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Angiosarcoma (70 unread)

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What the doctor orders - Daily Kos (blog)

Posted: February 14th, 2010, 3:25pm CST

What the doctor orders
Daily Kos (blog)
Other cardiac angiosarcoma patients who've had this surgery within the last ten years are out there, perhaps a baker's dozen at best. ...

PVC, the poison in your home - Dispatch Online

Posted: January 22nd, 2010, 9:02pm CST

PVC, the poison in your home
Dispatch Online
These health risks include angiosarcoma of the liver, lung cancer, brain cancer, lymphomas, leukeamia, and liver cirrhosis. When heated in a building fire, ...

Healthcare and you: be all you can be - Daily Kos (blog)

Posted: January 17th, 2010, 3:40pm CST

Healthcare and you: be all you can be
Daily Kos (blog)
by exmearden When I was first diagnosed with cardiac angiosarcoma in late August 2009, the first thing I did (once I caught my breath and recovered a bit ...

Terminal housekeeping - Daily Kos (blog)

Posted: January 10th, 2010, 7:16pm CST

Terminal housekeeping
Daily Kos (blog)
Just for kicks, the 2009 ICD-9-CM Diagnosis Code used to describe my condition (cardiac angiosarcoma) on my insurance and benefit claims forms is 198.89: ...

Atypical presentation of angiosarcoma of the scalp in the setting of Human ... - 7thSpace Interactive (press release)

Posted: December 19th, 2009, 3:44am CST

Atypical presentation of angiosarcoma of the scalp in the setting of Human ...
7thSpace Interactive (press release)
Angiosarcoma of the head and neck is an uncommon, aggressive malignant entity most commonly found in elderly Caucasian males. We present a case in a young ...

Phoenix Partners Group Donates $150000 to St. Jude Children's Research Hospital - dBusinessNews New York (press release)

Posted: December 9th, 2009, 8:55am CST

Phoenix Partners Group Donates $150000 to St. Jude Children's Research Hospital
dBusinessNews New York (press release)
Mr. Sawyer was a colleague who died in January 2007 after losing his battle with angiosarcoma, a very rare form of cancer. He continued his work at Phoenix ...

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Phoenix Partners Group Donates $150000 to St. Jude Children's Research Hospital - Earthtimes (press release)

Posted: December 9th, 2009, 7:51am CST

Phoenix Partners Group Donates $150000 to St. Jude Children's Research Hospital
Earthtimes (press release)
Mr. Sawyer was a colleague who died in January 2007 after losing his battle with angiosarcoma, a very rare form of cancer. He continued his work at Phoenix ...

and more »

Derby raises money for long-time fan - Ludington Daily News

Posted: December 7th, 2009, 9:12pm CST

Derby raises money for long-time fan
Ludington Daily News
The day was a chance for Doug Hendrickson Sr. — who was diagnosed with a form of cancer called angiosarcoma in December 2008 — to forget about his disease ...

Cercando la verità sul cvm - Estense.com

Posted: December 3rd, 2009, 3:05pm CST

Estense.com

Cercando la verità sul cvm
Estense.com
Si comincia a delineare che una delle patologie più frequentemente correlate all'esposizione a cvm è proprio l'angiosarcoma epatico, come sottolineato dallo ...
Cvm, quali effetti sulla salute?Estense.com

all 3 news articles »

Marchi: ”Ferrara quattro volte peggio di Marghera” - Estense.com

Posted: December 3rd, 2009, 3:05pm CST

Estense.com

Marchi: ”Ferrara quattro volte peggio di Marghera”
Estense.com
... tumori (l'altro è l'angiosarcoma epatico) per cui la scienza ha ritenuto esistere un nesso causale tra esposizione al cvm e insorgenza della malattia. ...

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PubMed - Angiosarcoma

Aortic Angiosarcoma: A Rare Cause for Leaking Thoracic Aneurysm.

Fetched: February 15th, 2010, 7:36am CST

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Aortic Angiosarcoma: A Rare Cause for Leaking Thoracic Aneurysm.

Cardiovasc Intervent Radiol. 2010 Feb 10;

Authors: Hales SL, Locke R, Sandison A, Jenkins M, Hamady M

Primary malignant tumours of the aorta are rare. They present with aneurysm formation, arterial occlusion, and embolic phenomenon. We report the case of a 56-year-old man whose initial presentation and investigations lead to emergency endovascular stenting of a descending thoracic aneurysm with a contained leak. Initial response was favourable, yet the patient presented again with worsening symptoms. The circum-aortic haematoma expanded by 50% on subsequent imaging, but no endoleak was identified. When altered bone marrow signal was identified on magnetic resonance imaging, the possibility of malignancy was considered. A metastatic skin lesion was then biopsied, which demonstrated morphological and immunohistochemical features consistent with metastases from a pleomorphic sarcoma of the aorta.

PMID: 20145931 [PubMed - as supplied by publisher]
Odontogenic myxofibroma synchronous with primary angiosarcoma of the spleen.

Fetched: February 15th, 2010, 7:36am CST

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Odontogenic myxofibroma synchronous with primary angiosarcoma of the spleen.

Br J Radiol. 2010 Jan;83(985):e10-3

Authors: Hadidy A, Alsharif A, Sheikh-Ali R, Abukhalaf M, Awidi A, Abukaraki A, Nimri C, Omari A

Odontogenic myxofibroma of the temporomandibular joint (TMJ) is a rare tumour; moreover, primary splenic angiosarcoma (PAS) in paediatric patients is extremely rare. We report on a 15-year-old boy who presented with right TMJ swelling and subsequently developed epigastric and right upper quadrant pain. The TMJ swelling proved to be odontogenic myxofibroma and the abdominal pain was a result of primary splenic angiosarcoma with hepatic metastasis. We report for the first time the synchronous presentation of PAS and odontogenic myxofibroma in a paediatric patient, and we describe the radiological features along with the histological diagnosis and clinical outcome. Uptake in (18)F-2-fluoro-2-deoxy-D-glucose positron emission tomography is also described for the first time for both these tumours.

PMID: 20139242 [PubMed - in process]
Atypical vascular lesion of the breast.

Fetched: February 15th, 2010, 7:36am CST

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Atypical vascular lesion of the breast.

J Am Acad Dermatol. 2010 Feb 4;

Authors: Mandrell J, Mehta S, McClure S

Atypical vascular lesions (AVLs) are vascular proliferations that develop after surgery and radiation for breast carcinoma and may represent precursors to angiosarcoma. AVLs are not well-known entities and currently lack official prognostic factors and guidelines for surgical treatment. We report the case of a patient who developed an AVL, vascular type, 4 years after lumpectomy and radiation therapy for ductal carcinoma in situ of the breast. The patient underwent wide local excision with 1-cm margins with subsequent pathologic examination confirming complete excision of the residual atypical vascular proliferation. This case highlights the importance of close cutaneous surveillance in patients with a history of surgery and radiation for breast carcinoma, and a low threshold for biopsy. More studies are needed to further delineate the risk of AVLs progressing to angiosarcoma and to identify histologic features or immunophenotypic markers, which may be predictive of this risk. Furthermore, formal treatment recommendations for these enigmatic entities would be helpful.

PMID: 20138394 [PubMed - as supplied by publisher]
Role of chemotherapy in the management of soft tissue sarcomas.

Fetched: February 15th, 2010, 7:36am CST

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Role of chemotherapy in the management of soft tissue sarcomas.

Expert Rev Anticancer Ther. 2010 Feb;10(2):249-60

Authors: Krikelis D, Judson I

Soft tissue sarcomas are a diverse group of rare tumors that comprise 1% of all cancers. Few randomized trials of chemotherapy have been performed but there is a clear role for agents such as doxorubicin and ifosfamide in the palliation of advanced disease. There is uncertainty as to whether sequential single-agent treatment is equivalent to combination chemotherapy. For the majority of histological subtypes adjuvant chemotherapy is not of proven value, although there may be situations where it is advantageous. However, there are other subtypes, such as the Ewing's sarcoma family tumors, for which chemotherapy is an essential part of primary management and has definitely improved survival. Apart from Ewing's sarcoma family tumor and rhabdomyosarcoma, there is increasing specialization of chemotherapy according to histological subtype, such as the use of taxanes for angiosarcoma, gemcitabine and docetaxel for leiomyosarcoma, and trabectedin for leiomyosarcoma and liposarcoma, especially the myxoid/round cell variant. Nevertheless, there are serious limitations to existing treatment and novel therapies need to be developed.

PMID: 20132000 [PubMed - in process]
[Angiosarcoma of the scalp: extension study with PET-CT.]

Fetched: February 15th, 2010, 7:36am CST

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[Angiosarcoma of the scalp: extension study with PET-CT.]

Rev Esp Med Nucl. 2010 Feb 1;

Authors: Sopena P, Uruburu E, Abreu P, Giménez A, Martínez B, Martínez C

PMID: 20129715 [PubMed - as supplied by publisher]
Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors.

Fetched: February 15th, 2010, 7:36am CST

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Mast cells in canine cutaneous hemangioma, hemangiosarcoma and mammary tumors.

Vet Res Commun. 2010 Feb 3;

Authors: Woldemeskel M, Rajeev S

Mast cell count (MCC) in 45 dogs with cutaneous hemangioma (HA, n = 12), hemangiosarcoma (HSA, n = 12), mammary adenoma (AD, n = 9) and mammary adenocarcinoma (AC, n = 12) was made using Toluidine blue stained sections. Antibodies against endothelial cell markers, Factor VIII and VEGF were used to visualize and determine the hot spot micro-vessel density (MVD). Total MCC and MCC along the invasive edges were significantly higher (p < 0.001) in canine mammary AC than in AD. The total MCC did not significantly differ (p > 0.05), in HSAs (8.6 +/- 3.3) than in HAs (5.5 +/- 2.8). There is a positive correlation (r = 0.14) between the hot spot MCC and MVD in mammary AC, although not significant (p = 0.3172), indicating that mast cells are associated with angiogenesis in canine mammary AC. This study suggests that mast cells may play an important role in neovascularization of canine cutaneous vascular and mammary neoplasms. Detailed studies encompassing correlation of MCC and MVD with clinical outcomes and prognosis in these neoplasms are recommended.

PMID: 20127412 [PubMed - as supplied by publisher]
Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical study of 45 cases.

Fetched: February 15th, 2010, 7:36am CST

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Sporadic cutaneous angiosarcomas generally lack hypoxia-inducible factor 1alpha: a histologic and immunohistochemical study of 45 cases.

Ann Diagn Pathol. 2010 Feb;14(1):15-22

Authors: Abedalthagafi M, Rushing EJ, Auerbach A, Desouki MM, Marwaha J, Wang Z, Fanburg-Smith JC

Cutaneous angiosarcoma (AS) is a rare malignant neoplasm of dermis composed of infiltrating cells of endothelial phenotype with overall poor prognosis. Although autocrine stimulation by vascular endothelial growth factor secretion may play a role in the pathogenesis of angiosarcoma, its mechanism has not been fully established. Hypoxia-inducible factor-1 (HIF-1) is a transcription factor that mediates cellular and systemic homeostatic responses to hypoxia.. The stability of HIF can regulate key proteins in angiogenesis and the alpha-subunit has been found in epithelial tumors, only 1 case of human retroperitoneal angiosarcoma, and rare vascular proliferations and tumors in knockout mice. We wanted to observe the utility of HIF-1alpha as a marker or explanatory factor in AS. Cases coded as "angiosarcoma" of dermis were culled and re-reviewed for inclusion as AS, based on patient folder, slides, and obtained immunohistochemistry including CD31 and smooth muscle actin (SMA). Hypoxia-inducible factor-1alpha was performed on a subset of cases, with additional available material. Forty-five cases met the criteria for AS; there were 17% females and 83% males, with a mean age at presentation of 67 years (range, 27-88 years). Tumors presented most commonly in the skin of the scalp followed by the left lower leg, face, nose, lower arm, neck, thigh, eyelid, ear, and temple. Associated basal cell carcinoma was noted in 1 patient; no others had other neoplasms or unrelated surgeries. There was no history of other primary, lymphedema, radiation, breast-associated, or thorotrast-induced angiosarcoma. The tumors ranged in size from 0.4 up to 9.5 cm, with a mean size of 2.4 cm. Histopathologically, most tumors were vasoformative, with either solid architecture (n = 35) or papillary endothelial hyperplasia-like foci (n = 7). All cases demonstrated infiltrative growth pattern, cytologic atypia, and mitotic activity, including atypical forms. Surface ulceration was present in 44% and solar elastosis in the most evaluable cases. Epithelioid morphology was present in 29% (n = 13) cases. Mild to moderate lymphocytic inflammatory response was noted in 62% (n = 28) cases. CD31 highlighted malignant endothelial cells. SMA (for pericytes) was generally absent. Hypoxia-inducible factor 1alpha was focally positive in cytoplasm of 3 of 18 (17%) cases studied. Treatment and follow-up data were only available on 4 cases: 2 died of disease within 4 years, 2 others had known recurrence within 2 years. Cutaneous angiosarcoma is largely found on the scalp of older individuals. Requirement for diagnosis includes extravascular proliferation of atypical endothelial cells with mitotic activity in vasoformative, solid, and papillary patterns. Absence of SMA can prove extravascular extension of tumor, outside their normal vessel confines. Cutaneous angiosarcoma generally lacks HIF-1alpha expression. Accordingly, the hypoxic response pathway is not thought to be a documentable common mechanism of angiogenesis in this entity.

PMID: 20123452 [PubMed - in process]
Primary and secondary angiosarcoma of the breast: The Mayo Clinic experience.

Fetched: February 15th, 2010, 7:36am CST

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Primary and secondary angiosarcoma of the breast: The Mayo Clinic experience.

J Surg Oncol. 2010 Jan 29;

Authors: Scow JS, Reynolds CA, Degnim AC, Petersen IA, Jakub JW, Boughey JC

BACKGROUND AND OBJECTIVES: Angiosarcoma of the breast can be divided into primary and secondary. The objective was to determine clinicopathologic factors associated with breast angiosarcoma and to compare primary versus secondary angiosarcoma. METHODS: Breast angiosarcoma cases at Mayo Clinic from 1960 to 2008 were identified. Clinicopathologic factors were reviewed. Characteristics of primary and secondary angiosarcoma were compared. RESULTS: Twenty-seven cases of primary angiosarcoma and 14 cases of secondary angiosarcoma were identified. The median age of primary angiosarcoma patients was lower than that of secondary angiosarcoma-43 years versus 73 years (P < 0.0001). Primary angiosarcoma more frequently presented with a mass, whereas secondary angiosarcoma presented with a rash (P < 0.0001). Median time from radiation to secondary angiosarcoma diagnosis was 6.8 years. Median tumor size was 7.0 cm for primary angiosarcoma and 5.0 cm for secondary angiosarcoma (P = 0.7). Tumors were high grade in 33% of primary angiosarcoma and 82% of secondary angiosarcoma (P = 0.02). Five-year survival for primary and secondary angiosarcoma was 46% and 69%, respectively (P = 0.8). CONCLUSION: Primary angiosarcoma occurs in younger patients than secondary and more frequently presents with a mass. Mastectomy is the mainstay of treatment for breast angiosarcoma. Breast angiosarcoma is a rare malignancy with poor long-term prognosis. J. Surg. Oncol. (c) 2010 Wiley-Liss, Inc.

PMID: 20119983 [PubMed - as supplied by publisher]
Eccrine angiomatous hamartoma: a rare multifocal variant with features suggesting trauma.

Fetched: February 15th, 2010, 7:36am CST

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Eccrine angiomatous hamartoma: a rare multifocal variant with features suggesting trauma.

Dermatol Online J. 2009;15(9):6

Authors: Naik V, Arsenovic N, Reed M

Eccrine angiomatous hamartoma (EAH) is a rare, benign cutaneous tumor characterized by proliferation of the eccrine gland elements closely associated with capillary angiomatosis and proliferation of other dermal elements, such as adipose tissue, hair and epidermis. Patients usually present with a solitary nodule on the extremities appearing at birth or during the prepubertal years. However multifocal lesions or late onset of this condition may occur. Eccrine angiomatous hamartoma is usually sporadic, but one familial case of the multifocal variant has been reported. The clinical presentation ranges from a simple angiomatous nodule to erythematous--purpuric plaques. Eccrine angiomatous hamartoma is generally asymptomatic but may occasionally be associated with pain and hyperhidrosis. We report a rare case of the multifocal variant of EAH in a 13-year-old girl, with histological features suggesting trauma. Clinically, this condition must be differentiated from other angiomatoses and a definitive diagnosis is based upon histology. Eccrine angiomatous hamartoma is a benign slowly growing lesion for which aggressive treatment is not indicated. Simple excision is reserved for painful or cosmetically disfiguring examples.

PMID: 19930993 [PubMed - indexed for MEDLINE]
Surgical treatment of primary cardiac sarcomas.

Fetched: February 15th, 2010, 7:36am CST

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Surgical treatment of primary cardiac sarcomas.

Tex Heart Inst J. 2009;36(5):451-2

Authors: Blackmon SH, Reardon MJ

PMID: 19876427 [PubMed - indexed for MEDLINE]
Clinical experience with anthracycline antibiotics-HPMA copolymer-human immunoglobulin conjugates.

Fetched: February 15th, 2010, 7:36am CST

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Clinical experience with anthracycline antibiotics-HPMA copolymer-human immunoglobulin conjugates.

Adv Drug Deliv Rev. 2009 Nov 12;61(13):1149-58

Authors: Rihova B

This paper reviews an early clinical experience with anthracycline (epirubicin; Epi or doxorubicin; Dox) containing an N-(2-hydroyxypropyl)methacrylamide copolymer carrier targeted with autologous or commercial human immunoglobulin in six patients aged 28-55 suffering from therapy-resistant metastatic cancer. More than 100 biochemical, hematological and immunological parameters, including nine tumor markers, were tested in blood samples taken 24 h after the first and up to 10 months after the last application. The intravenous application proceeded without serious adverse or side effects and did not require hospitalization. Cardiotoxicity was not observed. Four of six monitored patients attained stabilization of disease (liver ultrasound scan and bone computer tomography) with a very good quality of life lasting from seven up to 18 months. Positive response to the treatment was, among others, evaluated as decreased CA 15-3 and CEA tumor markers. In three of five tested patients the serum level of C-reactive protein was temporarily increased 72 h after the treatment. A stable or elevated number of peripheral blood reticulocytes together with activation of natural killer (NK) cells and lymphokine-activated killer (LAK) cells supports the data previously obtained in experimental animals pointing to a dual role, i.e. the cytotoxic and immunomobilizing character of doxorubicin-HPMA conjugates.

PMID: 19682512 [PubMed - indexed for MEDLINE]
Results of hepatic resection for primary hepatic angiosarcoma in adults.

Fetched: January 31st, 2010, 3:49pm CST

Results of hepatic resection for primary hepatic angiosarcoma in adults.

Med Sci Monit. 2010 Feb;16(2):CR61-66

Authors: Zhou YM, Li B, Yin ZM, Xu F, Wang B, Xu W, Liu P, Yang JM

Background: Primary hepatic angiosarcoma is an uncommon but aggressive malignancy with poor prognosis. The purpose of this study was to evaluate surgical outcomes of patients with the disease.<br /> Material/Methods: Medical records of 6 patients who underwent surgical resection for primary hepatic angiosarcoma at our institution between 1998 and 2006 were reviewed retrospectively.<br /> Results: There were 5 men and 1 woman who ranged in age from 44 to 77 years, with a mean of 55.5 years. The most common symptoms at diagnosis were pain in the right upper quadrant, abdominal distension, weakness and weight loss. None of these patients presented with intra-abdominal hemorrhage from tumor rupture. Right hepatectomy was performed in 3 cases, extended right hepatectomy in 1 case, and left hepatectomy in the remaining 2 cases. All 6 patients had solitary masses. One patient died of perioperative complication, and another patient with microscopic tumor residuals died of disease recurrence at 6 months. Of the other 4 patients with pathological free margins, 3 died of disease recurrence at 10, 14 and 17 months, and the remaining 1 has been alive without recurrence for 29 months.<br /> Conclusions: Although the overall outcome of surgical resection remains unsatisfactory, complete surgical resection may prolong survival of patients with solitary primary hepatic angiosarcoma without spontaneous rupture.<br />

PMID: 20110916 [PubMed - in process]
Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses.

Fetched: January 31st, 2010, 3:49pm CST

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Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses.

Cytopathology. 2010 Jan 22;

Authors: Pohar-Marinšek Z, Lamovec J

z. Pohar-Marinsek and J. Lamovec Angiosarcoma in FNA smears: diagnostic accuracy, morphology, immunocytochemistry and differential diagnoses Objective: The aim of our study was to analyse the diagnostic accuracy in recognizing angiosarcoma from fine needle aspiration (FNA) samples and to determine morphological features of angiosarcoma in cytology. Methods: FNA samples from 18 histologically confirmed angiosarcomas obtained between 1985 and 2009 were included in the study. Original cytological diagnoses were retrieved, smears reviewed and morphological features analysed: cellularity, smear pattern, cell morphology, contents of background. Outcome of immunocytochemistry was noted and additional reactions performed if material was available. Results: There were 13 primary angiosarcomas and five recurrent tumours; nine tumours were epithelioid. Twelve tumours were cytologically diagnosed as malignant, three as suspicious and three were judged unsatisfactory. Only two primary tumours were diagnosed as vascular. According to morphology, tumours were divided into those with predominantly epithelioid cells and those with predominantly spindle cells. Within these two groups were variations due to grade of tumour. Cytomorphology did not correlate well with histology in mixed and spindle cell types of angiosarcomas. Immunocytochemistry was applied in seven cases, specific vascular marker CD31 only twice at the time of diagnosis and three times retrospectively. Conclusions: Angiosarcomas are difficult to recognize on FNA smears when they lack the typical dual, spindle and epithelioid cell population and when they occur in internal organs where carcinomas are more common. Very few reliable data are available concerning specificity of CD31 on cytological material.

PMID: 20105214 [PubMed - as supplied by publisher]
Angiosarcoma of the breast with silicone granuloma: a case report.

Fetched: January 31st, 2010, 3:49pm CST

Angiosarcoma of the breast with silicone granuloma: a case report.

Kurume Med J. 2009;56(1-2):33-7

Authors: Takenaka M, Tanaka M, Isobe M, Yamaguchi R, Kojiro M, Shirouzu K

Angiosarcoma of the breast is a rare non-epithelial tumor and that accounts for less than 0.1% of primary malignancies of the breast. The disease has a relatively higher occurrence among young people, and its prognosis (3-year-survival of only 38%) is extremely poor compared to breast cancer. Here we present a case of an 87-year-old woman who had undergone bilateral breast augmentation with silicone injections in her youth. Although she became aware of a tumor in her right breast, she waited 8 years before seeking treatment. She felt the tumor growing and experienced swelling and pain, but she ended up declining therapy at that time. Two years later she was brought to our hospital by ambulance for continuous bleeding from the same tumor of the breast, which by that time was over 11 cm in diameter. We performed emergency mastectomy. The histological diagnosis was angiosarcoma of the breast with silicone granuloma.

PMID: 20103999 [PubMed - in process]
Surgical treatment of angiosarcoma of the scalp with superficial parotidectomy.

Fetched: January 31st, 2010, 3:49pm CST

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Surgical treatment of angiosarcoma of the scalp with superficial parotidectomy.

Ann Plast Surg. 2010 Feb;64(2):180-2

Authors: Lim SY, Pyon JK, Mun GH, Bang SI, Oh KS

Angiosarcomas of the scalp area are rare tumors mostly affecting elderly patients. In many series, potential treatment options for patients with scalp angiosarcoma have included surgery, radiation, and chemotherapy. Surgery combined with radiation therapy, however, did not appear to cure many patients. For these reasons, there is a serious need for the development of new approaches. We report our experience of 8 patients presenting angiosarcoma solely of the scalp. Our procedure consisted in radical tumor resection or the scalp with minimal 5-cm safety margins from the most peripheral scatted lesions with burring of the external table of the cranium, ipsilateral superficial parotidectomy, and ipsilateral upper neck dissection. After resection of the tumor of the scalp, the latissimus dorsi free flap was used for coverage of the defect. With prophylactic dissection of these regional lymph nodes, we could achieve better results and, at least, prolonged time to local recurrence and distant metastasis.

PMID: 20098103 [PubMed - in process]
Angiosarcoma-like metastatic carcinoma of the liver.

Fetched: January 31st, 2010, 3:49pm CST

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Angiosarcoma-like metastatic carcinoma of the liver.

Pathol Res Pract. 2010 Jan 22;

Authors: Suzuki H, Komatsu A, Fujioka Y, Yamashiro K, Takeda H, Hamada T

Two cases of metastatic carcinoma strikingly simulating angiosarcoma in the liver are described. The first case was a 53-year-old female with cystic liver tumors which were found 22 months after surgery for ureteral cancer. The second case was an 81-year-old female with multiple tumors in the liver and the pancreas, and a post-mortem examination was carried out. She had undergone surgery for skin cancer three years before. Both cases had an angiosarcoma-like appearance macroscopically and microscopically. Immunohistochemically, the tumor cells of both cases were negative for CD31, CD34, and Factor VIII-related antigen and positive for several types of cytokeratin, suggesting that they were not angiosarcomas but carcinomas. Angiosarcoma is the most common sarcoma arising in the liver. Thus, metastatic carcinoma, which resembles angiosarcoma, might be mistaken for angiosarcoma.

PMID: 20097483 [PubMed - as supplied by publisher]
Epithelioid hemangiosarcomas of the bovine urinary bladder: a histologic, immunohistochemical, and ultrastructural examination of four tumors.

Fetched: January 31st, 2010, 3:49pm CST

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Epithelioid hemangiosarcomas of the bovine urinary bladder: a histologic, immunohistochemical, and ultrastructural examination of four tumors.

J Vet Diagn Invest. 2010 Jan;22(1):116-9

Authors: Pires I, Silva F, Queiroga FL, Rodrigues P, Henriques R, Pinto CA, Lopes C

Epithelioid hemangiosarcoma is a specific variant of hemangiosarcoma that has recently been recognized in domestic animals. These malignant vascular neoplasms histologically resemble, and may be mistaken for, carcinomas. Four epithelioid hemangiosarcomas in the urinary bladders of 4 cows with severe enzootic hematuria are described in the current study. Grossly, the vesicular mucosa of the urinary bladder of each cow contained a single red elevated nodule. Histologically, each neoplasm was composed of short strands, cords, or nests of epithelioid, round, or slightly spindle-shaped endothelial cells that formed small vascular structures. Neoplastic cells were immunohistochemically positive for factor VIII-related antigen and vimentin, and were negative for cytokeratin and desmin. Ultrastructurally, the neoplastic cells often contained cytoplasmic intermediate filaments, a prominent granular endoplasmic reticulum, a Golgi complex, mitochondria, marked pinocytotic activity, and rare Weibel-Palade bodies. These neoplasms were diagnosed as epithelioid hemangiosarcomas based on their histologic, immunohistochemical, and ultrastructural features. The present report widens the spectrum of mesenchymal tumors of the bovine urinary bladder and aids in the characterization of these vascular neoplasms.

PMID: 20093698 [PubMed - in process]
FDG PET/CT in aortic angiosarcoma.

Fetched: January 31st, 2010, 3:49pm CST

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FDG PET/CT in aortic angiosarcoma.

Clin Nucl Med. 2010 Feb;35(2):134-7

Authors: Sibille L, Ilonca D, Oziol E, Gandilhon P, Micheau A, Vernhet-Kovacsik H, Pascal-Ortiz D

PMID: 20090470 [PubMed - in process]
Primary pleural epithelioid angiosarcoma. A case report and review of the literature.

Fetched: January 31st, 2010, 3:49pm CST

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Primary pleural epithelioid angiosarcoma. A case report and review of the literature.

Pathol Res Pract. 2010 Jan 18;

Authors: Dainese E, Pozzi B, Milani M, Rossi G, Grazia Pezzotta M, Vertemati G, Tricomi P, Sessa F

Malignant vascular tumors are uncommon sarcomas that arise from endothelial cells of small blood vessels and may affect every organ. Pleural localization is very exceptional, and only 48 cases have been reported in the English literature to date. Even if etiological factors implicated in the development of vascular sarcomas are still unclear, the strongest association with the disease was a history of chronic tuberculous pyothorax, observed only in Japanese patients, while prior radiotherapy and occupational exposure to asbestos have been reported in few Western cases. The mean age at diagnosis was 58 years, and the male to female ratio was 6:1. The overall prognosis was poor, and most of the patients died of disease soon after diagnosis. Histological features and clinical presentation often cause several problems in the differential diagnosis, particularly with mesothelioma and metastasis from poorly differentiated carcinomas. Immunohistochemistry plays an important role in identifying these rare entities, confirming the endothelial origin of the neoplasm with the expression of at least one of the vascular markers CD31, CD34, or factor VIII-related antigen. We report herein a further case of a 62-year-old man who presented with progressive dyspnea and bilateral massive hemothorax. The overall pathological and immunohistochemical features of the pleural specimens supported the diagnosis of epithelioid angiosarcoma.

PMID: 20089367 [PubMed - as supplied by publisher]
Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall.

Fetched: January 21st, 2010, 6:02pm CST

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Changing clinical presentation of angiosarcomas after breast cancer: from late tumors in edematous arms to earlier tumors on the thoracic wall.

Breast Cancer Res Treat. 2010 Jan 20;

Authors: Styring E, Fernebro J, Jönsson PE, Ehinger A, Engellau J, Rissler P, Rydholm A, Nilbert M, Vult von Steyern F

Angiosarcoma is a rare complication of breast cancer treatment. In order to define predictors, clinical presentation, and outcome, we characterized a population-based 50-year cohort of angiosarcomas after breast cancer. Clinical data were collected from all females with previous breast cancer who developed angiosarcomas/lymphangiosarcomas on the thoracic wall/upper extremity between 1958 and 2008 in the Southern Swedish health care region. In total, 31 angiosarcomas developed at a median age of 71 years. The patients formed two distinct groups; 14 females treated for breast cancer with radical mastectomy and radiotherapy 1949-1988 developed angiosarcomas in edematous arms (Stewart-Treves syndrome) after median 11 years, and 17 females treated by segmental resection, anti-hormonal treatment and radiotherapy 1980-2005 developed angiosarcomas in the irradiated field on the thoracic wall after median 7.3 years. The clinical presentations were heterogeneous and included hematoma-like lesions, multiple bluish-reddish nodules, and asymptomatic lumps. The overall 5-year survival was 16%. In this population-based cohort, the early angiosarcomas developed in edematous arms after radical mastectomies, whereas more recent cases occurred after a shorter time period in the irradiated fields following breast conserving surgery. We conclude that the clinical presentation of angiosarcomas has changed, parallel with altered treatment principles for breast cancer.

PMID: 20087653 [PubMed - as supplied by publisher]
Primary splenic angiosarcoma mimicking splenic lymphoma.

Fetched: January 20th, 2010, 9:02am CST

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Primary splenic angiosarcoma mimicking splenic lymphoma.

Intern Med. 2010;49(2):203-4

Authors: Suzuki K, Nakazato T, Mihara A, Sanada Y, Kakimoto T

PMID: 20075594 [PubMed - in process]
Primary spinal angiosarcoma.

Fetched: January 20th, 2010, 9:02am CST

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Primary spinal angiosarcoma.

J Clin Neurosci. 2010 Jan 12;

Authors: Liu ZH, Lee ST, Jung SM, Tu PH

Primary angiosarcoma of the spine is rare. To our knowledge, primary angiosarcoma in the posterior element of the spine has not been reported previously. A 39-year-old man suffered progressive numbness and paresis of the bilateral lower limbs. Neuroimaging showed a large dorsal extradural tumor compressing the spinal cord at the T11 level with bony destruction of the left foramen and posterior elements. Spinal angiography revealed a hypervascular tumor in the left T11 region. Successful preoperative endovascular embolization, laminectomy and removal of the tumor were performed.

PMID: 20074966 [PubMed - as supplied by publisher]
[Studies on claudins and prognostic factors in gastrointestinal diseases.]

Fetched: January 20th, 2010, 9:02am CST

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[Studies on claudins and prognostic factors in gastrointestinal diseases.]

Magy Onkol. 2009 Dec;53(4):377-83

Authors: Gyorffy H

Gastrointestinal tumors are highly ranked regarding tumoral mortality worldwide. The development and progression of gastrointestinal (GI) diseases go hand in hand with the changes of tight junctions (TJ). Claudins (CLDN) are the main TJ proteins, showing different expression by the different tissues, with the expressed CLDN profile being representative. I. We explored the changes of CLDN expression in Barrett's esophagus and related adenocarcinoma. CLDN2 and -3 expression in Barrett's esophagus was higher than in normal foveolar epithelium. Adenocarcinoma showed higher CLDN2 and -3 expression compared with normal and Barrett's epithelia. The similar CLDN expression profile of Barrett's esophagus and adenocarcinoma supports their sequential development. II. Gastric intestinal metaplasia showed higher expression of CLDN2, -3 and -4 as compared with normal antral foveolar mucosa. Tumors of small and large bowels exhibited higher CLDN2 expression when compared with normal epithelia. Colorectal adenoma and adenocarcinoma could not be differentiated according to their CLDN profile. Intestinal metaplasias of Barrett's esophagus and stomach show similar CLDN profile to small bowel epithelium. III. Studies on duodenal mucosa in celiac disease in childhood demonstrated CLDN2 and -3 expression to be higher than in normal mucosa. The expression was significantly higher in the distal part of the duodenum samples. This and the serious histological findings suggest that the distal duodenum is more adequate for biopsy testing. IV. Beside the epithelial cells, mesenchymal tumors express intercellular junctional proteins. Expression of claudins in gastrointestinal stromal tumors (GIST) and other mesenchymal neoplasia was also studied. The CLDN profile was found to be representative to the individual tumor. GIST, angiosarcoma, hemangioma, leiomyosarcoma and leiomyoma showed expression of various CLDNs. CLDN2 was detected in all entities. CLDN1, however, was found positive in leiomyosarcoma only. Leiomyoma, on the other hand, expressed only CLDN2. GISTs and leiomyosarcomas showed CLDN2, -3, -4, -5 and -7-expression. The angiogenic tumors revealed CLDN2 and -5 expression. The similar CLDN profile observable in GIST and leiomyosarcoma is suggestive of a histogenetic relationship. Smooth muscle and vessel tumors of different dignity could also be separated from each other based on CLDN profile.

PMID: 20071310 [PubMed - in process]
Cancer and non-cancer risks in normal and cancer-prone Trp53 heterozygous mice exposed to high-dose radiation.

Fetched: January 20th, 2010, 9:02am CST

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Cancer and non-cancer risks in normal and cancer-prone Trp53 heterozygous mice exposed to high-dose radiation.

Radiat Res. 2010 Jan;173(1):40-8

Authors: Carlisle SM, Burchart PA, Mitchel RE

This report tests the hypotheses that cancer proneness elevates risk from a high radiation exposure and that the risk response to high doses is qualitatively similar to that from low doses. Groups of about 170 female mice heterozygous for Trp53 (Trp53(+/-)) and their normal female littermates (Trp53(+/+)) were exposed at 7-8 weeks of age to (60)Co gamma-radiation doses of 0, 1, 2, 3 or 4 Gy at a high dose rate (0.5 Gy/min) or 4 Gy at a low dose rate (0.5 mGy/min). In the absence of radiation exposure, Trp53 heterozygosity reduced life span approximately equally for death from either cancer or non-cancer disease. Heterozygosity alone produced a 1.5-fold greater shortening of life span than a 4-Gy acute exposure. Per unit dose, life shortening from cancer or non-cancer disease was the same for normal mice and Trp53 heterozygous animals, indicating that, contrary to previous reports, Trp53 heterozygosity did not confer radiation sensitivity to high doses of gamma rays. In Trp53(+/-) mice with cancer, life shortening from acute doses up to 4 Gy was related to both increased tumor formation and decreased tumor latency. A similar tumor response was observed in normal mice, but only up to 2 Gy, indicating that above 2 Gy, normal Trp53 function protected against tumor initiation, and further life shortening reflected only decreased latency for cancer and non-cancer disease. Dose-rate reduction factors were 1.7-3.0 for both genotypes and all end points. We conclude that Trp53 gene function influences both cancer and non-cancer mortality in unexposed female mice and that Trp53-associated cancer proneness in vivo is not correlated with elevated radiation risk. Increased risk from high acute radiation doses contrasts with the decreased risk seen previously after low doses of radiation in both Trp53 normal and heterozygous female mice.

PMID: 20041758 [PubMed - indexed for MEDLINE]
CD10 is expressed in most epithelioid hemangioendotheliomas: a potential diagnostic pitfall.

Fetched: January 10th, 2010, 2:29pm CST

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CD10 is expressed in most epithelioid hemangioendotheliomas: a potential diagnostic pitfall.

Arch Pathol Lab Med. 2009 Dec;133(12):1965-8

Authors: Weinreb I, Cunningham KS, Perez-Ordoñez B, Hwang DM

CONTEXT: -Epithelioid hemangioendothelioma (EHE) is a vascular neoplasm that occasionally is difficult to distinguish from primary/metastatic carcinomas, particularly when EHEs express keratins. We recently encountered an EHE with strong CD10 positivity mimicking renal cell carcinoma. OBJECTIVE: -To examine sensitivity and specificity of CD10 in EHE. DESIGN: -Nine EHEs were stained with keratins, factor VIII, CD31, CD34, and CD10. Mimics of EHE were also retrieved and stained with CD10. RESULTS: -The EHE patients included 5 men and 4 women. Patients ranged in age from 24 to 74 years. Tumors were located in liver (3), skin (2), lung/pleura (2), and sternomastoid and mediastinum (1 each). Two had skin metastases. All EHEs were positive for vascular markers. A total of 7 of 9 primary tumors expressed cytoplasmic and intracytoplasmic luminal CD10. The 2 skin metastases were positive, whereas 2 primary skin EHEs were negative. Of the mimics, CD10 showed staining in 7 of 23 cases: 3 of 3 renal cell carcinomas, 1 of 7 other carcinomas, 2 of 3 epithelioid angiosarcomas, 1 of 3 melanomas, 0 of 3 mesotheliomas, and 0 of 4 epithelioid hemangiomas. CONCLUSIONS: -CD10 has a sensitivity of 78% (confidence interval, 63.6%-92.4%) and specificity of 70% (confidence interval, 54%-85.9%) for EHE. There is a growing list of tumors that show expression of CD10. Pathologists should be aware of this diagnostic pitfall.

PMID: 19961253 [PubMed - indexed for MEDLINE]
Managing malignant disease in dogs.

Fetched: January 10th, 2010, 2:29pm CST

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Managing malignant disease in dogs.

Vet Rec. 2009 Nov 7;165(19):576

Authors: Polton G

PMID: 19897876 [PubMed - indexed for MEDLINE]
Postradiation cutaneous vascular tumors of the breast: a review.

Fetched: January 3rd, 2010, 8:22pm CST

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Postradiation cutaneous vascular tumors of the breast: a review.

Semin Diagn Pathol. 2009 Aug;26(3):141-9

Authors: Weaver J, Billings SD

Postradiation vascular tumors fall into two categories: (1) postradiation cutaneous angiosarcoma, malignant vascular neoplasms with significant morbidity and mortality; and (2) atypical vascular lesions (AVL), vascular tumors that reportedly behave in a benign manner. Postradiation vascular tumors not only present a therapeutic problem for clinicians, but they present an increasingly common diagnostic dilemma for pathologists. Although first described separately 15 years ago, the relationship between postradiation cutaneous angiosarcoma and AVL remains controversial. It appears that, in at least some cases, angiosarcoma can arise in the context of AVL, suggesting that these lesions are part of a spectrum of the same disease process. This latter view point is supported by the significant clinical and histologic overlap found between both tumors. Herein, we will discuss the evolution of this topic while reviewing the various clinical, histopathologic, and prognostic characteristics of postradiation cutaneous angiosarcoma and AVL.

PMID: 20043513 [PubMed - in process]
Intraoral epithelioid hemangioendothelioma: a case report and review of the literature.

Fetched: January 1st, 2010, 4:55pm CST

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Intraoral epithelioid hemangioendothelioma: a case report and review of the literature.

Med Oral Patol Oral Cir Bucal. 2009 Dec 29;

Authors: Gordón-Núñez MA, Silva LM, Lopes MF, Neto SF, Maia AP, Galvao HC

The epithelioid hemangioendothelioma (EH) is an uncommon angiocentric neoplasm of borderline or intermediate malignant potential, between the hemangioma and conventional angiosarcoma. It is characterized by the proliferation of endothelial cells with epithelioid or histiocitóide morphology with vacuolated cytoplasm and occasional eosinophilic spindle cells. Shows potential for local recurrence as well as the ability to metastasize. Rarely affects the oral cavity, it have been described from 1975 until 2008 only 27 oral cases. Morphologically the EHs may be confused with other lesions, from a hemangioma to a squamous cell carcinoma, and thus immunohistochemical analysis is required. This paper reports the clinical and immunohistochemical characteristics of a case of EH in the gingiva of the tooth 35 of a 17 years-old-white-female. We present a review of the clinicopathological and immunohistochemical characteristics of the intraoral epithelioid hemangioendothelioma cases previously reported.

PMID: 20038915 [PubMed - as supplied by publisher]
Application of immunocytochemistry to the diagnosis of primary epithelioid angiosarcoma of the lung.

Fetched: December 27th, 2009, 9:49am CST

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Application of immunocytochemistry to the diagnosis of primary epithelioid angiosarcoma of the lung.

Med Mol Morphol. 2009 Dec;42(4):250-3

Authors: Kuroda N, Hamaguchi N, Inoue K, Ohara M, Mizuno K, Hayashi Y, Lee GH

Pulmonary epithelioid angiosarcoma is rare, and there are no descriptions of the immunocytochemistry of such a case. We report a case with focus on immunocytochemistry of imprint cytological specimens here. A 43-year-old Japanese man presented with cough. Brushing cytology of the tumor using a bronchoscope showed a malignant neoplasm. Subsequently, left lower lobectomy was undertaken. Imprint cytological material of the neoplastic cells noted some clusters of round, or oval, to polygonal epithelioid cells. Histological examination showed the proliferation of epithelioid neoplastic cells containing erythrocytes in the cytoplasm. The immunocytochemistry in imprint cytological specimens showed a focal positive reaction for von Willebrand factor, and the immunohistochemistry of the surgically resected lung tumor showed a focal positive reaction for Fli-1, von Willebrand factor, CD31, and CD34. Finally, we suggest that the immunocytochemical study of imprint cytological materials may supply available information in diagnosing angiosarcoma with epithelioid features lacking characteristic structures.

PMID: 20033373 [PubMed - in process]
Complete remission in a patient with multifocal metastatic cutaneous angiosarcoma with a combination of paclitaxel and sorafenib.

Fetched: December 27th, 2009, 9:49am CST

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Complete remission in a patient with multifocal metastatic cutaneous angiosarcoma with a combination of paclitaxel and sorafenib.

Br J Dermatol. 2009 Dec 21;

Authors: Donghi D, Dummer R, Cozzio A

PMID: 20030640 [PubMed - as supplied by publisher]
New CD3zeta allele showing a 9-bp deletion in the 3'-UT region of the gene.

Fetched: December 27th, 2009, 9:49am CST

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New CD3zeta allele showing a 9-bp deletion in the 3'-UT region of the gene.

Tissue Antigens. 2009 Oct;74(4):356-7

Authors: Aguinaga-Barrilero A, Rodríguez-Pérez N, Pérez-Blas M, Gutiérrez-Calvo A, Martín-Villa JM

We report here a non-previously described 9-bp deletion in the 3'-UT region of the CD3zeta gene, located in between two AREs.

PMID: 19775377 [PubMed - indexed for MEDLINE]
Atypical presentation of angiosarcoma of the scalp in the setting of Human Immunodeficiency Virus (HIV).

Fetched: December 22nd, 2009, 8:01am CST

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Atypical presentation of angiosarcoma of the scalp in the setting of Human Immunodeficiency Virus (HIV).

World J Surg Oncol. 2009 Dec 18;7(1):99

Authors: Govender PS

ABSTRACT: BACKGROUND: Angiosarcoma of the head and neck is an uncommon, aggressive malignant entity most commonly found in elderly Caucasian males. We present a case in a young black female with co-existing HIV. The atypical gender, age and race of the patient reflect the unusual clinical presentation of this case of angiosarcoma, attributable to the patient's HIV status. CASE PRESENTATION: A 22 year old patient presented with a large unresectable lesion over the occiput with surrounding ulceration, satellite lesions and associated lymphadenopathy. She is HIV-infected with a CD4 count of 360 cells/ul. She was not on antiretroviral treatment based on South African treatment guidelines advocating antiretroviral treatment when the CD4 count is below 200 cells /ul, in the absence of other AIDS-defining illnesses. The patient was treated with a course of ifosfamide and anthracyline based chemotherapy. Disease progression was noted on chemotherapy and she was subsequently palliated with a course of radiotherapy. She had a satisfactory response with an improvement in local symptoms. She is currently receiving symptomatic care. CONCLUSIONS: South Africa is at the epicenter of the HIV epidemic. Consequently, the management of patients in the field of oncology in our clinical practice is often burdened with malignancies manifesting with an atypical disease presentation and clinical course.

PMID: 20021674 [PubMed - as supplied by publisher]
[Diethylnitrosamine-induced carcinogenesis in PARP-1(-/-) and PARP-1(+/+) mice]

Fetched: December 22nd, 2009, 8:01am CST

[Diethylnitrosamine-induced carcinogenesis in PARP-1(-/-) and PARP-1(+/+) mice]

Vopr Onkol. 2009;55(5):608-11

Authors:

Our study is concerned with comparative analysis of diethylnitrosamine (DENA)-induced carcinogenesis in PARP-1 knock-out female mice PARP-1(-/-) and wild type animals PARP-1(+/+). No difference was recorded in relation to total tumor incidence (88 and 95%, respectively): cardia (87 and 84%, respectively), liver (80 and 66%, respectively). However, experimental animals PARP-1(-/-) tended to reveal incidence of cardia tumors with invasion as deep as the serosa higher than in PARP-1(+/+) mice (100 and 81%, respectively) and metastases to the liver and lung--27 and 7%, respectively. Relative incidence of angiosarcoma and holangiocarcinoma among liver tumors from PARP-1(-/-) mice was higher than that in wild type mice. Hence DENA induced the most aggressive tumors in PARP-1(-/-) knockout mice more often than in PARP-1(+/+) ones. Our results confirm the significance of the role of DNA repair in carcinogenesis.

PMID: 20020658 [PubMed - in process]
Postirradiation sarcoma: clinicopathologic features and role of chemotherapy in the treatment strategy.

Fetched: December 22nd, 2009, 8:01am CST

Postirradiation sarcoma: clinicopathologic features and role of chemotherapy in the treatment strategy.

Sarcoma. 2009;2009:764379

Authors: des Guetz G, Chapelier A, Mosseri V, Dorval T, Asselain B, Pouillart P

Purpose. An analysis of the clinicopathologic features and treatment of patients was performed to guide evaluation and management of postirradiation sarcoma. Patients and Methods. Between 1994 and 2001, 25 patients with postirradiation sarcoma were treated in one center with different chemotherapy, mainly in neoadjuvant setting (19). Tumors for which these patients received radiotherapy initially were mainly breast carcinoma (for 15 patients). The postirradiation sarcomas were of different histopathologic forms, most frequently osteosarcoma, leiomyosarcoma, and angiosarcoma. Results. Of the 25 patients, 19 were initially treated with chemotherapy. Nine of 19 pretreated patients achieved clinical partial response (RP = 47%). Leiomyosarcomas were good responders (3/4) and undifferentiated sarcoma (3/5). Responders were more often treated with MAID (6/8). Eight of the 9 responders underwent surgery. Two patients achieved complete histological response. Seven of the 9 good responders are alive with a median follow up of 24 months. For all treated patients, median follow up 24 months (6-84 months), overall survival and disease free survival were, respectively, 17/25 (68%), and 14/25 (56%). Conclusion. From our data, postirradiation sarcoma should not be managed differently from primary sarcoma. Chemotherapy has to be included in the treatment plan of postirradiation sarcoma, in future studies.

PMID: 20011664 [PubMed - in process]
Cutaneous Metastases of Malignant Melanoma: A Clinicopathologic Study of 192 Cases With Emphasis on the Morphologic Spectrum.

Fetched: December 22nd, 2009, 8:01am CST

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Cutaneous Metastases of Malignant Melanoma: A Clinicopathologic Study of 192 Cases With Emphasis on the Morphologic Spectrum.

Am J Dermatopathol. 2009 Dec 14;

Authors: Plaza JA, Torres-Cabala C, Evans H, Diwan HA, Suster S, Prieto VG

Metastatic melanoma represents one of the most common types of cutaneous metastases. In up to 5% of patients, metastatic melanoma can be the first manifestation of the disease. For the most part, the histologic diagnosis of metastatic melanoma poses little diagnostic difficulty; however, some metastases may adopt unusual or unfamiliar appearances mimicking other benign and malignant conditions. We present a study of 192 cases of cutaneous metastatic melanomas with special emphasis on their spectrum of morphologic features. The patients were 115 men and 77 women, 23-91 years of age (mean 57 years). Most tumors were located on the proximal legs, scalp, and arms and ranged from 0.8 to 3.0 cm. One hundred ten cases showed the classic morphologic appearance of melanoma (well-circumscribed epithelioid dermal/subcutaneous nodule), 82 cases showed unusual histologic appearances that mimicked other benign and malignant neoplasms. In 16 patients (8.3%), there was no evidence of primary melanoma and the cutaneous metastasis was the only manifestation of the disease. The histologic diagnosis of cutaneous metastatic melanoma can pose difficulties for diagnosis, especially in the face of an unknown primary neoplasm. Unusual features observed in this series included examples of cutaneous metastatic melanoma that closely simulated metastatic carcinoma, dermatofibroma, leiomyosarcoma, angiosarcoma, nevoid melanoma, halo nevus, blue nevi, and atypical fibroxanthoma. Several cases also showed rhabdoid, balloon cell, and alveolar features. Immunohistochemical stains plus careful clinical history helped to establish the correct diagnosis. Our series illustrates that the differential diagnosis of cutaneous metastatic melanoma can be broad and difficult. To the best of our knowledge, this is the largest series of cutaneous metastatic melanomas reported in the literature.

PMID: 20010406 [PubMed - as supplied by publisher]
Innominate artery aneurysm as presentation of angiosarcoma.

Fetched: December 22nd, 2009, 8:01am CST

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Innominate artery aneurysm as presentation of angiosarcoma.

Surgery. 2009 Dec 8;

Authors: Lu CY, Lu MS, Huang YK, Tsai FC, Lin PJ

PMID: 20004433 [PubMed - as supplied by publisher]
4.7 Biological modeling as a method for data evaluation and integration in toxicology.

Fetched: December 22nd, 2009, 8:01am CST

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4.7 Biological modeling as a method for data evaluation and integration in toxicology.

Hum Exp Toxicol. 2009 Feb;28(2-3):143-5

Authors: Barton HA

PMID: 19713382 [PubMed - indexed for MEDLINE]
An interesting case--not an innocent haematoma!

Fetched: December 22nd, 2009, 8:01am CST

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An interesting case--not an innocent haematoma!

Br J Oral Maxillofac Surg. 2009 Sep;47(6):499

Authors: Bhatia S, Thomas CV, Hodder SC

PMID: 19697456 [PubMed - indexed for MEDLINE]
A retrospective study of eyelid tumors from 43 cats.

Fetched: December 22nd, 2009, 8:01am CST

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A retrospective study of eyelid tumors from 43 cats.

Vet Pathol. 2009 Sep;46(5):916-27

Authors: Newkirk KM, Rohrbach BW

Submissions to the University of Tennessee pathology service from June 1999 to June 2008 were searched for feline cases of tumors involving the eyelids or nictitans. Forty-three tumors were identified. The average age at diagnosis was 10.4 years. Significantly more males than females had eyelid tumors. There were 12 squamous cell carcinomas (SCCs), 11 mast cell tumors (MCTs), 6 hemangiosarcomas (HSAs), 4 adenocarcinomas (ACAs), 3 peripheral nerve sheath tumors (PNSTs), 3 lymphomas, 3 apocrine hidrocystomas (AHCs), and 2 hemangiomas. Cats with MCTs were significantly younger than cats with all other tumor types combined. In contrast, cats with SCCs were significantly older than cats with other tumor types. The HSAs and SCCs were significantly more likely than other tumors to occur in nonpigmented areas. The MCTs, HSAs, AHCs, and hemangiomas did not recur after surgical excision. In contrast, the lymphomas, ACAs, SCCs, and PNSTs frequently recurred and/or resulted in death or euthanasia of the cat. The SCCs were significantly more likely to recur than the MCTs. The average survival time for cats with SCCs was 7.4 months. Although eyelid MCTs have been reported in cats, the prevalence in this study is much higher than previously described.

PMID: 19429997 [PubMed - indexed for MEDLINE]
Bilateral angiosarcoma of the breast detected by magnetic resonance imaging during pregnancy.

Fetched: December 9th, 2009, 7:36am CST

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Bilateral angiosarcoma of the breast detected by magnetic resonance imaging during pregnancy.

Int J Clin Oncol. 2009 Dec;14(6):560-3

Authors: Fujita T, Taira N, Ogasawara Y, Omori M, Doihara H

Angiosarcoma of the breast is an aggressive malignancy of endothelial origin with a tendency for localregional recurrence. The involvement of angiosarcomas in the bilateral breasts has rarely been documented. Of note, due to its rarity and typically unclear clinical findings upon examination, the diagnosis of a contralateral lesion can be difficult, particularly in women during pregnancy. Here we present a rare case of bilateral angiosarcoma of the breast during pregnancy. A 32-year-old woman was referred to our unit with complaints of progressive swelling of the left breast, with tenderness. Magnetic resonance imaging showed a small, circumscribed high-intensity area in the contralateral breast, with pattern similar to that of the lesion found in the left breast. The contralateral lesion revealed only equivocal findings with the other diagnostic modalities. Diagnosed as angiosarcoma preoperatively, excision of the bilateral tumors was performed. Histological findings of the removed bilateral tumors were compatible with high-grade angiosarcoma of the breast.

PMID: 19967497 [PubMed - in process]
The Adrenal Mass: Correlation of Histopathology with Imaging.

Fetched: December 9th, 2009, 7:36am CST

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The Adrenal Mass: Correlation of Histopathology with Imaging.

Ann Surg Oncol. 2009 Dec 4;

Authors: Yip L, Tublin ME, Falcone JA, Nordman CR, Stang MT, Ogilvie JB, Carty SE, Yim JH

BACKGROUND: Computed tomography (CT) and magnetic resonance (MR) imaging can help diagnose benign adrenal adenomas, but prior studies rely on nonoperative follow-up as proof of a lesion's benign nature. We examined adrenalectomy tissues to determine if imaging characteristics correlate with histopathologic findings. METHODS: We retrieved data for 196 consecutive adrenalectomies in 192 patients from 2000 to 2008. Imaging results were considered to signify benign adrenal adenoma if one or more of the following was present: Hounsfield units <10 on unenhanced CT, contrast-enhanced CT quantifying absolute contrast washout of >60% or relative contrast washout of >40%, or MR with chemical-shift imaging demonstrating loss of signal intensity on out-of-phase images. RESULTS: The sensitivity and specificity of preoperative imaging in predicting benign adrenal adenoma were 57 and 94%, respectively. Histopathology confirmed that all 66 adrenal masses with imaging characteristics suggesting benign adenoma were indeed benign lesions and included 61 benign adrenal adenomas and 5 benign nonadenomatous lesions (3 myelolipomas, 1 composite myelolipoma/adenoma, and 1 ganglioliponeuroma). The specificity of imaging in predicting benignity was 100%. Malignant adrenal lesions were diagnosed in 17/130 (13%) masses: 8 metastases, 7 adrenal cortical carcinomas, 1 epithelioid angiosarcoma, and 1 ganglioneuroblastoma. The sensitivity of imaging in identifying malignancy was 100%. No malignancies were diagnosed during postoperative follow-up (mean 6 months, range 0.2-67 months). CONCLUSION: CT or MR characteristics predicted the presence of benign lesions with 100% specificity. Every adrenal malignancy had CT or MR results that were inconsistent with benign adenoma (100% sensitivity). To exclude malignancy, adrenal masses with non-benign imaging characteristics should be resected.

PMID: 19960266 [PubMed - as supplied by publisher]
The use of multizone models to estimate an airborne chemical contaminant generation and decay profile: occupational exposures of hairdressers to vinyl chloride in hairspray during the 1960s and 1970s.

Fetched: December 9th, 2009, 7:36am CST

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The use of multizone models to estimate an airborne chemical contaminant generation and decay profile: occupational exposures of hairdressers to vinyl chloride in hairspray during the 1960s and 1970s.

Risk Anal. 2009 Dec;29(12):1699-725

Authors: Sahmel J, Unice K, Scott P, Cowan D, Paustenbach D

Vinyl chloride (VC) was used as a propellant in a limited percentage of aerosol hairspray products in the United States from approximately 1967 to 1973. The question has arisen whether occupational exposures of hairdressers to VC-containing hairsprays in hair salons were sufficient to increase the risk for developing hepatic angiosarcoma (HAS). Transient two-zone and steady-state three-zone models were used to estimate the historical airborne concentration of VC for individual hairdressers using hairspray as well as estimated contributions from other hairdressers in the same salon. Concentrations of VC were modeled for small, medium, and large salons, as well as a representative home salon. Model inputs were determined using published literature, and variability in these inputs was also considered using Monte Carlo techniques. The 95th percentile for the daily time-weighted average exposure for small, medium, and large salons, assuming a market-share fraction of VC-containing hairspray use from the Monte Carlo analysis, was about 0.3 ppm, and for the home salon scenario was 0.1 ppm. The 95th percentile value for the cumulative lifetime exposure of the hairdressers was 2.8 ppm-years for the home salon scenario and 2.0 ppm-years for the small, medium, and large salon scenarios. If using the assumption that all hairsprays used in a salon contained VC, the 95th percentile of the theoretical lifetime cumulative dose was estimated to be 52-79 ppm-years. Estimated lifetime doses were all below the threshold dose for HAS of about 300 to 500 ppm-years reported in the published epidemiology literature.

PMID: 19948002 [PubMed - in process]
Late recurrent hemarthrosis following knee arthroplasty associated with epithelioid angiosarcoma of bone.

Fetched: December 9th, 2009, 7:36am CST

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Late recurrent hemarthrosis following knee arthroplasty associated with epithelioid angiosarcoma of bone.

Knee. 2009 Nov 26;

Authors: Drexler M, Dolkart O, Amar E, Pritsch T, Dekel S

We report a case of recurrent hemarthrosis 1year following total knee arthroplasty in a patient with no bleeding diathesis, the hemarthrosis was found to be related to, and led to the diagnosis of high grade sarcoma of the proximal tibia. Twenty five years earlier, he sustained a lateral tibial plateau fracture and was treated with open reduction and plating. Sarcoma developing in association with a metallic orthopedic prosthesis or hardware is an uncommon, but well-recognized complication. Sarcomas that occur adjacent to orthopaedic prostheses or hardware are of varied types, but are usually osteosarcoma or malignant fibrous histiocytoma.

PMID: 19945286 [PubMed - as supplied by publisher]
Metastatic angiosarcoma of the lung with alveolar hemorrhage.

Fetched: December 9th, 2009, 7:36am CST

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Metastatic angiosarcoma of the lung with alveolar hemorrhage.

Jpn J Radiol. 2009 Nov;27(9):381-4

Authors: Saitoh J, Sakurai H, Suzuki Y, Katoh H, Takahashi T, Nakano T

A case of metastatic angiosarcoma of the lung with alveolar hemorrhage was experienced. A 76-year-old woman was diagnosed as stage IIb uterine cervical cancer. The cancer disappeared after radiotherapy. Five years later, she was readmitted because of severe pain around the right hip joint. Fracture of the neck of the right femur was found on roentgenogram. On chest CT and roentgenogram, spotted or restiform shadows with uncertain margins were found in the peripheral regions of the bilateral lung field. The lesions reached just underneath the pleura, and interstitial shadows such as ground-glass-like shadows and thickening of the interlobular walls were also found. These lesions were rapidly aggravated in the course of 1-2 weeks. She died after a short period of hospitalization (2 months) with pathological fracture. In autopsy, metastases of the tumor were found to bones, lungs, heart, and other organs that mainly occurred hematogenously. No recurrence of the uterine cervical cancer was detected. Tumor cells were polymorphic or ovoid, and occurred scattered individually or showed growth-forming small aggregates. By immunohistochemical staining, CD31, CD34 and Factor VIII were found to be positive, and the tumor was diagnosed as epithelioid angiosarcoma. The main findings in the lungs were intraalveolar hemorrhage consequent to tumor embolization.

PMID: 19943151 [PubMed - in process]
Primary right atrial angiosarcoma: atypical presentation and echocardiographic assessment of right atrial mass.

Fetched: November 27th, 2009, 11:17am CST

Primary right atrial angiosarcoma: atypical presentation and echocardiographic assessment of right atrial mass.

Echocardiography. 2009 Nov;26(10):1276-7

Authors: Sidhu MS, Singh HP, Chopra AK, Kapila D, Chopra S, Anand M

PMID: 19929874 [PubMed - in process]
Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis.

Fetched: November 27th, 2009, 11:17am CST

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Hemangiomas, angiosarcomas, and vascular malformations represent the signaling abnormalities of pathogenic angiogenesis.

Curr Mol Med. 2009 Nov;9(8):929-34

Authors: Arbiser JL, Bonner MY, Berrios RL

Angiogenesis is a major factor in the development of benign, inflammatory, and malignant processes of the skin. Endothelial cells are the effector cells of angiogenesis, and understanding their response to growth factors and inhibitors is critical to understanding the pathogenesis and treatment of skin disease. Hemangiomas, benign tumors of endothelial cells, represent the most common tumor of childhood. In our previous studies, we have found that tumor vasculature in human solid tumors expresses similarities in signaling to that of hemangiomas, making the knowledge of signaling in hemangiomas widely applicable. These similarities include expression of reactive oxygen, NFkB and akt in tumor vasculature. Furthermore, we have studied malignant vascular tumors, including hemangioendothelioma and angiosarcoma and have shown distinct signaling abnormalities in these tumors. The incidence of these tumors is expected to rise due to environmental insults, such as radiation and lumpectomy for breast cancer, dietary and industrial carcinogens (hepatic angiosarcoma), and chronic ultraviolet exposure and potential Agent Orange exposure. I hypothesize that hemangiomas, angiosarcomas, and vascular malformations represent the extremes of signaling abnormalities seen in pathogenic angiogenesis.

PMID: 19925405 [PubMed - in process]
Histological type of Thorotrast-induced liver tumors associated with the translocation of deposited radionuclides.

Fetched: November 27th, 2009, 11:17am CST

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Histological type of Thorotrast-induced liver tumors associated with the translocation of deposited radionuclides.

Cancer Sci. 2009 Oct 12;

Authors: Yamamoto Y, Chikawa J, Uegaki Y, Usuda N, Kuwahara Y, Fukumoto M

Exposure to internally deposited radionuclides is known to induce malignant tumors of various histological types. Thorotrast, a colloidal suspension of radioactive Thorium dioxide ((232)ThO(2)) that emits alpha-particles, was used as a radiographic contrast during World War II. Thorotrast is known to induce liver tumors, particularly intrahepatic cholangiocarcinoma (ICC) and angiosarcoma (AS), decades after injection. Therefore, patients injected with Thorotrast comprise a suitable study group to understand biological effects of internal ionizing radiation injury. Autoradiography and X-ray fluorescence spectrometry (XRF) were carried out on non-tumorous liver sections from Thorotrast-induced ICC (T-ICC) and Thorotrast-induced AS (T-AS). Autoradiography revealed that the slope of the regression line of the number of alpha tracks for the amount of deposited Thorium ((232)Th) was higher in non-tumorous parts of the liver with T-ICC than those with T-AS. XRF showed that the intensity ratio of Radium (Ra) to Thorium (Th) in non-tumorous liver tissue with T-ICC was significantly higher than that with T-AS. Furthermore, the mean (228)Ra/(232)Th radioactivity ratio at the time of death calculated was also significantly higher in T-ICC cases than in T-AS cases. These suggest that the metabolic behavior of radionuclides such as relocation and excretion, as well as the content of deposited radionuclides, is a major factor in determining the histological type of Thorotrast-induced liver tumors. (Cancer Sci 2009).

PMID: 19917057 [PubMed - as supplied by publisher]
A case report of primary gingival angiosarcoma.

Fetched: November 27th, 2009, 11:17am CST

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A case report of primary gingival angiosarcoma.

Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2009 Dec;108(6):e17-21

Authors: Uchiyama Y, Murakami S, Kishino M, Furukawa S

Angiosarcoma is a rare malignant neoplasm and primary angiosarcoma is extremely rare. This study reports clinico-pathological features and CT image finding of a case of primary angiosarcoma in the upper gingival and a review of previously reported cases of primary gingival angiosarcomas including the present case.

PMID: 19913715 [PubMed - in process]
Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face.

Fetched: November 27th, 2009, 11:17am CST

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Autocrine and paracrine roles of VEGF/VEGFR-2 and VEGF-C/VEGFR-3 signaling in angiosarcomas of the scalp and face.

Hum Pathol. 2009 Nov 12;

Authors: Tokuyama W, Mikami T, Masuzawa M, Okayasu I

Angiosarcoma of the skin is an extremely rare malignant tumor of vascular origin that usually arises in the scalp and face of elderly persons. To clarify its characteristic features and cell cycle kinetics, we quantitatively evaluated the expression of cell cycle-related molecules and vascular endothelial growth factors using immunohistochemical staining, for comparison with 2 benign vascular tumors of the skin, the capillary hemangioma and the cavernous hemangioma. Cell proliferation, determined with reference to the Ki-67 labeling index, was highest in angiosarcomas and lowest in cavernous hemangiomas (angiosarcomas versus capillary hemangioma, P = .014; capillary hemangioma versus cavernous hemangiomas, P = 1.4 x 10(-4)). Similar differences were also found in cyclin A, cyclin E, and p21(Waf1) expression. Expressions of cyclin D1 and p16(INK4A) were also significantly higher in angiosarcoma than in cavernous hemangioma. Expressions of these 5 proteins showed significant positive correlations with Ki-67 labeling indices (Spearman rho = 0.91-0.43). Expression levels of vascular endothelial growth factor and its receptor, VEGFR-2, were highest in angiosarcomas. VEGF-C expression in angiosarcomas was significantly higher than in cavernous hemangiomas, and its receptor VEGFR-3 expression was highest in angiosarcomas. Furthermore, significant positive correlations of these protein expression with Ki-67 labeling indices were noted (Spearman rho = 0.88-0.40). Among them, VEGFR-3 showed the highest correlation coefficient. These results suggest that not only VEGFR-2-mediated signal but also VEGFR-3-mediated signal may contribute to proliferation of vascular tumor cells as autocrine and paracrine signaling factors.

PMID: 19913279 [PubMed - as supplied by publisher]
Transient response of cardiac angiosarcoma to paclitaxel.

Fetched: November 27th, 2009, 11:17am CST

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Transient response of cardiac angiosarcoma to paclitaxel.

Eur J Cancer Care (Engl). 2009 Nov 11;

Authors: Castilla E, Pascual I, Roncalés F, Aguirre E, Del Río A

CASTILLA E., PASCUAL I., RONCALES F., AGUIRRE E. & RIO A. DEL (2009) European Journal of Cancer Care Transient response of cardiac angiosarcoma to paclitaxelMalignant tumours of the heart are a group of tumours with low incidence but very high mortality. Delays in diagnosis are common because of their multiple forms of presentation, and 80% present with metastases, further reducing the possibility for cure. We present here the case of a patient with primary cardiac angiosarcoma that highlights the misdiagnosis at clinical presentation, current diagnostic modalities and a possible new treatment using paclitaxel for cardiac angiosarcoma.

PMID: 19912298 [PubMed - as supplied by publisher]
Soft tissue sarcomas with complex genomic profiles.

Fetched: November 27th, 2009, 11:17am CST

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Soft tissue sarcomas with complex genomic profiles.

Virchows Arch. 2009 Nov 13;

Authors: Guillou L, Aurias A

Soft tissue sarcomas (STS) with complex genomic profiles (50% of all STS) are predominantly composed of spindle cell/pleomorphic sarcomas, including leiomyosarcoma, myxofibrosarcoma, pleomorphic liposarcoma, pleomorphic rhabdomyosarcoma, malignant peripheral nerve sheath tumor, angiosarcoma, extraskeletal osteosarcoma, and spindle cell/pleomorphic unclassified sarcoma (previously called spindle cell/pleomorphic malignant fibrous histiocytoma). These neoplasms show, characteristically, gains and losses of numerous chromosomes or chromosome regions, as well as amplifications. Many of them share recurrent aberrations (e.g., gain of 5p13-p15) that seem to play a significant role in tumor progression and/or metastatic dissemination. In this paper, we review the cytogenetic, molecular genetic, and clinicopathologic characteristics of the most common STS displaying complex genomic profiles. Features of diagnostic or prognostic relevance will be discussed when needed.

PMID: 19911195 [PubMed - as supplied by publisher]
Toxicant-associated steatohepatitis in vinyl chloride workers.

Fetched: November 27th, 2009, 11:17am CST

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Toxicant-associated steatohepatitis in vinyl chloride workers.

Hepatology. 2009 Nov 9;

Authors: Cave M, Falkner KC, Ray M, Joshi-Barve S, Brock G, Khan R, Bon Homme M, McClain CJ

Although nonalcoholic steatohepatitis (NASH) is typically associated with obesity, it has also been reported to occur in lean individuals exposed to industrial chemicals. Occupational exposure to vinyl chloride (VC) is a well-documented risk factor for hemangiosarcoma, but has not previously been associated with steatohepatitis. Here we evaluate liver biopsies from 25 nonobese, highly exposed VC workers for steatohepatitis. Next, we evaluate associated metabolic and cytokine abnormalities in affected workers controlled by 26 chemical workers with no to minimal VC exposures, and 11 unexposed, healthy volunteers. Among highly exposed VC workers the prevalence of steatohepatitis was 80%. Of these, 55% had fibrosis and four had hemangiosarcoma. We have coined the term toxicant-associated steatohepatitis (TASH) to describe this condition, which was not explained by obesity or alcohol. Although mean serum transaminases were normal in TASH, total cytokeratin 18, but not the caspase-cleaved fragment, was elevated. Despite the absence of obesity, workers with TASH had insulin resistance with reduced adiponectin levels. TASH was also associated with markedly elevated serum tumor necrosis factor alpha and interleukins 1beta, 6, and 8. Serum antioxidant activity was reduced in TASH. Conclusion: TASH occurred frequently in these nonobese VC workers with high cumulative exposures and normal liver enzymes. Elevated total cytokeratin 18 suggested the presence of necrotic cell death in TASH and may be a useful serologic biomarker. TASH was further characterized by insulin resistance, elevated proinflammatory cytokines, and impaired antioxidant defenses. The threshold VC exposure and the role of other chemical agents in TASH are as yet unknown. (HEPATOLOGY 2009.).

PMID: 19902480 [PubMed - as supplied by publisher]
Prostate cancer invading the rectum: a clinicopathological study of 18 cases.

Fetched: November 27th, 2009, 11:17am CST

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Prostate cancer invading the rectum: a clinicopathological study of 18 cases.

Pathology. 2009;41(6):539-43

Authors: Guo CC, Pisters LL, Troncoso P

AIMS: Prostate cancer may involve the rectum and cause severe perineal pain. The aim of this study was to understand the rectal involvement by prostate cancer and its clinical significance. METHODS: We evaluated pathological and clinical features of 18 cases of prostate cancer with rectal involvement. RESULTS: All patients presented with intractable perineal pain. Twelve patients received rectal biopsies, which revealed poorly differentiated prostatic adenocarcinoma (n = 6), squamous cell carcinoma (n = 3), angiosarcoma (n = 1), or no tumour (n = 2). All patients received palliative total pelvic exenteration, which demonstrated prostate cancer invading the rectal wall. In these resection specimens, the tumour consisted of poorly differentiated prostatic adenocarcinoma (n = 16), squamous cell carcinoma (n = 1), or angiosarcoma (n = 1). In addition, six cases of prostatic adenocarcinomas also showed focal squamous (n = 3) or high-grade neuroendocrine (n = 3) differentiation. Nine patients died at a mean time of 18 months (range, 2-69 months) after surgery. The remaining nine patients were alive with a mean follow-up time of 15 months (range, 3-34 months), but four patients developed distant metastases. CONCLUSIONS: Prostate cancer with rectal involvement often develops heterogeneous differentiation and carries a dismal prognosis.

PMID: 19900102 [PubMed - in process]
[Pulmonary metastatic angiosarcoma]

Fetched: November 27th, 2009, 11:17am CST

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[Pulmonary metastatic angiosarcoma]

Rev Prat. 2009 Oct 20;59(8):1047

Authors: Canler J, Couraud S, Etienne-Mastroïanni B, Girard N, Benabidallah S, Cordier JF

PMID: 19894437 [PubMed - in process]
Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion.

Fetched: November 27th, 2009, 11:17am CST

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Angiosarcoma, radiation-associated angiosarcoma, and atypical vascular lesion.

Arch Pathol Lab Med. 2009 Nov;133(11):1804-9

Authors: Lucas DR

Angiosarcoma, one of the least common sarcomas, has become increasingly important because of its association with radiation therapy, especially for breast cancer. Most are sporadic, presenting as cutaneous tumors in the scalp/face of elderly patients. However, angiosarcoma has a wide anatomic distribution including soft tissue, visceral organ, and osseous locations. Predisposing conditions include environmental exposures to chemical or radioactive sources. Radiation-associated angiosarcoma typically presents as a cutaneous tumor several years posttherapy. The latency for radiation-associated mammary angiosarcoma is relatively short, sometimes less than 3 years. Atypical vascular lesion refers to a small, usually lymphatic-type vascular proliferation in radiated skin. Although most atypical vascular lesions pursue a benign course, they recur and very rarely progress to angiosarcoma. Distinguishing this lesion from well-differentiated angiosarcoma in a biopsy can be challenging, especially because areas indistinguishable from atypical vascular lesion are found adjacent to angiosarcoma. Recently, vascular-type atypical vascular lesion, which resembles hemangioma, has been described, thus expanding the definition of this entity.

PMID: 19886715 [PubMed - indexed for MEDLINE]
Angiosarcoma of the scalp.

Fetched: November 27th, 2009, 11:17am CST

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Angiosarcoma of the scalp.

Indian J Plast Surg. 2009 Jan-Jun;42(1):118-21

Authors: Gupta MD, Chakrabarti N, Agrawal P, Narurkar S

Angiosarcoma is a relatively rare soft tissue tumour. It usually occurs in the head and neck, and especially in the scalp, in elderly people. Its presentation varies from a small plaque to multifocal nodules. The treatment depends on the extent of the disease. Most cases are treated with wide excision with reconstruction. Radiotherapy and chemotherapy are advocated in the recurrent or extensive lesions with regional or distant metastasis. Other modalities such as immunomodulation have been tried. A case of a 55-year-old female patient with a bleeding scalp lesion is presented. Initially thought to be a pyogenic granuloma, on excisional biopsy it was diagnosed as angiosarcoma with microscopic involvement of the margins. Wide excision with reconstruction using a local rotation flap was done at a second stage. The patient was not given postoperative radiotherapy or chemotherapy. There has been no recurrence for two years.

PMID: 19881033 [PubMed - in process]
Periaortic haemangiosarcoma in an African wild dog (Lycaon pictus).

Fetched: November 27th, 2009, 11:17am CST

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Periaortic haemangiosarcoma in an African wild dog (Lycaon pictus).

J S Afr Vet Assoc. 2009 Jun;80(2):108-10

Authors: Newell-Fugate A, Lane E

A 9-year-old apparently healthy male African wild dog (Lycaon pictus) was found dead in its enclosure at the De Wildt Cheetah and Wildlife Centre. Necropsy revealed a pericardium distended by approximately 250 ml of thick blood. A soft, red, lobulated mass was attached to the periaortic fat between the level of the aortic valves and the pericardial reflection. Histologically, the mass was consistent with a haemangiosarcoma. Other findings in the heart included mild to moderate ventricular hypertrophy and moderate, acute perivascular myocardial necrosis. Sudden death was attributed to acute heart failure precipitated by cardiac tamponade.

PMID: 19831274 [PubMed - indexed for MEDLINE]
[Atrial tumors in cardiac MRI]

Fetched: November 27th, 2009, 11:17am CST

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[Atrial tumors in cardiac MRI]

Rofo. 2009 Nov;181(11):1038-49

Authors: Kraemer N, Balzer JC, Schoth F, Neizel M, Kuehl H, Günther RW, Krombach G

Cardiac magnetic resonance imaging (MRI) is an important tool for the diagnosis of cardiac masses. Various cardiac tumors are predisposed to occurring in atrial structures. The aim of this review article is the description of atrial tumors and their morphological features in MRI. In general, cardiac tumors are rare: approximately 0.001 - 0.03 % in autopsy studies. About 75 % of them are benign. The most common cardiac tumor is the myxoma. They are predisposed to occur in the atria and show a characteristically strong hyperintense signal on T 2-wieghted images in MRI. In other sequences a heterogeneous pattern reflects its variable histological appearance. Lipomas exhibit a signal behavior identical to fatty tissue with a typical passive movement in cine imaging. Fibroelastomas are the most common tumors of the cardiac valves. Consisting of avascular fibrous tissue, they often present with hypointense signal intensities. Thrombi attached to their surface can cause severe emboli even in small tumors. Amongst primary cardiac malignancies, sarcomas are most common and favor the atria. Secondary malignancies of the heart are far more common than primary ones (20 - 40 times). In case of known malignancies, approximately 10 % of patients develop cardiac metastasis at the end of their disease. Lymphogenic metastases favor the pericardium, while hematogenic spread prefers the myocardium. Since they are not real atrial tumors, thrombi and anatomical structures of the atria have to be differentiated from other pathologies.

PMID: 19830642 [PubMed - indexed for MEDLINE]
[Persistent livid swelling of face and neck]

Fetched: November 27th, 2009, 11:17am CST

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[Persistent livid swelling of face and neck]

J Dtsch Dermatol Ges. 2009 Aug;7(8):719-21

Authors: Biesold S, Kowatzki D, Elsner P, Ziemer M

PMID: 19708954 [PubMed - indexed for MEDLINE]

Trial - Angiosarcoma

Paclitaxel + Bevacizumab (Avastin®) for the Treatment of Metastatic or Unresectable Angiosarcoma

Posted: January 21st, 2010, 9:00am CST

Condition: Hemangiosarcoma
Intervention: Drug: Paclitaxel in combination with Bevacizumab
Sponsors: Stanford University; Genentech
Not yet recruiting - verified February 2010

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