Condition: Brain Metastases
Interventions: Radiation: Stereotactic Radiosurgery (SRS); Radiation: Whole brain radiation (WBRT)
Sponsor: Sunnybrook Health Sciences Centre
Not yet recruiting
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Acinar Cell Carcinoma
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Trial - Brain Tumor (100 unread)
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Radiosurgery With or Without Whole Brain Radiation for Multiple Metastases
Posted: December 13th, 2018, 3:00pm GMT
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Impact of Nasoseptal Flap Harvest Technique on Olfaction Following Endoscopic Transsphenoidal Pituitary Surgery
Posted: December 12th, 2018, 3:00pm GMT
Conditions: Pituitary Tumor; Surgery; Olfactory Nerve Injuries
Intervention: Procedure: Electrocautery versus scalpel
Sponsor: St. Michael's Hospital, Toronto
Not yet recruiting -
Evaluating Structural and Functional Changes of Brain by fMRI and DTI in Patients With Intracranial Germ Cell Tumors
Posted: December 11th, 2018, 3:00pm GMT
Condition: Intracranial Germ Cell Tumor
Intervention: Radiation: radiotherapy
Sponsor: Beijing Neurosurgical Institute
Not yet recruiting -
Study of Osimertinib + SRS vs SRS Alone for Brain Metastases in EGFR Positive Patients
Posted: December 7th, 2018, 3:00pm GMT
Conditions: Lung Cancer Non-small Cell Stage IV; Brain Metastases
Interventions: Drug: Osimertinib; Radiation: Stereotactic radiotherapy
Sponsors: British Columbia Cancer Agency; AstraZeneca; Princess Margaret Hospital, Canada; Sunnybrook Health Sciences Centre
Not yet recruiting -
Study of RP1 Monotherapy and RP1 in Combination With Nivolumab
Posted: December 6th, 2018, 3:00pm GMT
Conditions: Cancer; Melanoma (Skin); Melanoma, Uveal; Melanoma, Ocular; Bladder Cancer; Mismatch Repair Deficiency; Microsatellite Instability; Non-melanoma Skin Cancer
Interventions: Biological: RP1; Biological: nivolumab
Sponsor: Replimune Inc.
Recruiting -
GDC-0084 in Combination With Trastuzumab for Patients With HER2-Positive Breast Cancer Brain Metastases
Posted: December 5th, 2018, 3:00pm GMT
Condition: Breast Cancer
Interventions: Drug: Trastuzumab; Drug: GDC-0084
Sponsors: Dana-Farber Cancer Institute; Kazia Therapeutics
Not yet recruiting -
Azoles Targeting Recurrent High Grade Gliomas
Posted: December 4th, 2018, 3:00pm GMT
Conditions: Brain Tumor, Recurrent; Cancer, Advanced; Glioma of Brain
Interventions: Drug: Ketoconazole; Drug: Posaconazole
Sponsor: University Health Network, Toronto
Not yet recruiting -
Studies of Chlorogenic Acid for Injection for Safety and Efficacy of Grade IV GBM Patients
Posted: November 29th, 2018, 3:00pm GMT
Condition: GBM
Interventions: Drug: Chlorogenic acid for Injection; Drug: Lomustine
Sponsor: Sichuan J.Z. Bio-chemical Science and Technology Development Co., Ltd
Recruiting -
Prevalence of Constitutional Mismatch-repair Deficiency Among Suspected Neurofibromatosis Type 1/Legius Syndrome Children Without a Malignancy and Without a NF1 or SPRED1 Mutation
Posted: November 28th, 2018, 3:00pm GMT
Condition: Neurofibromatosis Type 1
Intervention:
Sponsor: Medical University Innsbruck
Not yet recruiting -
Icotinib Combined With Radiation Therapy For NSCLC Patients With Brain Metastases and EGFR Mutation
Posted: November 27th, 2018, 3:00pm GMT
Conditions: Non-Small Cell Lung Cancer; Brain Metastases
Interventions: Drug: Icotinib; Radiation: WBRT or SRS
Sponsor: Betta Pharmaceuticals Co.,Ltd.
Not yet recruiting -
X-396(Ensartinib) Capsules in ALK-Positive NSCLC Patients With Brain Metastases
Posted: November 27th, 2018, 3:00pm GMT
Conditions: Nonsmall Cell Lung Cancer; Brain Metastases
Intervention: Drug: X-396(Ensartinib) Capsule
Sponsors: Fudan University; Betta Pharmaceuticals Co.,Ltd.
Not yet recruiting -
Pre-Operative or Post-Operative Stereotactic Radiosurgery in Treating Patients With Operative Metastatic Brain Tumors
Posted: November 21st, 2018, 3:00pm GMT
Conditions: Metastatic Malignant Neoplasm in the Brain; Solid Neoplasm
Interventions: Procedure: Conventional Surgery; Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Radiation: Stereotactic Radiosurgery
Sponsors: Mayo Clinic; National Cancer Institute (NCI)
Recruiting -
Whole Brain Radiation Therapy With Standard Temozolomide Chemo-Radiotherapy and Plerixafor in Treating Patients With Glioblastoma
Posted: November 19th, 2018, 3:00pm GMT
Conditions: Glioblastoma; Glioblastoma With Primitive Neuronal Component; Gliosarcoma; Malignant Glioma; Oligodendroglial Component Present
Interventions: Drug: Plerixafor; Drug: Temozolomide; Radiation: Whole-Brain Radiotherapy (WBRT); Radiation: Radiation Therapy
Sponsors: Lawrence Recht; Sanofi
Recruiting -
Safety and Efficacy of Transient Opening of the Blood-brain Barrier (BBB) With the SonoCloud-9
Posted: November 16th, 2018, 3:00pm GMT
Condition: Glioblastoma, Adult
Interventions: Device: SonoCloud-9; Drug: Carboplatin
Sponsor: CarThera
Not yet recruiting -
Pre-operative SRS or Post-operative SRS in Treating Cancer Patients With Brain Metastases
Posted: November 15th, 2018, 3:00pm GMT
Conditions: Malignant Neoplasm; Metastatic Malignant Neoplasm in the Brain
Interventions: Other: Quality-of-Life Assessment; Other: Questionnaire Administration; Radiation: Stereotactic Radiosurgery
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting -
TMZ Plus Apatinib in Newly Diagnosed High-grade Glioma：RCT
Posted: November 14th, 2018, 3:00pm GMT
Condition: Glioma
Interventions: Drug: apatinib; Drug: Temozolomide
Sponsor: The Second Hospital of Hebei Medical University
Not yet recruiting -
Clinical Benefit of Using Molecular Profiling to Determine an Individualized Treatment Plan for Patients With High Grade Glioma
Posted: November 12th, 2018, 3:00pm GMT
Conditions: Glioma; Glioma of Brain; Cancer; Pediatric Cancer; Pediatric Brain Tumor; Astrocytoma; Glioblastoma; Hemispheric
Intervention: Other: Specialized tumor board recommendation
Sponsors: University of California, San Francisco; Pacific Pediatric Neuro-Oncology Consortium
Recruiting -
Cancer Related Cognitive Impairment After Chemotherapy: Evaluation of Potential Therapeutic Interventions
Posted: November 9th, 2018, 3:00pm GMT
Condition: Cognitive Impairment
Interventions: Behavioral: Mindfulness; Behavioral: Physical training
Sponsor: KU Leuven
Recruiting -
Wise Cortical Strip for Intraoperative Neurophysiological Monitoring
Posted: November 6th, 2018, 3:00pm GMT
Conditions: Brain Tumor Adult; Epilepsy
Intervention: Device: Wise Cortical Strip
Sponsors: Wise S.r.l.; Genae; Fondazione Don Carlo Gnocchi Onlus
Not yet recruiting -
Temozolomide Combine With Intensity Modulated Radiation Therapy With Simultaneous Integrated Boost for Non Small Cell Lung Cancer Brain Metastases
Posted: November 6th, 2018, 3:00pm GMT
Condition: Non Small Cell Lung Cancer Metastatic
Interventions: Drug: Temozolomide capsules; Device: radiotherapy
Sponsor: Taizhou Hospital
Not yet recruiting -
Evaluation of Safety and Efficacy of Patients With Four and More Symptomatic Brain Metastases of Melanoma
Posted: November 2nd, 2018, 2:00pm GMT
Conditions: Metastatic Melanoma; Brain Metastases
Interventions: Biological: Nivolumab; Biological: Ipilimumab
Sponsor: University Hospital Tuebingen
Recruiting -
Phase I Study of Fractionated Stereotactic Radiation Therapy
Posted: October 31st, 2018, 2:00pm GMT
Condition: Brain Metastases
Intervention: Radiation: Fractionated Stereotactic Radiation Therapy
Sponsor: Albert Einstein College of Medicine, Inc.
Recruiting -
Fluoroglutamine PET/CT in Imaging Patients With Malignant Tumor
Posted: October 26th, 2018, 2:00pm GMT
Conditions: Cancer; Metastatic Cancer; Metastatic Brain Cancer
Intervention: Radiation: 18F-(2S,4R)4-fluoroglutamine
Sponsor: Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Recruiting -
Postoperative Cognitive Dysfunction in Patients Undergoing Pituitary Removal Surgery
Posted: October 25th, 2018, 2:00pm GMT
Condition: Pituitary Tumor
Intervention: Diagnostic Test: standardized minimental testing
Sponsor: Kocaeli University
Recruiting -
Avelumab With Radiotherapy in Patients With Leptomeningeal Disease
Posted: October 25th, 2018, 2:00pm GMT
Conditions: Leptomeningeal Metastases; Leptomeningeal Disease
Interventions: Drug: Avelumab; Radiation: Whole Brain Radiotherapy
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; Pfizer
Not yet recruiting -
Application of New Technologies in the Resection of Intracranial Tumors
Posted: October 24th, 2018, 2:00pm GMT
Condition: Intracranial Neoplasm
Intervention: Device: intraoperative neuronavigation ultrasound, intraoperative tractography, intraoperative fluorescence, advanced neuronavigation and intraoperative neurophysiology
Sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Not yet recruiting -
Nivolumab in People With IDH-Mutant Gliomas With and Without Hypermutator Phenotype
Posted: October 24th, 2018, 2:00pm GMT
Conditions: Glioma; Glioblastoma; High Grage Glioma; Low Grade Glioma; Malignant Glioma
Intervention: Drug: Nivolumab
Sponsor: National Cancer Institute (NCI)
Not yet recruiting -
Feasibility of the LUM Imaging System for Detection of Cancer to the Brain
Posted: October 24th, 2018, 2:00pm GMT
Conditions: Low Grade Glioma of Brain; Glioblastoma; Metastasis to Brain
Intervention: Combination Product: LUM Imaging System
Sponsor: Lumicell, Inc.
Not yet recruiting -
Multimodal Imaging of Hypoxia in Gliomas
Posted: October 23rd, 2018, 2:00pm GMT
Condition: Glioma
Intervention: Diagnostic Test: MRI Oxygen Saturation Map
Sponsor: University Hospital, Caen
Not yet recruiting -
The Effect of Cerebral Oxygenation on Postoperative Recovery in Intracranial Surgery
Posted: October 22nd, 2018, 2:00pm GMT
Condition: Intracranial Neoplasm
Interventions: Device: cerebral oxygen monitoring; Device: routine monitoring
Sponsor: Trakya University
Recruiting -
Blood Brain Barrier Disruption (BBBD) Using MRgFUS in the Treatment of Her2-positive Breast Cancer Brain Metastases
Posted: October 22nd, 2018, 2:00pm GMT
Conditions: Breast Cancer; Brain Metastases
Intervention: Device: ExAblate BBBD
Sponsor: InSightec
Not yet recruiting -
Dopamine D2 Receptors(D2R) Imaging in Nonfunctioning Pituitary Adenoma(NFPA)
Posted: October 22nd, 2018, 2:00pm GMT
Condition: Pituitary Adenoma
Interventions: Drug: Drug treatment; Other: Surgery
Sponsors: Zhebao Wu; Xinqiao Hospital of Chongqing; First Hospital of China Medical University; Beijing Tiantan Hospital; First Affiliated Hospital of Wenzhou Medical University; First Affiliated Hospital of Fujian Medical University; Peking Union Medical College Hospital; Huashan Hospital; Chinese PLA General Hospital
Not yet recruiting -
Afatinib on CNS Metastases and LMD in EGFR Mutation Positive NSCLC
Posted: October 18th, 2018, 2:00pm GMT
Conditions: Non-small Cell Lung Cancer; Leptomeningeal Disease; Central Nervous System Metastases
Intervention: Drug: Afatinib
Sponsor: National Cancer Centre, Singapore
Not yet recruiting -
The Effectiveness and Safety of Human Lumbar Puncture Assist Device (LPat)
Posted: October 18th, 2018, 2:00pm GMT
Conditions: Meningitis; Encephalitis; Guillain-Barré; Subarachnoid Hemorrhage; Intracranial Neoplasm; Intracranial CNS Disorder
Intervention: Device: LPat Device
Sponsors: Spartanburg Regional Healthcare System; Edward Via Virginia College of Osteopathic Medicine
Recruiting -
Study Of Palbociclib Combined With Chemotherapy In Pediatric Patients With Recurrent/Refractory Solid Tumors
Posted: October 17th, 2018, 2:00pm GMT
Conditions: Solid Tumors; Ewing Sarcoma; Rhabdoid Tumor; Rhabdomyosarcoma; Neuroblastoma; Medulloblastoma
Interventions: Drug: Palbociclib; Drug: Temozolomide; Drug: Irinotecan
Sponsor: Pfizer
Not yet recruiting -
Biomarker-Driven Therapy Using Immune Activators With Nivolumab in Patients With First Recurrence of Glioblastoma
Posted: October 16th, 2018, 2:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme
Interventions: Drug: Nivolumab; Drug: Anti-GITR Monoclonal Antibody MK-4166; Drug: IDO1 inhibitor INCB024360; Drug: Ipilimumab
Sponsors: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins; Bristol-Myers Squibb
Not yet recruiting -
Tumor Treating Fields With Chemoradiation in Newly Diagnosed GBM
Posted: October 15th, 2018, 2:00pm GMT
Conditions: Glioblastoma; Cancer of Brain; Glioblastoma Multiforme; Brain Tumor
Interventions: Device: Tumor Treating Fields; Drug: Temozolomide; Radiation: Radiation Therapy
Sponsors: Providence Health & Services; Providence Health & Services Brain & Spine Institute; University of California, San Francisco; NovoCure Ltd.
Not yet recruiting -
Precise DCE-MRI in Diagnosing Participants With Recurrent High Grade Glioma or Melanoma Brain Metastases
Posted: October 5th, 2018, 2:00pm GMT
Conditions: Brain Metastases; Glioma of Brain; Brain Tumor; Metastatic Melanoma
Interventions: Device: Dynamic Contrast-Enhanced Magnetic Resonance Imaging; Drug: Bevacizumab Injection
Sponsors: University of Southern California; National Cancer Institute (NCI)
Not yet recruiting -
Fractionated Stereotactic Radiotherapy vs. Single Session Radiosurgery in Patients With Larger Brain Metastases
Posted: October 5th, 2018, 2:00pm GMT
Condition: Cerebral Metastases of Solid Cancers
Interventions: Radiation: Radiosurgery; Radiation: Fractionated stereotactic radiotherapy
Sponsor: University of Erlangen-Nürnberg Medical School
Not yet recruiting -
Blood Biomarker Signature in Glioma
Posted: October 5th, 2018, 2:00pm GMT
Condition: Glioma of Brain
Intervention: Other: Non-interventional
Sponsors: Cancer Trials Ireland; Dublin City University
Recruiting -
Define the Optimal Uptake Time of 68Ga-OPS202 When Used as a PET (Positron Emission Tomography) Imaging Agent in Subjects With Newly Diagnosed Breast Cancer
Posted: October 5th, 2018, 2:00pm GMT
Condition: Breast Cancer
Intervention: Drug: Satoreotide trizoxetan
Sponsor: Ipsen
Recruiting -
Phase I Study of GDC-0084 in Pediatric Patients With Newly Diagnosed Diffuse Intrinsic Pontine Glioma or Diffuse Midline Gliomas
Posted: October 4th, 2018, 2:00pm GMT
Condition: Brain and Central Nervous System Tumors
Interventions: Drug: GDC-0084; Radiation: radiation therapy
Sponsors: St. Jude Children's Research Hospital; Kazia Therapeutics Limited
Recruiting -
HER2-CAR T Cells in Treating Participants With Brain or Leptomeningeal Metastases
Posted: October 4th, 2018, 2:00pm GMT
Conditions: HER2/Neu Positive; Malignant Neoplasm; Metastatic Malignant Neoplasm in the Brain; Metastatic Malignant Neoplasm in the Leptomeninges
Intervention: Biological: Chimeric Antigen Receptor T-Cell Therapy
Sponsors: City of Hope Medical Center; National Cancer Institute (NCI); Mustang Bio, Inc.
Recruiting -
Improving Brain Function After Breast Cancer Study
Posted: October 4th, 2018, 2:00pm GMT
Condition: Breast Cancer Survivors
Interventions: Behavioral: Kirtan Kriya meditation; Behavioral: Music listening program
Sponsor: University of Texas at Austin
Recruiting -
Detection of Brain Metastasis by MRI in Metastatic Colorectal Cancer Patients
Posted: October 3rd, 2018, 2:00pm GMT
Condition: Metastatic Colon Cancer
Intervention: Device: Magnetic resonance imaging
Sponsor: Poitiers University Hospital
Not yet recruiting -
A Study of Pyrotinib Plus Capecitabine in Patients With Brain Metastases From HER2-positive Metastatic Breast Cancer
Posted: October 1st, 2018, 2:00pm GMT
Condition: HER2 Positive Metastatic Breast Cancer
Intervention: Drug: Pyrotinib plus Capecitabine
Sponsor: Henan Cancer Hospital
Not yet recruiting -
DECT in Imaging Patients With Solid Organ Cancer With Intracranial Metastasis
Posted: September 26th, 2018, 2:00pm GMT
Conditions: Malignant Neoplasm; Metastatic Malignant Neoplasm in the Brain
Intervention: Procedure: Dual-Energy Computed Tomography
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting -
Non-invasive Glioma Characterization Through Molecular Imaging
Posted: September 25th, 2018, 2:00pm GMT
Conditions: Glioma; Brain Tumor; Primary Brain Tumor; Malignant Glioma; Malignant Primary Brain Tumor
Intervention: Diagnostic Test: 3T MRI Scanner
Sponsor: University of Miami
Not yet recruiting -
Utility of Perfusion MRI to Detect Radiation Necrosis in Patients With Brain Metastases
Posted: September 21st, 2018, 2:00pm GMT
Conditions: Invasive Malignant Neoplasm; Metastatic Malignant Neoplasm in the Brain
Interventions: Procedure: Dynamic Susceptibility Contrast-MRI (DSC-MRI); Procedure: Magnetic Resonance Imaging (MRI)
Sponsor: Emory University
Not yet recruiting -
Evaluation of Ad-RTS-hIL-12 + Veledimex in Subjects With Recurrent or Progressive Glioblastoma, a Substudy to ATI001-102
Posted: September 20th, 2018, 2:00pm GMT
Condition: Glioblastoma
Interventions: Biological: Ad-RTS-hIL-12; Drug: veledimex
Sponsor: Ziopharm
Recruiting -
9-ING-41 in Patients With Advanced Cancers
Posted: September 20th, 2018, 2:00pm GMT
Conditions: Cancer; Lymphoma; Pancreatic Cancer; Glioblastoma Multiforme; Sarcoma; Breast Cancer; Bladder Cancer; Renal Cancer; Ovarian Cancer; Refractory Cancer; Refractory Neoplasm; Refractory Non-Hodgkin Lymphoma; Refractory Brain Tumor; Pancreatic Adenocarcinoma; Resistant Cancer; Neoplasm Metastasis; Neoplasm of Bone; Neoplasm, Breast; Neoplasm of Lung; Neoplasms,Colorectal; Neoplasms Pancreatic; Malignant Glioma; Malignancies; Malignancies Multiple; Bone Metastases; Bone Neoplasm; Bone Cancer; Pancreas Cancer; Pancreatic Neoplasms; Breast Neoplasms
Interventions: Drug: 9-ING-41; Drug: Gemcitabine - 21 day cycle; Drug: Doxorubicin.; Drug: Lomustine; Drug: Carboplatin.; Drug: Nab paclitaxel.; Drug: Paclitaxel.; Drug: Gemcitabine - 28 day cycle
Sponsors: Actuate Therapeutics Inc.; Developmental Therapeutics Consortium
Recruiting -
Spectroscopic Magnetic Resonance Imaging of Glioma
Posted: September 19th, 2018, 2:00pm GMT
Condition: Brain Tumor-Glioma
Intervention: Diagnostic Test: MEGA-PRESS sequence Magnetic Resonance Spectroscopy
Sponsor: University of Minnesota - Clinical and Translational Science Institute
Not yet recruiting -
Feasibility of Endosphenoidal Coil Placement for Imaging of the Sella During Transsphenoidal Surgery
Posted: September 19th, 2018, 2:00pm GMT
Condition: Pituitary Neoplasm
Intervention: Device: ENDOSPHENOIDAL COIL
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS)
Not yet recruiting -
Nasal Packing Following Endoscopic Endonasal Pituitary Resection
Posted: September 19th, 2018, 2:00pm GMT
Condition: Pituitary Tumor
Intervention: Other: No nasal packing.
Sponsors: Ottawa Hospital Research Institute; The Physicians' Services Incorporated Foundation
Not yet recruiting -
Presence of a Localized or Diffuse Pruritus in a Population With One or Several, Primitive or Secondary, Brain Tumor(s)
Posted: September 17th, 2018, 2:00pm GMT
Conditions: Pruritus; Brain Tumor
Intervention:
Sponsor: University Hospital, Brest
Not yet recruiting -
DM-CHOC-PEN for Brain Tumors in AYA Subjects
Posted: September 13th, 2018, 2:00pm GMT
Conditions: Advanced Cancer; Brain Metastases
Intervention: Drug: DM-CHOC-PEN
Sponsor: DEKK-TEC, Inc.
Not yet recruiting -
Treatment With Azacitidine of Recurrent Gliomas With IDH1/2 Mutation
Posted: September 12th, 2018, 2:00pm GMT
Condition: Recurrent IDH1/2 Mutated Glioma
Intervention: Drug: Azacitidine
Sponsor: Assistance Publique - Hôpitaux de Paris
Not yet recruiting -
Vegetative Monitoring During Brainstem-associated Surgery
Posted: September 11th, 2018, 2:00pm GMT
Conditions: Brain Tumor, Recurrent; Vestibular Schwannoma; Brainstem Neoplasm; Brainstem Glioma
Intervention: Procedure: Intraoperative Monitoring during resection of brain tumor
Sponsor: University Hospital Tuebingen
Recruiting -
BATs in Patients With Breast Cancer and Leptomeningeal Metastases
Posted: September 7th, 2018, 2:00pm GMT
Conditions: Breast Cancer Female; Leptomeningeal Metastases
Intervention: Drug: HER2 BATs
Sponsor: University of Virginia
Not yet recruiting -
Communicating About Sexual Concerns and Dysfunction Effectively (CASCADE) Program
Posted: September 5th, 2018, 2:00pm GMT
Condition: Cancer
Intervention: Behavioral: Communicating About Sexual Concerns and Dysfunction Effectively
Sponsor: Duke University
Recruiting -
Trial of C134 in Patients With Recurrent GBM
Posted: September 5th, 2018, 2:00pm GMT
Conditions: Glioblastoma Multiforme of Brain; Anaplastic Astrocytoma of Brain; Gliosarcoma of Brain
Intervention: Biological: C134
Sponsor: University of Alabama at Birmingham
Not yet recruiting -
Phase 1 Study of the Dual MDM2/MDMX Inhibitor ALRN-6924 in Pediatric Cancer
Posted: August 31st, 2018, 2:00pm GMT
Conditions: Leukemia; Brain Tumor; Solid Tumor; Lymphoma
Interventions: Drug: ALRN-6924; Drug: Cytarabine
Sponsors: Dana-Farber Cancer Institute; TeamConnor Childhood Cancer Foundation; Cookies for Kids' Cancer
Recruiting -
First Line Treatment in EGFR Mutation Positive Advanced NSCLC Patients With Central Nervous System Metastases
Posted: August 31st, 2018, 2:00pm GMT
Conditions: Non-small Cell Lung Cancer; EGFR Gene Mutation; Brain Metastases
Interventions: Drug: AZD3759; Drug: Erlotinib; Drug: Gefitinib
Sponsor: Alpha Biopharma (Jiangsu) Co., Ltd.
Recruiting -
Multi-antigen T Cell Infusion Against Neuro-oncologic Disease
Posted: August 29th, 2018, 2:00pm GMT
Condition: Brain Tumor
Intervention: Biological: TAA-T
Sponsors: Catherine Bollard; Children's Research Institute
Recruiting -
A Safety and Tolerability Study of INCAGN02390 in Select Advanced Malignancies
Posted: August 29th, 2018, 2:00pm GMT
Conditions: Cervical Cancer; Gastric Cancer; Stomach Cancer; Gastroesophageal Junction Cancer; Esophageal Cancer; Hepatocellular Carcinoma; Melanoma; Uveal Melanoma; Merkel Cell Carcinoma; Mesothelioma; MSI; Non-small Cell Lung Cancer; NSCLC; Ovarian Cancer; Squamous Cell Carcinoma of the Head and Neck; Small Cell Lung Cancer; Renal Cell Carcinoma; RCC; Triple-negative Breast Cancer; Urothelial Carcinoma; Mismatch Repair Deficiency
Intervention: Drug: INCAGN02390
Sponsor: Incyte Corporation
Recruiting -
Feasibility of FMISO in Brain Tumors
Posted: August 28th, 2018, 2:00pm GMT
Condition: Malignant Brain Neoplasm
Interventions: Drug: ¹⁸F-Fluoromisonidazole; Procedure: Computed Tomography; Procedure: Magnetic Resonance Imaging; Procedure: Positron Emission Tomography
Sponsors: OHSU Knight Cancer Institute; National Cancer Institute (NCI)
Not yet recruiting -
Avoiding Cardiac Toxicity in Lung Cancer Patients Treated With Curative-intent Radiotherapy
Posted: August 24th, 2018, 2:00pm GMT
Condition: Lung Cancer
Intervention: Diagnostic Test: Blood tests & cardiac imaging
Sponsors: Sally Falk; The Leeds Teaching Hospitals NHS Trust; University of Manchester; University of Leeds; Manchester University NHS Foundation Trust
Not yet recruiting -
To Reduce the Use of Chemotherapy in Elderly Patients With ER-positive and HER2-positive Breast Cancer (TOUCH)
Posted: August 23rd, 2018, 2:00pm GMT
Conditions: Breast Cancer; Estrogen Receptor Positive Tumor; HER2-positive Breast Cancer
Interventions: Drug: Paclitaxel; Drug: Trastuzumab; Drug: Pertuzumab; Drug: Palbociclib; Drug: Letrozole
Sponsors: International Breast Cancer Study Group; Pfizer; Hoffmann-La Roche
Not yet recruiting -
non_invasive_aICP_Tumor
Posted: August 22nd, 2018, 2:00pm GMT
Conditions: Tumor, Brain; Intracranial Pressure Increase
Intervention: Device: Non-invasive measurement of intracranial pressure
Sponsor: Kantonsspital Aarau
Recruiting -
MRI Predictors of Response to Tumor Treating Fields
Posted: August 22nd, 2018, 2:00pm GMT
Condition: Glioblastoma Multiforme
Intervention:
Sponsor: New York Methodist Hospital
Not yet recruiting -
Sunitinib in Sarcomas of the Central Nervous System
Posted: August 22nd, 2018, 2:00pm GMT
Conditions: Gliosarcoma; Central Nervous System Sarcoma
Interventions: Drug: Sunitinib; Device: wGT3x-BT
Sponsor: National Cancer Institute (NCI)
Not yet recruiting -
Dendritic Cell Therapy for Brain Metastases From Breast- or Lung Cancer
Posted: August 20th, 2018, 2:00pm GMT
Conditions: Brain Metastases; Lung Cancer Metastatic; Breast Cancer Metastatic
Intervention: Biological: DCVax-Direct
Sponsors: Northwest Biotherapeutics; Mayo Clinic
Not yet recruiting -
EGFR806-specific CAR T Cell Locoregional Immunotherapy for EGFR-positive Recurrent or Refractory Pediatric CNS Tumors
Posted: August 20th, 2018, 2:00pm GMT
Conditions: Central Nervous System Tumor, Pediatric; Glioma; Ependymoma; Medulloblastoma; Germ Cell Tumor; Atypical Teratoid/Rhabdoid Tumor; Primitive Neuroectodermal Tumor; Choroid Plexus Carcinoma; Pineoblastoma
Intervention: Biological: EGFR806-specific chimeric antigen receptor (CAR) T cell
Sponsor: Seattle Children's Hospital
Not yet recruiting -
Eribulin in Brain Metastases From HER2-negative Breast Cancer
Posted: August 20th, 2018, 2:00pm GMT
Condition: Metastatic Breast Cancer
Intervention: Drug: Eribulin
Sponsors: Institut Paoli-Calmettes; Eisai Inc.
Not yet recruiting -
Efficacy and Safety of Perampanel in Combination in Glioma-refractory Epilepsy
Posted: August 17th, 2018, 2:00pm GMT
Condition: Refractory Epilepsy
Interventions: Drug: Perampanel; Drug: conventional antiepileptic treatment
Sponsor: Assistance Publique Hopitaux De Marseille
Not yet recruiting -
A Study of Ad-RTS-hIL-12 With Veledimex in Combination With Nivolumab in Subjects With Glioblastoma; a Substudy to ATI001-102
Posted: August 17th, 2018, 2:00pm GMT
Condition: Glioblastoma
Interventions: Biological: Ad-RTS-hIL-12; Drug: veledimex; Drug: Nivolumab
Sponsor: Ziopharm
Recruiting -
Hyponatremia Study (Delayed Hyponatremia After Pituitary Surgery)
Posted: August 17th, 2018, 2:00pm GMT
Conditions: Hyponatremia; Hyponatremic; Pituitary Tumor; Pituitary; Surgery
Intervention: Other: Fluid Restricted Group
Sponsor: Washington University School of Medicine
Recruiting -
Pilot Imaging Study of Leukemia
Posted: August 16th, 2018, 2:00pm GMT
Condition: Acute Leukemia
Intervention: Drug: FLT imaging
Sponsor: Children's Research Institute
Recruiting -
Standard Chemotherapy vs. Chemotherapy Guided by Cancer Stem Cell Test in Recurrent Glioblastoma
Posted: August 15th, 2018, 2:00pm GMT
Condition: Recurrent Glioblastoma
Interventions: Diagnostic Test: ChemoID assay; Drug: Chemotherapy
Sponsor: Cordgenics, LLC
Recruiting -
Surgical Tissue Flap to Bypass the Blood Brain Barrier in GBM
Posted: August 14th, 2018, 2:00pm GMT
Conditions: Glioblastoma; Glioblastoma Multiforme; GBM; Brain Cancer
Intervention: Procedure: Tissue autograft of pedicled temporoparietal fascial (TPF) or pericranial flap to bypass the blood brain barrier (BBB)
Sponsor: Northwell Health
Recruiting -
Study to Develop Head Stabilizer for Use During Brain Radiation Therapy
Posted: August 14th, 2018, 2:00pm GMT
Conditions: Brain Diseases; Brain Cancer
Interventions: Device: Wiersma Head Stabilizer; Device: AlignRT system
Sponsor: University of Chicago
Recruiting -
Combination Chemotherapy With Pazopanib in Children and Adolescents With Relapsed/Refractory Solid Tumors
Posted: August 14th, 2018, 2:00pm GMT
Conditions: Relapsed Pediatric Solid Tumor; Refractory Pediatric Solid Tumor
Interventions: Drug: Pazopanib; Drug: Ifosfamide; Drug: Carboplatin; Drug: Etoposide
Sponsors: Samsung Medical Center; Ministry of Health, Republic of Korea
Not yet recruiting -
The Impact of Neurocognitive Function in Patients With Multiple Brain Metastases Receiving Whole Brain Radiation Therapy
Posted: August 13th, 2018, 2:00pm GMT
Condition: Brain Metastases
Intervention:
Sponsor: Guangdong Association of Clinical Trials
Not yet recruiting -
Safety of BBB Disruption Using NaviFUS System in Recurrent Glioblastoma Multiforme (GBM) Patients
Posted: August 13th, 2018, 2:00pm GMT
Conditions: Glioblastoma Multiforme; Brain Tumor; Glioblastoma; Glioma; Neoplasms; Neoplasms, Nerve Tissue
Intervention: Device: NaviFUS System
Sponsors: NaviFUS Corporation; Chang Gung Memorial Hospital
Recruiting -
Prediction of Sphenoid Septation in MRI Compared With CT and Intraoperative Findings During Endoscopic Pituitary Adenoma Surgery
Posted: August 9th, 2018, 2:00pm GMT
Condition: Pituitary Adenoma
Intervention: Procedure: comparison of data from MRI with data from CT compared with intraoperative data from endoscopic pituitary adenoma surgery
Sponsor: University Hospital, Basel, Switzerland
Recruiting -
Role of MR Spectroscopy in Brain Tumors
Posted: August 8th, 2018, 2:00pm GMT
Condition: Brain Neoplasms
Intervention: Device: MRI Spectroscopy
Sponsor: Assiut University
Recruiting -
Randomized Control Trial for Awake vs. Asleep Craniotomy for Non-eloquent Gliomas
Posted: August 8th, 2018, 2:00pm GMT
Condition: Intracranial Glioma
Interventions: Procedure: Awake Anesthesia Protocol; Procedure: Non-awake Anesthesia Protocol
Sponsor: Mayo Clinic
Not yet recruiting -
Assessment of Sensory Gating, Attention, and Executive Control in Breast Cancer
Posted: August 7th, 2018, 2:00pm GMT
Condition: Breast Cancer
Interventions: Other: SAE battery; Behavioral: Assessments
Sponsors: Memorial Sloan Kettering Cancer Center; The City College of New York
Recruiting -
Brain Monitoring for High Risk of Brain Metastases in Metastatic Breast Cancer
Posted: August 6th, 2018, 2:00pm GMT
Conditions: Metastatic Breast Cancer With HER2 Positive; Triple Negative Breast Cancer
Intervention: Procedure: Brain MRI
Sponsor: Yonsei University
Not yet recruiting -
Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption for Treatment of Glioma
Posted: August 6th, 2018, 2:00pm GMT
Condition: Glioblastoma
Intervention: Device: Focused Ultrasound (FUS) BBB Disruption
Sponsor: InSightec
Recruiting -
Predictive Role and HuR Mechanisms of Regulation in the Brain Tumours
Posted: August 3rd, 2018, 2:00pm GMT
Condition: Brain Tumours
Intervention:
Sponsor: Central Hospital, Nancy, France
Recruiting -
The Effect of Vitamin D3 on Postoperative Pain in Patients Undergoing Craniotomy
Posted: August 3rd, 2018, 2:00pm GMT
Condition: Brain Neoplasms
Intervention: Drug: vitamin D
Sponsor: Shahid Beheshti University
Recruiting -
Cytomegalovirus (CMV) RNA-Pulsed Dendritic Cells for Pediatric Patients With Newly Diagnosed Glioblastoma, Recurrent Malignant Glioma or Recurrent Medulloblastoma
Posted: August 3rd, 2018, 2:00pm GMT
Conditions: Glioblastoma; Malignant Glioma; Medulloblastoma Recurrent; Pediatric Glioblastoma Multiforme; Pediatric Brain Tumor, Recurrent; Pediatric Brain Tumor
Interventions: Biological: CMV-DCs with GM-CSF; Biological: Td (tetanus toxoid)
Sponsors: Gary Archer Ph.D.; National Institutes of Health (NIH)
Recruiting -
ANG1005 in Leptomeningeal Disease From Breast Cancer
Posted: August 3rd, 2018, 2:00pm GMT
Conditions: Leptomeningeal Carcinomatosis; Leptomeningeal Metastases; Brain Metastases; HER2-negative Breast Cancer
Interventions: Drug: ANG1005; Drug: Physician's Best Choice
Sponsor: Angiochem Inc
Not yet recruiting -
Endostar Combine With Radiotherapy in Brain Metastasis of NSCLC
Posted: August 3rd, 2018, 2:00pm GMT
Condition: Non-small Cell Lung Cancer
Interventions: Drug: endostar; Drug: Placebos; Radiation: radiotherapy
Sponsor: Wuhan Union Hospital, China
Recruiting -
Neurocognitive Risks in Children With Solid Tumors
Posted: August 1st, 2018, 2:00pm GMT
Condition: Solid Tumor in Children
Interventions: Other: The WISC-IV; Other: The CMS (CHILD MEMORY SCALE); Other: CONNERS; Other: BRIEF; Other: PEDS-QL; Other: State Trait Anxiety Inventory; Other: Child Depression Inventory
Sponsor: Gustave Roussy, Cancer Campus, Grand Paris
Recruiting -
A Trial for Treatment of Cancer Patients With Multiple Brain Metastases Undergoing Whole-Brain Radiotherapy
Posted: July 31st, 2018, 2:00pm GMT
Condition: Multiple Brain Metastases
Interventions: Drug: BMX-001; Radiation: Whole Brain Radiation Therapy
Sponsors: BioMimetix JV, LLC; Duke Cancer Institute; National Cancer Institute (NCI)
Recruiting -
Tumor-Treating Fields Therapy in Preventing Brain Tumors in Participants With Extensive-Stage Small Cell Lung Cancer
Posted: July 31st, 2018, 2:00pm GMT
Condition: Extensive Stage Small Cell Lung Carcinoma
Interventions: Procedure: Tumor Treating Fields (TTF) Therapy; Device: NovoTTF-200A Device; Other: Quality-of-Life Assessment
Sponsors: Albert Attia; NovoCure Ltd.
Recruiting -
Navigated Repetitive Transcranial Magnetic Stimulation in Improving Motor Rehabilitation in Participants With Grade II-IV Brain Tumors
Posted: July 30th, 2018, 2:00pm GMT
Condition: Brain Neoplasm
Interventions: Other: Questionnaire Administration; Procedure: Transcranial Magnetic Stimulation
Sponsors: M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting -
A Phase 1b Study of PTC596 in Children With Newly Diagnosed Diffuse Intrinsic Pontine Glioma and High Grade Glioma
Posted: July 30th, 2018, 2:00pm GMT
Conditions: High Grade Glioma; Diffuse Intrinsic Pontine Glioma
Interventions: Drug: PTC596; Radiation: Radiotherapy
Sponsors: Children's Hospital Medical Center, Cincinnati; PTC Therapeutics
Recruiting