solid Stress - An Open-label Losartan Study
Posted: May 15th, 2019, 2:00pm GMT
Conditions: Glioblastoma; Brain Metastases
Intervention: Drug: Losartan
Sponsor: Kyrre Eeg Emblem
Not yet recruiting -
Rehabilitation and Longitudinal Follow-up of Cognition in Adult Lower Grade Gliomas
Posted: May 14th, 2019, 2:00pm GMT
Condition: Low-grade Glioma
Interventions: Device: ReMind iPad app; Device: Healthy SMS texting; Behavioral: In-person cognitive rehabilitation
Sponsors: University of California, San Francisco; University of Tilburg; University of California, Berkeley
Not yet recruiting -
The ASsessment and Physiotherapy managEment of Ataxia in Children Following Surgical Resection of Posterior Fossa Tumour
Posted: May 10th, 2019, 2:00pm GMT
Conditions: Ataxia; Posterior Fossa Tumor
Intervention: Other: Therapist
Sponsor: Alder Hey Children's NHS Foundation Trust
Recruiting -
Bioenergetic Profiling and Cognition in GBM Patients
Posted: May 7th, 2019, 2:00pm GMT
Condition: Glioblastoma
Interventions: Procedure: Cognitive Assessment; Diagnostic Test: Blood Collection; Diagnostic Test: Bioenergetic Profiling
Sponsor: Wake Forest University Health Sciences
Not yet recruiting -
Study of the Bromodomain (BRD) and Extra-Terminal Domain (BET) Inhibitor BMS-986158 in Pediatric Cancer
Posted: May 3rd, 2019, 2:00pm GMT
Conditions: Solid Tumor, Childhood; Lymphoma; Brain Tumor, Pediatric
Intervention: Drug: BMS-986158
Sponsors: Dana-Farber Cancer Institute; Stand Up To Cancer
Not yet recruiting -
Adoptive Transfer of Tumor Infiltrating Lymphocytes for Advanced Solid Cancers
Posted: May 2nd, 2019, 2:00pm GMT
Conditions: Gastric Cancer; Colorectal Cancer; Pancreatic Cancer; Sarcoma; Mesothelioma; Neuroendocrine Tumors; Squamous Cell Cancer; Merkel Cell Carcinoma; Mismatch Repair Deficiency; Microsatellite Instability
Interventions: Biological: Tumor Infiltrating Lymphocytes (TIL); Drug: Fludarabine + Cyclophosphamide combination
Sponsor: Udai Kammula
Not yet recruiting -
A Study of Pyrotinib Plus Vinorelbine in Patients With Brain Metastases From HER2-positive Metastatic Breast Cancer
Posted: May 1st, 2019, 2:00pm GMT
Conditions: Breast Cancer; Brain Metastases
Intervention: Drug: Pyrotinib Plus Vinorelbine
Sponsor: Chinese Academy of Medical Sciences
Recruiting -
Nasal Irrigation Apply in Patients After Transsphenoidal Pituitary Tumor Resection
Posted: May 1st, 2019, 2:00pm GMT
Condition: Pituitary Tumor
Intervention: Behavioral: nasal irrigation
Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Recruiting -
18F-Fluciclovine PET to Distinguish Tumor Progression From Radiation Necrosis
Posted: April 29th, 2019, 2:00pm GMT
Condition: Secondary Malignant Neoplasm of Brain and Cerebral Meninges
Interventions: Drug: 18F-fluciclovine; Device: PET/CT of the brain
Sponsor: Case Comprehensive Cancer Center
Recruiting -
Capecitabine and Temozolomide for Treatment of Recurrent Pituitary Adenomas
Posted: April 29th, 2019, 2:00pm GMT
Condition: Recurrent Pituitary Adenomas
Interventions: Drug: Capecitabine; Drug: Temozolomide
Sponsor: Weill Medical College of Cornell University
Recruiting -
Intratumorally-Administered Topotecan Using Convection-Enhanced Delivery in Patients With Grade III/ IV Glioma
Posted: April 25th, 2019, 2:00pm GMT
Condition: Glioma of Brain
Intervention: Drug: Topotecan
Sponsor: H. Lee Moffitt Cancer Center and Research Institute
Recruiting -
Extended Support for Persons With Pituitary Tumours After Surgery
Posted: April 25th, 2019, 2:00pm GMT
Conditions: Pituitary Tumor Benign; Surgery
Intervention: Other: person-centred practice
Sponsor: Göteborg University
Recruiting -
18F-Fluciclovine PET and Multiparametric MR Imaging
Posted: April 24th, 2019, 2:00pm GMT
Condition: Brain Tumor, Recurrent, Adult
Intervention: Drug: PET/CT with F-Fluciclovine (Axumin)
Sponsors: Loma Linda University; Blue Earth Diagnostics
Not yet recruiting -
Efficacy of Nivolumab for Recurrent IDH Mutated High-Grade Gliomas
Posted: April 24th, 2019, 2:00pm GMT
Conditions: High Grade Glioma; Brain Cancer
Intervention: Drug: Nivolumab
Sponsors: Assistance Publique - Hôpitaux de Paris; Bristol-Myers Squibb
Not yet recruiting -
RIvoraxaban in Mitral Stenosis
Posted: April 24th, 2019, 2:00pm GMT
Conditions: Mitral Stenosis; Rheumatic Heart Disease; Atrial Fibrillation; Anticoagulant Adverse Reaction
Interventions: Drug: Rivaroxaban; Drug: Warfarin
Sponsors: Rajaie Cardiovascular Medical and Research Center; National Institute for Medical research and Development (NIMAD); Abidi Pharmaceuticals
Recruiting -
F18 Fluciclovine PET/CT in Assessing Tumor Volume and Radiation Therapy Response in Patients With Glioblastoma Undergoing Surgery
Posted: April 24th, 2019, 2:00pm GMT
Condition: Glioblastoma
Interventions: Procedure: Computed Tomography; Other: Fluciclovine F18; Procedure: Positron Emission Tomography
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting -
V-Boost Immunotherapy in Glioblastoma Multiforme Brain Cancer
Posted: April 16th, 2019, 2:00pm GMT
Conditions: Glioblastoma Multiforme; Glioma of Brain
Intervention: Biological: V-Boost
Sponsor: Immunitor LLC
Recruiting -
BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations
Posted: April 15th, 2019, 2:00pm GMT
Conditions: IDH1 Mutation; IDH2 Mutation; Recurrent Glioblastoma; Recurrent WHO Grade II Glioma; Recurrent WHO Grade III Glioma
Interventions: Drug: PARP Inhibitor BGB-290; Drug: Temozolomide; Procedure: Therapeutic Conventional Surgery
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; National Cancer Institute (NCI); BeiGene
Not yet recruiting -
Phase 1 Trial of Engineered HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors
Posted: April 11th, 2019, 2:00pm GMT
Conditions: Neoplasms, Brain; Glioblastoma Multiforme; Glioblastoma of Cerebellum; Neoplasms; Astrocytoma; Astrocytoma, Cerebellar; Neuroectodermal Tumors; Neuroectodermal Tumors, Primitive; Cerebellar PNET, Childhood; Cerebellar Neoplasms; Cerebellar Neoplasms, Primary; Cerebellar Neoplasm, Malignant; Cerebellar Neoplasm Malignant Primary; Neoplasm Metastases; Neoplasm Malignant; Neoplasms, Neuroepithelial; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Central Nervous System Neoplasms, Primary; Central Nervous System Neoplasms, Malignant; Nervous System Neoplasms; Neoplasms by Site; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Medulloblastoma Recurrent; HSV; Virus; Pediatric Brain Tumor; Nervous System Cancer; Primitive Neuroectodermal Tumor (PNET) of Cerebellum
Intervention: Biological: G207
Sponsor: University of Alabama at Birmingham
Not yet recruiting -
An Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain Metastasis
Posted: April 11th, 2019, 2:00pm GMT
Condition: Brain Metastases
Interventions: Drug: encorafenib; Drug: binimetinib
Sponsor: Array BioPharma
Recruiting -
Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery
Posted: April 5th, 2019, 2:00pm GMT
Condition: Medulloblastoma, Childhood
Intervention: Drug: CX 4945
Sponsors: Pediatric Brain Tumor Consortium; St. Jude Children's Research Hospital; National Cancer Institute (NCI)
Not yet recruiting -
Optune Device - TT Field Plus Nivolumab and Ipilimumab for Melanoma With Brain Metastasis
Posted: April 4th, 2019, 2:00pm GMT
Condition: Melanoma With Brain Metastasis
Interventions: Device: Optune; Biological: Nivolumab; Biological: Ipilimumab
Sponsors: Washington University School of Medicine; NovoCure Ltd.
Not yet recruiting -
Oncolytic Adenovirus DNX-2401 in Treating Patients With Recurrent High-Grade Glioma
Posted: April 1st, 2019, 2:00pm GMT
Conditions: IDH1 wt Allele; Recurrent Anaplastic Astrocytoma; Recurrent Glioblastoma; Recurrent Gliosarcoma; Recurrent Malignant Glioma
Interventions: Biological: Oncolytic Adenovirus Ad5-DNX-2401; Procedure: Therapeutic Conventional Surgery
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting -
The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)
Posted: April 1st, 2019, 2:00pm GMT
Conditions: Cancer, All Types; Cancer of Liver; Cancer of Stomach; Cancer of Head and Neck; Cancer of Rectum; Cancer of Kidney; Cancer of Esophagus; Cancer of Colon; Cancer Skin; Cancer of Cervix; Cancer, Metastatic; Cancer of Larynx; Cancer of Neck; Cancer of Lung; Cancer of Brain and Nervous System; Cancer of Vulva, Disseminated; Cancer of Pancreas; Sarcoma; GIST; Small-cell Lung Cancer; Adenocarcinoma Lung; Cancer of Prostate; Cancer, Advanced; Adrenal Cancer; Testicular Cancer; Uterine Cancer; Bronchoalveolar Cell Lung Cancer; Cancer Unknown Primary; Glioblastoma Multiforme; Oligodendroglioma; Breast Cancer; Renal Cell Carcinoma; Hepatocellular Carcinoma; Cholangiocarcinoma; Squamous Cell Carcinoma; Transitional Cell Carcinoma; Cancer, Other; Cancer, Anal; Melanoma; Cancer, Bile Duct; Cancer, Bladder; Cancer Cords Vocal; Cancers Cell Neuroendocrine; Cancer Differentiated Poorly; Cancer, Anaplastic Thyroid
Intervention:
Sponsors: SpeciCare; Dana-Farber Cancer Institute; Kalispell Regional Medical Center; Georgia Institute of Technology; Ontario Institute for Cancer Research; SEngine Precision Medicine; Helomics
Recruiting -
PD L 506 for Stereotactic Interstitial Photodynamic Therapy of Newly Diagnosed Supratentorial IDH Wild-type Glioblastoma
Posted: April 1st, 2019, 2:00pm GMT
Condition: Glioblastoma
Intervention: Drug: 5-aminolevulinic acid
Sponsor: photonamic GmbH & Co. KG
Not yet recruiting -
Fimepinostat in Treating Brain Tumors in Children and Young Adults
Posted: March 28th, 2019, 2:00pm GMT
Conditions: Diffuse Intrinsic Pontine Glioma; Recurrent Anaplastic Astrocytoma; Recurrent Glioblastoma; Recurrent Malignant Glioma; Recurrent Medulloblastoma
Interventions: Drug: Fimepinostat; Procedure: Therapeutic Conventional Surgery
Sponsors: Sabine Mueller, MD, PhD; Pacific Pediatric Neuro-Oncology Consortium; Cannonball Kids' Cancer Foundation; Curis, Inc.
Recruiting -
Circulatory Function in Laparoscopic Radical Cystectomy for Bladder Cancer
Posted: March 27th, 2019, 2:00pm GMT
Conditions: Circulatory Function; Laparoscopic Radical Cystectomy for Bladder Cancer
Intervention:
Sponsor: RenJi Hospital
Recruiting -
Translational Study of Nivolumab in Combination With Bevacizumab for Recurrent Glioblastoma
Posted: March 26th, 2019, 2:00pm GMT
Condition: Recurrent Adult Brain Tumor
Interventions: Drug: Nivolumab; Drug: Bevacizumab
Sponsors: Ulrik Lassen; Herlev Hospital; University of Copenhagen
Recruiting -
Intraoperative Fluorescence With Augmented Reality
Posted: March 25th, 2019, 2:00pm GMT
Conditions: Vascular; Lesion, Central Nervous System; Brain Tumor; Cerebral Aneurysm; Cerebral AVM
Interventions: Device: GLOW800; Drug: indocyanine green (ICG)
Sponsor: Cedars-Sinai Medical Center
Not yet recruiting -
MRI Screening Versus SYMptom-directed Surveillance for Brain Metastases Among Patients With Triple Negative or HER2+ MBC
Posted: March 19th, 2019, 2:00pm GMT
Conditions: Breast Neoplasm; Brain Metastases; Triple Negative Breast Cancer; HER2-positive Breast Cancer
Intervention: Diagnostic Test: MRI screening
Sponsors: Sunnybrook Health Sciences Centre; Harvard University
Recruiting -
Validation of Readiband™ Actigraph and Associated Sleep/Wake Classification Algorithms
Posted: March 18th, 2019, 2:00pm GMT
Conditions: Glioma; Glioblastoma
Intervention: Device: Readiband Sleep Tracking
Sponsor: Allina Health System
Recruiting -
Epilepsy-related Brain Tumors Register
Posted: March 15th, 2019, 2:00pm GMT
Condition: Epilepsy
Intervention:
Sponsor: Groupe Hospitalier Paris Saint Joseph
Recruiting -
Low Dose Ipilimumab With Pembrolizumab in Treating Patients With Melanoma That Has Spread to the Brain
Posted: March 13th, 2019, 2:00pm GMT
Conditions: Clinical Stage IV Cutaneous Melanoma; Metastatic Malignant Neoplasm in the Brain; Metastatic Melanoma; Pathologic Stage IV Cutaneous Melanoma
Interventions: Biological: Ipilimumab; Biological: Pembrolizumab
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI); Merck Sharp & Dohme Corp.
Recruiting -
Promotion of Well-being of Young Adult Brain Cancer Survivors
Posted: March 12th, 2019, 2:00pm GMT
Condition: Brain Tumor, Pediatric
Intervention: Behavioral: Brief Internet-based Behavioral Activation Intervention
Sponsor: University of Wisconsin, Madison
Recruiting -
Selumetinib Versus Carboplatin/Vincristine in Treating Patients With Newly Diagnosed or Previously Untreated NF1-Associated Low-Grade Glioma
Posted: March 12th, 2019, 2:00pm GMT
Conditions: Low Grade Glioma; Neurofibromatosis Type 1; Visual Pathway Glioma
Interventions: Drug: Carboplatin; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Selumetinib; Drug: Selumetinib Sulfate; Drug: Vincristine; Drug: Vincristine Sulfate
Sponsor: National Cancer Institute (NCI)
Not yet recruiting -
LIFE - Lung Cancer, Immunotherapy, Frailty, Effect
Posted: March 12th, 2019, 2:00pm GMT
Conditions: Non-small Cell Lung Cancer; Quality of Life; Brain Metastases; Venous Thromboembolism
Interventions: Diagnostic Test: CT-scans extended; Diagnostic Test: MRI scan of the brain; Other: Prospective registration of irAEs; Behavioral: Quality of Life questionnaires
Sponsors: University of Southern Denmark; Odense University Hospital; University of Copenhagen; Odense Patient Data Explorative Network; Region of Southern Denmark
Recruiting -
Solriamfetol in Improving Sleep in Patients With Grade II-IV Glioma
Posted: March 11th, 2019, 2:00pm GMT
Conditions: Glioma; Glioblastoma
Intervention: Drug: Soliramfetol
Sponsors: Wake Forest University Health Sciences; National Cancer Institute (NCI)
Not yet recruiting -
Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers
Posted: March 11th, 2019, 2:00pm GMT
Conditions: Advanced Malignant Neoplasm; ALK Fusion Protein Expression; ALK Gene Amplification; ALK Gene Mutation; Locally Advanced Malignant Solid Neoplasm; Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Neoplasm in the Central Nervous System; Metastatic Malignant Solid Neoplasm; ROS1 Fusion Positive; ROS1 Gene Amplification; ROS1 Gene Mutation
Interventions: Drug: Brigatinib; Other: Laboratory Biomarker Analysis; Other: Quality-of-Life Assessment; Other: Questionnaire Administration
Sponsors: Sameek Roychowdhury; National Cancer Institute (NCI)
Not yet recruiting -
Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastatic (1-3 Metastases) Cancer
Posted: March 5th, 2019, 3:00pm GMT
Condition: Metastatic Tumors
Interventions: Radiation: palliative radiotherapy; Radiation: Stereotactic ablative radiotherapy
Sponsors: British Columbia Cancer Agency; London Regional Cancer Program, Canada; Beatson Institute for Cancer Research, Scotland; The Alfred; Beacon Hospital, Ireland
Not yet recruiting -
The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients.
Posted: March 4th, 2019, 3:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme; Glioblastoma Multiforme of Brain; Astrocytoma, Grade IV; Brain Tumor; Brain Cancer; Brain Neoplasms
Interventions: Procedure: Awake craniotomy; Procedure: Craniotomy under general anesthesia
Sponsors: Jasper Gerritsen; Elisabeth-TweeSteden Ziekenhuis; University Medical Center Groningen; Medical Center Haaglanden; Clinical Trial Center Erasmus MC
Recruiting -
Carvedilol With Chemotherapy in Second Line Glioblastoma and Response of Circulating Tumor Cells
Posted: March 4th, 2019, 3:00pm GMT
Conditions: Glioblastoma Multiforme; Glioblastoma
Intervention: Drug: Carvedilol
Sponsors: West Virginia University; West Virginia Clinical and Translational Science Institute
Not yet recruiting -
Ex Vivo Drug Sensitivity Testing and Mutation Profiling
Posted: March 1st, 2019, 3:00pm GMT
Conditions: Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Large Cell Lymphoma; Refractory Childhood Acute Lymphoblastic Leukemia; Refractory Childhood Hodgkin Lymphoma; Refractory Childhood Malignant Germ Cell Neoplasm; Recurrent Childhood Brain Tumor; Recurrent Childhood Brainstem Glioma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Childhood Ependymoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Gliosarcoma; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Intervention:
Sponsors: Florida International University; Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Recruiting -
Exercise and Nutrition Interventions During Chemotherapy K07
Posted: February 28th, 2019, 3:00pm GMT
Condition: Neuropathy;Peripheral
Interventions: Behavioral: EXCAP Exercise; Behavioral: Nutrition Education
Sponsors: University of Rochester; National Cancer Institute (NCI)
Not yet recruiting -
Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
Posted: February 21st, 2019, 3:00pm GMT
Condition: Brain Cancer
Intervention: Drug: Hyperpolarized [13C]Pyruvate
Sponsor: University of Texas Southwestern Medical Center
Not yet recruiting -
Longitudinal Analysis of the Health-related Quality of Life in Glioma Patients
Posted: February 21st, 2019, 3:00pm GMT
Condition: Glioma of Brain
Intervention:
Sponsor: Universitaire Ziekenhuizen Leuven
Recruiting -
Cancer Adverse Effects PReventIon With Care & Exercise: the CAPRICE Study
Posted: February 21st, 2019, 3:00pm GMT
Conditions: Breast Neoplasm Female; Cardiotoxicity; Anthracyclines; Physical Activity
Intervention: Other: Exercise Training
Sponsors: University Hospital Inselspital, Berne; Spital STS AG; Bürgerspital Solothurn; University of Bern
Not yet recruiting -
Ph0/2 Ribociclib & Everolimus
Posted: February 8th, 2019, 3:00pm GMT
Conditions: Glioblastoma Multiforme; Glioma of Brain
Interventions: Drug: Ribociclib; Drug: Everolimus 2.5 MG
Sponsors: St. Joseph's Hospital and Medical Center, Phoenix; Ivy Brain Tumor Center; Barrow Neurological Institute
Recruiting -
Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors
Posted: February 5th, 2019, 3:00pm GMT
Condition: Primary Brain Neoplasm
Interventions: Drug: Hyperpolarized Carbon C 13 Pyruvate; Procedure: Magnetic Resonance Spectroscopic Imaging
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Not yet recruiting -
Lidocaine and Perioperative Cytokine Levels in Blood and Cerebrospinal Fluid in Cerebral Aneurysm Patients
Posted: January 30th, 2019, 3:00pm GMT
Condition: Aneurysm, Cerebral
Intervention: Drug: Lidocaine
Sponsor: Clinical Hospital Centre Zagreb
Not yet recruiting -
Radiotherapy of Multiple Brain Metastases Using AGuIX®
Posted: January 28th, 2019, 3:00pm GMT
Conditions: Brain Metastases, Adult; Radiotherapy
Interventions: Drug: AGuIX®; Radiation: Whole Brain Radiation Therapy
Sponsors: University Hospital, Grenoble; NH TherAguix SAS
Recruiting -
Molecular Imaging of Pituitary Adenomas
Posted: January 24th, 2019, 3:00pm GMT
Condition: Pituitary Adenoma
Intervention: Diagnostic Test: PET imaging
Sponsors: Cardiff University; Cardiff and Vale University Health Board
Recruiting -
Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases
Posted: January 17th, 2019, 3:00pm GMT
Conditions: Metastatic Breast Cancer; Brain Metastases
Interventions: Drug: Nivolumab; Radiation: Stereotactic Radiosurgery
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; Bristol-Myers Squibb
Recruiting -
Modulating the GIP System in Patients With Acromegaly Due to a Pituitary Tumor
Posted: January 16th, 2019, 3:00pm GMT
Condition: Acromegaly Due to Pituitary Adenoma
Interventions: Other: GIP-A; Other: Placebo
Sponsors: University of Copenhagen; Rigshospitalet, Denmark; Aarhus University Hospital; Aalborg University Hospital; Odense University Hospital; Herlev and Gentofte Hospital
Not yet recruiting -
Copanlisib and Fulvestrant in Treating Postmenopausal Patients With ER+ and HER2- Metastatic Breast Cancer Progressing After Aromatase and CDK 4/6 Inhibitors Treatment
Posted: January 15th, 2019, 3:00pm GMT
Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Estrogen Receptor Positive; HER2/Neu Negative; Metastatic Breast Carcinoma; Metastatic Malignant Neoplasm in the Brain; Postmenopausal; Prognostic Stage IV Breast Cancer AJCC v8
Interventions: Drug: Copanlisib; Drug: Fulvestrant
Sponsor: National Cancer Institute (NCI)
Not yet recruiting -
Apatinib Combined With Radiotherapy in Patient With BM From Drive Gene Negative NSCLC
Posted: January 11th, 2019, 3:00pm GMT
Condition: NSCLC
Intervention: Drug: Apatinib
Sponsor: Hubei Cancer Hospital
Not yet recruiting -
Docetaxel Combined With Carboplatin Plus Anlotinib as First Line Treatment in NSCLC
Posted: January 10th, 2019, 3:00pm GMT
Condition: NSCLC
Interventions: Drug: Anlotinib; Drug: Docetaxel; Drug: Carboplatin
Sponsors: Tongji Hospital; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Not yet recruiting -
Study to Evaluate Ibudilast and TMZ Combo Treatment in Recurrent GBM
Posted: December 20th, 2018, 3:00pm GMT
Conditions: Glioblastoma; Recurrent Glioblastoma; GBM; Recurrent GBM
Interventions: Drug: MN-166; Drug: Temozolomide
Sponsor: MediciNova
Recruiting -
18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning For a Short Course of Proton Beam Radiation Therapy
Posted: December 18th, 2018, 3:00pm GMT
Conditions: Glioblastoma; Malignant Glioma
Interventions: Procedure: Computed Tomography; Other: Fluorodopa F 18; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Radiation: Proton Beam Radiation Therapy; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Temozolomide
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting -
Safety and Efficacy of L19TNF in Patients With Isocitrate Dehydrogenase (IDH) Wildtype WHO Grade III / IV Glioma at First Relapse
Posted: December 18th, 2018, 3:00pm GMT
Condition: Glioma of Brain
Intervention: Drug: L19TNF
Sponsor: Philogen S.p.A.
Not yet recruiting -
Impact of Nasoseptal Flap Harvest Technique on Olfaction Following Endoscopic Transsphenoidal Pituitary Surgery
Posted: December 12th, 2018, 3:00pm GMT
Conditions: Pituitary Tumor; Surgery; Olfactory Nerve Injuries
Intervention: Procedure: Electrocautery versus scalpel
Sponsor: St. Michael's Hospital, Toronto
Recruiting -
Study of RP1 Monotherapy and RP1 in Combination With Nivolumab
Posted: December 6th, 2018, 3:00pm GMT
Conditions: Cancer; Melanoma (Skin); Melanoma, Uveal; Melanoma, Ocular; Bladder Cancer; Mismatch Repair Deficiency; Microsatellite Instability; Non-melanoma Skin Cancer
Interventions: Biological: RP1; Biological: nivolumab
Sponsor: Replimune Inc.
Recruiting -
GDC-0084 in Combination With Trastuzumab for Patients With HER2-Positive Breast Cancer Brain Metastases
Posted: December 5th, 2018, 3:00pm GMT
Condition: Breast Cancer
Interventions: Drug: Trastuzumab; Drug: GDC-0084
Sponsors: Dana-Farber Cancer Institute; Kazia Therapeutics Limited
Recruiting -
Azoles Targeting Recurrent High Grade Gliomas
Posted: December 4th, 2018, 3:00pm GMT
Conditions: Brain Tumor, Recurrent; Cancer, Advanced; Glioma of Brain
Interventions: Drug: Ketoconazole (KCZ); Drug: Posaconazole (PCZ)
Sponsor: University Health Network, Toronto
Not yet recruiting -
Safety and Efficacy of Transient Opening of the Blood-brain Barrier (BBB) With the SonoCloud-9
Posted: November 16th, 2018, 3:00pm GMT
Condition: Glioblastoma, Adult
Interventions: Device: SonoCloud-9; Drug: Carboplatin
Sponsor: CarThera
Recruiting -
Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma
Posted: November 12th, 2018, 3:00pm GMT
Conditions: Glioma; Glioma of Brain; Cancer; Pediatric Cancer; Pediatric Brain Tumor; Astrocytoma; Glioblastoma; Hemispheric
Intervention: Other: Specialized tumor board recommendation
Sponsors: University of California, San Francisco; Pacific Pediatric Neuro-Oncology Consortium
Recruiting -
Wise Cortical Strip for Intraoperative Neurophysiological Monitoring
Posted: November 6th, 2018, 3:00pm GMT
Conditions: Brain Tumor Adult; Epilepsy
Intervention: Device: Wise Cortical Strip
Sponsors: Wise S.r.l.; Genae; Fondazione Don Carlo Gnocchi Onlus
Recruiting -
Temozolomide Combine With Intensity Modulated Radiation Therapy With Simultaneous Integrated Boost for Non Small Cell Lung Cancer Brain Metastases
Posted: November 6th, 2018, 3:00pm GMT
Condition: Non Small Cell Lung Cancer Metastatic
Interventions: Drug: Temozolomide capsules; Device: radiotherapy
Sponsor: Taizhou Hospital
Not yet recruiting -
Feasibility of the LUM Imaging System for Detection of Cancer to the Brain
Posted: October 24th, 2018, 2:00pm GMT
Conditions: Low Grade Glioma of Brain; Glioblastoma; Metastasis to Brain
Intervention: Combination Product: LUM Imaging System
Sponsor: Lumicell, Inc.
Recruiting -
Blood Brain Barrier Disruption (BBBD) Using MRgFUS in the Treatment of Her2-positive Breast Cancer Brain Metastases
Posted: October 22nd, 2018, 2:00pm GMT
Conditions: Breast Cancer; Brain Metastases
Intervention: Device: ExAblate BBBD
Sponsor: InSightec
Not yet recruiting -
Biomarker-Driven Therapy Using Immune Activators With Nivolumab in Patients With First Recurrence of Glioblastoma
Posted: October 16th, 2018, 2:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme
Interventions: Drug: Nivolumab; Drug: Anti-GITR Monoclonal Antibody MK-4166; Drug: IDO1 inhibitor INCB024360; Drug: Ipilimumab
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Bristol-Myers Squibb
Recruiting -
Tumor Treating Fields With Chemoradiation in Newly Diagnosed GBM
Posted: October 15th, 2018, 2:00pm GMT
Conditions: Glioblastoma; Cancer of Brain; Glioblastoma Multiforme; Brain Tumor
Interventions: Device: Tumor Treating Fields; Drug: Temozolomide; Radiation: Radiation Therapy
Sponsors: Providence Health & Services; Providence Health & Services Brain & Spine Institute; University of California, San Francisco; NovoCure Ltd.
Not yet recruiting -
Define the Optimal Uptake Time of 68Ga-OPS202 When Used as a PET (Positron Emission Tomography) Imaging Agent in Subjects With Newly Diagnosed Breast Cancer
Posted: October 5th, 2018, 2:00pm GMT
Condition: Breast Cancer
Intervention: Drug: Satoreotide trizoxetan
Sponsor: Ipsen
Recruiting -
Precise DCE-MRI in Diagnosing Participants With Recurrent High Grade Glioma or Melanoma Brain Metastases
Posted: October 5th, 2018, 2:00pm GMT
Conditions: Brain Metastases; Glioma of Brain; Brain Tumor; Metastatic Melanoma
Interventions: Device: Dynamic Contrast-Enhanced Magnetic Resonance Imaging; Drug: Bevacizumab Injection
Sponsors: University of Southern California; National Cancer Institute (NCI)
Not yet recruiting -
Improving Brain Function After Breast Cancer Study
Posted: October 4th, 2018, 2:00pm GMT
Condition: Breast Cancer Survivors
Interventions: Behavioral: Kirtan Kriya meditation; Behavioral: Music listening program
Sponsor: University of Texas at Austin
Recruiting -
Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas
Posted: October 4th, 2018, 2:00pm GMT
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: GDC-0084; Radiation: radiation therapy
Sponsors: St. Jude Children's Research Hospital; Kazia Therapeutics Limited
Recruiting -
Detection of Brain Metastasis by MRI in Metastatic Colorectal Cancer Patients
Posted: October 3rd, 2018, 2:00pm GMT
Condition: Metastatic Colon Cancer
Intervention: Device: Magnetic resonance imaging
Sponsor: Poitiers University Hospital
Recruiting