Conditions: Glioblastoma Multiforme; Glioma of Brain
Intervention: Biological: V-Boost
Sponsor: Immunitor LLC
Recruiting
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18650 items (18650 unread) in 74 feeds
Acinar Cell Carcinoma
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Acinic Cell Carcinoma
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Adenoid Cystic Carcinoma
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Adrenal Gland Cancer
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Ampulla Of Vater
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Anal Cancer
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Angiosarcoma
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Appendix Cancer
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Bile Duct Cancer
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Brain and CNS
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Carcinoid
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Endocrine/Neuroendocrine
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Gall Bladder Cancer
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Hemangioendothelioma
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Hepatoblastoma
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Pancreas
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Phyllodes
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PMP and Mucinous Tumors
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Rhabdomyosarcoma
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Sarcoma
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Trial - Brain Tumor (100 unread)
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V-Boost Immunotherapy in Glioblastoma Multiforme Brain Cancer
Posted: April 16th, 2019, 2:00pm GMT
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BGB-290 and Temozolomide in Treating Patients With Recurrent Gliomas With IDH1/2 Mutations
Posted: April 15th, 2019, 2:00pm GMT
Conditions: IDH1 Mutation; IDH2 Mutation; Recurrent Glioblastoma; Recurrent WHO Grade II Glioma; Recurrent WHO Grade III Glioma
Interventions: Drug: PARP Inhibitor BGB-290; Drug: Temozolomide; Procedure: Therapeutic Conventional Surgery
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; National Cancer Institute (NCI); BeiGene
Not yet recruiting -
Phase 1 Trial of Engineered HSV G207 in Children With Recurrent or Refractory Cerebellar Brain Tumors
Posted: April 11th, 2019, 2:00pm GMT
Conditions: Neoplasms, Brain; Glioblastoma Multiforme; Glioblastoma of Cerebellum; Neoplasms; Astrocytoma; Astrocytoma, Cerebellar; Neuroectodermal Tumors; Neuroectodermal Tumors, Primitive; Cerebellar PNET, Childhood; Cerebellar Neoplasms; Cerebellar Neoplasms, Primary; Cerebellar Neoplasm, Malignant; Cerebellar Neoplasm Malignant Primary; Neoplasm Metastases; Neoplasm Malignant; Neoplasms, Neuroepithelial; Neoplasms, Germ Cell and Embryonal; Neoplasms by Histologic Type; Neoplasms, Glandular and Epithelial; Neoplasms, Nerve Tissue; Central Nervous System Neoplasms, Primary; Central Nervous System Neoplasms, Malignant; Nervous System Neoplasms; Neoplasms by Site; Brain Diseases; Central Nervous System Diseases; Nervous System Diseases; Medulloblastoma Recurrent; HSV; Virus; Pediatric Brain Tumor; Nervous System Cancer; Primitive Neuroectodermal Tumor (PNET) of Cerebellum
Intervention: Biological: G207
Sponsor: University of Alabama at Birmingham
Not yet recruiting -
An Open-Label, Randomized, Multicenter Trial of Encorafenib + Binimetinib Evaluating a Standard-dose and a High-dose Regimen in Patients With BRAFV600-mutant Melanoma Brain Metastasis
Posted: April 11th, 2019, 2:00pm GMT
Condition: Brain Metastases
Interventions: Drug: encorafenib; Drug: binimetinib
Sponsor: Array BioPharma
Recruiting -
Testing the Safety and Tolerability of CX-4945 in Patients With Recurrent Medulloblastoma Who May or May Not Have Surgery
Posted: April 5th, 2019, 2:00pm GMT
Condition: Medulloblastoma, Childhood
Intervention: Drug: CX 4945
Sponsors: Pediatric Brain Tumor Consortium; St. Jude Children's Research Hospital; National Cancer Institute (NCI)
Not yet recruiting -
Optune Device - TT Field Plus Nivolumab and Ipilimumab for Melanoma With Brain Metastasis
Posted: April 4th, 2019, 2:00pm GMT
Condition: Melanoma With Brain Metastasis
Interventions: Device: Optune; Biological: Nivolumab; Biological: Ipilimumab
Sponsors: Washington University School of Medicine; NovoCure Ltd.
Not yet recruiting -
Oncolytic Adenovirus DNX-2401 in Treating Patients With Recurrent High-Grade Glioma
Posted: April 1st, 2019, 2:00pm GMT
Conditions: IDH1 wt Allele; Recurrent Anaplastic Astrocytoma; Recurrent Glioblastoma; Recurrent Gliosarcoma; Recurrent Malignant Glioma
Interventions: Biological: Oncolytic Adenovirus Ad5-DNX-2401; Procedure: Therapeutic Conventional Surgery
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting -
The PIONEER Initiative: Precision Insights On N-of-1 Ex Vivo Effectiveness Research Based on Individual Tumor Ownership (Precision Oncology)
Posted: April 1st, 2019, 2:00pm GMT
Conditions: Cancer, All Types; Cancer of Liver; Cancer of Stomach; Cancer of Head and Neck; Cancer of Rectum; Cancer of Kidney; Cancer of Esophagus; Cancer of Colon; Cancer Skin; Cancer of Cervix; Cancer, Metastatic; Cancer of Larynx; Cancer of Neck; Cancer of Lung; Cancer of Brain and Nervous System; Cancer of Vulva, Disseminated; Cancer of Pancreas; Sarcoma; GIST; Small-cell Lung Cancer; Adenocarcinoma Lung; Cancer of Prostate; Cancer, Advanced; Adrenal Cancer; Testicular Cancer; Uterine Cancer; Bronchoalveolar Cell Lung Cancer; Cancer Unknown Primary; Glioblastoma Multiforme; Oligodendroglioma; Breast Cancer; Renal Cell Carcinoma; Hepatocellular Carcinoma; Cholangiocarcinoma; Squamous Cell Carcinoma; Transitional Cell Carcinoma; Cancer, Other; Cancer, Anal; Melanoma; Cancer, Bile Duct; Cancer, Bladder; Cancer Cords Vocal; Cancers Cell Neuroendocrine; Cancer Differentiated Poorly; Cancer, Anaplastic Thyroid
Intervention:
Sponsors: SpeciCare; Dana-Farber Cancer Institute; Kalispell Regional Medical Center; Georgia Institute of Technology; Ontario Institute for Cancer Research; SEngine Precision Medicine; Helomics
Recruiting -
PD L 506 for Stereotactic Interstitial Photodynamic Therapy of Newly Diagnosed Supratentorial IDH Wild-type Glioblastoma
Posted: April 1st, 2019, 2:00pm GMT
Condition: Glioblastoma
Intervention: Drug: 5-aminolevulinic acid
Sponsor: photonamic GmbH & Co. KG
Not yet recruiting -
Fimepinostat in Treating Brain Tumors in Children and Young Adults
Posted: March 28th, 2019, 2:00pm GMT
Conditions: Diffuse Intrinsic Pontine Glioma; Recurrent Anaplastic Astrocytoma; Recurrent Glioblastoma; Recurrent Malignant Glioma; Recurrent Medulloblastoma
Interventions: Drug: Fimepinostat; Procedure: Therapeutic Conventional Surgery
Sponsors: Sabine Mueller, MD, PhD; Pacific Pediatric Neuro-Oncology Consortium; Cannonball Kids' Cancer Foundation; Curis, Inc.
Not yet recruiting -
Circulatory Function in Laparoscopic Radical Cystectomy for Bladder Cancer
Posted: March 27th, 2019, 2:00pm GMT
Conditions: Circulatory Function; Laparoscopic Radical Cystectomy for Bladder Cancer
Intervention:
Sponsor: RenJi Hospital
Recruiting -
Translational Study of Nivolumab in Combination With Bevacizumab for Recurrent Glioblastoma
Posted: March 26th, 2019, 2:00pm GMT
Condition: Recurrent Adult Brain Tumor
Interventions: Drug: Nivolumab; Drug: Bevacizumab
Sponsors: Ulrik Lassen; Herlev Hospital; University of Copenhagen
Recruiting -
Intraoperative Fluorescence With Augmented Reality
Posted: March 25th, 2019, 2:00pm GMT
Conditions: Vascular; Lesion, Central Nervous System; Brain Tumor; Cerebral Aneurysm; Cerebral AVM
Interventions: Device: GLOW800; Drug: indocyanine green (ICG)
Sponsor: Cedars-Sinai Medical Center
Not yet recruiting -
MRI Screening Versus SYMptom-directed Surveillance for Brain Metastases Among Patients With Triple Negative or HER2+ MBC
Posted: March 19th, 2019, 2:00pm GMT
Conditions: Breast Neoplasm; Brain Metastases; Triple Negative Breast Cancer; HER2-positive Breast Cancer
Intervention: Diagnostic Test: MRI screening
Sponsors: Sunnybrook Health Sciences Centre; Harvard University
Recruiting -
Validation of Readiband™ Actigraph and Associated Sleep/Wake Classification Algorithms
Posted: March 18th, 2019, 2:00pm GMT
Conditions: Glioma; Glioblastoma
Intervention: Device: Readiband Sleep Tracking
Sponsor: Allina Health System
Recruiting -
Epilepsy-related Brain Tumors Register
Posted: March 15th, 2019, 2:00pm GMT
Condition: Epilepsy
Intervention:
Sponsor: Groupe Hospitalier Paris Saint Joseph
Recruiting -
Low Dose Ipilimumab With Pembrolizumab in Treating Patients With Melanoma That Has Spread to the Brain
Posted: March 13th, 2019, 2:00pm GMT
Conditions: Clinical Stage IV Cutaneous Melanoma; Metastatic Malignant Neoplasm in the Brain; Metastatic Melanoma; Pathologic Stage IV Cutaneous Melanoma
Interventions: Biological: Ipilimumab; Biological: Pembrolizumab
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI); Merck Sharp & Dohme Corp.
Recruiting -
Promotion of Well-being of Young Adult Brain Cancer Survivors
Posted: March 12th, 2019, 2:00pm GMT
Condition: Brain Tumor, Pediatric
Intervention: Behavioral: Brief Internet-based Behavioral Activation Intervention
Sponsor: University of Wisconsin, Madison
Recruiting -
Selumetinib Versus Carboplatin/Vincristine in Treating Patients With Newly Diagnosed or Previously Untreated NF1-Associated Low-Grade Glioma
Posted: March 12th, 2019, 2:00pm GMT
Conditions: Low Grade Glioma; Neurofibromatosis Type 1; Visual Pathway Glioma
Interventions: Drug: Carboplatin; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Selumetinib; Drug: Selumetinib Sulfate; Drug: Vincristine; Drug: Vincristine Sulfate
Sponsor: National Cancer Institute (NCI)
Not yet recruiting -
LIFE - Lung Cancer, Immunotherapy, Frailty, Effect
Posted: March 12th, 2019, 2:00pm GMT
Conditions: Non-small Cell Lung Cancer; Quality of Life; Brain Metastases; Venous Thromboembolism
Interventions: Diagnostic Test: CT-scans extended; Diagnostic Test: MRI scan of the brain; Other: Prospective registration of irAEs; Behavioral: Quality of Life questionnaires
Sponsors: University of Southern Denmark; Odense University Hospital; University of Copenhagen; Odense Patient Data Explorative Network; Region of Southern Denmark
Recruiting -
Solriamfetol in Improving Sleep in Patients With Grade II-IV Glioma
Posted: March 11th, 2019, 2:00pm GMT
Conditions: Glioma; Glioblastoma
Intervention: Drug: Soliramfetol
Sponsors: Wake Forest University Health Sciences; National Cancer Institute (NCI)
Not yet recruiting -
Brigatinib in Treating Patients With ALK and ROS1 Gene Alterations and Locally Advanced or Metastatic Solid Cancers
Posted: March 11th, 2019, 2:00pm GMT
Conditions: Advanced Malignant Neoplasm; ALK Fusion Protein Expression; ALK Gene Amplification; ALK Gene Mutation; Locally Advanced Malignant Solid Neoplasm; Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Neoplasm in the Central Nervous System; Metastatic Malignant Solid Neoplasm; ROS1 Fusion Positive; ROS1 Gene Amplification; ROS1 Gene Mutation
Interventions: Drug: Brigatinib; Other: Laboratory Biomarker Analysis; Other: Quality-of-Life Assessment; Other: Questionnaire Administration
Sponsors: Sameek Roychowdhury; National Cancer Institute (NCI)
Not yet recruiting -
Stereotactic Ablative Radiotherapy for Comprehensive Treatment of Oligometastatic (1-3 Metastases) Cancer
Posted: March 5th, 2019, 3:00pm GMT
Condition: Metastatic Tumors
Interventions: Radiation: palliative radiotherapy; Radiation: Stereotactic ablative radiotherapy
Sponsors: British Columbia Cancer Agency; London Regional Cancer Program, Canada; Beatson Institute for Cancer Research, Scotland; The Alfred; Beacon Hospital, Ireland
Not yet recruiting -
The SAFE-Trial: Awake Craniotomy Versus Surgery Under General Anesthesia for Glioblastoma Patients.
Posted: March 4th, 2019, 3:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme; Glioblastoma Multiforme of Brain; Astrocytoma, Grade IV; Brain Tumor; Brain Cancer; Brain Neoplasms
Interventions: Procedure: Awake craniotomy; Procedure: Craniotomy under general anesthesia
Sponsors: Jasper Gerritsen; Elisabeth-TweeSteden Ziekenhuis; University Medical Center Groningen; Medical Center Haaglanden; Clinical Trial Center Erasmus MC
Recruiting -
Carvedilol With Chemotherapy in Second Line Glioblastoma and Response of Circulating Tumor Cells
Posted: March 4th, 2019, 3:00pm GMT
Conditions: Glioblastoma Multiforme; Glioblastoma
Intervention: Drug: Carvedilol
Sponsors: West Virginia University; West Virginia Clinical and Translational Science Institute
Not yet recruiting -
Ex Vivo Drug Sensitivity Testing and Mutation Profiling
Posted: March 1st, 2019, 3:00pm GMT
Conditions: Recurrent Childhood Acute Myeloid Leukemia; Recurrent Childhood Acute Lymphoblastic Leukemia; Recurrent Childhood Large Cell Lymphoma; Refractory Childhood Acute Lymphoblastic Leukemia; Refractory Childhood Hodgkin Lymphoma; Refractory Childhood Malignant Germ Cell Neoplasm; Recurrent Childhood Brain Tumor; Recurrent Childhood Brainstem Glioma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Childhood Soft Tissue Sarcoma; Recurrent Childhood Ependymoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Gliosarcoma; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive
Intervention:
Sponsors: Florida International University; Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Recruiting -
Exercise and Nutrition Interventions During Chemotherapy K07
Posted: February 28th, 2019, 3:00pm GMT
Condition: Neuropathy;Peripheral
Interventions: Behavioral: EXCAP Exercise; Behavioral: Nutrition Education
Sponsors: University of Rochester; National Cancer Institute (NCI)
Not yet recruiting -
Imaging Oxidative Metabolism and Neurotransmitter Synthesis in the Human Brain
Posted: February 21st, 2019, 3:00pm GMT
Condition: Brain Cancer
Intervention: Drug: Hyperpolarized [13C]Pyruvate
Sponsor: University of Texas Southwestern Medical Center
Not yet recruiting -
Longitudinal Analysis of the Health-related Quality of Life in Glioma Patients
Posted: February 21st, 2019, 3:00pm GMT
Condition: Glioma of Brain
Intervention:
Sponsor: Universitaire Ziekenhuizen Leuven
Recruiting -
Cancer Adverse Effects PReventIon With Care & Exercise: the CAPRICE Study
Posted: February 21st, 2019, 3:00pm GMT
Conditions: Breast Neoplasm Female; Cardiotoxicity; Anthracyclines; Physical Activity
Intervention: Other: Exercise Training
Sponsors: University Hospital Inselspital, Berne; Spital STS AG; Bürgerspital Solothurn; University of Bern
Not yet recruiting -
Ph0/2 Ribociclib & Everolimus
Posted: February 8th, 2019, 3:00pm GMT
Conditions: Glioblastoma Multiforme; Glioma of Brain
Interventions: Drug: Ribociclib; Drug: Everolimus 2.5 MG
Sponsors: St. Joseph's Hospital and Medical Center, Phoenix; Ivy Brain Tumor Center; Barrow Neurological Institute
Recruiting -
Hyperpolarized Carbon C 13 Pyruvate in Diagnosing Glioma in Patients With Brain Tumors
Posted: February 5th, 2019, 3:00pm GMT
Condition: Primary Brain Neoplasm
Interventions: Drug: Hyperpolarized Carbon C 13 Pyruvate; Procedure: Magnetic Resonance Spectroscopic Imaging
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Not yet recruiting -
Lidocaine and Perioperative Cytokine Levels in Blood and Cerebrospinal Fluid in Cerebral Aneurysm Patients
Posted: January 30th, 2019, 3:00pm GMT
Condition: Aneurysm, Cerebral
Intervention: Drug: Lidocaine
Sponsor: Clinical Hospital Centre Zagreb
Not yet recruiting -
Radiotherapy of Multiple Brain Metastases Using AGuIX®
Posted: January 28th, 2019, 3:00pm GMT
Conditions: Brain Metastases, Adult; Radiotherapy
Interventions: Drug: AGuIX®; Radiation: Whole Brain Radiation Therapy
Sponsors: University Hospital, Grenoble; NH TherAguix SAS
Recruiting -
Molecular Imaging of Pituitary Adenomas
Posted: January 24th, 2019, 3:00pm GMT
Condition: Pituitary Adenoma
Intervention: Diagnostic Test: PET imaging
Sponsors: Cardiff University; Cardiff and Vale University Health Board
Recruiting -
Stereotactic Radiation and Nivolumab in the Management of Metastatic Breast Cancer Brain Metastases
Posted: January 17th, 2019, 3:00pm GMT
Conditions: Metastatic Breast Cancer; Brain Metastases
Interventions: Drug: Nivolumab; Radiation: Stereotactic Radiosurgery
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; Bristol-Myers Squibb
Recruiting -
Modulating the GIP System in Patients With Acromegaly Due to a Pituitary Tumor
Posted: January 16th, 2019, 3:00pm GMT
Condition: Acromegaly Due to Pituitary Adenoma
Interventions: Other: GIP-A; Other: Placebo
Sponsors: University of Copenhagen; Rigshospitalet, Denmark; Aarhus University Hospital; Aalborg Universitetshospital; Odense University Hospital; Herlev and Gentofte Hospital
Not yet recruiting -
Copanlisib and Fulvestrant in Treating Postmenopausal Patients With ER+ and HER2- Metastatic Breast Cancer Progressing After Aromatase and CDK 4/6 Inhibitors Treatment
Posted: January 15th, 2019, 3:00pm GMT
Conditions: Anatomic Stage IV Breast Cancer AJCC v8; Estrogen Receptor Positive; HER2/Neu Negative; Metastatic Breast Carcinoma; Metastatic Malignant Neoplasm in the Brain; Postmenopausal; Prognostic Stage IV Breast Cancer AJCC v8
Interventions: Drug: Copanlisib; Drug: Fulvestrant
Sponsor: National Cancer Institute (NCI)
Not yet recruiting -
Apatinib Combined With Radiotherapy in Patient With BM From Drive Gene Negative NSCLC
Posted: January 11th, 2019, 3:00pm GMT
Condition: NSCLC
Intervention: Drug: Apatinib
Sponsor: Hubei Cancer Hospital
Not yet recruiting -
Docetaxel Combined With Carboplatin Plus Anlotinib as First Line Treatment in NSCLC
Posted: January 10th, 2019, 3:00pm GMT
Condition: NSCLC
Interventions: Drug: Anlotinib; Drug: Docetaxel; Drug: Carboplatin
Sponsors: Tongji Hospital; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Not yet recruiting -
Study to Evaluate Ibudilast and TMZ Combo Treatment in Recurrent GBM
Posted: December 20th, 2018, 3:00pm GMT
Conditions: Glioblastoma; Recurrent Glioblastoma; GBM; Recurrent GBM
Interventions: Drug: MN-166; Drug: Temozolomide
Sponsor: MediciNova
Recruiting -
18F-DOPA-PET/MRI Scan in Imaging Elderly Patients With Newly Diagnosed Grade IV Malignant Glioma or Glioblastoma During Planning For a Short Course of Proton Beam Radiation Therapy
Posted: December 18th, 2018, 3:00pm GMT
Conditions: Glioblastoma; Malignant Glioma
Interventions: Procedure: Computed Tomography; Other: Fluorodopa F 18; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography; Radiation: Proton Beam Radiation Therapy; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Drug: Temozolomide
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting -
Safety and Efficacy of L19TNF in Patients With Isocitrate Dehydrogenase (IDH) Wildtype WHO Grade III / IV Glioma at First Relapse
Posted: December 18th, 2018, 3:00pm GMT
Condition: Glioma of Brain
Intervention: Drug: L19TNF
Sponsor: Philogen S.p.A.
Not yet recruiting -
Impact of Nasoseptal Flap Harvest Technique on Olfaction Following Endoscopic Transsphenoidal Pituitary Surgery
Posted: December 12th, 2018, 3:00pm GMT
Conditions: Pituitary Tumor; Surgery; Olfactory Nerve Injuries
Intervention: Procedure: Electrocautery versus scalpel
Sponsor: St. Michael's Hospital, Toronto
Recruiting -
Study of RP1 Monotherapy and RP1 in Combination With Nivolumab
Posted: December 6th, 2018, 3:00pm GMT
Conditions: Cancer; Melanoma (Skin); Melanoma, Uveal; Melanoma, Ocular; Bladder Cancer; Mismatch Repair Deficiency; Microsatellite Instability; Non-melanoma Skin Cancer
Interventions: Biological: RP1; Biological: nivolumab
Sponsor: Replimune Inc.
Recruiting -
GDC-0084 in Combination With Trastuzumab for Patients With HER2-Positive Breast Cancer Brain Metastases
Posted: December 5th, 2018, 3:00pm GMT
Condition: Breast Cancer
Interventions: Drug: Trastuzumab; Drug: GDC-0084
Sponsors: Dana-Farber Cancer Institute; Kazia Therapeutics Limited
Recruiting -
Azoles Targeting Recurrent High Grade Gliomas
Posted: December 4th, 2018, 3:00pm GMT
Conditions: Brain Tumor, Recurrent; Cancer, Advanced; Glioma of Brain
Interventions: Drug: Ketoconazole (KCZ); Drug: Posaconazole (PCZ)
Sponsor: University Health Network, Toronto
Not yet recruiting -
Safety and Efficacy of Transient Opening of the Blood-brain Barrier (BBB) With the SonoCloud-9
Posted: November 16th, 2018, 3:00pm GMT
Condition: Glioblastoma, Adult
Interventions: Device: SonoCloud-9; Drug: Carboplatin
Sponsor: CarThera
Recruiting -
Wise Cortical Strip for Intraoperative Neurophysiological Monitoring
Posted: November 6th, 2018, 3:00pm GMT
Conditions: Brain Tumor Adult; Epilepsy
Intervention: Device: Wise Cortical Strip
Sponsors: Wise S.r.l.; Genae; Fondazione Don Carlo Gnocchi Onlus
Recruiting -
Temozolomide Combine With Intensity Modulated Radiation Therapy With Simultaneous Integrated Boost for Non Small Cell Lung Cancer Brain Metastases
Posted: November 6th, 2018, 3:00pm GMT
Condition: Non Small Cell Lung Cancer Metastatic
Interventions: Drug: Temozolomide capsules; Device: radiotherapy
Sponsor: Taizhou Hospital
Not yet recruiting -
Feasibility of the LUM Imaging System for Detection of Cancer to the Brain
Posted: October 24th, 2018, 2:00pm GMT
Conditions: Low Grade Glioma of Brain; Glioblastoma; Metastasis to Brain
Intervention: Combination Product: LUM Imaging System
Sponsor: Lumicell, Inc.
Recruiting -
Blood Brain Barrier Disruption (BBBD) Using MRgFUS in the Treatment of Her2-positive Breast Cancer Brain Metastases
Posted: October 22nd, 2018, 2:00pm GMT
Conditions: Breast Cancer; Brain Metastases
Intervention: Device: ExAblate BBBD
Sponsor: InSightec
Not yet recruiting -
Biomarker-Driven Therapy Using Immune Activators With Nivolumab in Patients With First Recurrence of Glioblastoma
Posted: October 16th, 2018, 2:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme
Interventions: Drug: Nivolumab; Drug: Anti-GITR Monoclonal Antibody MK-4166; Drug: IDO1 inhibitor INCB024360; Drug: Ipilimumab
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Bristol-Myers Squibb
Recruiting -
Tumor Treating Fields With Chemoradiation in Newly Diagnosed GBM
Posted: October 15th, 2018, 2:00pm GMT
Conditions: Glioblastoma; Cancer of Brain; Glioblastoma Multiforme; Brain Tumor
Interventions: Device: Tumor Treating Fields; Drug: Temozolomide; Radiation: Radiation Therapy
Sponsors: Providence Health & Services; Providence Health & Services Brain & Spine Institute; University of California, San Francisco; NovoCure Ltd.
Not yet recruiting -
Define the Optimal Uptake Time of 68Ga-OPS202 When Used as a PET (Positron Emission Tomography) Imaging Agent in Subjects With Newly Diagnosed Breast Cancer
Posted: October 5th, 2018, 2:00pm GMT
Condition: Breast Cancer
Intervention: Drug: Satoreotide trizoxetan
Sponsor: Ipsen
Recruiting -
Improving Brain Function After Breast Cancer Study
Posted: October 4th, 2018, 2:00pm GMT
Condition: Breast Cancer Survivors
Interventions: Behavioral: Kirtan Kriya meditation; Behavioral: Music listening program
Sponsor: University of Texas at Austin
Recruiting -
Detection of Brain Metastasis by MRI in Metastatic Colorectal Cancer Patients
Posted: October 3rd, 2018, 2:00pm GMT
Condition: Metastatic Colon Cancer
Intervention: Device: Magnetic resonance imaging
Sponsor: Poitiers University Hospital
Recruiting -
Non-invasive Glioma Characterization Through Molecular Imaging
Posted: September 25th, 2018, 2:00pm GMT
Conditions: Glioma; Brain Tumor; Primary Brain Tumor; Malignant Glioma; Malignant Primary Brain Tumor
Intervention: Diagnostic Test: 3T MRI Scanner
Sponsor: University of Miami
Recruiting -
Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases
Posted: September 21st, 2018, 2:00pm GMT
Conditions: Invasive Malignant Neoplasm; Metastatic Malignant Neoplasm in the Brain
Interventions: Procedure: Dynamic Susceptibility Contrast-MRI (DSC-MRI); Procedure: Magnetic Resonance Imaging (MRI)
Sponsor: Emory University
Recruiting -
9-ING-41 in Patients With Advanced Cancers
Posted: September 20th, 2018, 2:00pm GMT
Conditions: Cancer; Lymphoma; Pancreatic Cancer; Glioblastoma Multiforme; Sarcoma; Breast Cancer; Bladder Cancer; Renal Cancer; Ovarian Cancer; Refractory Cancer; Refractory Neoplasm; Refractory Non-Hodgkin Lymphoma; Refractory Brain Tumor; Pancreatic Adenocarcinoma; Resistant Cancer; Neoplasm Metastasis; Neoplasm of Bone; Neoplasm, Breast; Neoplasm of Lung; Neoplasms,Colorectal; Neoplasms Pancreatic; Malignant Glioma; Malignancies; Malignancies Multiple; Bone Metastases; Bone Neoplasm; Bone Cancer; Pancreas Cancer; Pancreatic Neoplasms; Breast Neoplasms
Interventions: Drug: 9-ING-41; Drug: Gemcitabine - 21 day cycle; Drug: Doxorubicin.; Drug: Lomustine; Drug: Carboplatin.; Drug: Nab paclitaxel.; Drug: Paclitaxel.; Drug: Gemcitabine - 28 day cycle
Sponsors: Actuate Therapeutics Inc.; Developmental Therapeutics Consortium
Recruiting -
BATs in Patients With Breast Cancer and Leptomeningeal Metastases
Posted: September 7th, 2018, 2:00pm GMT
Conditions: Breast Cancer Female; Leptomeningeal Metastases
Intervention: Drug: HER2 BATs
Sponsor: University of Virginia
Recruiting -
Trial of C134 in Patients With Recurrent GBM
Posted: September 5th, 2018, 2:00pm GMT
Conditions: Glioblastoma Multiforme of Brain; Anaplastic Astrocytoma of Brain; Gliosarcoma of Brain
Intervention: Biological: C134
Sponsor: University of Alabama at Birmingham
Not yet recruiting -
Phase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric Cancer
Posted: August 31st, 2018, 2:00pm GMT
Conditions: Leukemia; Brain Tumor; Solid Tumor; Lymphoma
Interventions: Drug: ALRN-6924; Drug: Cytarabine
Sponsors: Dana-Farber Cancer Institute; TeamConnor Childhood Cancer Foundation; Cookies for Kids' Cancer; Aileron Therapeutics
Recruiting -
A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies
Posted: August 29th, 2018, 2:00pm GMT
Conditions: Cervical Cancer; Gastric Cancer; Stomach Cancer; Gastroesophageal Junction Cancer; Esophageal Cancer; Hepatocellular Carcinoma; Melanoma; Uveal Melanoma; Merkel Cell Carcinoma; Mesothelioma; MSI; Non-small Cell Lung Cancer; NSCLC; Ovarian Cancer; Squamous Cell Carcinoma of the Head and Neck; Small Cell Lung Cancer; Renal Cell Carcinoma; RCC; Triple-negative Breast Cancer; Urothelial Carcinoma; Mismatch Repair Deficiency
Intervention: Drug: INCAGN02390
Sponsor: Incyte Corporation
Recruiting -
Avoiding Cardiac Toxicity in Lung Cancer Patients Treated With Curative-intent Radiotherapy
Posted: August 24th, 2018, 2:00pm GMT
Condition: Lung Cancer
Intervention: Diagnostic Test: Blood tests & cardiac imaging
Sponsors: Elizabeth Craven; The Leeds Teaching Hospitals NHS Trust; University of Manchester; University of Leeds; Manchester University NHS Foundation Trust
Not yet recruiting -
Pilot Imaging Study of Leukemia
Posted: August 16th, 2018, 2:00pm GMT
Condition: Acute Leukemia
Intervention: Drug: FLT imaging
Sponsors: Kirsten Williams; Children's Research Institute
Not yet recruiting -
Awake vs. Asleep Craniotomy for Non-eloquent Gliomas
Posted: August 8th, 2018, 2:00pm GMT
Condition: Intracranial Glioma
Interventions: Procedure: Awake Anesthesia Protocol; Procedure: Non-awake Anesthesia Protocol
Sponsor: Mayo Clinic
Not yet recruiting -
Assessment of Sensory Gating, Attention, and Executive Control in Breast Cancer
Posted: August 7th, 2018, 2:00pm GMT
Condition: Breast Cancer
Interventions: Other: SAE battery; Behavioral: Assessments
Sponsors: Memorial Sloan Kettering Cancer Center; The City College of New York
Recruiting -
Brain Monitoring for High Risk of Brain Metastases in Metastatic Breast Cancer
Posted: August 6th, 2018, 2:00pm GMT
Conditions: Metastatic Breast Cancer With HER2 Positive; Triple Negative Breast Cancer
Intervention: Procedure: Brain MRI
Sponsor: Yonsei University
Not yet recruiting -
Navigated Repetitive Transcranial Magnetic Stimulation in Improving Motor Rehabilitation in Participants With Grade II-IV Brain Tumors
Posted: July 30th, 2018, 2:00pm GMT
Condition: Brain Neoplasm
Interventions: Other: Questionnaire Administration; Procedure: Transcranial Magnetic Stimulation
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting -
A Biospecimen Collection Study in BRAF-V600E Mutated Recurrent Gliomas
Posted: July 20th, 2018, 2:00pm GMT
Conditions: Glioma; BRAF V600E; Pleomorphic Xantho-Astrocytoma; Glioblastoma
Intervention: Procedure: Surgical Cohort
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Musella Foundation
Recruiting -
Therapeutic Targeting of Sex Differences in Pediatric Brain Tumor Glycolysis
Posted: July 19th, 2018, 2:00pm GMT
Condition: Pediatric Brain Tumor
Interventions: Procedure: Ketogenic diet; Drug: BCNU
Sponsor: Washington University School of Medicine
Not yet recruiting -
Dose and Volume Escalation of Preoperative Brain Irradiation in GBM Patients -the POBIG Trial -
Posted: July 11th, 2018, 2:00pm GMT
Condition: Glioblastoma Multiforme
Intervention: Radiation: Preoperative brain irradiation (single fraction)
Sponsor: The Netherlands Cancer Institute
Not yet recruiting -
Study of Tozuleristide and the Canvas Imaging System in Pediatric Subjects With CNS Tumors Undergoing Surgery
Posted: July 6th, 2018, 2:00pm GMT
Condition: Pediatric Central Nervous System Tumor
Interventions: Drug: tozuleristide; Device: Canvas System
Sponsors: Blaze Bioscience Inc.; Pacific Pediatric Neuro-Oncology Consortium
Recruiting -
Effect of Exercise on Cancer-Related Fatigue
Posted: July 3rd, 2018, 2:00pm GMT
Conditions: Cancer-related Problem/Condition; Exercise
Interventions: Behavioral: TEHE only; Behavioral: Auricular Point Acupressure; Behavioral: Mindfulness body scan
Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Not yet recruiting -
Magnesium Sulphate Versus Lidocaine for Control of Emergence Hypertension
Posted: June 25th, 2018, 2:00pm GMT
Conditions: Craniotomy; Hypertension
Interventions: Drug: Magnesium sulphate; Drug: Lidocaine Hydrochloride; Drug: Normal saline
Sponsor: Ahmed Mohamed ELbadawy
Recruiting -
Hyperpolarized Carbon C 13 Pyruvate Magnetic Resonance Spectroscopic Imaging in Detecting Lactate and Bicarbonate in Participants With Central Nervous System Tumors
Posted: June 21st, 2018, 2:00pm GMT
Conditions: Malignant Central Nervous System Neoplasm; Metastatic Malignant Neoplasm in the Central Nervous System
Interventions: Other: Gadolinium; Drug: Hyperpolarized Carbon C 13 Pyruvate; Procedure: Magnetic Resonance Imaging; Procedure: Magnetic Resonance Spectroscopic Imaging
Sponsor: Daniel M. Spielman
Recruiting -
Safety and Feasibility of Preoperative and Intraoperative Image-Guided Resection of Gliomas
Posted: May 31st, 2018, 2:00pm GMT
Condition: Brain Tumor Adult
Interventions: Other: MR Perfusion Scan; Other: 2HG Spectroscopy Scan
Sponsor: University of Utah
Recruiting -
Osimertinib With Stereotactic Radiosurgery (SRS) in Brain Metastases From EGFR Positive NSCLC
Posted: May 24th, 2018, 2:00pm GMT
Conditions: NSCLC; Non-small Cell Lung Cancer
Intervention: Drug: Osimertinib
Sponsor: Case Comprehensive Cancer Center
Recruiting -
Intraoperative Ultrasound Guided Glioma Surgery; a Randomised, Controlled Trial.
Posted: May 21st, 2018, 2:00pm GMT
Condition: Glioma
Intervention: Procedure: ultrasound guided surgery.
Sponsors: Erasmus Medical Center; Stichting Coolsingel
Recruiting -
CB-839 With Radiation Therapy and Temozolomide in Treating Participants With IDH-Mutated Diffuse Astrocytoma or Anaplastic Astrocytoma
Posted: May 18th, 2018, 2:00pm GMT
Conditions: Anaplastic Astrocytoma, IDH-Mutant; Diffuse Astrocytoma, IDH-Mutant; IDH1 Gene Mutation; IDH2 Gene Mutation
Interventions: Drug: Glutaminase Inhibitor CB-839 Hydrochloride; Other: Questionnaire Administration; Radiation: Radiation Therapy; Drug: Temozolomide
Sponsor: National Cancer Institute (NCI)
Recruiting -
TN-TC11G (THC+CBD) Combination With Temozolomide and Radiotherapy in Patients With Newly-diagnosed Glioblastoma
Posted: May 18th, 2018, 2:00pm GMT
Condition: Glioblastoma
Interventions: Drug: TN-TC11G; Drug: Temozolomide Oral Product; Radiation: Radiotherapy
Sponsors: Grupo Español de Investigación en Neurooncología; Medical Cannabis Bike Tour; Voices Against Brain Cancer; Tilray
Not yet recruiting -
Atezolizumab in Combination With Carboplatin Plus Pemetrexed in Chemotherapy-naïve Patients With Asymptomatic Brain Metastasis
Posted: May 16th, 2018, 2:00pm GMT
Condition: Non-small Cell Lung Cancer Stage IV
Intervention: Drug: Atezolizumab
Sponsor: Spanish Lung Cancer Group
Recruiting -
Comparison of 6-fluoro-[18F]-L-dihydroxyphenylalanine (18F-DOPA) Positron Emission Tomography (PET) and Multiparametric Resonance Magnetic Imagery (RMI) in Initial Exploration of Glial Tumors
Posted: May 15th, 2018, 2:00pm GMT
Conditions: Brain Neoplasms; Adult Brain Tumor
Intervention: Diagnostic Test: PET imagery
Sponsor: Center Eugene Marquis
Recruiting -
Study of Proton Radiation to the Brain and Spinal Cord for Patients With Leptomeningeal Metastases
Posted: May 9th, 2018, 2:00pm GMT
Condition: Leptomeningeal Metastases
Intervention: Radiation: Proton craniospinal irradiation (CSI)
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting -
A Randomised Phase II Trial of Osimertinib With or Without SRS for EGFR Mutated NSCLC With Brain Metastases
Posted: April 13th, 2018, 2:00pm GMT
Condition: Metastatic Non Small Cell Lung Cancer
Interventions: Drug: Osimertinib; Radiation: Stereotactic Radiosurgery (SRS)
Sponsor: Trans-Tasman Radiation Oncology Group (TROG)
Not yet recruiting -
Evaluation of Functional Magnetic Resonance Imaging (fMRI) in Patients Who Speak Two Languages Fluently
Posted: April 12th, 2018, 2:00pm GMT
Conditions: Glioma; Glioma of Brain; Glioma of Spinal Cord
Interventions: Behavioral: Multilingual Aphasia Examination; Diagnostic Test: Language paradigms + RS fMRI; Diagnostic Test: Language paradigms + RS fMRI + one anatomical sequence
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting -
INO-5401 and INO-9012 Delivered by Electroporation (EP) in Combination With Cemiplimab (REGN2810) in Newly-Diagnosed Glioblastoma (GBM)
Posted: April 9th, 2018, 2:00pm GMT
Condition: Glioblastoma
Interventions: Biological: INO-5401; Biological: INO-9012; Biological: Cemiplimab; Radiation: Radiation Therapy; Drug: Temozolomide
Sponsor: Inovio Pharmaceuticals
Recruiting -
Radiosurgery Plus NovoTTF-200A for Metastatic Small Cell Lung Cancer to the Brain
Posted: April 5th, 2018, 2:00pm GMT
Conditions: Brain Metastases; Small Cell Lung Cancer
Interventions: Device: NovoTTF-200A; Radiation: Stereotactic Radiosurgery (SRS)
Sponsors: Drexell Hunter Boggs; NovoCure Ltd.
Recruiting -
Dose Escalation Study of CLR 131 in Children and Adolescents With Relapsed or Refractory Malignant Brain Cancer, Neuroblastoma, Rhabdomyosarcoma, Ewings Sarcoma, and Osteosarcoma
Posted: March 27th, 2018, 2:00pm GMT
Conditions: Pediatric Solid Tumor; Pediatric Lymphoma; Pediatric Brain Tumor
Intervention: Drug: CLR 131
Sponsor: Cellectar Biosciences, Inc.
Recruiting -
Testing Ramipril to Prevent Memory Loss in People With Glioblastoma
Posted: March 23rd, 2018, 2:00pm GMT
Conditions: Glioblastoma; Radiotherapy; Complications; Cognitive Decline; Chemoradiation
Intervention: Drug: Ramipril
Sponsors: Wake Forest University Health Sciences; National Cancer Institute (NCI)
Recruiting -
Early Palliative Care Intervention in Malignant Glioma
Posted: March 20th, 2018, 2:00pm GMT
Condition: Malignant Glioma
Intervention: Behavioral: Palliative Care
Sponsors: Duke University; Duke Cancer Institute
Recruiting -
A First in Human Study Using 89Zr-cRGDY Ultrasmall Silica Particle Tracers for Malignant Brain Tumors
Posted: March 14th, 2018, 2:00pm GMT
Condition: Brain Cancer
Interventions: Drug: 89Zr-DFO-cRGDY-PEG-Cy5-C' dots PET Imaging; Other: Blood and Urine samples
Sponsor: Memorial Sloan Kettering Cancer Center
Recruiting -
Improved Therapy Response Assessment in Metastatic Brain Tumors
Posted: March 8th, 2018, 3:00pm GMT
Condition: Brain Metastases
Interventions: Diagnostic Test: Magnetic Resonance Imaging; Radiation: Stereotactic Radiosurgery; Drug: Ipilimumab, nivolumab or pembrolizumab
Sponsors: Oslo University Hospital; Hospital of Southern Norway Trust; Ostfold Hospital Trust; St. Olavs Hospital; Massachusetts General Hospital; Dana-Farber Cancer Institute; University Medical Center Groningen; University of Texas Southwestern Medical Center; South-Eastern Norway Regional Health Authority; Norwegian Cancer Society
Recruiting -
Radiologic Pathologic Correlation of Advanced MR Imaging to Guide the Biopsy of Cerebral Malignancies
Posted: March 8th, 2018, 3:00pm GMT
Condition: Brain Lesion
Interventions: Procedure: Advanced Magnetic Resonance Imaging Scan; Procedure: Standard of Care Brain Biopsy and Tumor Removal
Sponsor: M.D. Anderson Cancer Center
Recruiting -
EDO-S101 for MGMT Unmethylated Glioblastoma (nGBM)
Posted: March 2nd, 2018, 3:00pm GMT
Conditions: Malignant Neoplasms of Eye Brain and Other Parts of Central Nervous System; Unmethylated Glioblastoma
Interventions: Drug: EDO-S101; Radiation: Radiation Therapy
Sponsors: M.D. Anderson Cancer Center; Mundipharma-EDO GmbH
Recruiting -
SYNERGY-AI: Artificial Intelligence Based Precision Oncology Clinical Trial Matching and Registry
Posted: March 2nd, 2018, 3:00pm GMT
Conditions: Cancer, Metastatic; Cancer; Cancer of Pancreas; Cancer of Liver; Cancer of Stomach; Cancer Liver; Cancer of Rectum; Cancer of Kidney; Cancer of Esophagus; Cancer of Cervix; Cancer of Colon; Cancer of Larynx; Cancer, Lung; Cancer, Breast; Cancer, Advanced; Cancer Prostate; Cancer of Neck; Cancer of Skin; Neuroendocrine Tumors; Carcinoma; Mismatch Repair Deficiency; BRCA Gene Rearrangement; Non Hodgkin Lymphoma; Leukemia; Non Small Cell Lung Cancer; Cholangiocarcinoma; Glioblastoma; Central Nervous System Tumor; Melanoma; Urothelial Carcinoma; Bladder Cancer; Ovarian Cancer; Endometrial Cancer; Testicular Cancer; Breast Cancer
Intervention: Other: Clinical Trial Matching
Sponsor: Massive Bio, Inc.
Recruiting -
Phase II Trial of Seizure Prophylaxis in Suspected Primary Glioma Patients Undergoing Craniotomy
Posted: February 16th, 2018, 3:00pm GMT
Conditions: Glioma; Glioma of Brain; Brain Tumor
Interventions: Drug: Lacosamide; Drug: Levetiracetam
Sponsor: Duke University
Recruiting -
Vemurafenib Plus Cobimetinib After Radiosurgery in Patients With BRAF-mutant Melanoma Brain Metastases
Posted: February 13th, 2018, 3:00pm GMT
Conditions: Malignant Melanoma Stage IV; BRAF V600 Mutation; Brain Metastases
Interventions: Drug: Vemurafenib; Drug: Cobimetinib
Sponsor: Technische Universität Dresden
Recruiting -
Normal Saline Vrs Balanced i.v. Fluids in Neurosurgery
Posted: February 12th, 2018, 3:00pm GMT
Conditions: Benign Neoplasms; Vascular Malformations, Brain
Interventions: Other: Normal saline; Other: Balanced fluid
Sponsors: Clinical Hospital Centre Zagreb; Sisters of Mercy University Hospital
Recruiting