Rare Cancer News & Clinical Trials

ClinicalTrials (415 unread)

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Internal Radiation Therapy in Treating Patients With Liver Metastases From Neuroendocrine Tumors

Posted: April 25th, 2007, 8:00am MDT

Conditions: Head and Neck Cancer; Islet Cell Tumor; Metastatic Cancer; Pheochromocytoma
Interventions: Drug: octreotide acetate; Radiation: yttrium Y 90 resin microspheres
Sponsors: Vanderbilt-Ingram Cancer Center; Vanderbilt-Ingram Cancer Center; National Cancer Institute (NCI)
Terminated - verified May 2012

Permalink for 'Phase 2 Study of the Poly(ADP-Ribose) Polymerase Inhibitor E7016 in Combination With Temozolomide in Subjects With Wild Type BRAF Stage IV or Unresectable Stage III Melanoma'

Phase 2 Study of the Poly(ADP-Ribose) Polymerase Inhibitor E7016 in Combination With Temozolomide in Subjects With Wild Type BRAF Stage IV or Unresectable Stage III Melanoma

Posted: May 22nd, 2012, 8:00am MDT

Conditions: Wild Type BRAF Stage IV Melanoma; Unresectable Stage III Melanoma
Interventions: Drug: E7016; Drug: E7016 plus TMZ
Sponsors: Eisai Inc.; Eisai Inc.
Recruiting - verified May 2012

Systemic Therapy With Interferon, Interleukin-2 and BRAF Inhibitor

Posted: May 18th, 2012, 8:00am MDT

Condition: Melanoma
Interventions: Drug: Vemurafenib; Drug: IL-2; Drug: Interferon Alpha-2b
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Not yet recruiting - verified May 2012

Potential Imaging and Molecular Predictors of Response to Novel Therapies in Metastatic Pancreatic Neuroendocrine Tumors

Posted: May 16th, 2012, 8:00am MDT

Condition: Pancreatic Neuroendocrine Cancer
Intervention: Other: MRI
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified May 2012

Dabrafenib Plus Trametinib vs Vemurafenib Alone in Unresectable or Metastatic BRAF V600E/K Cutaneous Melanoma

Posted: May 10th, 2012, 8:00am MDT

Condition: Melanoma
Interventions: Drug: Dabrafenib; Drug: Vemurafenib; Drug: Trametinib
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Not yet recruiting - verified May 2012

Permalink for 'A Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With INCB024360 or Placebo in Subjects With Unresectable or Metastatic Melanoma'

A Phase 1/2 Randomized, Blinded, Placebo Controlled Study of Ipilimumab in Combination With INCB024360 or Placebo in Subjects With Unresectable or Metastatic Melanoma

Posted: May 9th, 2012, 8:00am MDT

Condition: Metastatic Melanoma
Interventions: Drug: INCB024360 in combination with ipilimumab; Drug: Placebo in combination with ipilimumab; Drug: INCB024360 in combination with ipilimumab; Drug: INCB024360 in combination with ipilimumab
Sponsors: Incyte Corporation; Incyte Corporation
Recruiting - verified May 2012

Permalink for 'Extension Study to the Open-label, Multi-center, Expanded Access Study of Everolimus in Patients With Advanced Neuroendocrine Tumors'

Extension Study to the Open-label, Multi-center, Expanded Access Study of Everolimus in Patients With Advanced Neuroendocrine Tumors

Posted: May 7th, 2012, 8:00am MDT

Condition: Neuroendocrine Tumors
Intervention: Drug: RAD001
Sponsors: Novartis; Novartis Pharmaceuticals
Not yet recruiting - verified May 2012

Autonomic Phenotype Before and After Akt Inhibition

Posted: May 4th, 2012, 8:00am MDT

Condition: Diagnosis of Melanoma
Interventions: Behavioral: Autonomic Function Tests; Other: supine and standing catecholamines
Sponsors: Vanderbilt University; Vanderbilt University
Recruiting - verified May 2012

Expanded Access Protocol Using I131-MIBG

Posted: May 1st, 2012, 8:00am MDT

Conditions: Neuroblastoma; Pheochromocytoma; Paraganglioma
Intervention: Radiation: I-131 MIBG
Sponsors: Jubilant DraxImage Inc.; Jubilant DraxImage Inc.
Available - verified April 2012

Doxycycline, Temozolomide and Ipilimumab in Melanoma

Posted: April 30th, 2012, 8:00am MDT

Condition: Melanoma
Interventions: Drug: Doxycycline; Drug: Ipilimumab; Drug: Temozolomide
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; National Institutes of Health (NIH); National Cancer Institute (NCI)
Not yet recruiting - verified May 2012

Vorinostat in Treating Patients With Metastatic Melanoma of the Eye

Posted: April 26th, 2012, 8:00am MDT

Condition: Intraocular Melanoma
Interventions: Drug: vorinostat; Genetic: gene expression analysis; Genetic: mutation analysis; Genetic: western blotting; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); Memorial Sloan-Kettering Cancer Center; National Cancer Institute (NCI)
Recruiting - verified April 2012

Permalink for 'A Open-Label, Multiple Ascending Dose Study of DS-3078a, an Oral TORC1/2 Kinase Inhibitor, in Subjects With Advanced Solid Tumors or Lymphomas'

A Open-Label, Multiple Ascending Dose Study of DS-3078a, an Oral TORC1/2 Kinase Inhibitor, in Subjects With Advanced Solid Tumors or Lymphomas

Posted: April 26th, 2012, 8:00am MDT

Conditions: Advanced Solid Tumor; Lymphoma
Intervention: Drug: DS-3078a
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.
Recruiting - verified April 2012

Vemurafenib and White Blood Cell Therapy for Advanced Melanoma

Posted: April 24th, 2012, 8:00am MDT

Conditions: Metastatic Cancer; Melanoma
Interventions: Drug: Vemurafenib; Drug: Young TIL; Drug: Cyclophosphamide; Drug: Fludarabine; Drug: Aldesleukin
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified April 2012

A Multipeptide Vaccine Plus Toll-Like Receptor Agonists in Melanoma Patients

Posted: April 24th, 2012, 8:00am MDT

Condition: Melanoma
Interventions: Biological: MELITAC 12.1 + Montanide ISA-51 + lipopolysaccharide (LPS); Biological: MELITAC 12.1 + Montanide ISA-51 + polyICLC
Sponsors: University of Virginia; University of Virginia; UVA Human Immune Therapy Center; National Cancer Institute (NCI); Oncovir, Inc.
Not yet recruiting - verified April 2012

Transfer of Genetically Engineered Lymphocytes in Melanoma Patients

Posted: April 24th, 2012, 8:00am MDT

Condition: Melanoma
Interventions: Biological: Dose 1; Biological: Dose 2; Biological: Dose 3; Biological: Dose 4
Sponsors: Loyola University; Loyola University; National Cancer Institute (NCI)
Not yet recruiting - verified April 2012

Permalink for 'Study Of Zelboraf (Vemurafenib) in Patients With Locally-Advanced, Unresectable, Stage IIIc Or Metastatic Melanoma and Activating Exon 15 BRAF Mutations Other Than V600E'

Study Of Zelboraf (Vemurafenib) in Patients With Locally-Advanced, Unresectable, Stage IIIc Or Metastatic Melanoma and Activating Exon 15 BRAF Mutations Other Than V600E

Posted: April 24th, 2012, 8:00am MDT

Condition: Malignant Melanoma
Intervention: Drug: Zelboraf (vemurafenib)
Sponsors: Genentech; Genentech
Recruiting - verified April 2012

Ipilimumab for Uveal Melanoma

Posted: April 23rd, 2012, 8:00am MDT

Condition: Melanoma
Intervention: Drug: Ipilimumab
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Bristol-Myers Squibb
Not yet recruiting - verified April 2012

Permalink for 'A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma'

A Study Comparing Trametinib and Dabrafenib Combination Therapy to Dabrafenib Monotherapy in Subjects With BRAF-mutant Melanoma

Posted: April 23rd, 2012, 8:00am MDT

Condition: Melanoma
Interventions: Drug: dabrafenib plus trametinib; Drug: dabrafenib plus trametinib placebo
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Recruiting - verified May 2012

Clinical Trial of a Therapeutic Vaccine With NY-ESO-1 in Combination With the Adjuvant MPLA

Posted: April 21st, 2012, 8:00am MDT

Conditions: Cancer.; Melanoma.; Ovarian Cancer.; Lung Cancer.
Interventions: Biological: NY-ESO-1 combined with MPLA; Biological: NY-ESO-1 combined with MPLA vaccine
Sponsors: Instituto de Investigação em Imunologia; Instituto de Investigação em Imunologia; Butantan Institute
Not yet recruiting - verified April 2012

Evaluate Safety and Tolerability of Pasireotide LAR in Combination With Everolimus in Advanced Metastatic NETs

Posted: April 11th, 2012, 8:00am MDT

Condition: Neuroendocrine Tumors
Interventions: Drug: RAD001; Drug: SOM230
Sponsors: Novartis; Novartis Pharmaceuticals
Not yet recruiting - verified May 2012

Permalink for 'A Study Comparing Treatment With 177Lu-DOTA0-Tyr3-Octreotate to Octreotide LAR in Patients With Inoperable, Progressive, Somatostatin Receptor Positive Midgut Carcinoid Tumours'

A Study Comparing Treatment With 177Lu-DOTA0-Tyr3-Octreotate to Octreotide LAR in Patients With Inoperable, Progressive, Somatostatin Receptor Positive Midgut Carcinoid Tumours

Posted: April 10th, 2012, 8:00am MDT

Conditions: Carcinoid Tumor of the Small Bowel; Neuroendocrine Tumour
Interventions: Drug: Octreotide; Drug: Octreotide; Drug: 177Lu-DOTA0-Tyr3-Octreotate
Sponsors: Advanced Accelerator Applications; Advanced Accelerator Applications; Pierrel Research Europe GmbH
Not yet recruiting - verified April 2012

Pilot Study Evaluating Sulforaphane in Atypical Nevi-Precursor Lesions

Posted: March 29th, 2012, 8:00am MDT

Conditions: Atypical Nevi; Melanoma
Interventions: Drug: broccoli sprout extract - sulforaphane (BSE-SFN); Drug: broccoli sprout extract - sulforaphane (BSE-SFN); Drug: broccoli sprout extract - sulforaphane (BSE-SFN)
Sponsors: University of Pittsburgh; John Kirkwood
Not yet recruiting - verified March 2012

Concurrent Ipilimumab and Stereotactic Ablative Radiation Therapy (SART) for Oligometastatic But Unresectable Melanoma

Posted: March 26th, 2012, 8:00am MDT

Condition: Melanoma
Interventions: Drug: Ipilimumab; Radiation: Stereotactic Ablative Radiosurgery (SART)
Sponsors: Comprehensive Cancer Centers of Nevada; Wolfram Samlowski; Comprehensive Cancer Centers of Nevada
Not yet recruiting - verified April 2012

Everolimus Combined With Octeotride LAR to Treat Advanced GI NET

Posted: March 26th, 2012, 8:00am MDT

Condition: Gastrointestinal Neoplasms
Interventions: Drug: Everolimus; Drug: octeotride LAR
Sponsors: Grupo Espanol de Tumores Neuroendocrinos; Grupo Espanol de Tumores Neuroendocrinos
Recruiting - verified April 2012

Anesthesia and Cancer Recurrence im Malignant Melanoma

Posted: March 13th, 2012, 8:00am MDT

Condition: Malignant Melanoma
Interventions: Procedure: Spinal anesthesia with Bupivacaine hyperbar 0.5 %; Procedure: General anesthesia with Sufentanil, Propofol and Rocuronium and Sevoflurane
Sponsors: University Hospital Muenster; University Hospital Muenster
Recruiting - verified March 2012

Permalink for 'Vemurafenib (R05185426) in Poor Performance Status Patients With Unresectable Locally Advanced or Metastatic Melanoma Harboring a V600E/K Mutation'

Vemurafenib (R05185426) in Poor Performance Status Patients With Unresectable Locally Advanced or Metastatic Melanoma Harboring a V600E/K Mutation

Posted: November 15th, 2011, 8:00am MST

Condition: Melanoma
Intervention: Drug: vemurafenib
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Genentech
Recruiting - verified May 2012

A Study of CDX-1127 in Patients With Select Solid Tumor Types or Hematologic Cancers

Posted: October 12th, 2011, 8:00am MDT

Conditions: CD27 Expressing B-cell Malignancies; CD27 Expressing Solid Tumors; Chronic Lymphocytic Leukemia; Burkett's Lymphoma; Mantle Cell Lymphoma; Primary Lymphoma of the Central Nervous System; Marginal Zone B Cell Lymphoma; Solid Tumor; Metastatic Melanoma; Renal (Clear) Cell Carcinoma; Hormone-refractory Prostate Adenocarcinoma; Ovarian Cancer; Colorectal Adenocarcinoma; Non-small Cell Lung Cancer
Intervention: Drug: CDX-1127
Sponsors: Celldex Therapeutics; Celldex Therapeutics
Recruiting - verified May 2012

Biomarkers for Angiogenesis in Renal Cell Carcinoma and Neuro-endocrine Tumours.

Posted: July 19th, 2011, 8:00am MDT

Conditions: Carcinoma; Carcinoma, Renal Cell; Neuroendocrine Tumors; Carcinoid Tumor; Pancreatic Islet Cell Tumors
Intervention: Other: Blood sampling by vena punction.
Sponsors: University Medical Centre Groningen; University Medical Centre Groningen
Completed - verified May 2012

Granulocyte Macrophage-Colony Stimulating Factor and Ipilimumab as Therapy in Melanoma

Posted: May 27th, 2011, 8:00am MDT

Condition: Malignant Melanoma, Metastatic
Interventions: Biological: Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF); Biological: Ipilimumab
Sponsors: Northern California Melanoma Center; Lynn E. Spitler, MD; University of California, San Francisco
Recruiting - verified May 2012

Dose Escalation Study of Pasireotide (SOM230) in Patients With Advanced Neuroendocrine Tumors (NETs)

Posted: May 18th, 2011, 8:00am MDT

Condition: Neuroendocrine Tumors
Intervention: Drug: Pasireotide LAR
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012

A Trial Looking at Nilotinib to Treat Acral and Mucosal Melanoma Skin Cancer That Has Spread

Posted: April 13th, 2011, 8:00am MDT

Conditions: Mucosal Lentiginous Melanoma; Acral Lentiginous Malignant Melanoma
Intervention: Drug: nilotinib
Sponsors: Institute of Cancer Research, United Kingdom; Institute of Cancer Research, United Kingdom; Royal Marsden NHS Foundation Trust
Recruiting - verified April 2011

Safety and Efficacy of RAD001 in Chinese Patients With Advanced Pulmonary Neuroendocrine Tumor

Posted: March 24th, 2011, 8:00am MDT

Condition: Lung Neuroendocrine Neoplasm
Intervention: Drug: RAD001
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012

MelaViD: A Trial on Vitamin D Supplementation for Resected Stage II Melanoma Patients

Posted: December 21st, 2010, 8:00am MST

Condition: Melanoma
Interventions: Drug: Vitamin D3 ( Colecalciferol); Other: placebo
Sponsors: European Institute of Oncology; European Institute of Oncology
Recruiting - verified August 2011

Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma

Posted: September 9th, 2010, 8:00am MDT

Conditions: Vestibular Schwannoma; Acoustic Neuroma
Intervention: Radiation: Fractionated proton radiation
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; National Cancer Institute (NCI)
Recruiting - verified May 2012

Permalink for 'Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma'

Study to Assess Safety, Pharmacokinetics, and Efficacy of Oral CC-223 for Patients With Advanced Solid Tumors, Non-Hodgkin Lymphoma or Multiple Myeloma

Posted: August 5th, 2010, 8:00am MDT

Conditions: Multiple Myeloma; Diffuse Large B-Cell Lymphoma; Glioblastoma Multiforme; Hepatocellular Carcinoma; Non-Small Cell Lung Cancer; Gastrointestinal Neuroendocrine Tumors of Non-Pancreatic Origin; Hormone Receptor-Positive Breast Cancer
Intervention: Drug: CC-223
Sponsors: Celgene Corporation; Celgene Corporation
Recruiting - verified May 2012

Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas

Posted: May 7th, 2010, 8:00am MDT

Conditions: Acoustic Schwannoma; Adult Anaplastic Meningioma; Adult Ependymoma; Adult Grade I Meningioma; Adult Grade II Meningioma; Adult Meningeal Hemangiopericytoma; Adult Papillary Meningioma; Neurofibromatosis Type 1; Neurofibromatosis Type 2; Recurrent Adult Brain Tumor
Intervention: Biological: bevacizumab
Sponsors: Northwestern University; Northwestern University
Recruiting - verified May 2012

NIR-Guided Sentinel Lymph Node Mapping in Melanoma

Posted: May 6th, 2010, 8:00am MDT

Condition: Melanoma
Intervention: Procedure: Sentinel Lymph Node Mapping
Sponsors: Dana-Farber Cancer Institute; Dana-Farber Cancer Institute; Beth Israel Deaconess Medical Center
Completed - verified May 2012

Ipilimumab + Temozolomide in Metastatic Melanoma

Posted: May 6th, 2010, 8:00am MDT

Condition: Metastatic Melanoma
Interventions: Drug: Ipilimumab; Drug: Temozolomide
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Bristol-Myers Squibb
Active, not recruiting - verified May 2012

Study of LX1606 in Subjects With Symptomatic Carcinoid Syndrome

Posted: April 12th, 2010, 8:00am MDT

Condition: Symptoms of Carcinoid Syndrome
Interventions: Drug: Low Dose LX1606 - Day 1 (start); Drug: Mid-low dose LX1606 - Day 15 (start); Drug: Mid-high dose LX1606 - Day 29 (start); Drug: High dose LX1606 - Day 43 (start); Drug: 4-Week Open Label Dose Extension; Drug: 72-Week Open Label Dose Extension
Sponsors: Lexicon Pharmaceuticals; Lexicon Pharmaceuticals
Active, not recruiting - verified May 2012

Permalink for 'A Study of Immunotherapy With TIL (Tumor Infiltrating Lymphocytes) in Combination With Intra-tumoral Injections of Interferon Gamma-adenovirus (Ad-IFNg) in Patients With Stage IIIc or Stage IV Metastatic Melanoma (AJCC)(Protocol TIL-Ad-INFg)'

A Study of Immunotherapy With TIL (Tumor Infiltrating Lymphocytes) in Combination With Intra-tumoral Injections of Interferon Gamma-adenovirus (Ad-IFNg) in Patients With Stage IIIc or Stage IV Metastatic Melanoma (AJCC)(Protocol TIL-Ad-INFg)

Posted: March 8th, 2010, 8:00am MST

Condition: Metastatic Melanoma
Intervention: Other: TIL-Ad-INFg
Sponsors: Nantes University Hospital; Nantes University Hospital
Recruiting - verified April 2012

High Dose Interleukin-2 Followed by Intermittent Low Dose Temozolomide in Patients With Melanoma

Posted: March 4th, 2010, 8:00am MST

Condition: Malignant Melanoma
Interventions: Drug: Interleukin-2; Drug: Interleukin-2; Drug: Temozolomide
Sponsors: Penn State University; Penn State University
Recruiting - verified May 2012

$Permalink for 'Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors'$

Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors

Posted: February 25th, 2010, 8:00am MST

Conditions: Brain and Central Nervous System Tumors; Extra-adrenal Paraganglioma
Interventions: Drug: temozolomide; Drug: vorinostat; Genetic: DNA methylation analysis; Genetic: western blotting; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Active, not recruiting - verified November 2010

Phase II Study of Tesetaxel in Metastatic Melanoma

Posted: February 5th, 2010, 8:00am MST

Conditions: Advanced Melanoma; Cancer
Intervention: Drug: Tesetaxel
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Genta Incorporated
Recruiting - verified April 2012

$Permalink for 'Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features'$

Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features

Posted: January 13th, 2010, 8:00am MST

Conditions: Adrenocortical Carcinoma; Gastrointestinal Carcinoid Tumor; Kidney Cancer; Neuroblastoma; Retinoblastoma; Sarcoma
Interventions: Biological: Seneca Valley virus-001; Drug: cyclophosphamide; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Recruiting - verified May 2012

Safety and Efficacy Study of Electrotransfer of Plasmid AMEP to Treat Advanced or Metastatic Melanoma

Posted: January 8th, 2010, 8:00am MST

Condition: Melanoma
Intervention: Biological: naked DNA coding for protein AMEP
Sponsors: BioAlliance Pharma SA; BioAlliance Pharma SA
Recruiting - verified May 2012

Safety, Immune and Tumor Response to a Multi-component Immune Based Therapy (MKC1106-MT) for Patients With Melanoma

Posted: December 3rd, 2009, 8:00am MST

Conditions: Stage III Melanoma; Stage IV Melanoma
Intervention: Biological: MKC1106-MT
Sponsors: Mannkind Corporation; Mannkind Corporation
Terminated - verified May 2012

Stage IV Surgery Versus Best Medical Therapy

Posted: November 12th, 2009, 8:00am MST

Condition: Stage IV Resectable Melanoma
Interventions: Procedure: Surgery; Procedure: Surgery plus 2 adjuvant doses of BCG; Other: best medical therapy
Sponsors: John Wayne Cancer Institute; John Wayne Cancer Institute; Melanoma Research Alliance
Recruiting - verified May 2012

Safety Study of PLX108-01 in Patients With Solid Tumors

Posted: October 28th, 2009, 8:00am MDT

Conditions: Solid Tumors; Mucoepidermal Carcinoma (MEC) of the Salivary Gland; Pigmented Villo-nodular Synovitis (PVNS); Gastrointestinal Stromal Tumors (GIST); Anaplastic Thyroid Carcinoma (ATC); Solid Tumors With Documented Malignant Pleural or Peritoneal Effusions; Malignant Peripheral Nerve Sheath Tumor (MPNST); Neurofibromatosis Type I (NF-1); Melanoma; Schwannomatosis
Intervention: Drug: PLX3397
Sponsors: Plexxikon; Plexxikon
Recruiting - verified May 2012

A Study Evaluating Efficacy of ABT-888 in Combination With Temozolomide in Metastatic Melanoma

Posted: December 1st, 2008, 8:00am MST

Conditions: Skin Cancer; Melanoma; Metastatic Melanoma
Interventions: Drug: temozolomide; Drug: ABT-888; Drug: Placebo
Sponsors: Abbott; Abbott
Active, not recruiting - verified March 2012

A Study of V934/V935 Vaccine in Cancer Patients With Selected Solid Tumors (V934-002 AM 4)

Posted: September 15th, 2008, 8:00am MDT

Conditions: Non-Small Cell Lung Carcinoma; Breast Cancer; Melanoma; Upper GI Tract Carcinoma; Colon Carcinoma; Renal Cell Carcinoma; Bladder Carcinoma; Prostate Cancer
Interventions: Biological: V935; Biological: V934
Sponsors: Merck; Merck
Completed - verified April 2012

Effect of Intravitreal Ranibizumab on Radiation Retinopathy Following Plaque Brachytherapy for Choroidal Melanoma

Posted: September 9th, 2008, 8:00am MDT

Conditions: Radiation Retinopathy; Choroidal Melanoma
Interventions: Drug: Ranibizumab; Drug: ranibizumab
Sponsors: The New York Eye Cancer Center; The New York Eye Cancer Center; Genentech
Completed - verified April 2012

A Phase 1b Study of MDX-1106 in Subjects With Advanced or Recurrent Malignancies

Posted: August 4th, 2008, 8:00am MDT

Conditions: Metastatic Castration-resistant Prostrate Cancer (mCRPC); Renal Cell Carcinoma (RCC); Metastatic Melanoma (MEL); Non-small Cell Lung Cancer (NSCLC)
Interventions: Biological: BMS-936558 (MDX-1106); Biological: BMS-936558 (MDX-1106); Biological: BMS-936558 (MDX-1106); Biological: BMS-936558 (MDX-1106); Biological: BMS-936558 (MDX-1106)
Sponsors: Bristol-Myers Squibb; Bristol-Myers Squibb; Ono Pharmaceutical Company, Ltd.
Active, not recruiting - verified May 2012

Phase II Trial of (IL-2) With Priming and (GM-CSF) in Patients With Advanced Melanoma

Posted: February 4th, 2008, 8:00am MST

Condition: Malignant Melanoma
Intervention: Drug: GM-CSF
Sponsors: Mt. Sinai Medical Center, Miami; Mt. Sinai Medical Center, Miami; Bayer; Chiron Corporation
Completed - verified May 2012

Phase II Trial Of ZK-EPO (ZK 219477) In Metastatic Melanoma

Posted: January 10th, 2008, 8:00am MST

Condition: Melanoma
Intervention: Drug: EpothiloneZK
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; H. Lee Moffitt Cancer Center and Research Institute; Bayer
Active, not recruiting - verified May 2012

A Phase I/II Study of Dasatinib and Dacarbazine

Posted: January 8th, 2008, 8:00am MST

Condition: Metastatic Melanoma
Intervention: Drug: Dasatinib and Dacarbazine (DTIC)
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; H. Lee Moffitt Cancer Center and Research Institute; Bristol-Myers Squibb
Active, not recruiting - verified May 2012

Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract

Posted: December 21st, 2007, 8:00am MST

Conditions: Esophageal Cancer; Bile Duct Neoplasms; Gastric Cancer; Liver Cancer; Melanoma; Pancreatic Cancer; Sarcoma
Intervention:
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; National Cancer Institute (NCI)
Recruiting - verified May 2012

Safety Study of Modified Vaccinia Virus to Cancer

Posted: December 13th, 2007, 8:00am MST

Conditions: Melanoma; Breast Cancer; Head and Neck Squamous Cell Cancer; Liver Cancer; Colorectal Cancer; Pancreatic Adenocarcinoma
Interventions: Biological: Vaccinia virus (vvDD-CDSR); Biological: Vaccinia virus (vvDD-CDSR); Biological: Vaccinia virus (vvDD-CDSR)
Sponsors: University of Pittsburgh; University of Pittsburgh
Recruiting - verified April 2012

Permalink for 'Radiofrequency Therapy-Induced Endogenous Heat-Shock Proteins With or Without Radiofrequency Ablation or Cryotherapy in Treating Patients With Stage IV Melanoma'

Radiofrequency Therapy-Induced Endogenous Heat-Shock Proteins With or Without Radiofrequency Ablation or Cryotherapy in Treating Patients With Stage IV Melanoma

Posted: December 5th, 2007, 8:00am MST

Condition: Melanoma (Skin)
Interventions: Biological: sargramostim; Other: immunoenzyme technique; Other: immunohistochemistry staining method; Other: immunologic technique; Other: laboratory biomarker analysis; Procedure: biopsy; Procedure: cryosurgery; Procedure: radiofrequency ablation
Sponsors: Mayo Clinic; Mayo Clinic; National Cancer Institute (NCI)
Active, not recruiting - verified May 2012

Interleukin-21 in Treating Patients With Metastatic or Recurrent Malignant Melanoma

Posted: August 8th, 2007, 8:00am MDT

Condition: Melanoma (Skin)
Interventions: Biological: recombinant human interleukin-21; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Active, not recruiting - verified May 2012

TheraSphere for the Treatment of Liver Metastases

Posted: August 2nd, 2007, 8:00am MDT

Conditions: Colorectal Cancer; Carcinoma, Neuroendocrine; Neoplasm Metastasis
Intervention: Device: Yttrium 90 glass microspheres
Sponsors: Nordion (Canada) Inc.; Nordion (Canada) Inc.
Completed - verified October 2011

Sample Collection From Melanoma Patients

Posted: July 24th, 2007, 8:00am MDT

Condition: Melanoma
Interventions: Procedure: Blood Sample; Procedure: Tumor Sample
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified May 2012

Compassionate Use Trial for Unresectable Melanoma With Ipilimumab

Posted: June 29th, 2007, 8:00am MDT

Condition: Melanoma
Intervention: Drug: Ipilimumab
Sponsors: Bristol-Myers Squibb; Bristol-Myers Squibb
Available - verified May 2012

A Phase II Trial OF Carboplatin, ABI-007 (Abraxane) And Sorafenib (BAY 43-9006) in Metastatic Melanoma

Posted: May 30th, 2007, 8:00am MDT

Condition: Malignant Melanoma
Interventions: Drug: Sorafenib (BAY 43-9006); Drug: ABI-007(Abraxane)
Sponsors: Mt. Sinai Medical Center, Miami; Mt. Sinai Medical Center, Miami; Celgene Corporation; Bayer
Completed - verified May 2012

Permalink for 'Vaccine Therapy and Resiquimod in Treating Patients With Stage II, Stage III, or Stage IV Melanoma That Has Been Completely Removed by Surgery'

Vaccine Therapy and Resiquimod in Treating Patients With Stage II, Stage III, or Stage IV Melanoma That Has Been Completely Removed by Surgery

Posted: May 3rd, 2007, 8:00am MDT

Condition: Melanoma (Skin)
Intervention: Drug: resiquimod
Sponsors: Mayo Clinic; Mayo Clinic; National Cancer Institute (NCI)
Active, not recruiting - verified May 2012

Vaccine Therapy and GM-CSF With or Without Low-Dose Aldesleukin in Treating Patients With Stage II, Stage III, or Stage IV Melanoma

Posted: May 3rd, 2007, 8:00am MDT

Condition: Melanoma (Skin)
Interventions: Biological: MART-1 antigen; Biological: IL-2; Biological: gp100 antigen; Biological: GM-CSF; Biological: MART-1a peptide
Sponsors: Mayo Clinic; Mayo Clinic; National Cancer Institute (NCI)
Active, not recruiting - verified May 2012

Internal Radiation Therapy in Treating Patients With Liver Metastases From Neuroendocrine Tumors

Posted: April 25th, 2007, 8:00am MDT

Aldesleukin in Patients With Metastatic Renal Cell Carcinoma and Metastatic Melanoma

Posted: December 21st, 2006, 8:00am MST

Conditions: Metastatic Renal Cell Carcinoma; Metastatic Melanoma
Intervention: Drug: Aldesleukin
Sponsors: Novartis; Novartis Pharmaceuticals
Completed - verified April 2012

Palonosetron for Prevention of Biochemotherapy Induced Nausea and Vomiting

Posted: December 14th, 2006, 8:00am MST

Condition: Melanoma
Intervention: Drug: Palonosetron
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Eisai Inc.
Completed - verified April 2012

Safety Study of PLX4032 in Patients With Solid Tumors

Posted: November 28th, 2006, 8:00am MST

Conditions: Malignant Melanoma; Colorectal Carcinoma
Intervention: Drug: PLX4032
Sponsors: Plexxikon; Plexxikon; Roche Pharma AG
Active, not recruiting - verified May 2012

A Study of Volociximab in Metastatic Melanoma

Posted: August 24th, 2006, 8:00am MDT

Condition: Stage IV Melanoma
Intervention: Drug: volociximab
Sponsors: Abbott; Abbott; Biogen Idec
Terminated - verified April 2012

Safety of TKI258 in Advanced/Metastatic Melanoma Subjects

Posted: March 14th, 2006, 8:00am MST

Condition: Melanoma
Intervention: Drug: TKI258
Sponsors: Novartis; Novartis Pharmaceuticals
Completed - verified April 2012

Phase II Trial of Ontak With Metastatic Melanoma

Posted: March 3rd, 2006, 8:00am MST

Condition: Malignant Melanoma
Intervention: Drug: Denileukin diftitox
Sponsors: James Graham Brown Cancer Center; James Graham Brown Cancer Center; University of Louisville
Completed - verified April 2012

Permalink for 'Study to Investigate the Antiproliferative Effect of Octreotide in Patients With Metastasized Neuroendocrine Tumors of the Midgut'

Study to Investigate the Antiproliferative Effect of Octreotide in Patients With Metastasized Neuroendocrine Tumors of the Midgut

Posted: September 13th, 2005, 8:00am MDT

Condition: Neuroendocrine Tumors
Interventions: Drug: Octreotide LAR (Long-acting release); Drug: Placebo
Sponsors: Philipps University Marburg Medical Center; Carmen Schade-Brittinger
Active, not recruiting - verified May 2012

Permalink for 'Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for Medulloblastoma or Pineoblastoma'

Proton Beam Radiation Therapy in Treating Young Patients Who Have Undergone Biopsy or Surgery for Medulloblastoma or Pineoblastoma

Posted: March 15th, 2005, 8:00am MST

Conditions: Brain and Central Nervous System Tumors; Long-term Effects Secondary to Cancer Therapy in Children
Intervention: Radiation: radiation therapy
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; National Cancer Institute (NCI)
Active, not recruiting - verified May 2012

17-N-Allylamino-17-Demethoxygeldanamycin in Treating Patients With Metastatic Malignant Melanoma

Posted: March 3rd, 2005, 8:00am MST

Condition: Melanoma (Skin)
Intervention: Drug: tanespimycin
Sponsors: National Cancer Institute (NCI); Cancer Research UK; National Cancer Institute (NCI)
Completed - verified March 2008

Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma

Posted: November 1st, 1999, 8:00am MST

Conditions: Kidney Cancer; Melanoma (Skin); Metastatic Cancer; Ovarian Cancer; Sarcoma
Intervention: Radiation: stereotactic radiosurgery
Sponsors: National Cancer Institute (NCI); Eastern Cooperative Oncology Group; National Cancer Institute (NCI)
Completed - verified July 2003

Studying Genes in Samples From Younger Patients With Rhabdomyosarcoma

Posted: April 24th, 2012, 8:00am MDT

Condition: Sarcoma
Interventions: Genetic: mutation analysis; Genetic: nucleic acid sequencing; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Active, not recruiting - verified April 2012

Intensity-Modulated Radiation Therapy in Treating Younger Patients With Lung Metastases

Posted: April 23rd, 2012, 8:00am MDT

Conditions: Adult Rhabdomyosarcoma; Lung Metastases; Metastatic Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Previously Treated Childhood Rhabdomyosarcoma; Recurrent Adult Soft Tissue Sarcoma; Recurrent Childhood Rhabdomyosarcoma; Recurrent Ewing Sarcoma/Peripheral Primitive Neuroectodermal Tumor; Recurrent Wilms Tumor and Other Childhood Kidney Tumors; Stage IV Adult Soft Tissue Sarcoma; Stage IV Wilms Tumor; Stage V Wilms Tumor; Unspecified Adult Solid Tumor, Protocol Specific; Unspecified Childhood Solid Tumor, Protocol Specific
Intervention: Radiation: intensity-modulated radiation therapy
Sponsors: Children's Memorial Hospital; Children's Memorial Hospital; Northwestern University; National Cancer Institute (NCI)
Recruiting - verified April 2012

PK/PD of XM22 in Children With Ewing Family of Tumors or Rhabdomyosarcoma

Posted: April 18th, 2012, 8:00am MDT

Condition: Ewing Family of Tumors, Rhabdomyosarcoma
Intervention: Drug: Lipegfilgrastim
Sponsors: Teva Pharmaceutical Industries; Merckle GmbH
Not yet recruiting - verified May 2012

$Permalink for 'Vincristine and Irinotecan With or Without Temozolomide in Children and Adults With Refractory or Relapsed Rhabdomyosarcoma : International Randomized Trial'$

Vincristine and Irinotecan With or Without Temozolomide in Children and Adults With Refractory or Relapsed Rhabdomyosarcoma : International Randomized Trial

Posted: May 16th, 2011, 8:00am MDT

Condition: RHABDOMYOSARCOMA
Interventions: Drug: Vincristine, Irinotecan; Drug: Vincristine-Irinotecan-Temozolomide
Sponsors: Centre Oscar Lambret; Centre Oscar Lambret; SFCE
Recruiting - verified May 2012

$Permalink for 'Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features'$

Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features

Posted: January 13th, 2010, 8:00am MST

Early Detection of Graft-Versus-Host Disease in Patients Undergoing a Donor Bone Marrow Transplant

Posted: May 9th, 2009, 8:00am MDT

Condition: Lymphoma
Intervention:
Sponsors: Mayo Clinic; Mayo Clinic; National Cancer Institute (NCI)
Active, not recruiting - verified May 2012

Combination Chemotherapy in Treating Patients With Sarcoma

Posted: April 18th, 2008, 8:00am MDT

Conditions: Ovarian Cancer; Sarcoma
Interventions: Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: ifosfamide; Drug: vincristine sulfate; Procedure: adjuvant therapy; Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery; Radiation: brachytherapy; Radiation: intraoperative radiation therapy; Radiation: radiation therapy
Sponsors: Mayo Clinic; Mayo Clinic; National Cancer Institute (NCI)
Active, not recruiting - verified May 2012

Traumeel® S in Preventing and Treating Mucositis in Young Patients Undergoing Stem Cell Transplantation

Posted: April 7th, 2004, 8:00am MDT

Conditions: Kidney Cancer; Leukemia; Lymphoma; Neuroblastoma; Oral Complications; Sarcoma
Intervention: Dietary Supplement: Traumeel S
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Completed - verified November 2010

Soblidotin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma

Posted: July 8th, 2003, 8:00am MDT

Condition: Sarcoma
Intervention: Drug: soblidotin
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.; National Cancer Institute (NCI)
Completed - verified May 2012

$Permalink for 'Exatecan Mesylate in Treating Children With Relapsed or Refractory Rhabdomyosarcoma'$

Exatecan Mesylate in Treating Children With Relapsed or Refractory Rhabdomyosarcoma

Posted: March 6th, 2003, 8:00am MST

Condition: Sarcoma
Intervention: Drug: exatecan mesylate
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.
Completed - verified May 2012

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Sarcoma

Posted: November 1st, 1999, 8:00am MST

Condition: Sarcoma
Interventions: Biological: filgrastim; Drug: cisplatin; Drug: doxorubicin hydrochloride; Drug: ifosfamide; Drug: melphalan; Procedure: peripheral blood stem cell transplantation
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI)
Active, not recruiting - verified May 2012

Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

Posted: November 1st, 1999, 8:00am MST

Condition: Sarcoma
Interventions: Biological: dactinomycin; Biological: filgrastim; Biological: sargramostim; Drug: cyclophosphamide; Drug: vincristine sulfate; Radiation: radiation therapy
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Completed - verified November 2010

Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas

Posted: March 27th, 2012, 8:00am MDT

Conditions: Chordoma; Desmoid Tumor; Sarcoma
Interventions: Genetic: DNA analysis; Genetic: microarray analysis; Genetic: polymerase chain reaction; Other: laboratory biomarker analysis; Other: mass spectrometry
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Active, not recruiting - verified March 2012

Soblidotin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma

Posted: July 8th, 2003, 8:00am MDT

Condition: Sarcoma
Intervention: Drug: soblidotin
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.; National Cancer Institute (NCI)
Completed - verified May 2012

Use of Racotumomab in Patients With Pediatric Tumors Expressing N-glycolylated Gangliosides

Posted: May 10th, 2012, 8:00am MDT

Conditions: Neuroblastoma; Ewing's Sarcoma; Wilm's Tumor; Retinoblastoma; Glioma
Intervention: Drug: racotumomab
Sponsors: Laboratorio Elea S.A.C.I.F. y A.; Laboratorio Elea S.A.C.I.F. y A.; Ministry of Science and Technology
Recruiting - verified May 2012

Treatment With Medroxyprogesterone Acetate Plus LNG-IUS in Young Women With Early Stage Endometrial Cancer

Posted: May 7th, 2012, 8:00am MDT

Condition: Endometrial Cancer
Intervention: Device: MIrena(LNG-IUS), oral MPA
Sponsors: Korean Gynecologic Oncology Group; Korean Gynecologic Oncology Group
Recruiting - verified May 2012

Permalink for 'A Treatment Trial Comparing Gemcitabine and Pazopanib Versus Gemcitabine and Docetaxel for Patients With Advanced Soft Tissue Sarcoma'

A Treatment Trial Comparing Gemcitabine and Pazopanib Versus Gemcitabine and Docetaxel for Patients With Advanced Soft Tissue Sarcoma

Posted: May 4th, 2012, 8:00am MDT

Condition: Sarcoma
Interventions: Drug: Gemcitabine and Pazopanib; Drug: Gemcitabine and Docetaxel
Sponsors: Medical University of South Carolina; Medical University of South Carolina; GlaxoSmithKline
Not yet recruiting - verified May 2012

A Study of RO5045377 in Combination With Doxorubicin in Patients With Soft Tissue Sarcoma

Posted: May 4th, 2012, 8:00am MDT

Condition: Sarcoma
Interventions: Drug: RO5045337; Drug: doxorubicin
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Not yet recruiting - verified May 2012

Aerosol IL-2 for Pulmonary Metastases

Posted: April 30th, 2012, 8:00am MDT

Conditions: Sarcoma; Solid Tumors; Pulmonary Metastases; Lung Metastases; Osteosarcomas; Ewing Sarcoma
Interventions: Drug: Aerosol IL-2; Procedure: Symptom Assessment
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Shannon Wilkes Foundation
Not yet recruiting - verified May 2012

Contribution of F18-FDG PET/CT to the Early Assessment of Pazopanib Therapy Efficacy in Advanced Soft Tissue Sarcoma

Posted: April 30th, 2012, 8:00am MDT

Condition: Soft Tissue Sarcoma (STS)
Intervention: Other: F18-FGD PET/CT
Sponsors: Hadassah Medical Organization; Hadassah Medical Organization
Not yet recruiting - verified April 2012

A Open-Label, Multiple Ascending Dose Study of DS-3078a, an Oral TORC1/2 Kinase Inhibitor, in Subjects With Advanced Solid Tumors or Lymphomas

Posted: April 26th, 2012, 8:00am MDT

Conditions: Advanced Solid Tumor; Lymphoma
Intervention: Drug: DS-3078a
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.
Recruiting - verified April 2012

Studying Genes in Samples From Younger Patients With Rhabdomyosarcoma

Posted: April 24th, 2012, 8:00am MDT

Intensity-Modulated Radiation Therapy in Treating Younger Patients With Lung Metastases

Posted: April 23rd, 2012, 8:00am MDT

A Survivorship Care Plan for Gynaecological Cancer Patients

Posted: April 20th, 2012, 8:00am MDT

Conditions: Adenocarcinoma of the Gastroesophageal Junction; Cervical Cancer; Endometrial Cancer; Esophageal Cancer; Fallopian Tube Cancer; Gastric Cancer; Ovarian Cancer; Sarcoma; Vaginal Cancer; Vulvar Cancer
Intervention:
Sponsors: Royal Marsden NHS Foundation Trust; Royal Marsden NHS Foundation Trust; University of Surrey
Recruiting - verified April 2012

Olaparib in Adults With Recurrent/Metastatic Ewing's Sarcoma

Posted: April 18th, 2012, 8:00am MDT

Condition: Ewing's Sarcoma
Intervention: Drug: Olaparib
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Not yet recruiting - verified April 2012

PK/PD of XM22 in Children With Ewing Family of Tumors or Rhabdomyosarcoma

Posted: April 18th, 2012, 8:00am MDT

Condition: Ewing Family of Tumors, Rhabdomyosarcoma
Intervention: Drug: Lipegfilgrastim
Sponsors: Teva Pharmaceutical Industries; Merckle GmbH
Not yet recruiting - verified May 2012

Phase Ib Trial of Folate Binding Protein Vaccine in Ovarian Cancer

Posted: April 16th, 2012, 8:00am MDT

Conditions: Ovarian Cancer; Endometrial Cancer
Interventions: Biological: E39 peptide vaccine; Other: Clinical tracking for disease progression/recurrence
Sponsors: San Antonio Military Medical Center; COL George Peoples, MD, FACS
Recruiting - verified April 2012

Study of Safety and Efficacy of Gemcitabine and Docetaxel With MORAb-004 in Metastatic Soft Tissue Sarcoma

Posted: April 4th, 2012, 8:00am MDT

Condition: Metastatic Soft Tissue Sarcoma
Interventions: Drug: MORAb-004; Drug: Gemcitabine; Drug: Docetaxel
Sponsors: Morphotek; Morphotek
Not yet recruiting - verified April 2012

Clinical Relevance of ROS (V-ros UR2 Sarcoma Virus Oncogene Homolog) Aberrations in Solid Tumours

Posted: April 2nd, 2012, 8:00am MDT

Condition: Cancer
Intervention:
Sponsors: National University Hospital, Singapore; National University Hospital, Singapore
Recruiting - verified April 2012

Collaborative Advanced Stage Tissue Lung Cancer (CASTLE) Network

Posted: March 28th, 2012, 8:00am MDT

Conditions: Non-small Cell Lung Cancer Metastatic; Small Cell Lung Carcinoma
Intervention: Other: therapeutic interventions
Sponsors: Vanderbilt-Ingram Cancer Center; David P. Carbone, M.D. PhD; Addario Lung Cancer Institute (ALCMI)
Recruiting - verified April 2012

Studying Genes in Tissue Samples From Younger and Adolescent Patients With Soft Tissue Sarcomas

Posted: March 27th, 2012, 8:00am MDT

Acupuncture Point Stimulation for Treatment of Chemotherapy Nausea and Vomiting

Posted: December 13th, 2011, 8:00am MST

Conditions: Childhood Acute Lymphoblastic Leukemia; Childhood Acute Myeloid Leukemia/Other Myeloid Malignancies; Ewing Sarcoma; Vomiting in Infants and/or Children; Osteosarcoma
Interventions: Procedure: electroacupuncture therapy; Other: questionnaire administration; Procedure: electroacupuncture therapy
Sponsors: Stanford University; Stanford University; National Cancer Institute (NCI)
Recruiting - verified May 2012

Pilot Study Using a PET Gamma Probe to Evaluate Lymph Nodes in Endometrial Cancer

Posted: October 19th, 2011, 8:00am MDT

Condition: Endometrial Cancer
Interventions: Procedure: lymphadenectomy; Procedure: therapeutic conventional therapy; Procedure: Positron Emission Tomography/ Computed Tomography; Radiation: fludeoxyglucose F 18
Sponsors: University Health Network, Toronto; University Health Network, Toronto
Recruiting - verified May 2012

$Permalink for 'Vincristine and Irinotecan With or Without Temozolomide in Children and Adults With Refractory or Relapsed Rhabdomyosarcoma : International Randomized Trial'$

Vincristine and Irinotecan With or Without Temozolomide in Children and Adults With Refractory or Relapsed Rhabdomyosarcoma : International Randomized Trial

Posted: May 16th, 2011, 8:00am MDT

Permalink for 'Study to Assess Safety and Tolerability of Oral CC-115 for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma or Multiple Myeloma'

Study to Assess Safety and Tolerability of Oral CC-115 for Patients With Advanced Solid Tumors, Non-Hodgkin's Lymphoma or Multiple Myeloma

Posted: May 12th, 2011, 8:00am MDT

Conditions: Multiple Myeloma; Non-Hodgkin's Lymphoma; Glioblastoma Multiforme; Head and Neck Squamous Cell Cancer; Triple Negative Breast Cancer; Hormone Receptor-Positive Breast Cancer; Castration-Resistant Prostate Cancer; Ewing's Family of Sarcomas
Intervention: Drug: CC-115
Sponsors: Celgene Corporation; Celgene Corporation
Recruiting - verified May 2012

High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull

Posted: April 28th, 2011, 8:00am MDT

Conditions: Chordoma of Spine; Chordoma of Sacrum; Chordoma of Base of Skull; Chondrosarcoma of the Spine; Chondrosarcoma of the Sacrum
Intervention: Radiation: High Dose Intensity Modulated Proton Radiation
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Not yet recruiting - verified May 2012

Permalink for 'Maximum Tolerated Dose Study of Belinostat (PXD-101)in Combination With Paclitaxel Plus Carboplatin in Chemotherapy-Naive Patients With Stage IV Non-Small-Cell Lung Cancer (NSCLC)'

Maximum Tolerated Dose Study of Belinostat (PXD-101)in Combination With Paclitaxel Plus Carboplatin in Chemotherapy-Naive Patients With Stage IV Non-Small-Cell Lung Cancer (NSCLC)

Posted: February 28th, 2011, 8:00am MST

Condition: Stage IV Non-small Cell Lung Cancer
Intervention: Drug: Belionstat, Carboplatin, Paclitaxel
Sponsors: Spectrum Pharmaceuticals, Inc; Spectrum Pharmaceuticals, Inc; TopoTarget A/S
Recruiting - verified May 2012

Permalink for 'Continuing vs Intermittent Trabectedin-regimen in Patients With Advanced Soft Tissue Sarcoma Experiencing Response or Stable Disease After the 6th Cycle'

Continuing vs Intermittent Trabectedin-regimen in Patients With Advanced Soft Tissue Sarcoma Experiencing Response or Stable Disease After the 6th Cycle

Posted: February 23rd, 2011, 8:00am MST

Conditions: Soft Tissue Sarcoma; Uterine Sarcoma
Interventions: Drug: Trabectedin; Other: Drug: holiday
Sponsors: Centre Oscar Lambret; Centre Oscar Lambret; Groupe Sarcome Français; Groupe d’études des Tumeurs Osseuses
Recruiting - verified May 2012

Effects of Maraviroc (MVC) on HIV-related Kaposi's Sarcoma (KS)

Posted: December 20th, 2010, 8:00am MST

Condition: Kaposi's Sarcoma
Intervention: Drug: Maraviroc
Sponsors: University of California, San Francisco; University of California, San Francisco; Pfizer; ViiV Healthcare
Enrolling by invitation - verified May 2012

$Permalink for 'To Evaluate the Safety, Activity and Pharmacokinetics of Marqibo in Children and Adolescents With Refractory Cancer'$

To Evaluate the Safety, Activity and Pharmacokinetics of Marqibo in Children and Adolescents With Refractory Cancer

Posted: October 15th, 2010, 8:00am MDT

Conditions: Sarcoma; Neuroblastoma; Wilms Tumor; Leukemia; Lymphoma; Brain Tumors
Intervention: Drug: Marqibo
Sponsors: Talon Therapeutics, Inc; Talon Therapeutics, Inc; National Cancer Institute (NCI)
Recruiting - verified May 2012

Metformin and Endometrial Cancer

Posted: September 17th, 2010, 8:00am MDT

Condition: Endometrial Cancer
Intervention: Drug: Metformin
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; American Cancer Society
Recruiting - verified May 2012

Surveillance Study of Patients With Newly Diagnosed Osteosarcoma

Posted: September 1st, 2010, 8:00am MDT

Condition: Osteosarcoma
Intervention: Drug: Mifamurtide
Sponsors: Millennium Pharmaceuticals, Inc.; Millennium Pharmaceuticals, Inc.
Recruiting - verified April 2012

Study of Palifosfamide-tris in Combination With Doxorubicin in Patients With Front-line Metastatic Soft Tissue Sarcoma

Posted: July 21st, 2010, 8:00am MDT

Condition: Soft Tissue Sarcoma
Interventions: Drug: doxorubicin in combination with palifosfamide-tris; Drug: doxorubicin in combination with placebo
Sponsors: ZIOPHARM; ZIOPHARM
Recruiting - verified April 2012

A Study of RO5045337 in Patients With Liposarcomas Prior to Debulking Surgery

Posted: June 11th, 2010, 8:00am MDT

Condition: Sarcoma
Intervention: Drug: RO5045337
Sponsors: Hoffmann-La Roche; Hoffmann-La Roche
Completed - verified May 2012

Study of Oral Darinaparsin in Patients With Advanced Solid Tumors

Posted: June 4th, 2010, 8:00am MDT

Condition: Advanced Solid Tumors
Intervention: Drug: darinaparsin
Sponsors: ZIOPHARM; ZIOPHARM
Completed - verified May 2012

$Permalink for 'Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features'$

Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features

Posted: January 13th, 2010, 8:00am MST

Genomic Analysis of Pediatric Bone Tumors

Posted: January 11th, 2010, 8:00am MST

Condition: Bone Cancer
Intervention:
Sponsors: Stanford University; Stanford University
Recruiting - verified May 2012

Quantitative MR Biomarkers for Sarcoma Treatment

Posted: November 20th, 2009, 8:00am MST

Condition: Soft Tissue Tumors
Intervention: Procedure: MRI Scan of soft tissue tumor
Sponsors: University of Michigan; University of Michigan; National Institutes of Health (NIH)
Completed - verified April 2012

Safety Study of PLX108-01 in Patients With Solid Tumors

Posted: October 28th, 2009, 8:00am MDT

Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment

Posted: June 27th, 2009, 8:00am MDT

Conditions: Brain and Central Nervous System Tumors; Sarcoma; Unspecified Childhood Solid Tumor, Protocol Specific
Interventions: Drug: pazopanib hydrochloride; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Active, not recruiting - verified August 2011

Permalink for 'A Study of Ridaforolimus in Non-Small Cell Lung Cancer (NSCLC) Patients With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutations (MK-8669-021 AM1)'

A Study of Ridaforolimus in Non-Small Cell Lung Cancer (NSCLC) Patients With Kirsten Rat Sarcoma Viral Oncogene Homolog (KRAS) Mutations (MK-8669-021 AM1)

Posted: January 7th, 2009, 8:00am MST

Condition: Non-Small Cell Lung Cancer
Interventions: Drug: Lead-In Ridaforolimus; Drug: Comparator: Blinded Ridaforolimus; Drug: Comparator: Blinded Placebo
Sponsors: Merck; Merck; Ariad Pharmaceuticals
Active, not recruiting - verified May 2012

A Placebo-Controlled Study Evaluating the Potential Effects of Trabectedin on the Heart in Patients With Advanced Cancer

Posted: November 4th, 2008, 8:00am MST

Condition: Neoplasm Metastases
Intervention: Drug: trabectedin
Sponsors: Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; Johnson & Johnson Pharmaceutical Research & Development, L.L.C.; PharmaMar
Completed - verified May 2012

Combined Biological Treatment and Chemotherapy for Patients With Inoperable Cholangiocarcinoma

Posted: October 22nd, 2008, 8:00am MDT

Condition: Cholangiocarcinoma
Interventions: Drug: Gemcitabine, Oxaliplatin, Capecitabine,; Drug: Panitumumab, Gemcitabine, Oxaliplatin, Capecitabine
Sponsors: Vejle Hospital; Vejle Hospital
Recruiting - verified May 2012

Treatment of Patients With RAD001 Who Have Progressive Sarcoma

Posted: October 6th, 2008, 8:00am MDT

Condition: Progressive Sarcoma
Intervention: Drug: Everolimus/RAD001
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012

Permalink for 'Evaluation of Paclitaxel (Taxol, NSC #673089), Carboplatin (Paraplatin, NSC #241240), and BSI-201 (NSC #746045, IND #71,677) in the Treatment of Advanced, Persistent, or Recurrent Uterine Carcinosarcoma'

Evaluation of Paclitaxel (Taxol, NSC #673089), Carboplatin (Paraplatin, NSC #241240), and BSI-201 (NSC #746045, IND #71,677) in the Treatment of Advanced, Persistent, or Recurrent Uterine Carcinosarcoma

Posted: May 28th, 2008, 8:00am MDT

Condition: Uterine Carcinosarcoma
Intervention: Drug: Carboplatin, paclitaxel, BSI-201
Sponsors: Sanofi-Aventis; Sanofi-Aventis; BiPar Sciences; Gynecologic Oncology Group
Completed - verified May 2012

Combination Chemotherapy in Treating Patients With Sarcoma

Posted: April 18th, 2008, 8:00am MDT

Dynamic Contrast Enhanced MRI(DCE-MRI)of Bone Tumors

Posted: January 10th, 2008, 8:00am MST

Conditions: Sarcoma; Bone Tumor
Intervention: Other: DCE-MRI
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; New York Presbyterian Hospital; University of Oregon; University College, London; Montefiore Hospital
Active, not recruiting - verified May 2012

Collection of Tissue & Blood From Patients w/ Benign & Malignant Tumors of the Soft Tissue & Gastrointestinal Tract

Posted: December 21st, 2007, 8:00am MST

Evaluation of Carboplatin/Paclitaxel/Bevacizumab in the Treatment of Advanced Stage Endometrial Carcinoma

Posted: August 8th, 2007, 8:00am MDT

Condition: Endometrial Cancer
Intervention: Drug: Carboplatin/Paclitaxel/Bevacizumab
Sponsors: Ohio State University; David O'Malley; Genentech
Active, not recruiting - verified May 2012

Safety and Efficacy Study of REOLYSIN® in the Treatment of Bone and Soft Tissue Sarcomas Metastatic to the Lung

Posted: July 16th, 2007, 8:00am MDT

Conditions: Osteosarcoma; Ewing Sarcoma Family Tumors; Malignant Fibrous Histiocytoma; Sarcoma, Synovial; Fibrosarcoma; Leiomyosarcoma
Intervention: Biological: REOLYSIN®
Sponsors: Oncolytics Biotech; Oncolytics Biotech
Completed - verified May 2012

Study of Insulin Resistance and Endometrial Cancer in Harris County, Texas

Posted: July 2nd, 2007, 8:00am MDT

Condition: Endometrial Cancer
Intervention: Behavioral: Questionnaire
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified April 2012

Development of Serologic Assays for Human Herpes Virus-8

Posted: October 31st, 2006, 8:00am MST

Condition: Herpesvirus 8, Human
Intervention:
Sponsors: National Institutes of Health Clinical Center (CC); National Institutes of Health Clinical Center (CC)
Completed - verified June 2011

Racial Disparity in Endometrial Cancer

Posted: September 11th, 2006, 8:00am MDT

Condition: Endometrial Cancer
Intervention:
Sponsors: James Graham Brown Cancer Center; James Graham Brown Cancer Center
Terminated - verified April 2012

Evaluate PKs and Efficacy Assessment of Palifermin in Patients With Sarcoma

Posted: December 19th, 2005, 8:00am MST

Conditions: Sarcoma; Oral Mucositis
Interventions: Drug: Palifermin; Drug: Placebo; Drug: Adriamycin (Doxorubicin); Drug: Ifosfamide; Drug: Vincristine; Drug: Cisplatin
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Completed - verified April 2012

A Phase II Trial of Adjuvant Radiation Therapy With Ifosfamide in Patients With MMT of the Uterus

Posted: October 3rd, 2005, 8:00am MDT

Condition: Uterine Cancer
Interventions: Drug: Ifosfamide; Procedure: Radiation Therapy
Sponsors: Montefiore Medical Center; Montefiore Medical Center
Completed - verified April 2012

Imatinib Mesylate in Patients With Various Types of Malignancies Involving Activated Tyrosine Kinase Enzymes

Posted: September 13th, 2005, 8:00am MDT

Conditions: Hypereosinophilic Syndrome; Systemic Mastocytosis; Chronic Myelomonocytic Leukemia; Dermatofibrosarcoma
Intervention: Drug: imatinib mesylate
Sponsors: Novartis; Novartis Pharmaceuticals
Recruiting - verified April 2012

Traumeel® S in Preventing and Treating Mucositis in Young Patients Undergoing Stem Cell Transplantation

Posted: April 7th, 2004, 8:00am MDT

Soblidotin in Treating Patients With Advanced or Metastatic Soft Tissue Sarcoma

Posted: July 8th, 2003, 8:00am MDT

Condition: Sarcoma
Intervention: Drug: soblidotin
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.; National Cancer Institute (NCI)
Completed - verified May 2012

Permalink for 'Exatecan Mesylate in Treating Patients With Ewing's Sarcoma, Primitive Neuroectodermal Tumor, or Desmoplastic Small Round Cell Tumor'

Exatecan Mesylate in Treating Patients With Ewing's Sarcoma, Primitive Neuroectodermal Tumor, or Desmoplastic Small Round Cell Tumor

Posted: March 6th, 2003, 8:00am MST

Condition: Sarcoma
Intervention: Drug: exatecan mesylate
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.
Completed - verified May 2012

$Permalink for 'Exatecan Mesylate in Treating Children With Relapsed or Refractory Rhabdomyosarcoma'$

Exatecan Mesylate in Treating Children With Relapsed or Refractory Rhabdomyosarcoma

Posted: March 6th, 2003, 8:00am MST

Condition: Sarcoma
Intervention: Drug: exatecan mesylate
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.
Completed - verified May 2012

Vincristine, Doxorubicin, Cyclophosphamide and Dexrazoxane (VACdxr) in High Risk Ewing's Sarcoma Patients

Posted: May 29th, 2002, 8:00am MDT

Condition: Ewing's Sarcoma
Interventions: Drug: Vincristine; Drug: Doxorubicin; Drug: Cyclophosphamide; Drug: Dexrazoxane; Biological: ImmTher
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Active, not recruiting - verified May 2012

Permalink for 'UCN-01 and Irinotecan in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple-Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)'

UCN-01 and Irinotecan in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple-Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)

Posted: March 8th, 2002, 8:00am MST

Condition: Cancer
Interventions: Drug: 7-hydroxystaurosporine; Drug: irinotecan hydrochloride; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); University of Virginia; National Cancer Institute (NCI); Washington University Siteman Cancer Center
Completed - verified August 2009

Permalink for 'Phase I Trial of the Combination of Zidovudine and Recombinant Interleukin-2 in Patients With Persistent Generalized Lymphadenopathy'

Phase I Trial of the Combination of Zidovudine and Recombinant Interleukin-2 in Patients With Persistent Generalized Lymphadenopathy

Posted: November 2nd, 1999, 8:00am MST

Condition: HIV Infections
Interventions: Drug: Zidovudine; Drug: Aldesleukin
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified April 2012

Permalink for 'A Phase I Study of the Combination of Recombinant GM-CSF, AZT, and Chemotherapy (ABV) (Adriamycin, Bleomycin, Vincristine) in AIDS and Kaposi's Sarcoma'

A Phase I Study of the Combination of Recombinant GM-CSF, AZT, and Chemotherapy (ABV) (Adriamycin, Bleomycin, Vincristine) in AIDS and Kaposi's Sarcoma

Posted: November 2nd, 1999, 8:00am MST

Conditions: Sarcoma, Kaposi; HIV Infections
Interventions: Drug: Bleomycin sulfate; Drug: Vincristine sulfate; Drug: Doxorubicin hydrochloride; Drug: Zidovudine; Drug: Sargramostim
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified April 2012

A Phase I/II Study of Recombinant Interleukin-4 in AIDS and Kaposi's Sarcoma

Posted: November 2nd, 1999, 8:00am MST

Conditions: Sarcoma, Kaposi; HIV Infections
Intervention: Drug: Interleukin-4
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified April 2012

Permalink for 'Open Label Phase I Study To Evaluate the Safety of Combination Therapy With AZT and Interferon-Beta in Patients With AIDS Related Kaposi's Sarcoma'

Open Label Phase I Study To Evaluate the Safety of Combination Therapy With AZT and Interferon-Beta in Patients With AIDS Related Kaposi's Sarcoma

Posted: November 2nd, 1999, 8:00am MST

Conditions: Sarcoma, Kaposi; HIV Infections
Interventions: Drug: Interferon beta-1b; Drug: Zidovudine
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified May 2012

Permalink for 'A Phase I Trial of Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor (rHuGM-CSF), Recombinant Alpha Interferon and Azidothymidine (AZT) in AIDS-Associated Kaposi's Sarcoma'

A Phase I Trial of Recombinant Human Granulocyte-Macrophage Colony Stimulating Factor (rHuGM-CSF), Recombinant Alpha Interferon and Azidothymidine (AZT) in AIDS-Associated Kaposi's Sarcoma

Posted: November 2nd, 1999, 8:00am MST

Conditions: Sarcoma, Kaposi; HIV Infections
Interventions: Drug: Interferon alfa-2b; Drug: Zidovudine; Drug: Sargramostim
Sponsors: National Institute of Allergy and Infectious Diseases (NIAID); National Institute of Allergy and Infectious Diseases (NIAID)
Completed - verified May 2012

Radiation Therapy or Observation Only in Treating Patients With Endometrial Cancer Who Have Undergone Surgery

Posted: November 1st, 1999, 8:00am MST

Condition: Endometrial Cancer
Intervention: Radiation: radiation therapy
Sponsors: NCIC Clinical Trials Group; NCIC Clinical Trials Group
Completed - verified April 2012

Combination Chemotherapy and Peripheral Stem Cell Transplantation in Treating Patients With Sarcoma

Posted: November 1st, 1999, 8:00am MST

Radiation Therapy in Treating Patients With Newly Diagnosed Brain Metastases From Kidney Cancer, Melanoma, or Sarcoma

Posted: November 1st, 1999, 8:00am MST

Chemotherapy in Treating Patients With Advanced Sarcoma

Posted: November 1st, 1999, 8:00am MST

Conditions: Ovarian Cancer; Sarcoma
Interventions: Biological: filgrastim; Drug: doxorubicin hydrochloride; Drug: ifosfamide
Sponsors: Swiss Group for Clinical Cancer Research; Swiss Group for Clinical Cancer Research
Completed - verified May 2012

Combination Chemotherapy With or Without Radiation Therapy in Treating Patients With Newly Diagnosed Rhabdomyosarcoma

Posted: November 1st, 1999, 8:00am MST

A Study Comparing Treatment With 177Lu-DOTA0-Tyr3-Octreotate to Octreotide LAR in Patients With Inoperable, Progressive, Somatostatin Receptor Positive Midgut Carcinoid Tumours

Posted: April 10th, 2012, 8:00am MDT

Biomarkers for Angiogenesis in Renal Cell Carcinoma and Neuro-endocrine Tumours.

Posted: July 19th, 2011, 8:00am MDT

Study of LX1606 in Subjects With Symptomatic Carcinoid Syndrome

Posted: April 12th, 2010, 8:00am MDT

$Permalink for 'Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features'$

Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features

Posted: January 13th, 2010, 8:00am MST

Internal Radiation Therapy in Treating Patients With Liver Metastases From Neuroendocrine Tumors

Posted: April 25th, 2007, 8:00am MDT

UCN-01 and Irinotecan in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple-Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)

Posted: March 8th, 2002, 8:00am MST

Akt Inhibitor MK2206 in Treating Patients With Progressive, Recurrent, or Metastatic Adenoid Cyst Carcinoma

Posted: May 22nd, 2012, 8:00am MDT

Condition: Head and Neck Cancer
Interventions: Drug: Akt inhibitor MK2206; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); Cancer and Leukemia Group B; National Cancer Institute (NCI)
Not yet recruiting - verified May 2012

Intensity-Modulated or Proton Radiation Therapy for Sinonasal Malignancy

Posted: October 21st, 2011, 8:00am MDT

Conditions: Adenoid Cystic Carcinoma; Squamous Cell Carcinoma; Sinonasal Carcinoma; Sinonasal Undifferentiated Carcinoma
Interventions: Radiation: Proton radiation therapy; Radiation: Intensity-modulated radiotherapy
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; National Institutes of Health (NIH); National Cancer Institute (NCI)
Recruiting - verified April 2012

Gemcitabine and Doxorubicin in Treating Patients With Recurrent or Progressive Head and Neck Cancer

Posted: July 30th, 2007, 8:00am MDT

Condition: Head and Neck Cancer
Interventions: Drug: doxorubicin hydrochloride; Drug: gemcitabine hydrochloride; Other: laboratory biomarker analysis; Other: liquid chromatography; Other: mass spectrometry
Sponsors: Medical University of South Carolina; Medical University of South Carolina
Completed - verified April 2012

UCN-01 and Irinotecan in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple-Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)

Posted: March 8th, 2002, 8:00am MST

Cevimeline in Treating Patients With Dry Mouth Caused by Radiation Therapy for Head and Neck Cancer

Posted: June 6th, 2001, 8:00am MDT

Conditions: Head and Neck Cancer; Oral Complications; Radiation Toxicity
Intervention: Drug: cevimeline hydrochloride
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.
Completed - verified May 2012

The Value of Botox-A for Management of Low Anterior Resection Syndrome

Posted: April 27th, 2012, 8:00am MDT

Conditions: Low Anterior Resection Syndrome; Rectal Cancer
Intervention: Drug: intra-rectal Botulinum toxin A injection
Sponsors: Centre hospitalier de l'Université de Montréal (CHUM); Centre hospitalier de l'Université de Montréal (CHUM); Allergan
Recruiting - verified June 2011

Permalink for 'A Phase II Study of Lymphodepletion Followed by Autologous Tumor-Infiltrating Lymphocytes and High-Dose AJdesleukin for HumanPapillomavirus-Associated Cancers'

A Phase II Study of Lymphodepletion Followed by Autologous Tumor-Infiltrating Lymphocytes and High-Dose AJdesleukin for HumanPapillomavirus-Associated Cancers

Posted: April 24th, 2012, 8:00am MDT

Conditions: Cervical Cancer; Oropharyngeal Cancer; Vaginal Cancer; Anal Cancer; Penile Cancer
Interventions: Drug: Fluderabine; Drug: Cycolphosphamide; Biological: Young TIL; Biological: Aldesleukin
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified April 2012

Radiochemotherapy With Panitumumab in the Localised Epidermoid Carcinoma of the Anus

Posted: April 6th, 2012, 8:00am MDT

Conditions: Epidermoid Carcinoma; Anus
Interventions: Drug: radiochemotherapy; Drug: Panitumumab
Sponsors: Federation Francophone de Cancerologie Digestive; Federation Francophone de Cancerologie Digestive
Not yet recruiting - verified April 2012

Collecting and Studying Tissue Samples From Patients With HIV-Associated Malignancies

Posted: March 29th, 2012, 8:00am MDT

Conditions: Anal Cancer; Cervical Cancer; Lung Cancer; Lymphoma; Nonneoplastic Condition
Interventions: Genetic: DNA analysis; Genetic: RNA analysis; Genetic: gene expression analysis; Genetic: polymorphism analysis; Other: biologic sample preservation procedure; Other: flow cytometry; Other: laboratory biomarker analysis; Other: medical chart review
Sponsors: National Cancer Institute (NCI); AIDS Associated Malignancies Clinical Trials Consortium; National Cancer Institute (NCI)
Not yet recruiting - verified March 2012

ScopeGuide-assisted Colonoscopy Versus Conventional Colonoscopy

Posted: September 14th, 2011, 8:00am MDT

Conditions: Colonic Neoplasms; Iron Deficiency Anemia; Diarrhea
Intervention: Device: Olympus ScopeGuide
Sponsors: University of Alberta; Christopher Teshima
Recruiting - verified April 2012

Alkagin Paste in the Prevention of Radiation Dermatitis

Posted: August 2nd, 2011, 8:00am MDT

Conditions: Anus Neoplasms; Rectal Neoplasms; Urogenital Neoplasms
Interventions: Other: Aveeno cream; Other: Alkagin paste
Sponsors: Sir Mortimer B. Davis - Jewish General Hospital; Dr. Te Vuong; Avario Healthcare
Recruiting - verified May 2012

Nimotuzumab With Radiotherapy in the Treatment of Anal Canal Cancers

Posted: June 24th, 2011, 8:00am MDT

Condition: Squamous Cell Carcinoma of Anal Canal
Interventions: Drug: Nimotuzumab; Radiation: Intensity Modulated Radiation Therapy (IMRT)
Sponsors: Sir Mortimer B. Davis - Jewish General Hospital; Dr. Te Vuong; YM BioSciences
Recruiting - verified May 2012

Indocyanine Green Fluorescent Molecular Imaging of the Gastrointestinal Tract

Posted: April 27th, 2010, 8:00am MDT

Conditions: High Risk Polyposis Syndrome; Distal Colonic Lesions; Colorectal Polyps
Intervention: Drug: indocyanine green
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Dana-Farber Cancer Institute; National Cancer Institute (NCI); Damon Runyon Cancer Research Foundation
Recruiting - verified April 2012

UCN-01 and Irinotecan in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple-Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)

Posted: March 8th, 2002, 8:00am MST

Human Placental-Derived Stem Cell Transplantation

Posted: April 25th, 2012, 8:00am MDT

Conditions: Mucopolysaccharidosis I; Mucopolysaccharidosis VI; Adrenoleukodystrophy; Niemann-Pick Disease; Metachromatic Leukodystrophy; Wolman Disease; Krabbe's Disease; Gaucher's Disease; Fucosidosis; Batten Disease; Severe Aplastic Anemia; Diamond-Blackfan Anemia; Amegakaryocytic Thrombocytopenia; Myelodysplastic Syndrome; Acute Myelogenous Leukemia; Acute Lymphocytic Leukemia
Intervention: Drug: Human Placental Derived Stem Cell
Sponsors: New York Medical College; New York Medical College
Not yet recruiting - verified April 2012

An Open-label, Multi-center, Expanded Access Study of Pasireotide s.c. in Patients With Cushing's Disease

Posted: April 12th, 2012, 8:00am MDT

Condition: Cushing's Disease
Intervention: Drug: Pasireotide sub-cutaneous formulation
Sponsors: Novartis; Novartis Pharmaceuticals
Available - verified April 2012

Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome?

Posted: November 15th, 2011, 8:00am MST

Conditions: Cushing's Syndrome; Adrenal Incidentalomas; Alcoholism; Obesity
Intervention:
Sponsors: Haukeland University Hospital; Haukeland University Hospital
Recruiting - verified May 2012

Permalink for 'Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders'

Study Evaluating The Safety And Efficacy Of Varenicline and Bupropion For Smoking Cessation In Subjects With And Without A History Of Psychiatric Disorders

Posted: October 14th, 2011, 8:00am MDT

Condition: Smoking Cessation
Interventions: Drug: Placebo; Drug: varenicline tartrate; Drug: bupropion hydrochloride; Drug: Nicotine Replacement Therapy Patch
Sponsors: Pfizer; Pfizer; GlaxoSmithKline
Recruiting - verified May 2012

Cediranib and Olaparib in Combination for Recurrent Ovarian or Triple-Negative Breast Cancer

Posted: April 29th, 2010, 8:00am MDT

Conditions: Ovarian Cancer; Primary Peritoneal Cancer; Fallopian Tube Cancer
Interventions: Drug: cediranib; Drug: olaparib
Sponsors: Dana-Farber Cancer Institute; Dana-Farber Cancer Institute; Massachusetts General Hospital; Beth Israel Deaconess Medical Center; University of Chicago; National Cancer Institute (NCI)
Recruiting - verified April 2012

$Permalink for 'Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors'$

Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors

Posted: February 25th, 2010, 8:00am MST

$Permalink for 'Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features'$

Seneca Valley Virus-001 and Cyclophosphamide in Treating Young Patients With Relapsed or Refractory Neuroblastoma, Rhabdomyosarcoma, or Rare Tumors With Neuroendocrine Features

Posted: January 13th, 2010, 8:00am MST

Treating Patients With Prostate Cancer That Did Not Respond to Hormone Therapy

Posted: April 11th, 2007, 8:00am MDT

Condition: Prostate Cancer
Interventions: Drug: ketoconazole; Drug: lenalidomide; Drug: therapeutic hydrocortisone
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Active, not recruiting - verified May 2012

Bortezomib With or Without Hormone Therapy in Treating Patients With Relapsed Prostate Cancer

Posted: February 7th, 2005, 8:00am MST

Condition: Prostate Cancer
Interventions: Drug: bicalutamide; Drug: bortezomib; Drug: flutamide; Drug: goserelin acetate; Drug: leuprolide acetate
Sponsors: Medical University of South Carolina; Medical University of South Carolina
Completed - verified April 2012

Docetaxel, Radiation Therapy, and Hormone Therapy in Treating Patients With Locally Advanced Prostate Cancer

Posted: December 8th, 2004, 8:00am MST

Condition: Prostate Cancer
Interventions: Drug: bicalutamide; Drug: docetaxel; Drug: goserelin acetate; Drug: leuprolide acetate; Procedure: adjuvant therapy; Procedure: neoadjuvant therapy; Radiation: radiation therapy
Sponsors: Medical University of South Carolina; Medical University of South Carolina
Active, not recruiting - verified April 2012

Polyphenon E in Treating Patients With High-Risk of Colorectal Cancer

Posted: May 23rd, 2012, 8:00am MDT

Conditions: Advanced Colorectal Adenomas; Adenocarcinoma of the Colon; Stage I Colon Cancer; Stage II Colon Cancer; Stage III Colon Cancer
Interventions: Drug: defined green tea catechin extract; Other: placebo; Other: questionnaire administration; Other: laboratory biomarker analysis
Sponsors: Mayo Clinic; Mayo Clinic; National Cancer Institute (NCI)
Not yet recruiting - verified May 2012

Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury

Posted: May 22nd, 2012, 8:00am MDT

Conditions: Traumatic Brain Injury; Subdural Hematoma; Cerebral Contusion; Head Injury; Cerebral Edema
Interventions: Drug: Induced, sustained hypernatremia using hypertonic saline; Drug: Standard of care (hypertonic saline and mannitol; serum sodium)
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Not yet recruiting - verified May 2012

A Comparison of MRI Perfusion and FDG PET/CT to Distinguish Between Radiation Injury and Tumor Progression

Posted: May 21st, 2012, 8:00am MDT

Condition: Brain Cancer
Intervention: Other: MRI perfusion and PET/CT scans
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified May 2012

Procedural Pain Treatment With Transmucosal Sublingual Fentanyl Tablet in Colonoscopy Patients

Posted: May 21st, 2012, 8:00am MDT

Conditions: Colonoscopy; Pain
Interventions: Drug: Fentanyl; Drug: Placebo
Sponsors: Turku University Hospital; Turku University Hospital
Recruiting - verified May 2012

Permalink for 'Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors'

Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors

Posted: May 18th, 2012, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: carboplatin; Drug: etoposide; Drug: ifosfamide; Procedure: therapeutic conventional surgery; Radiation: 3-dimensional conformal radiation therapy; Radiation: intensity-modulated radiation therapy
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Not yet recruiting - verified May 2012

Systemic Therapy With Interferon, Interleukin-2 and BRAF Inhibitor

Posted: May 18th, 2012, 8:00am MDT

A Study of Tabalumab in Participants With Previously Treated Multiple Myeloma (MM)

Posted: May 16th, 2012, 8:00am MDT

Condition: Multiple Myeloma
Interventions: Drug: Placebo; Drug: Dexamethasone; Drug: Bortezomib; Biological: Tabalumab
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Not yet recruiting - verified May 2012

Social Cognition in Children Treated for a Brain Tumour

Posted: May 11th, 2012, 8:00am MDT

Conditions: Social Behaviour; Brain Neoplasms; Cystic Fibrosis
Intervention:
Sponsors: University Medical Centre Groningen; University Medical Centre Groningen; Radboud University; Universitaire Ziekenhuizen Leuven
Recruiting - verified May 2012

Permalink for 'Duloxetine Hydrochloride in Treating Muscle, Bone, and Joint Pain in Patients With Early-Stage Breast Cancer Receiving Hormone Therapy'

Duloxetine Hydrochloride in Treating Muscle, Bone, and Joint Pain in Patients With Early-Stage Breast Cancer Receiving Hormone Therapy

Posted: May 11th, 2012, 8:00am MDT

Conditions: Breast Cancer; Musculoskeletal Complications; Pain; Therapy-related Toxicity
Interventions: Drug: duloxetine hydrochloride; Other: placebo
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Not yet recruiting - verified May 2012

Perioperative Magnesium Sulphate as a Cerebral Protector in Neurosurgical Patients

Posted: May 10th, 2012, 8:00am MDT

Conditions: Seizures (Incl Subtypes); Brain Tumor
Interventions: Drug: Magnesium Sulfate; Other: Sodium Chloride
Sponsors: Fundacion Clinic per a la Recerca Biomédica; Sara Varea
Not yet recruiting - verified May 2012

Permalink for 'Safety and Efficacy of Cannabidiol for Grade I/II Acute Graft Versus Host Disease (GVHD) After Allogeneic Stem Cell Transplantation'

Safety and Efficacy of Cannabidiol for Grade I/II Acute Graft Versus Host Disease (GVHD) After Allogeneic Stem Cell Transplantation

Posted: May 9th, 2012, 8:00am MDT

Condition: Graft Versus Host Disease
Intervention: Drug: Cannabidiol
Sponsors: Rabin Medical Center; Rabin Medical Center
Not yet recruiting - verified May 2012

Longitudinal Study of Biomarkers

Posted: May 8th, 2012, 8:00am MDT

Condition: Central Nervous System Tumor
Intervention:
Sponsors: Children's Memorial Hospital; Children's Memorial Hospital
Recruiting - verified May 2012

MicroRNAs in Patients With Neurofibromatosis Type 1

Posted: May 8th, 2012, 8:00am MDT

Conditions: Glioma; Neurofibromatosis Type 1
Intervention:
Sponsors: Children's Memorial Hospital; Children's Memorial Hospital
Recruiting - verified May 2012

Permalink for 'Combination Chemotherapy With or Without Rituximab in Treating Younger Patients With Stage III-IV Non-Hodgkin Lymphoma or B-Cell Acute Leukemia'

Combination Chemotherapy With or Without Rituximab in Treating Younger Patients With Stage III-IV Non-Hodgkin Lymphoma or B-Cell Acute Leukemia

Posted: May 8th, 2012, 8:00am MDT

Conditions: Leukemia; Lymphoma
Interventions: Biological: rituximab; Drug: cyclophosphamide; Drug: cytarabine; Drug: doxorubicin hydrochloride; Drug: etoposide; Drug: hydrocortisone sodium succinate; Drug: leucovorin calcium; Drug: methotrexate; Drug: methylprednisolone; Drug: prednisone; Drug: vincristine sulfate
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Not yet recruiting - verified May 2012

Intrathecal Rituximab in Lymphoid Malignancies Involving Central Nervous System

Posted: May 8th, 2012, 8:00am MDT

Conditions: Leukemia; Lymphoid Malignancies; Metastatic Malignant Neoplasm to the Leptomeninges
Intervention: Drug: Intrathecal Rituximab
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Not yet recruiting - verified May 2012

Permalink for 'Phase I Study of Cabazitaxel, Mitoxantrone, and Prednisone (CAMP) for Patients With Metastatic Castration-Resistant Prostate Cancer and no Prior Chemotherapy'

Phase I Study of Cabazitaxel, Mitoxantrone, and Prednisone (CAMP) for Patients With Metastatic Castration-Resistant Prostate Cancer and no Prior Chemotherapy

Posted: May 7th, 2012, 8:00am MDT

Condition: Metastatic Castration-resistant Prostate Cancer
Interventions: Drug: Cabazitaxel; Drug: Mitoxantrone; Drug: Prednisone; Drug: Pegfilgrastim
Sponsors: University of California, San Francisco; Andrea Harzstark; Sanofi-Aventis
Not yet recruiting - verified May 2012

Mirtazapine Plus Gemcitabine Versus Gemcitabine in Metastasis Pancreatic Cancer

Posted: May 5th, 2012, 8:00am MDT

Condition: Pancreatic Cancer
Interventions: Drug: Mirtazapine plus gemcitabine; Drug: Gemcitabine, placebo
Sponsors: Tianjin Medical University Cancer Institute and Hospital; Tianjin Medical University Cancer Institute and Hospital
Not yet recruiting - verified May 2012

Permalink for 'Decitabine and Vorinostat With CD3/CD19 Depleted Haploidentical Donor NK Cells for Treatment of High Risk Myelodysplastic Syndromes'

Decitabine and Vorinostat With CD3/CD19 Depleted Haploidentical Donor NK Cells for Treatment of High Risk Myelodysplastic Syndromes

Posted: May 4th, 2012, 8:00am MDT

Condition: Myelodysplastic Syndrome
Interventions: Drug: Decitabine; Drug: Vorinostat; Biological: Interleukin-2; Other: Natural killer (NK) cells
Sponsors: Masonic Cancer Center, University of Minnesota; Masonic Cancer Center, University of Minnesota
Not yet recruiting - verified May 2012

A Prospective Phase III Trial to Compare Stereotactic Radiosurgery Versus Whole Brain Radiation Therapy

Posted: May 3rd, 2012, 8:00am MDT

Condition: Brain Neoplasms
Interventions: Radiation: Stereotactic Radiosurgery (SRS); Radiation: Whole Brain Radiation Therapy (WBRT); Behavioral: Questionnaires; Behavioral: Cognitive Function Tests
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Not yet recruiting - verified May 2012

Aerosol IL-2 for Pulmonary Metastases

Posted: April 30th, 2012, 8:00am MDT

Structural and Functional Imaging and Cognitive Functions in Ovarian Cancer

Posted: April 30th, 2012, 8:00am MDT

Conditions: Fallopian Tube Cancer; Ovarian Cancer; Peritoneal Cancer
Interventions: Other: Neuroimaging & Neuropsychological Evaluation; Other: Neuroimaging & Neuropsychological Evaluation
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Weill Medical College of Cornell University
Recruiting - verified May 2012

ch14.18 Pharmacokinetic Study in High-risk Neuroblastoma

Posted: April 30th, 2012, 8:00am MDT

Condition: Neuroblastoma
Interventions: Biological: ch14.18 -NCI; Biological: ch14.18-UTC; Biological: Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF); Biological: Aldesleukin (IL-2); Drug: Isotretinoin
Sponsors: United Therapeutics; United Therapeutics
Not yet recruiting - verified May 2012

$Permalink for 'Pomalidomide (POM) in Combination With Low Dose Dexamethasone (LD-Dex) in Patients With Relapsed or Refractory Multiple Myeloma'$

Pomalidomide (POM) in Combination With Low Dose Dexamethasone (LD-Dex) in Patients With Relapsed or Refractory Multiple Myeloma

Posted: April 27th, 2012, 8:00am MDT

Condition: Multiple Myeloma
Intervention: Drug: Pomalidomide
Sponsors: Celgene Corporation; Celgene Corporation
Available - verified May 2012

The Value of Botox-A for Management of Low Anterior Resection Syndrome

Posted: April 27th, 2012, 8:00am MDT

Permalink for 'Liposomal Cytarabine in the Treatment of Central Nervous System Resistant or Relapsed Acute Lymphoblastic Leukemia in Children'

Liposomal Cytarabine in the Treatment of Central Nervous System Resistant or Relapsed Acute Lymphoblastic Leukemia in Children

Posted: April 27th, 2012, 8:00am MDT

Condition: Acute Lymphoblastic Leukemia
Intervention: Drug: liposomal cytarabine
Sponsors: National Cancer Institute, Naples; National Cancer Institute, Naples; Santobono-Pausilpon Hospital; Azienda Ospedaliera Universitaria di Bologna Policlinico S. Orsola Malpighi; University of Bologna
Recruiting - verified May 2012

Permalink for 'Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant'

Vaccine Therapy in Preventing Cytomegalovirus Infection in Patients With Hematological Malignancies Undergoing Donor Stem Cell Transplant

Posted: April 26th, 2012, 8:00am MDT

Conditions: Accelerated Phase Chronic Myelogenous Leukemia; Adult Acute Lymphoblastic Leukemia in Remission; Adult Acute Myeloid Leukemia in Remission; Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities; Adult Acute Myeloid Leukemia With Del(5q); Adult Acute Myeloid Leukemia With Inv(16)(p13;q22); Adult Acute Myeloid Leukemia With t(15;17)(q22;q12); Adult Acute Myeloid Leukemia With t(16;16)(p13;q22); Adult Acute Myeloid Leukemia With t(8;21)(q22;q22); Adult Acute Promyelocytic Leukemia (M3); Adult Nasal Type Extranodal NK/T-cell Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; Chronic Eosinophilic Leukemia; Chronic Myelomonocytic Leukemia; Chronic Phase Chronic Myelogenous Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cytomegalovirus Infection; de Novo Myelodysplastic Syndromes; Essential Thrombocythemia; Extramedullary Plasmacytoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Isolated Plasmacytoma of Bone; Monoclonal Gammopathy of Undetermined Significance; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Peripheral T-cell Lymphoma; Polycythemia Vera; Post-transplant Lymphoproliferative Disorder; Previously Treated Myelodysplastic Syndromes; Primary Central Nervous System Hodgkin Lymphoma; Primary Central Nervous System Non-Hodgkin Lymphoma; Primary Myelofibrosis; Progressive Hairy Cell Leukemia, Initial Treatment; Prolymphocytic Leukemia; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Acute Myeloid Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Refractory Multiple Myeloma; Relapsing Chronic Myelogenous Leukemia; Secondary Acute Myeloid Leukemia; Secondary Myelodysplastic Syndromes; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Multiple Myeloma; Stage I Small Lymphocytic Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage II Multiple Myeloma; Stage IIA Mycosis Fungoides/Sezary Syndrome; Stage IIB Mycosis Fungoides/Sezary Syndrome; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Adult T-cell Leukemia/Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Cutaneous T-cell Non-Hodgkin Lymphoma; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Grade 3 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Multiple Myeloma; Stage III Small Lymphocytic Lymphoma; Stage IIIA Mycosis Fungoides/Sezary Syndrome; Stage IIIB Mycosis Fungoides/Sezary Syndrome; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Adult T-cell Leukemia/Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Small Lymphocytic Lymphoma; Stage IVA Mycosis Fungoides/Sezary Syndrome; Stage IVB Mycosis Fungoides/Sezary Syndrome; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Large Granular Lymphocyte Leukemia; Untreated Adult Acute Myeloid Leukemia; Untreated Hairy Cell Leukemia; Waldenström Macroglobulinemia
Interventions: Biological: tetanus-CMV fusion peptide vaccine; Other: laboratory biomarker analysis
Sponsors: City of Hope Medical Center; City of Hope Medical Center; National Cancer Institute (NCI)
Not yet recruiting - verified April 2012

Three Anthracyclines, Two Types of Consolidation With Different ARA-C Doses and Maintenance in Adult AML

Posted: April 26th, 2012, 8:00am MDT

Condition: Acute Myeloid Leukemia
Intervention: Drug: daunorubicine, idarubicine, mitoxantrone
Sponsors: National Research Center for Hematology, Russia; National Research Center for Hematology, Russia
Recruiting - verified April 2012

Human Placental-Derived Stem Cell Transplantation

Posted: April 25th, 2012, 8:00am MDT

Stress Management Training for Latinas Receiving Chemotherapy

Posted: April 23rd, 2012, 8:00am MDT

Conditions: Cancer; Stress
Interventions: Behavioral: Spanish-Language Self-Administered Training Plus Usual Care (SL-SAT); Behavioral: Usual Care Only
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; H. Lee Moffitt Cancer Center and Research Institute; American Cancer Society; University of Miami
Recruiting - verified May 2012

Vorinostat and Concurrent Whole Brain Radiotherapy for Brain Metastasis

Posted: April 23rd, 2012, 8:00am MDT

Condition: Brain Metastasis
Interventions: Drug: Vorinostat; Drug: Placebo
Sponsors: National Taiwan University Hospital; National Taiwan University Hospital
Not yet recruiting - verified April 2012

Safety Study of Replication-competent Adenovirus (Delta-24-rgd) in Patients With Recurrent Glioblastoma

Posted: April 19th, 2012, 8:00am MDT

Conditions: Brain Tumor; Recurring Glioblastoma
Intervention: Biological: delta-24-RGD adenovirus
Sponsors: Erasmus Medical Center; Erasmus Medical Center; VU University Medical Center
Recruiting - verified April 2012

Efficacy and Safety Evaluation of Carbamazepine for Prevention of Chemotherapy-induced Nausea and Vomiting.

Posted: April 19th, 2012, 8:00am MDT

Condition: Chemotherapy-induced Nausea and Vomiting
Intervention: Drug: Carbamazepine
Sponsors: Faculdade de Medicina do ABC; Faculdade de Medicina do ABC
Recruiting - verified April 2012

Phase I/II Bevacizumab Versus Bevacizumab Plus TPI 287 for Recurrent Glioblastoma

Posted: April 18th, 2012, 8:00am MDT

Conditions: Brain Neoplasms; Central Nervous System Neoplasms
Interventions: Drug: TPI287; Drug: Bevacizumab
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Archer Biosciences, Inc.
Not yet recruiting - verified April 2012

Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Patients With Brain Tumors

Posted: April 17th, 2012, 8:00am MDT

Conditions: Adult Anaplastic Astrocytoma; Adult Anaplastic Ependymoma; Adult Anaplastic Meningioma; Adult Anaplastic Oligodendroglioma; Adult Brain Stem Glioma; Adult Choroid Plexus Tumor; Adult Craniopharyngioma; Adult Diffuse Astrocytoma; Adult Ependymoblastoma; Adult Ependymoma; Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Adult Grade I Meningioma; Adult Grade II Meningioma; Adult Medulloblastoma; Adult Meningeal Hemangiopericytoma; Adult Mixed Glioma; Adult Myxopapillary Ependymoma; Adult Oligodendroglioma; Adult Papillary Meningioma; Adult Pilocytic Astrocytoma; Adult Pineal Gland Astrocytoma; Adult Pineoblastoma; Adult Pineocytoma; Adult Subependymal Giant Cell Astrocytoma; Adult Subependymoma; Adult Supratentorial Primitive Neuroectodermal Tumor (PNET); Meningeal Melanocytoma; Nonmalignant Neoplasm; Recurrent Adult Brain Tumor; Tumors Metastatic to Brain
Interventions: Drug: pioglitazone hydrochloride; Other: laboratory biomarker analysis; Radiation: external beam radiation therapy; Radiation: 3-dimensional conformal radiation therapy; Radiation: intensity-modulated radiation therapy; Procedure: management of therapy complications
Sponsors: Comprehensive Cancer Center of Wake Forest University; Comprehensive Cancer Center of Wake Forest University; National Cancer Institute (NCI)
Recruiting - verified April 2012

Prophylactic Cranial Irradiation in Patients With Lung Adenocarcinoma With High Risk of Brain Metastasis

Posted: April 17th, 2012, 8:00am MDT

Condition: Lung Cancer
Intervention: Radiation: Prophylactic Cranial Irradiation
Sponsors: Instituto Nacional de Cancerologia de Mexico; Instituto Nacional de Cancerologia de Mexico
Not yet recruiting - verified May 2012

Drug Interaction Study of SAR302503 in Patients With Solid Tumor

Posted: April 13th, 2012, 8:00am MDT

Condition: Solid Tumor
Interventions: Drug: SAR302503; Drug: omeprazol; Drug: metoprolol; Drug: midazolam
Sponsors: Sanofi-Aventis; Sanofi-Aventis
Not yet recruiting - verified April 2012

Botulinum Toxin A (Botox) in Tissue Expander Breast Reconstruction

Posted: April 13th, 2012, 8:00am MDT

Conditions: Breast Cancer; Pain, Postoperative; BRCA1 Mutation; BRCA2 Mutation; Breast Diseases; Neoplasms
Interventions: Drug: Botulinum Toxin Type A; Drug: Sodium Chloride Solution
Sponsors: Mayo Clinic; Mayo Clinic
Not yet recruiting - verified May 2012

An Open-label, Multi-center, Expanded Access Study of Pasireotide s.c. in Patients With Cushing's Disease

Posted: April 12th, 2012, 8:00am MDT

Condition: Cushing's Disease
Intervention: Drug: Pasireotide sub-cutaneous formulation
Sponsors: Novartis; Novartis Pharmaceuticals
Available - verified April 2012

A Pilot Study to Determine the Effect of Sulfasalazine on Glutamate Levels Detected by MRS in Patients With Glioma

Posted: April 11th, 2012, 8:00am MDT

Condition: Brain Tumor
Intervention: Drug: Sulfasalazine
Sponsors: University of Alabama at Birmingham; University of Alabama at Birmingham
Recruiting - verified April 2012

Erlotinib Plus Pemetrexed to Treat Lung Adenocarcinoma With Brain Metastases

Posted: April 11th, 2012, 8:00am MDT

Conditions: Lung Adenocarcinoma; Brain Metastases
Interventions: Drug: erlotinib; Drug: pemetrexed; Drug: cisplatin; Drug: erlotinib
Sponsors: Guangzhou Medical College; Guangzhou Medical College
Recruiting - verified April 2012

Study of ACY-1215 in Combination With Lenalidomide, and Dexamethasone in Multiple Myeloma

Posted: April 11th, 2012, 8:00am MDT

Condition: Multiple Myeloma
Interventions: Drug: ACY-1215; Drug: lenalidomide; Drug: Dexamethasone
Sponsors: Acetylon Pharmaceuticals Incorporated; Acetylon Pharmaceuticals Incorporated
Not yet recruiting - verified April 2012

Permalink for 'Study of Pomalidomide to Evaluate the Pharmacokinetics and Safety for Patients With Multiple Myeloma and Impaired Renal Function'

Study of Pomalidomide to Evaluate the Pharmacokinetics and Safety for Patients With Multiple Myeloma and Impaired Renal Function

Posted: April 10th, 2012, 8:00am MDT

Condition: Multiple Myeloma
Interventions: Drug: Oral Pomalidomide (POM) and Oral Dexamethasone (LD-DEX) (Cohort A); Drug: Oral Pomalidomide (POM) and Oral Dexamethasone (LD-DEX) (Cohort B)
Sponsors: Celgene Corporation; Celgene Corporation
Not yet recruiting - verified April 2012

Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme

Posted: April 9th, 2012, 8:00am MDT

Conditions: Adult Giant Cell Glioblastoma; Adult Glioblastoma; Adult Gliosarcoma; Recurrent Adult Brain Tumor
Interventions: Drug: aminolevulinic acid; Procedure: therapeutic conventional surgery
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; National Cancer Institute (NCI)
Not yet recruiting - verified April 2012

Carfilzomib, Lenalidomide, and Dexamethasone in High-Risk Smoldering Multiple Myeloma: A Clinical and Correlative Study

Posted: April 5th, 2012, 8:00am MDT

Condition: Multiple Myeloma
Interventions: Drug: Carfilzomib; Drug: Lenalidomide; Drug: Dexamethasone
Sponsors: National Institutes of Health Clinical Center (CC); National Cancer Institute (NCI)
Recruiting - verified March 2012

Chloroquine as an Anti-autophagic Radiosensitizing Drug in Stage I-III Small Cell Lung Cancer

Posted: April 3rd, 2012, 8:00am MDT

Condition: Small Cell Lung Cancer
Intervention: Drug: Chloroquine
Sponsors: Maastricht Radiation Oncology; Maastricht Radiation Oncology
Not yet recruiting - verified April 2012

Targeted BEACOPP Variants in Patients With Newly Diagnosed Advanced Classical Hodgkin Lymphoma

Posted: April 2nd, 2012, 8:00am MDT

Condition: Hodgkin Lymphoma
Interventions: Drug: Etoposide; Drug: Cyclophosphamide; Drug: Doxorubicin; Drug: Prednisone; Drug: Procarbazine; Drug: Dexamethasone; Drug: Dacarbazine; Drug: Brentuximab Vedotin
Sponsors: University of Cologne; University of Cologne
Not yet recruiting - verified March 2012

$Permalink for 'Investigation of Vorinostat in Combination With Intravenous Fludarabine, Mitoxantrone, and Dexamethasone in Patients With Relapsed or Refractory Mantle Cell Lymphoma'$

Investigation of Vorinostat in Combination With Intravenous Fludarabine, Mitoxantrone, and Dexamethasone in Patients With Relapsed or Refractory Mantle Cell Lymphoma

Posted: March 30th, 2012, 8:00am MDT

Condition: Mantle Cell Lymphoma
Intervention: Drug: Fludarabine, Mitoxantrone, Dexamethasone, Vorinostat
Sponsors: Samsung Medical Center; Samsung Medical Center
Not yet recruiting - verified April 2012

Calcium Homeostasis in Acromegaly: Effect of Surgical/Medical Treatment and Comparison With Nonfunctioning Pituitary Tumors

Posted: March 29th, 2012, 8:00am MDT

Conditions: Acromegaly; Nonfunctioning Pituitary Tumor
Intervention:
Sponsors: Emory University; Emory University
Recruiting - verified March 2012

Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis Gliomas

Posted: March 29th, 2012, 8:00am MDT

Condition: Pediatric High Risk Gliomas
Intervention: Drug: Combination of two marketed drugs (irinotecan and cisplatin)
Sponsors: Hospital Sant Joan de Deu; Hospital Sant Joan de Deu; Fundació Sant Joan de Déu; Spanish National Health System
Recruiting - verified April 2012

Phase 3 Study With Carfilzomib and Dexamethasone Versus Velcade and Dexamethasone for Relapsed Multiple Myeloma Patients

Posted: March 28th, 2012, 8:00am MDT

Condition: Multiple Myeloma
Interventions: Drug: Carfilzomib plus dexamethasone; Drug: Velcade plus dexamethasone
Sponsors: Onyx Pharmaceuticals; Onyx Pharmaceuticals
Not yet recruiting - verified April 2012

A Phase II Trial to Assess TroVax® Plus Chemotherapy in Patients With Malignant Pleural Mesothelioma

Posted: March 28th, 2012, 8:00am MDT

Conditions: Malignant; Pleural; Mesothelioma
Interventions: Biological: TroVax®; Drug: Pemetrexed; Drug: Cisplatin; Dietary Supplement: Vitamin B12; Dietary Supplement: Folic Acid; Drug: Dexamethasone
Sponsors: Wales Cancer Trials Unit; Wales Cancer Trials Unit; Velindre NHS Trust; June Hancock Mesothelioma Research Fund; Velindre Cancer Centre Stepping Stones Appeal
Not yet recruiting - verified March 2012

Treatment of Severe Mucositis Pain With Oral Ketamine Mouthwash

Posted: March 27th, 2012, 8:00am MDT

Condition: Mucositis
Intervention: Drug: Ketamine
Sponsors: West Virginia University; Aaron Cumpston, PharmD
Recruiting - verified March 2012

Dorsal Penile Block for Post-Robotic Prostatectomy Foley Discomfort

Posted: March 26th, 2012, 8:00am MDT

Conditions: Prostate Cancer; Robotic Prostatectomy; Foley Catheter Discomfort
Interventions: Drug: Bupivacaine; Drug: Saline
Sponsors: Columbia University; Columbia University
Recruiting - verified March 2012

$Permalink for 'A Study Of Inotuzumab Ozogamicin Versus Investigator's Choice Of Chemotherapy In Patients With Relapsed Or Refractory Acute Lymphoblastic Leukemia'$

A Study Of Inotuzumab Ozogamicin Versus Investigator's Choice Of Chemotherapy In Patients With Relapsed Or Refractory Acute Lymphoblastic Leukemia

Posted: March 26th, 2012, 8:00am MDT

Condition: Acute Lymphoblastic Leukemia
Interventions: Drug: inotuzumab ozogamicin; Drug: FLAG (fludarabine, cytarabine and G-CSF); Drug: HIDAC (high dose cytarabine); Drug: cytarabine and mitoxantrone
Sponsors: Pfizer; Pfizer; Union Chimique Belge
Not yet recruiting - verified May 2012

Impact of Perioperative Intravenous Fluid Utilization on Postoperative Outcomes

Posted: March 24th, 2012, 8:00am MDT

Conditions: Benign Neoplasm of Intestinal Tract; Primary Malignant Neoplasm of Intestinal Tract; Secondary Malignant Neoplasm of Intestinal Tract
Interventions: Procedure: Normal fluid volume; Procedure: Reduced fluid volume
Sponsors: The Cleveland Clinic; The Cleveland Clinic
Recruiting - verified March 2012

Pharmacokinetic Drug-drug Interaction Study of Dovitinib (TKI258) in Patients With Advanced Solid Tumors

Posted: March 23rd, 2012, 8:00am MDT

Condition: Advanced Solid Tumors, Excluding Breast Cancer
Interventions: Drug: caffeine; Drug: diclofenac; Drug: omeprazole; Drug: midazolam; Drug: TKI258
Sponsors: Novartis; Novartis Pharmaceuticals
Not yet recruiting - verified May 2012

$Permalink for 'Phase II Study of Sipuleucel-T and 1-MT for Patients With Refractory Metastatic Prostate Cancer'$

Phase II Study of Sipuleucel-T and 1-MT for Patients With Refractory Metastatic Prostate Cancer

Posted: March 20th, 2012, 8:00am MDT

Condition: Metastatic Castration Resistant Prostate Cancer
Interventions: Biological: 1-MT; Biological: Sipuleucel-T; Other: Placebo
Sponsors: Masonic Cancer Center, University of Minnesota; Masonic Cancer Center, University of Minnesota
Not yet recruiting - verified April 2012

Quality of Life Outcomes Following Minimally Invasive and Open Esophagectomy for Esophageal Cancer

Posted: March 16th, 2012, 8:00am MDT

Condition: Esophageal Cancer
Interventions: Behavioral: Quality of Life instruments, FACT-E, Symptom Assessment Scale, Brief Pain Inventory and Daily Analgesic Log; Behavioral: Quality of Life instruments, FACT-E, Symptom Assessment Scale, Brief Pain Inventory and Daily Analgesic Log
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified May 2012

Anesthesia and Cancer Recurrence im Malignant Melanoma

Posted: March 13th, 2012, 8:00am MDT

Permalink for 'Nelfinavir and Lenalidomide/Dexamethasone in Patients With Progressive Multiple Myeloma That Have Failed Lenalidomide-containing Therapy'

Nelfinavir and Lenalidomide/Dexamethasone in Patients With Progressive Multiple Myeloma That Have Failed Lenalidomide-containing Therapy

Posted: March 8th, 2012, 8:00am MST

Condition: Multiple Myeloma
Interventions: Drug: Nelfinavir; Drug: Lenalidomide; Drug: Dexamethasone
Sponsors: Swiss Group for Clinical Cancer Research; Swiss Group for Clinical Cancer Research
Recruiting - verified May 2012

Permalink for 'Pathway M-1: Sphenopalatine Ganglion Stimulation for the Treatment of Chronic or High Frequency, High Disability Migraine Headache'

Pathway M-1: Sphenopalatine Ganglion Stimulation for the Treatment of Chronic or High Frequency, High Disability Migraine Headache

Posted: February 20th, 2012, 8:00am MST

Conditions: Chronic Migraine; High Frequency, High Disability Migraine
Intervention: Device: ATI Neurostimulation System
Sponsors: Autonomic Technologies, Inc.; Autonomic Technologies, Inc.
Recruiting - verified May 2012

Immune Reconstitution in Oncology Patients Following Autologous Stem Cell Transplant

Posted: February 17th, 2012, 8:00am MST

Conditions: Solid Tumor; Brain Tumor; Lymphoma
Intervention: Other: Blood samples obtained
Sponsors: St. Jude Children's Research Hospital; St. Jude Children's Research Hospital
Recruiting - verified February 2012

Comparison of the Local Anaesthetics Articaine and Bupivacaine in Treatment of Acute Sternum Pain After Heart Surgery

Posted: February 16th, 2012, 8:00am MST

Conditions: Diseases of Mitral Valve; Aortic Valve Disorder; Atrial Septal Defects; Intracardiac Myxoma
Interventions: Drug: Articaine hydrochloride 2% solution; Drug: Sodium Chloride
Sponsors: Helsinki University Central Hospital; Helsinki University Central Hospital
Recruiting - verified April 2012

Efficacy of Diclofenac BCG Irrigations

Posted: February 14th, 2012, 8:00am MST

Condition: Bladder Cancer
Interventions: Drug: Abitren; Drug: Placebo
Sponsors: Carmel Medical Center; Carmel Medical Center
Not yet recruiting - verified May 2012

Clinical Usefulness and Quality of Life of OROS Hydromorphone in Patients Who Have Not Been Treated With a Strong Opioid

Posted: February 10th, 2012, 8:00am MST

Condition: Pain
Intervention: Drug: Hydromorphone HCI OROS
Sponsors: Janssen Korea, Ltd., Korea; Janssen Korea, Ltd., Korea
Recruiting - verified May 2012

MRI and Diffusion Tensor Imaging of the Motor and Language Pathways to Optimize Brain Tumor Resection

Posted: February 9th, 2012, 8:00am MST

Condition: Brain Cancer
Intervention: Procedure: preoperative fMRI and DTI with tractography
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center
Recruiting - verified May 2012

Hepatic Arterial Infusion in Treating Patients With Locally Advanced, Non-Metastatic Cholangiocarcinoma

Posted: January 25th, 2012, 8:00am MST

Conditions: Cholangiocarcinoma; Liver Neoplasms
Interventions: Drug: floxuridine, dexamethasone; Drug: floxuridine, dexamethasone, gemcitabine hydrochloride; Drug: floxuridine, dexamethasone, gemcitabine hydrochloride, oxaliplatin
Sponsors: Washington University School of Medicine; Washington University School of Medicine
Recruiting - verified May 2012

$Permalink for 'ACE-011 With Lenalidomide+Dexamethasone for Relapsed/Refractory Multiple Myeloma'$

ACE-011 With Lenalidomide+Dexamethasone for Relapsed/Refractory Multiple Myeloma

Posted: January 8th, 2012, 8:00am MST

Condition: Multiple Myeloma
Interventions: Drug: ACE-011; Drug: Lenalidomide; Drug: Dexamethasone
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Recruiting - verified May 2012

Palatability of Experimental Cigarettes

Posted: January 3rd, 2012, 8:00am MST

Condition: Smoking
Interventions: Other: Very low level nicotine containing cigarette; Other: Low nicotine level cigarette; Other: Moderate level nicotine cigarette
Sponsors: Masonic Cancer Center, University of Minnesota; Masonic Cancer Center, University of Minnesota
Recruiting - verified May 2012

Community Network Program

Posted: January 3rd, 2012, 8:00am MST

Condition: Psychosocial Problem
Interventions: Behavioral: Health Education; Behavioral: Questionnaires; Behavioral: Telephone Counseling Sessions; Drug: Nicotine Patches
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; National Institutes of Health (NIH)
Recruiting - verified May 2012

Maintenance Plasma Exchange for Neuromyelitis Optica

Posted: December 23rd, 2011, 8:00am MST

Conditions: Neuromyelitis Optica; Neuromyelitis Optica Spectrum Disorder; Recurrent Idiopathic Longitudinally Extensive Transverse Myelitis
Intervention: Procedure: Plasma exchange (PLEX)
Sponsors: Mayo Clinic; Mayo Clinic; CaridianBCT
Not yet recruiting - verified May 2012

Phase I Study of 5-Fluorouracil in Children and Young Adults With Recurrent Ependymoma

Posted: December 21st, 2011, 8:00am MST

Conditions: Central Nervous System Malignancies; Ependymoma
Intervention: Drug: 5-fluorouracil
Sponsors: St. Jude Children's Research Hospital; St. Jude Children's Research Hospital
Recruiting - verified May 2012

Fosaprepitant in Patients Receiving Ifosfamide-based Regimen

Posted: December 8th, 2011, 8:00am MST

Conditions: Sarcoma; Chemotherapy-induced Nausea and Vomiting; Effects of Chemotherapy; Adverse Effects of Medical Drugs
Interventions: Drug: Fosaprepitant; Drug: Dexamethasone; Drug: 5HT3 receptor antagonist; Drug: Ifosfamide-based chemotherapy (AI); Drug: Doxorubicin; Drug: Mesna; Drug: Ifosfamide; Drug: Vincristine
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Merck
Recruiting - verified May 2012

Safety and Efficacy Study of Botulinum Toxin Type A to Treat Glabellar Lines

Posted: December 1st, 2011, 8:00am MST

Condition: Glabellar Frown Lines
Intervention: Biological: MT10109
Sponsors: Medy-Tox; Medy-Tox
Recruiting - verified April 2012

Mibefradil Dihydrochloride and Temozolomide in Treating Patients With Recurrent Glioma

Posted: November 23rd, 2011, 8:00am MST

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: mibefradil dihydrochloride; Drug: temozolomide; Other: 3'-deoxy-3'-[18F]fluorothymidine; Other: pharmacological study
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI); Tau Therapeutics LLC
Recruiting - verified April 2012

GRN1005 Alone or in Combination With Trastuzumab in Breast Cancer Patients With Brain Metastases

Posted: November 16th, 2011, 8:00am MST

Conditions: Breast Cancer; Brain Metastases
Interventions: Drug: GRN1005; Drug: Trastuzumab
Sponsors: Geron Corporation; Geron Corporation
Recruiting - verified May 2012

Does Serum-DXM Increase Diagnostic Accuracy of the Overnight DXM Suppression Test in the Work-up of Cushing's Syndrome?

Posted: November 15th, 2011, 8:00am MST

Intravenous Acetaminophen for Craniotomy Patients

Posted: November 9th, 2011, 8:00am MST

Condition: Craniotomy
Interventions: Drug: Acetaminophen; Other: No acetaminophen
Sponsors: Swedish Medical Center; Swedish Medical Center; Cadence Pharmaceuticals
Recruiting - verified May 2012

Defined Green Tea Catechin Extract in Treating Patients With Plasma Cell Neoplasm Or Smoldering Multiple Myeloma

Posted: October 27th, 2011, 8:00am MDT

Conditions: Monoclonal Gammopathy of Undetermined Significance; Smoldering Multiple Myeloma
Interventions: Dietary Supplement: defined green tea catechin extract; Biological: laboratory biomarker analysis
Sponsors: Barbara Ann Karmanos Cancer Institute; Barbara Ann Karmanos Cancer Institute; National Cancer Institute (NCI)
Recruiting - verified April 2012

Silencing Inflammatory Activity by Injecting Nanocort in Patients at Risk for Atherosclerotic Disease

Posted: October 13th, 2011, 8:00am MDT

Conditions: Atherosclerosis; Inflammation
Interventions: Drug: liposomal prednisolone; Drug: Placebo
Sponsors: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA); Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Recruiting - verified May 2012

A Study of CDX-1127 in Patients With Select Solid Tumor Types or Hematologic Cancers

Posted: October 12th, 2011, 8:00am MDT

Ultra Low Dose Interleukin-2 in Healthy Volunteers

Posted: September 30th, 2011, 8:00am MDT

Condition: Hematologic Diseases
Interventions: Drug: Interleukin-2 (100,000 international units); Drug: Interleukin-2 (200,000 international units)
Sponsors: National Institutes of Health Clinical Center (CC); National Heart, Lung, and Blood Institute (NHLBI)
Recruiting - verified September 2011

$Permalink for 'Efficacy and Safety of R-HAD Alone or in Combination With Bortezomib in Patients With Relapsed or Refractory MCL'$

Efficacy and Safety of R-HAD Alone or in Combination With Bortezomib in Patients With Relapsed or Refractory MCL

Posted: September 28th, 2011, 8:00am MDT

Condition: Mantle Cell Lymphoma
Interventions: Drug: Rituximab; Drug: High dose Ara-C; Drug: Dexamethasone; Drug: Bortezomib
Sponsors: European Mantle Cell Lymphoma Network; Dr. M. Dreyling (co-chairman); Klinikum der Universitaet Muenchen, Grosshadern; ClinAssess GmbH, Leverkusen; GELARC Service de Pharmacovigilance, Pierre Benite
Recruiting - verified May 2012

Permalink for 'Efficacy and Safety of Palonosetron Intravenous in Prevention of Chemotherapy Induced Nausea and Vomiting in Pediatric Patients'

Efficacy and Safety of Palonosetron Intravenous in Prevention of Chemotherapy Induced Nausea and Vomiting in Pediatric Patients

Posted: September 21st, 2011, 8:00am MDT

Condition: Chemotherapy-Induced Nausea and Vomiting
Interventions: Drug: Palonosetron; Drug: Palonosetron; Drug: Ondansetron
Sponsors: Helsinn Healthcare SA; Helsinn Healthcare SA
Recruiting - verified May 2012

Pomalidomide in Combination With High Dose Dexamethasone and Oral Cyclophosphamide

Posted: September 9th, 2011, 8:00am MDT

Condition: Myeloma
Interventions: Drug: Pomalidomide; Drug: Dexamethasone; Drug: Cyclophosphamide
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; H. Lee Moffitt Cancer Center and Research Institute; Celgene Corporation
Recruiting - verified May 2012

$Permalink for 'A Study to Evaluate the Use of Chloroquine in Combination With VELCADE and Cyclophosphamide in Patients With Relapsed and Refractory Multiple Myeloma'$

A Study to Evaluate the Use of Chloroquine in Combination With VELCADE and Cyclophosphamide in Patients With Relapsed and Refractory Multiple Myeloma

Posted: September 8th, 2011, 8:00am MDT

Condition: Multiple Myeloma
Interventions: Drug: Cyclophosphamide; Drug: Velcade; Drug: Chloroquine
Sponsors: New York University School of Medicine; New York University School of Medicine; Millennium Pharmaceuticals, Inc.
Recruiting - verified April 2012

Permalink for 'A Dose Escalation Study of the Histone Deacetylase Inhibitor (HDACi) JNJ 26481585 in Combination With VELCADE (Bortezomib) and Dexamethasone for Patients With Relapsed Multiple Myeloma'

A Dose Escalation Study of the Histone Deacetylase Inhibitor (HDACi) JNJ 26481585 in Combination With VELCADE (Bortezomib) and Dexamethasone for Patients With Relapsed Multiple Myeloma

Posted: August 30th, 2011, 8:00am MDT

Condition: Multiple Myeloma
Intervention: Drug: JNJ-2641585 / VELCADE / Dexamethasone
Sponsors: Janssen Research & Development, LLC; Janssen Research & Development, LLC
Recruiting - verified May 2012

Permalink for 'A Study to Demonstrate Improvement in Symptoms of Constipation in Subjects That Require Around-the-clock Opioid Pain Killer Therapy'

A Study to Demonstrate Improvement in Symptoms of Constipation in Subjects That Require Around-the-clock Opioid Pain Killer Therapy

Posted: August 18th, 2011, 8:00am MDT

Conditions: Pain; Constipation
Interventions: Drug: oxycodone/naloxone prolonged release (OXN PR) tablets; Drug: oxycodone prolonged release (OxyPR) tablets
Sponsors: Mundipharma Research GmbH & Co KG; Mundipharma Research GmbH & Co KG
Recruiting - verified May 2012

NHL16: Study For Newly Diagnosed Patients With Acute Lymphoblastic Lymphoma

Posted: August 17th, 2011, 8:00am MDT

Condition: Lymphoblastic Lymphoma
Interventions: Drug: prednisone, vincristine, daunorubicin, PEG-asparaginase, methotrexate, hydrocortisone, cytarabine (IT-MH)A treatment, cyclophosphamide, cytarabine, thioguanine; Drug: PEG- asparaginase, High-Dose Methotrexate (HD-MTX) and Mercaptopurine; Drug: Dexamethasone, Doxorubicin; Vincristine; Mercaptopurine; PEG- Asparaginase, Cyclophosphamide, and Cytarabine; Drug: dexamethasone, cytarabine, etoposide, pegaspargase, clofarabine, cyclophosphamide; Drug: Intrathecal chemotherapy
Sponsors: St. Jude Children's Research Hospital; St. Jude Children's Research Hospital; National University, Singapore
Recruiting - verified April 2012

Bevacizumab With or Without Surgery for Adult Glioblastomas

Posted: August 9th, 2011, 8:00am MDT

Conditions: Glioblastoma; Brain Neoplasm
Intervention: Procedure: Craniotomy
Sponsors: National Institutes of Health Clinical Center (CC); National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified April 2012

Beta-Tricalcium Phosphate Bone Graft in Treating Patients Undergoing Surgery For Metastatic Spine Cancer

Posted: July 29th, 2011, 8:00am MDT

Conditions: Adult Spinal Cord Neoplasm; Spinal Bone Metastases; Spinal Cord Compression
Interventions: Procedure: musculoskeletal complications management/prevention; Procedure: bone graft; Procedure: quality-of-life assessment; Other: questionnaire administration
Sponsors: USC/Norris Comprehensive Cancer Center; USC/Norris Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified May 2012

Fosaprepitant (EMEND® IV) In Salvage Treatment of Chemotherapy-Induced Vomiting (MK-0517-030 AM1)

Posted: July 28th, 2011, 8:00am MDT

Conditions: Nausea; Vomiting
Interventions: Drug: fosaprepitant dimeglumine; Drug: 5HT3 RA; Drug: dexamethasone
Sponsors: Merck; Merck
Recruiting - verified May 2012

Carfilzomib, Lenalidomide, and Dexamethasone in New Multiple Myeloma Patients

Posted: July 23rd, 2011, 8:00am MDT

Permalink for 'Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma'

Temsirolimus, Dexamethasone, Mitoxantrone Hydrochloride, Vincristine Sulfate, and Pegaspargase in Treating Young Patients With Relapsed Acute Lymphoblastic Leukemia or Non-Hodgkin Lymphoma

Posted: July 21st, 2011, 8:00am MDT

Conditions: Leukemia; Lymphoma
Interventions: Drug: dexamethasone; Drug: methotrexate; Drug: mitoxantrone hydrochloride; Drug: pegaspargase; Drug: temsirolimus; Drug: vincristine sulfate; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Recruiting - verified May 2012

Nuvigil or Placebo in Newly Diagnosed Malignant Glioma

Posted: July 21st, 2011, 8:00am MDT

Condition: Malignant Glioma
Interventions: Drug: Nuvigil®; Drug: Placebo
Sponsors: H. Lee Moffitt Cancer Center and Research Institute; H. Lee Moffitt Cancer Center and Research Institute; Cephalon
Recruiting - verified May 2012

Cyclophosphamide and Pulse Dexamethasone With Rapamycin or Hydroxychloroquine

Posted: July 14th, 2011, 8:00am MDT

Condition: Myeloma
Interventions: Drug: Hydroxychloroquine; Drug: Rapamycin
Sponsors: Abramson Cancer Center of the University of Pennsylvania; Abramson Cancer Center of the University of Pennsylvania
Recruiting - verified May 2012

$Permalink for 'Hypofractionated Stereotactic Radiotherapy With Bevacizumab in the Treatment of Recurrent Malignant Glioma'$

Hypofractionated Stereotactic Radiotherapy With Bevacizumab in the Treatment of Recurrent Malignant Glioma

Posted: July 8th, 2011, 8:00am MDT

Conditions: Brain Cancer; MALIGNANT GLIOMA; Glioblastoma; Anaplastic Astrocytoma (AA); Anaplastic Oligodendroglioma (AO); Anaplastic Oligo-astrocytoma (AOA); Anaplastic Mixed Gliomas; Malignant Glioma NOS
Intervention: Other: Bevacizumab & stereotactic radiotherapy
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Genentech; Columbia University; University of California, San Francisco
Recruiting - verified May 2012

Alloreactive Haploidentical Natural Killer (NK) Cells With Busulfan and Fludarabine/ATG

Posted: July 7th, 2011, 8:00am MDT

Conditions: Leukemia; Chronic Myelogenous Leukemia
Interventions: Drug: Fludarabine; Drug: Busulfan; Procedure: NK cell infusion:; Drug: Interleukin-2; Drug: Anti-Thymocyte Globulin; Procedure: Allogeneic related Stem Cell Transplant; Drug: Tacrolimus; Drug: Methotrexate
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; National Cancer Institute (NCI)
Recruiting - verified April 2012

Olaparib and Temozolomide in Treating Patients With Relapsed Glioblastoma

Posted: July 7th, 2011, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: olaparib; Drug: temozolomide; Genetic: gene expression analysis; Genetic: protein expression analysis; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: diffusion-weighted magnetic resonance imaging; Procedure: dynamic contrast-enhanced magnetic resonance imaging; Procedure: therapeutic conventional surgery
Sponsors: Cancer Research UK; Cancer Research UK
Recruiting - verified April 2012

Permalink for 'Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis'

Bortezomib/Dexamethasone (BD), Followed By Autologous Stem Cell Transplantation and Maintenance Bortezomib/Dexamethasone For the Initial Treatment of Monoclonal Immunoglobulin Deposition Disease (MIDD) Associated With Multiple Myeloma and AL Amyloidosis

Posted: June 27th, 2011, 8:00am MDT

Conditions: Light Chain Deposition Disease (LCDD or MIDD); Light Chain and Heavy Chain Deposition Disease (LHCDD or MIDD); Monoclonal Immunoglobulin Deposition Disease (MIDD); Amyloidosis
Intervention: Drug: Bortezomib/Dexamethasone (BD), Followed By Autologous STC & Maintenance Bortezomib/Dexamethasone
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; Millennium Pharmaceuticals, Inc.
Recruiting - verified May 2012

Hypernatremia for the Prevention and Treatment of Cerebral Edema in Traumatic Brain Injury

Posted: May 22nd, 2012, 8:00am MDT

A Comparison of MRI Perfusion and FDG PET/CT to Distinguish Between Radiation Injury and Tumor Progression

Posted: May 21st, 2012, 8:00am MDT

Imaging Biomarkers of Tissue Microstructure and Vasculature as Predictors of Glioblastoma Multiforme

Posted: May 21st, 2012, 8:00am MDT

Condition: Glioblastoma
Intervention: Radiation: Magnetic Resonance Imaging (MRI)
Sponsors: Medical University of South Carolina; Medical University of South Carolina
Recruiting - verified December 2011

Chemotherapy Followed by Radiation Therapy in Treating Younger Patients With Newly Diagnosed Localized Central Nervous System Germ Cell Tumors

Posted: May 18th, 2012, 8:00am MDT

Multi Dose Effects of a Berry Extract Upon Moodand Cognition in Healthy Young Adults

Posted: May 17th, 2012, 8:00am MDT

Condition: Healthy
Intervention: Dietary Supplement: Fresh berry extract.
Sponsors: Northumbria University; Northumbria University; The New Zealand Institute for Plant & Food Research Ltd
Completed - verified May 2012

Implementing a Tool to Identify Risk for Venous Thromboembolism in Cancer Patients

Posted: May 16th, 2012, 8:00am MDT

Conditions: Venous Thromboembolism; Deep-Vein Thrombosis; Pulmonary Embolism; Cancer
Intervention:
Sponsors: Ottawa Hospital Research Institute; Ottawa Hospital Research Institute; The Ottawa Hospital Academic Medical Organization (TOHAMO)
Not yet recruiting - verified May 2012

Social Cognition in Children Treated for a Brain Tumour

Posted: May 11th, 2012, 8:00am MDT

Perioperative Magnesium Sulphate as a Cerebral Protector in Neurosurgical Patients

Posted: May 10th, 2012, 8:00am MDT

Type II Diabetes Mellitus in Patients Exposed to Pravastatin and Paroxetine

Posted: May 10th, 2012, 8:00am MDT

Condition: Diabetes Mellitus, Type 2
Interventions: Drug: Pravastatin alone; Drug: Paroxetine alone; Drug: Pravastatin and paroxetine combined
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Active, not recruiting - verified May 2012

Longitudinal Study of Biomarkers

Posted: May 8th, 2012, 8:00am MDT

Condition: Central Nervous System Tumor
Intervention:
Sponsors: Children's Memorial Hospital; Children's Memorial Hospital
Recruiting - verified May 2012

A Prospective Phase III Trial to Compare Stereotactic Radiosurgery Versus Whole Brain Radiation Therapy

Posted: May 3rd, 2012, 8:00am MDT

Lapatinib With Temozolomide and Regional Radiation Therapy for Patients With Newly-Diagnosed Glioblastoma Multiforme

Posted: May 2nd, 2012, 8:00am MDT

Condition: Newly Diagnosed Glioblastoma Multiforme
Intervention: Other: Lapatinib/Temozolomide/radiation
Sponsors: Jonsson Comprehensive Cancer Center; Jonsson Comprehensive Cancer Center; GlaxoSmithKline
Recruiting - verified May 2012

Structural and Functional Imaging and Cognitive Functions in Ovarian Cancer

Posted: April 30th, 2012, 8:00am MDT

A Phase I Study to Investigate Tolerability and Efficacy of ALECSAT Administered to Glioblastoma Multiforme Patients

Posted: April 27th, 2012, 8:00am MDT

Condition: Glioblastoma Multiforme
Intervention: Biological: ALECSAT cell based immunotherapy
Sponsors: CytoVac A/S; CytoVac A/S
Enrolling by invitation - verified April 2012

Cabozantinib in Advanced Solid Malignancies

Posted: April 26th, 2012, 8:00am MDT

Conditions: Lung Cancer; Solid Tumor (Not Breast or Prostate Cancers)
Intervention: Drug: Cabozantinib
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital
Not yet recruiting - verified May 2012

Human Placental-Derived Stem Cell Transplantation

Posted: April 25th, 2012, 8:00am MDT

Studying Gene Expression and Location in Samples From Patients With Brain Tumors

Posted: April 24th, 2012, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Interventions: Genetic: gene expression analysis; Genetic: genetic linkage analysis; Genetic: microarray analysis; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis
Sponsors: National Cancer Institute (NCI); Children's Oncology Group; National Cancer Institute (NCI)
Active, not recruiting - verified April 2012

A Repeated Instruction by Telephone on the Day Before Colonoscopy to Patients Undergoing Colonoscopy

Posted: April 24th, 2012, 8:00am MDT

Conditions: Bowel Preparation Score; Adenoma
Intervention: Other: telephone education
Sponsors: Fourth Military Medical University; Fourth Military Medical University
Recruiting - verified April 2012

Vorinostat and Concurrent Whole Brain Radiotherapy for Brain Metastasis

Posted: April 23rd, 2012, 8:00am MDT

Safety Study of Replication-competent Adenovirus (Delta-24-rgd) in Patients With Recurrent Glioblastoma

Posted: April 19th, 2012, 8:00am MDT

A Study in Recurrent Glioblastoma (GB)

Posted: April 19th, 2012, 8:00am MDT

Condition: Glioblastoma
Interventions: Drug: LY2157299 monohydrate; Drug: Lomustine; Drug: Placebo
Sponsors: Eli Lilly and Company; Eli Lilly and Company
Recruiting - verified May 2012

Phase I/II Bevacizumab Versus Bevacizumab Plus TPI 287 for Recurrent Glioblastoma

Posted: April 18th, 2012, 8:00am MDT

Pioglitazone Hydrochloride in Preventing Radiation-Induced Cognitive Dysfunction in Patients With Brain Tumors

Posted: April 17th, 2012, 8:00am MDT

Prophylactic Cranial Irradiation in Patients With Lung Adenocarcinoma With High Risk of Brain Metastasis

Posted: April 17th, 2012, 8:00am MDT

Chemotherapy-Induced Cognitive Impairment

Posted: April 12th, 2012, 8:00am MDT

Condition: Cognitive Symptoms
Intervention:
Sponsors: Washington University School of Medicine; Jay F. Piccirillo, MD; Washington University Siteman Cancer Center; Barnes-Jewish Hospital Foundation
Recruiting - verified April 2012

An Open-label, Multi-center, Expanded Access Study of Pasireotide s.c. in Patients With Cushing's Disease

Posted: April 12th, 2012, 8:00am MDT

Condition: Cushing's Disease
Intervention: Drug: Pasireotide sub-cutaneous formulation
Sponsors: Novartis; Novartis Pharmaceuticals
Available - verified April 2012

A Pilot Study to Determine the Effect of Sulfasalazine on Glutamate Levels Detected by MRS in Patients With Glioma

Posted: April 11th, 2012, 8:00am MDT

Condition: Brain Tumor
Intervention: Drug: Sulfasalazine
Sponsors: University of Alabama at Birmingham; University of Alabama at Birmingham
Recruiting - verified April 2012

Erlotinib Plus Pemetrexed to Treat Lung Adenocarcinoma With Brain Metastases

Posted: April 11th, 2012, 8:00am MDT

The Management of Postoperative Craniotomy Pain in Pediatric Patients

Posted: April 10th, 2012, 8:00am MDT

Conditions: Post Craniotomy Surgery; Cancer; Epilepsy; Vascular Malformations; Craniofacial Reconstructive Surgery
Intervention:
Sponsors: Johns Hopkins University; Johns Hopkins University
Enrolling by invitation - verified April 2012

Aminolevulinic Acid in Visualizing a Tumor During Surgery in Patients With Glioblastoma Multiforme

Posted: April 9th, 2012, 8:00am MDT

Calcium Homeostasis in Acromegaly: Effect of Surgical/Medical Treatment and Comparison With Nonfunctioning Pituitary Tumors

Posted: March 29th, 2012, 8:00am MDT

Conditions: Acromegaly; Nonfunctioning Pituitary Tumor
Intervention:
Sponsors: Emory University; Emory University
Recruiting - verified March 2012

Irinotecan in Combination With Cisplatin in Pediatric Patients With Unfavorable Prognosis Gliomas

Posted: March 29th, 2012, 8:00am MDT

Study of DC Vaccination Against Glioblastoma

Posted: March 26th, 2012, 8:00am MDT

Conditions: Glioma; Glioblastoma Multiforme; Neoplasms
Interventions: Procedure: Surgery; Drug: Chemotherapy; Radiation: Radiotherapy; Biological: DC vaccination; Drug: blank placebo
Sponsors: Huashan Hospital; Huashan Hospital; Fudan University
Recruiting - verified March 2012

Impact of Perioperative Intravenous Fluid Utilization on Postoperative Outcomes

Posted: March 24th, 2012, 8:00am MDT

Mibefradil Dihydrochloride and Temozolomide in Treating Patients With Recurrent Glioma

Posted: November 23rd, 2011, 8:00am MST

$Permalink for 'Hypofractionated Stereotactic Radiotherapy With Bevacizumab in the Treatment of Recurrent Malignant Glioma'$

Hypofractionated Stereotactic Radiotherapy With Bevacizumab in the Treatment of Recurrent Malignant Glioma

Posted: July 8th, 2011, 8:00am MDT

PPX and Concurrent Radiation for Newly Diagnosed Glioblastoma Without MGMT Methylation

Posted: July 8th, 2011, 8:00am MDT

Conditions: Glioblastoma Multiforme; Anaplastic Glioma
Interventions: Drug: PPX (CT2103); Drug: Temozolomide
Sponsors: Brown University; Debora G. Isdale; Yale University; Milton S. Hershey Medical Center; University of Washington; University of Massachusetts, Worcester; Maine Medical Center
Recruiting - verified May 2012

Proton Radiation Therapy for Low Grade Gliomas

Posted: May 17th, 2011, 8:00am MDT

Conditions: Low Grade Gliomas; Protoplasmic Astrocytomas; Fibrillary Astrocytomas; Gemistocytic Astrocytomas; Oligoastrocytomas; Oligodendrogliomas; Other WHO Grade II/IV Gliomas
Intervention: Radiation: Proton radiation
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; National Cancer Institute (NCI)
Recruiting - verified May 2012

TPI 287 in Breast Cancer Metastatic to the Brain

Posted: April 7th, 2011, 8:00am MDT

Condition: Breast Cancer
Intervention: Drug: TPI 287
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; Archer Biosciences, Inc.
Active, not recruiting - verified April 2012

Bosutinib in Adult Patients With Recurrent Glioblastoma

Posted: March 28th, 2011, 8:00am MDT

Condition: Glioblastoma
Intervention: Drug: bosutinib
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Dana-Farber Cancer Institute; Brigham and Women's Hospital; Pfizer
Recruiting - verified April 2012

A Study Of Everolimus, Trastuzumab And Vinorelbine In HER2-Positive Breast Cancer Brain Metastases

Posted: February 25th, 2011, 8:00am MST

Condition: HER-2 Positive Breast Cancer
Interventions: Drug: Everolimus; Drug: Vinorelbine; Drug: Trastuzumab
Sponsors: UNC Lineberger Comprehensive Cancer Center; UNC Lineberger Comprehensive Cancer Center; Novartis Pharmaceuticals
Recruiting - verified April 2012

Early Cardiac Toxicity of Adjuvant CT in Elderly BC.

Posted: February 18th, 2011, 8:00am MST

Condition: Breast Cancer
Intervention: Drug: epirubicin, cyclophosphamide, docetaxel
Sponsors: Jules Bordet Institute; Jules Bordet Institute; Sanofi-Aventis
Recruiting - verified February 2011

Neurofeedback and Pain

Posted: January 14th, 2011, 8:00am MST

Conditions: Pain; Peripheral Neuropathy
Interventions: Behavioral: EEG biofeedback (BF) Group; Behavioral: Wait-List Control (WLC) Group; Behavioral: Follow UP Questionnaires
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified May 2012

$Permalink for 'GDC-0449 in Treating Younger Patients With Recurrent or Refractory Medulloblastoma'$

GDC-0449 in Treating Younger Patients With Recurrent or Refractory Medulloblastoma

Posted: November 10th, 2010, 8:00am MST

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: vismodegib; Other: laboratory biomarker analysis; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Pediatric Brain Tumor Consortium; National Cancer Institute (NCI)
Recruiting - verified April 2012

In-Room PET in Proton Radiation Therapy

Posted: October 25th, 2010, 8:00am MDT

Conditions: Brain Tumor; Head and Neck Tumor; Skull Base Tumor
Intervention: Procedure: PET scan
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; National Cancer Institute (NCI)
Recruiting - verified May 2012

$Permalink for 'To Evaluate the Safety, Activity and Pharmacokinetics of Marqibo in Children and Adolescents With Refractory Cancer'$

To Evaluate the Safety, Activity and Pharmacokinetics of Marqibo in Children and Adolescents With Refractory Cancer

Posted: October 15th, 2010, 8:00am MDT

Prospective Cohort Study With Central Nervous System Evaluation in Diffuse Large B-cell Lymphoma

Posted: September 8th, 2010, 8:00am MDT

Condition: Diffuse Large B-cell Lymphoma
Intervention: Procedure: CSF analysis
Sponsors: Samsung Medical Center; Samsung Medical Center; Asan Medical Center; Yonsei University; National Cancer Center, Korea; Korea Cancer Center Hospital; Korea University
Recruiting - verified May 2012

R04929097 and Bevacizumab in Treating Patients With Progressive or Recurrent Malignant Glioma

Posted: August 25th, 2010, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Interventions: Biological: bevacizumab; Drug: gamma-secretase/Notch signalling pathway inhibitor RO4929097
Sponsors: National Cancer Institute (NCI); National Cancer Institute (NCI)
Not yet recruiting - verified May 2012

A Study Evaluating INIPARIB in Combination With Chemotherapy to Treat Triple Negative Breast Cancer Brain Metastasis

Posted: July 28th, 2010, 8:00am MDT

Conditions: Estrogen Receptor Negative (ER-Negative) Breast Cancer; Progesterone Receptor Negative (PR-Negative) Breast Cancer; Human Epidermal Growth Factor Receptor 2 Negative (HER2-Negative) Breast Cancer; Brain Metastases
Intervention: Drug: INIPARIB + irinotecan
Sponsors: Sanofi-Aventis; Sanofi-Aventis; UNC Lineberger Comprehensive Cancer Center
Recruiting - verified May 2012

Cellular Immunotherapy Study for Brain Cancer

Posted: June 11th, 2010, 8:00am MDT

Conditions: Gliomas; Anaplastic Astrocytoma; Anaplastic Oligodendroglioma; Anaplastic Mixed Glioma; Glioblastoma Multiforme
Intervention: Drug: alloCTL
Sponsors: University of California, Los Angeles; University of California, Los Angeles; National Institutes of Health (NIH); National Cancer Institute (NCI)
Recruiting - verified June 2010

RO4929097 in Treating Patients With Recurrent or Progressive Glioblastoma

Posted: May 11th, 2010, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: gamma-secretase inhibitor RO4929097; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: adjuvant therapy; Procedure: neoadjuvant therapy; Procedure: therapeutic conventional surgery
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified May 2012

Bevacizumab in Treating Patients With Recurrent or Progressive Meningiomas

Posted: May 7th, 2010, 8:00am MDT

Permalink for 'Prospective Assessment of Quality of Life (QOL) in Pediatric Patients Treated With Radiation Therapy for Brain Tumors and Non-central Nervous System (Non-CNS) Malignancies'

Prospective Assessment of Quality of Life (QOL) in Pediatric Patients Treated With Radiation Therapy for Brain Tumors and Non-central Nervous System (Non-CNS) Malignancies

Posted: April 30th, 2010, 8:00am MDT

Conditions: Brain Tumors; Non-CNS Malignancies
Intervention: Other: Quality of Life surveys completed at specified timepoints
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; M.D. Anderson Cancer Center
Recruiting - verified April 2012

High Dose Chemotherapy and Stem Cell Transplant for Non-Hodgkin's Lymphoma or Central Nervous System (CNS) Lymphoma

Posted: April 30th, 2010, 8:00am MDT

Conditions: Non-Hodgkin's Lymphoma; CNS Lymphoma
Intervention: Procedure: High-dose chemotherapy with autologous stem cell transplant
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Genentech; Otsuka America Pharmaceutical; Dana-Farber Cancer Institute
Recruiting - verified April 2012

PF-00299804 in Adult Patients With Relapsed/Recurrent Glioblastoma

Posted: April 27th, 2010, 8:00am MDT

Conditions: Glioblastoma; GBM; Glioblastoma Multiforme
Intervention: Drug: PF-00299804
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Dana-Farber Cancer Institute; Brigham and Women's Hospital; Henry Ford Hospital; Pfizer
Recruiting - verified April 2012

Study of the Safety and Efficacy of Dichloroacetate (DCA) in Brain Tumors

Posted: April 23rd, 2010, 8:00am MDT

Condition: Brain Tumor
Intervention: Drug: Dichloroacetate
Sponsors: University of Florida; University of Florida; National Center for Research Resources (NCRR)
Recruiting - verified May 2012

Molecular Analysis of Samples From Patients With Diffuse Intrinsic Pontine Glioma and Brainstem Glioma

Posted: April 19th, 2010, 8:00am MDT

Conditions: Diffuse Intrinsic Pontine Glioma; Brainstem Glioma
Intervention:
Sponsors: Children's Research Institute; Children's Research Institute
Recruiting - verified April 2012

Assessment of Sleep Complaints in Brain Tumor Survivors

Posted: April 12th, 2010, 8:00am MDT

Condition: Brain Tumors
Intervention:
Sponsors: St. Jude Children's Research Hospital; St. Jude Children's Research Hospital
Recruiting - verified April 2012

Brain Metastasis in Breast Cancer Patients

Posted: February 25th, 2010, 8:00am MST

Condition: Breast Cancer
Intervention: Drug: Trastuzumab or Lapatinib
Sponsors: GlaxoSmithKline; GlaxoSmithKline
Active, not recruiting - verified April 2012

$Permalink for 'Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors'$

Vorinostat and Temozolomide in Treating Young Patients With Relapsed or Refractory Primary Brain Tumors or Spinal Cord Tumors

Posted: February 25th, 2010, 8:00am MST

Standard Dose Bevacizumab Versus Low Dose Bevacizumab Plus Lomustine (CCNU) for Recurrent Glioblastoma Multiforme (GBM)

Posted: February 10th, 2010, 8:00am MST

Conditions: Brain Cancer; Glioblastoma
Interventions: Drug: Standard Dose Bevacizumab; Drug: Low Dose Bevacizumab; Drug: Lomustine
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified May 2012

rRp450-Phase I Trial in Liver Metastases and Primary Liver Tumors

Posted: January 13th, 2010, 8:00am MST

Conditions: Liver Metastases; Primary Liver Cancers
Intervention: Biological: administration of rRp450 into the hepatic artery
Sponsors: Massachusetts General Hospital; Kenneth K. Tanabe, MD; National Cancer Institute (NCI)
Recruiting - verified April 2012

Consent for Obtaining Additional Bone Marrow Specimens at Time of Diagnostic Bone Marrow Procedure

Posted: January 11th, 2010, 8:00am MST

Conditions: Brain Cancer; Cancer
Intervention: Procedure: Bone marrow specimen banking
Sponsors: Stanford University; Stanford University
Recruiting - verified May 2012

Proton Beam Radiation Therapy in Treating Patients With Low Grade Gliomas

Posted: December 2nd, 2009, 8:00am MST

Conditions: Adult Brain Tumor; Adult Brain Stem Glioma; Adult Diffuse Astrocytoma; Adult Ependymoma; Adult Grade II Meningioma; Adult Melanocytic Lesion; Adult Meningeal Hemangiopericytoma; Adult Mixed Glioma; Adult Oligodendroglioma; Adult Pineal Gland Astrocytoma; Adult Pineocytoma; Recurrent Adult Brain Tumor
Interventions: Radiation: proton beam radiation therapy; Procedure: quality-of-life assessment; Other: questionnaire administration
Sponsors: Abramson Cancer Center of the University of Pennsylvania; Abramson Cancer Center of the University of Pennsylvania
Recruiting - verified May 2012

Magnetic Resonance Imaging in Evaluating Response to RadiationTherapy in Patients With High Grade Glioma

Posted: November 19th, 2009, 8:00am MST

Condition: Brain Tumor
Interventions: Procedure: Magnetic Resonance Imaging; Procedure: Diffusion Tensor Imaging; Procedure: Magnetic Resonance Spectroscopic Imaging; Procedure: Dynamic Contract-Enhanced magnetic resonance imaging; Procedure: Diffusion-weighted magnetic resonance imaging
Sponsors: Abramson Cancer Center of the University of Pennsylvania; Abramson Cancer Center of the University of Pennsylvania
Recruiting - verified May 2012

Multi-centre UK Study of the Acetylcholinesterase Inhibitor Donepezil in Early Dementia Associated With Parkinson's Disease

Posted: November 16th, 2009, 8:00am MST

Condition: Parkinson's Disease
Intervention: Drug: Donepezil
Sponsors: Newcastle-upon-Tyne Hospitals NHS Trust; Sharon Erb; University of Newcastle Upon-Tyne; University of Cambridge; University of Manchester; University of Birmingham; Bangor University; London School of Economics and Political Science; University College, London; Lancashire Care Trust; Institute for Ageing and Health, Newcastle University; King's College London
Not yet recruiting - verified November 2009

Vascular Endothelial Growth Factor (VEGF) Levels in Brain Tumor Patients

Posted: September 25th, 2009, 8:00am MDT

Conditions: Glioma; Meningioma
Intervention: Procedure: Blood test
Sponsors: Marquette General Health System; Marquette General Health System; Upper Michigan Brain Tumor Center
Withdrawn - verified April 2012

GDC-0449 in Treating Patients With Recurrent Glioblastoma Multiforme That Can Be Removed by Surgery

Posted: September 18th, 2009, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: Hedgehog antagonist GDC-0449; Procedure: therapeutic conventional surgery
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Active, not recruiting - verified May 2012

Cediranib Maleate and Cilengitide in Treating Patients With Progressive or Recurrent Glioblastoma

Posted: September 17th, 2009, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: cediranib maleate; Drug: cilengitide; Other: enzyme-linked immunosorbent assay; Other: flow cytometry; Other: laboratory biomarker analysis; Procedure: magnetic resonance imaging
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Recruiting - verified May 2012

Expanded Access Trial of Plant Expressed Recombinant Glucocerebrosidase (prGCD) in Patients With Gaucher Disease

Posted: August 18th, 2009, 8:00am MDT

Condition: Gaucher Disease
Intervention: Drug: Plant cell expressed recombinant glucocerebrosidase (prGCD)
Sponsors: Protalix; Protalix
Available - verified May 2012

A Pilot Study of Using Video Images in Advance Care Planning in Malignant Glioma Patients

Posted: August 7th, 2009, 8:00am MDT

Condition: Advanced Brain Cancer
Intervention: Behavioral: Video intervention
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Foundation for Informed Medical Decision Making
Completed - verified April 2012

Protocol to Distinguish Tumor Recurrence From Treatment-Related Necrosis in Patients With High Grade Gliomas

Posted: July 20th, 2009, 8:00am MDT

Condition: Recurrent High Grade Gliomas
Intervention: Device: 3T MRI
Sponsors: Dartmouth-Hitchcock Medical Center; Dartmouth-Hitchcock Medical Center
Recruiting - verified May 2012

Pazopanib Hydrochloride in Treating Young Patients With Solid Tumors That Have Relapsed or Not Responded to Treatment

Posted: June 27th, 2009, 8:00am MDT

Treatment of Recurrent Primary or Secondary Central Nervous System (CNS) Lymphoma With ALIMTA (Pemetrexed)

Posted: June 5th, 2009, 8:00am MDT

Condition: Central Nervous System Lymphoma
Intervention: Drug: pemetrexed
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Beth Israel Deaconess Medical Center; Eli Lilly and Company; Dana-Farber Cancer Institute
Recruiting - verified April 2012

Evaluation of [18F]-FMISO for Non Operated Glioblastoma

Posted: May 19th, 2009, 8:00am MDT

Condition: Glioblastoma
Intervention: Procedure: 18F]-FMISO PET-CT
Sponsors: University Hospital, Bordeaux; University Hospital, Bordeaux
Recruiting - verified April 2012

Ramucirumab or Anti-PDGFR Alpha Monoclonal Antibody IMC-3G3 in Treating Patients With Recurrent Glioblastoma Multiforme

Posted: May 7th, 2009, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Interventions: Biological: anti-PDGFR alpha monoclonal antibody IMC-3G3; Biological: ramucirumab
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI); ImClone LLC
Recruiting - verified April 2012

MsFLASH-01: Escitalopram for Menopausal Symptoms in Midlife Women

Posted: May 5th, 2009, 8:00am MDT

Conditions: Hot Flashes; Menopause; Vasomotor Symptoms
Interventions: Drug: Escitalopram; Other: Placebo
Sponsors: Fred Hutchinson Cancer Research Center; Fred Hutchinson Cancer Research Center; National Institute on Aging (NIA); Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD); National Center for Complementary and Alternative Medicine (NCCAM); Office of Research on Women's Health (ORWH)
Completed - verified May 2012

Fatigue, Sleep and Cytokines in Primary Brain Tumor (PBT) Patients

Posted: April 3rd, 2009, 8:00am MDT

Condition: Brain Cancer
Intervention: Behavioral: Questionnaire
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified April 2012

Monthly SOM230C for Recurrent or Progressive Meningioma

Posted: March 9th, 2009, 8:00am MDT

Condition: Meningioma
Intervention: Drug: SOM230C
Sponsors: Dana-Farber Cancer Institute; Patrick Y. Wen, MD; Brigham and Women's Hospital; Massachusetts General Hospital; Novartis
Active, not recruiting - verified April 2012

Randomized Gefitinib Trial

Posted: December 10th, 2008, 8:00am MST

Condition: Non Small Cell Lung Cancer
Interventions: Drug: Gefitinib; Drug: Platinum
Sponsors: Fondazione Humanitas per la Ricerca; Fondazione Humanitas per la Ricerca
Completed - verified October 2010

Autologous Dendritic Cells Pulsed With Autologous Apoptotic Tumor Cells Administered to Patients With Brain Tumors

Posted: December 5th, 2008, 8:00am MST

Condition: Brain Tumors
Interventions: Drug: DC/AAT; Drug: DC/AAT-Flu; Drug: DC/KLH
Sponsors: Rockefeller University; Rockefeller University; Memorial Sloan-Kettering Cancer Center
Recruiting - verified May 2012

Chemotherapeutic Agents in Brain/Breast

Posted: November 20th, 2008, 8:00am MST

Conditions: Breast Cancer; Metastatic Cancer
Interventions: Drug: capecitabine; Drug: cyclophosphamide; Drug: doxorubicin hydrochloride; Drug: gemcitabine hydrochloride; Drug: lapatinib ditosylate; Drug: paclitaxel; Drug: vinorelbine ditartrate; Drug: Trastuzumab
Sponsors: Case Comprehensive Cancer Center; Case Comprehensive Cancer Center; Department of Defense; National Cancer Institute (NCI)
Recruiting - verified May 2012

ABT-888, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Posted: October 9th, 2008, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: temozolomide; Drug: veliparib; Genetic: DNA methylation analysis; Genetic: gene expression analysis; Genetic: mutation analysis; Genetic: proteomic profiling; Other: high performance liquid chromatography; Other: immunoenzyme technique; Other: laboratory biomarker analysis; Other: mass spectrometry; Other: pharmacogenomic studies; Other: pharmacological study; Procedure: adjuvant therapy; Radiation: radiation therapy
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Completed - verified May 2012

Prophylactic Cranial Irradiation (PCI) for Small Cell Carcinoma of the Urothelium

Posted: September 18th, 2008, 8:00am MDT

Condition: Bladder Cancer
Interventions: Radiation: PCI; Other: Brain X-ray
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified May 2012

Brain Tumor Patient-Caregiver Congruence, MD Anderson Symptom Inventory-Brain Tumor Module (MDASI-BT)

Posted: September 5th, 2008, 8:00am MDT

Condition: Brain Tumor
Intervention: Behavioral: Questionnaire
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Active, not recruiting - verified May 2012

Pilot Study of MGd + High-dose MTX-Based Chemoimmunotherapy + RT for Newly Dx PCNSL

Posted: August 13th, 2008, 8:00am MDT

Conditions: Brain and Central Nervous System Tumors; Lymphoma; Neurotoxicity
Interventions: Biological: Rituximab; Drug: Cytarabine; Drug: Methotrexate; Drug: Motexafin gadolinium; Drug: Procarbazine hydrochloride; Drug: Vincristine sulfate; Radiation: Radiation therapy
Sponsors: Northwestern University; Northwestern University; Pharmacyclics
Withdrawn - verified May 2012

Temodal (Temozolomide) Post Marketing Surveillance Protocol (Study P05557AM2)

Posted: July 25th, 2008, 8:00am MDT

Conditions: Glioblastoma; Glioma; Astrocytoma
Interventions: Drug: Temozolomide; Radiation: Radiotherapy
Sponsors: Schering-Plough; Schering-Plough
Completed - verified May 2012

Permalink for 'Magnetic Resonance Temperature Imaging & Imaging-Guided Laser Induced Thermal Therapy for Treatment of Metastatic Brain Tumors'

Magnetic Resonance Temperature Imaging & Imaging-Guided Laser Induced Thermal Therapy for Treatment of Metastatic Brain Tumors

Posted: July 21st, 2008, 8:00am MDT

Condition: Brain Tumor
Intervention: Procedure: Visualase® Thermal Therapy System
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center; BioTex, Inc.
Recruiting - verified May 2012

Permalink for 'A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Patients With Brain Metastases'

A Phase I Study of ABT-888 in Combination With Conventional Whole Brain Radiation Therapy (WBRT) in Cancer Patients With Brain Metastases

Posted: March 28th, 2008, 8:00am MDT

Conditions: Nervous System Neoplasms; Brain Diseases; Central Nervous System Diseases; Neoplasm Metastasis; Brain Neoplasms
Interventions: Drug: ABT-888; Radiation: Whole Brain Radiation Therapy
Sponsors: Abbott; Abbott
Recruiting - verified May 2012

Assessment of 18FLT PET-CT for Volume Definition of High-grade Gliomas (GLIO-TEP)

Posted: February 15th, 2008, 8:00am MST

Conditions: High-grade Glioma; Astrocytoma; Glioblastoma
Intervention: Radiation: 18F Fluorothymidine PET CT
Sponsors: University Hospital, Bordeaux; University Hospital, Bordeaux
Completed - verified May 2012

Dasatinib in Treating Patients With Metastatic or Unresectable Solid Tumor or Lymphoma

Posted: January 30th, 2008, 8:00am MST

Conditions: Brain and Central Nervous System Tumors; Liver Cancer; Lymphoma; Small Intestine Cancer; Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: dasatinib; Other: pharmacological study
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Recruiting - verified May 2012

Ph I Dasatinib + Erlotinib in Recurrent MG

Posted: January 25th, 2008, 8:00am MST

Conditions: Glioblastoma; Gliosarcoma
Intervention: Drug: Erlotinib and Dasatinib
Sponsors: Duke University; Duke University; Bristol-Myers Squibb; Genentech
Completed - verified April 2012

A Phase I Study of ABT 510 for Newly Diagnosed Glioblastoma Multiforme

Posted: December 26th, 2007, 8:00am MST

Condition: Brain Tumor
Intervention: Drug: ABT 510
Sponsors: University of Alabama at Birmingham; University of Alabama at Birmingham
Completed - verified May 2012

$Permalink for 'Karenitecin in Pediatric Patients With Refractory or Recurrent Solid Tumors N10010)'$

Karenitecin in Pediatric Patients With Refractory or Recurrent Solid Tumors N10010)

Posted: December 20th, 2007, 8:00am MST

Condition: Solid Tumors
Intervention: Drug: Kareniticin and cyclophosphamide
Sponsors: Baylor College of Medicine; Baylor College of Medicine; Pediatric Brain Tumor Consortium
Completed - verified May 2012

Gossypol in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme

Posted: October 5th, 2007, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: R-(-)-gossypol acetic acid; Genetic: protein expression analysis; Other: immunoenzyme technique; Other: laboratory biomarker analysis
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Active, not recruiting - verified April 2012

Early Detection of Cardiotoxicity During Sunitinib or Sorafenib Chemotherapy Using Cardiac Biomarkers

Posted: September 18th, 2007, 8:00am MDT

Condition: Advanced Cancers
Intervention: Behavioral: Questionnaire
Sponsors: M.D. Anderson Cancer Center; M.D. Anderson Cancer Center
Recruiting - verified May 2012

Hydroxychloroquine, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme

Posted: June 13th, 2007, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: hydroxychloroquine; Drug: temozolomide; Genetic: mutation analysis; Genetic: polymerase chain reaction; Other: immunologic technique; Other: laboratory biomarker analysis; Other: pharmacological study; Procedure: adjuvant therapy; Radiation: 3-dimensional conformal radiation therapy; Radiation: intensity-modulated radiation therapy
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Active, not recruiting - verified May 2012

Pazopanib in Treating Patients With Recurrent Glioblastoma

Posted: April 9th, 2007, 8:00am MDT

Condition: Brain and Central Nervous System Tumors
Intervention: Drug: pazopanib hydrochloride
Sponsors: National Cancer Institute (NCI); North American Brain Tumor Consortium; National Cancer Institute (NCI)
Completed - verified October 2008

Erlotinib and Sorafenib in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme

Posted: March 7th, 2007, 8:00am MST

Condition: Brain and Central Nervous System Tumors
Interventions: Drug: erlotinib hydrochloride; Drug: sorafenib tosylate; Genetic: gene expression analysis; Genetic: mutation analysis; Other: immunohistochemistry staining method; Other: laboratory biomarker analysis; Other: mass spectrometry; Other: pharmacological study; Procedure: biopsy
Sponsors: Sidney Kimmel Comprehensive Cancer Center; Sidney Kimmel Comprehensive Cancer Center; National Cancer Institute (NCI)
Completed - verified May 2012

Levetiracetam in Treating Patients With Seizures Caused by Brain Metastases

Posted: December 20th, 2006, 8:00am MST

Conditions: Brain and Central Nervous System Tumors; Seizure; Unspecified Adult Solid Tumor, Protocol Specific
Interventions: Drug: levetiracetam; Procedure: quality-of-life assessment
Sponsors: Northwestern University; Northwestern University; National Cancer Institute (NCI)
Withdrawn - verified May 2012

Mutation Analysis and Copy Number Changes of KRAS and BRAF Gene in Taiwanese Cases of Biliary Tact Adenocarcinoma

Posted: April 27th, 2012, 8:00am MDT

Condition: Biliary Tract Adenocarcinoma
Intervention:
Sponsors: Far Eastern Memorial Hospital; Far Eastern Memorial Hospital
Active, not recruiting - verified December 2010

ERCP-based Sampling of Indeterminate Bile Duct Strictures

Posted: April 17th, 2012, 8:00am MDT

Condition: Indeterminate Bile Duct Stricture
Interventions: Procedure: Multiple brushings; Procedure: Multimodality tissue sampling
Sponsors: Indiana University; Indiana University; National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Recruiting - verified April 2012

The Adoptive Immunotherapy for Solid Tumors Using Modified Autologous Cytokine-induced Killer Cells

Posted: April 5th, 2012, 8:00am MDT

Condition: Cholangiocarcinoma
Intervention: Drug: cytokine induced killer cells
Sponsors: Siriraj Hospital; Siriraj Hospital; Mahidol University
Recruiting - verified April 2012

Study of Hepatic Arterial Infusion to Treat Hilar Cholangiocarcinoma

Posted: April 4th, 2012, 8:00am MDT

Condition: Cholangiocarcinoma
Intervention: Drug: Oxaliplatin, Fluorouracil, Leucovorin, Capecitabine
Sponsors: Peking University; Peking University
Recruiting - verified April 2012

Clinical Relevance of ROS (V-ros UR2 Sarcoma Virus Oncogene Homolog) Aberrations in Solid Tumours

Posted: April 2nd, 2012, 8:00am MDT

Condition: Cancer
Intervention:
Sponsors: National University Hospital, Singapore; National University Hospital, Singapore
Recruiting - verified April 2012

BKM120 in Cancers With PIK3CA Activating Mutations

Posted: December 27th, 2011, 8:00am MST

Conditions: Lung Cancer; Breast Cancer; Colorectal Cancer; Cholangiocarcinoma; Solid Tumors
Intervention: Drug: BKM120
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; Novartis Pharmaceuticals
Recruiting - verified April 2012

Combination Chemotherapy Plus Panitumumab or Bevacizumab for Inoperable Cholangiocarcinoma Without KRAS Mutations

Posted: September 20th, 2010, 8:00am MDT

Condition: Cholangiocarcinoma
Interventions: Drug: Gemcitabine; Drug: Oxaliplatin; Drug: Capecitabine; Drug: Panitumumab; Drug: Bevacizumab
Sponsors: Vejle Hospital; Vejle Hospital
Recruiting - verified May 2012

Permalink for 'Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma'

Sorafenib Tosylate and Erlotinib Hydrochloride in Treating Patients With Locally Advanced, Unresectable, or Metastatic Gallbladder Cancer or Cholangiocarcinoma

Posted: March 24th, 2010, 8:00am MDT

Conditions: Extrahepatic Bile Duct Cancer; Gallbladder Cancer
Interventions: Drug: erlotinib hydrochloride; Drug: sorafenib tosylate
Sponsors: National Cancer Institute (NCI); Southwest Oncology Group; National Cancer Institute (NCI)
Active, not recruiting - verified September 2011

A Study of Gemcitabine as an Adjuvant Treatment for Cholangiocarcinoma After Surgical Resection

Posted: January 5th, 2010, 8:00am MST

Condition: Cholangiocarcinoma
Intervention: Drug: Gemcitabine
Sponsors: National Cancer Center, Korea; National Cancer Center, Korea; Dong-A Pharmaceutical Co., Ltd.
Recruiting - verified April 2012

Erlotinib for Chemoprevention in Trisomy 7 Positive Primary Sclerosing Cholangitis (PSC)

Posted: August 5th, 2009, 8:00am MDT

Conditions: Primary Sclerosing Cholangitis; Trisomy 7; Cholangiocarcinoma; Chemoprevention
Intervention: Drug: Erlotinib (Tarceva)
Sponsors: Mayo Clinic; Mayo Clinic; Genentech
Recruiting - verified May 2012

Combined Biological Treatment and Chemotherapy for Patients With Inoperable Cholangiocarcinoma

Posted: October 22nd, 2008, 8:00am MDT

Proton Beam Irradiation for the Treatment of Unresectable Hepatocellular Cancer or Hepatic Metastases

Posted: April 23rd, 2007, 8:00am MDT

Conditions: Hepatocellular Cancer; Cholangiocarcinoma; Hepatic Metastases
Intervention: Procedure: Proton Beam Radiation
Sponsors: Massachusetts General Hospital; Massachusetts General Hospital; National Cancer Institute (NCI); Dana-Farber Cancer Institute; Brigham and Women's Hospital
Active, not recruiting - verified May 2012

DX-8951f in Treating Patients With Biliary Cancer

Posted: July 5th, 2000, 8:00am MDT

Conditions: Extrahepatic Bile Duct Cancer; Gallbladder Cancer; Liver Cancer
Intervention: Drug: exatecan mesylate
Sponsors: Daiichi Sankyo Inc.; Daiichi Sankyo Inc.
Completed - verified May 2012

Patency of a Prototype 16 Fr Plastic Biliary Stent in the Palliation of Malignant Distal Biliary Strictures.

Posted: April 30th, 2012, 8:00am MDT

Conditions: Stricture; Obstruction; Cancer
Intervention: Device: 16 Fr plastic stent
Sponsors: Mayo Clinic; Mayo Clinic
Not yet recruiting - verified May 2012

ERCP-based Sampling of Indeterminate Bile Duct Strictures

Posted: April 17th, 2012, 8:00am MDT

The Adoptive Immunotherapy for Solid Tumors Using Modified Autologous Cytokine-induced Killer Cells

Posted: April 5th, 2012, 8:00am MDT

Condition: Cholangiocarcinoma
Intervention: Drug: cytokine induced killer cells
Sponsors: Siriraj Hospital; Siriraj Hospital; Mahidol University
Recruiting - verified April 2012

Permalink for 'Prospective Phase II Trial on Prophylactic Perihepatic Lymphadenectomy in Patients With Colorectal Cancer With Liver Metastasis'

Prospective Phase II Trial on Prophylactic Perihepatic Lymphadenectomy in Patients With Colorectal Cancer With Liver Metastasis

Posted: March 27th, 2012, 8:00am MDT

Condition: Colorectal Cancer With Liver Metastasis
Intervention: Procedure: perihepatic lymphadenectomy
Sponsors: Gachon University Gil Medical Center; Gachon University Gil Medical Center
Recruiting - verified March 2012

Bile and Bile Duct/Pancreatic Duct Brushings Database for Patients With Pancreato-biliary Stricture

Posted: March 26th, 2012, 8:00am MDT

Conditions: Pancreatic Duct Strictures; Biliary Duct Strictures
Intervention: Other: sample collection
Sponsors: The Cleveland Clinic; The Cleveland Clinic
Recruiting - verified March 2012

Classical Procedure Versus Intrahepatic Glisson's Approach

Posted: March 26th, 2012, 8:00am MDT

Conditions: Liver Diseases; Liver Neoplasms; Hepatic Haemangioma
Interventions: Procedure: intrahepatic Glisson's approach; Procedure: classical hepatectomy
Sponsors: Southwest Hospital, China; Shuguo Zheng, MD
Enrolling by invitation - verified March 2012

Ambulant Laparoscopic Nephrectomy; Are There Limiting Factors

Posted: May 12th, 2012, 8:00am MDT

Condition: Nephrectomy
Intervention: Procedure: Ambulant laparoscopic nephrectmy
Sponsors: University Hospital Roskilde; University Hospital Roskilde
Not yet recruiting - verified May 2012

Surgery and Oxaliplatin or Mitomycin C in Treating Patients With Tumors of the Appendix

Posted: April 17th, 2012, 8:00am MDT

Conditions: Carcinoma of the Appendix; Primary Peritoneal Cavity Cancer
Interventions: Drug: mitomycin C; Drug: oxaliplatin; Procedure: therapeutic conventional surgery; Other: quality-of-life assessment; Drug: hyperthermic intraperitoneal chemotherapy
Sponsors: Comprehensive Cancer Center of Wake Forest University; Comprehensive Cancer Center of Wake Forest University; National Cancer Institute (NCI)
Recruiting - verified October 2009

Permalink for 'Cytoreduction Followed by Normothermic Versus Hyperthermic Intraperitoneal Intraoperative Chemoperfusion (HIPEC): a Study in Peritoneal Carcinomatosis'

Cytoreduction Followed by Normothermic Versus Hyperthermic Intraperitoneal Intraoperative Chemoperfusion (HIPEC): a Study in Peritoneal Carcinomatosis

Posted: April 6th, 2012, 8:00am MDT

Condition: Peritoneal Carcinomatosis
Interventions: Procedure: Hyperthermic intraoperative Peritoneal Chemoperfusion; Procedure: Hyperthermic intraoperative Peritoneal Chemoperfusion; Drug: Hyperthermic intraoperative Peritoneal Chemoperfusion
Sponsors: University Hospital, Ghent; University Hospital, Ghent; University Ghent
Not yet recruiting - verified April 2012

Temsirolimus Plus Neratinib for Patients With Metastatic HER2-Amplified or Triple Negative Breast Cancer

Posted: April 22nd, 2010, 8:00am MDT

Condition: Breast Cancer
Intervention: Drug: Temsirolimus plus Neratinib
Sponsors: Memorial Sloan-Kettering Cancer Center; Memorial Sloan-Kettering Cancer Center; National Comprehensive Cancer Network; Wyeth Pharmaceuticals, Inc., a Pfizer Company
Recruiting - verified May 2012

Permalink for 'Study to Evaluate the Efficacy and Safety of Treatment With Bendamustine in Combination With Ofatumumab in Previously Untreated Patients With Indolent B-Cell Non-Hodgkin's Lymphoma (NHL)'

Study to Evaluate the Efficacy and Safety of Treatment With Bendamustine in Combination With Ofatumumab in Previously Untreated Patients With Indolent B-Cell Non-Hodgkin's Lymphoma (NHL)

Posted: April 14th, 2010, 8:00am MDT

Condition: Non-Hodgkin's Lymphoma (NHL)
Intervention: Drug: Bendamustine and Ofatumumab
Sponsors: Teva Pharmaceutical Industries; Cephalon
Completed - verified April 2012

Permalink for 'Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer'

Intraperitoneal Hyperthermic Perfusion With Oxaliplatin in Treating Patients With Stage IV Peritoneal Cancer Due to Appendix Cancer or Colorectal Cancer

Posted: April 9th, 2007, 8:00am MDT

Conditions: Carcinoma of the Appendix; Colorectal Cancer; Primary Peritoneal Cavity Cancer
Intervention: Drug: oxaliplatin
Sponsors: Comprehensive Cancer Center of Wake Forest University; Comprehensive Cancer Center of Wake Forest University; National Cancer Institute (NCI)
Completed - verified April 2012

UCN-01 and Irinotecan in Treating Patients With Metastatic or Unresectable Solid Tumors or Triple-Negative Breast Cancer (Currently Accruing Only Triple-negative Breast Cancer Patients Since 6/8/2007)

Posted: March 8th, 2002, 8:00am MST

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Rare Cancer News & Clinical Trials » ClinicalTrials

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ClinicalTrials (415 unread)

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